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The map label for this gene is acd-8

Identifier: 11498741

GI number: 11498741

Start: 1016291

End: 1017454

Strand: Reverse

Name: acd-8

Synonym: AF1141

Alternate gene names: 11498741

Gene position: 1017454-1016291 (Counterclockwise)

Preceding gene: 11498742

Following gene: 11498726

Centisome position: 46.71

GC content: 52.66

Gene sequence:

>1164_bases
ATGGCAATCGGTTTTACCTTTACCGAGGAGCAGGAGGATATAAGGAGAGCTGCAAGAGAGTTTGCGGAGAAGGAGTTCAC
GCCTGAGCTGGCGAGGGAGTGCGACAGGGAGGAGAAGTTCCCCTACGAGCTGTGGAAGAAGTGTGCAAAGCTTGGCTTTC
ATGCTGTCGACATCCCTGAGGAGTACGGTGGAGGCGGTTATGGGCCGATAGAGAAGATGATTGTGATGGAAGAGTTCTCA
GCCGTCAACCCCGGCCTCGGACTTGCGTGTTTGCTACCGACCTTCGGCTTTGAAATTCTTGTTCTGCACGGCAGCGAGGA
GCAGAAGGAGAAGTGGCTGACGAAGCTTGCAAGGGGAGACGTGATAATGGGCATGGCCAACACTGAGCCTGATGCGGGCA
GCGATGCTGCAAACATCAAAACGAGGGCCGTTAAGGAGGGAGATGAGTGGGTGATTAACGGGACGAAGCAGTTCATCAGC
AACGGCTCCATTGCGGACTTTCTGCTCGTCACTGCAAGGACGAGGGAGATGGACCCCAAGGCTAAGCACAGGGGAATAAG
CTACTTCATCGTTGAGACGAACAGGGAGGGTTACAAGGCGAACAAAATTAAGGGCAAGATGGGAATCAGGGCGACTGACA
CAGCAGAAATCAGCTTCAGCAATGTAAGAGTTCCGGCAGAGAACCTTGTCGGAGAGGAGGGCAAGGGATTCTACTACATG
ATGGAGTTCTTCGACATGAGCAGAGTGTGGGTTGGAGCGCAGGCTGTGGGGATTGCCAAAGGGGCTTTGAAGCTCGTAAT
TGACTACGTGAAGCAGAGAAAGGCCTTCAACGTTCCCCTCGCAACCTTCCAGTACATACAGTTCAAGATTGCCGAACTGG
CAACAAAGATTGAGGCTGCAAGAACCCTCGTTTACAGAGCCGCTGCTGTGCAGGTTGAGCAGGGCAAGCCTGACAACACC
CTCTCATCCATGGCGAAGTGGTATGCTGGAGAGGTGGCAGTTGAAACAGCCAACTGGGCTCTGCAGTTCCACGGAGGCTA
CGGATACATCGATGAGTATGCGATAAACCAGTTCTACAGGGATGCCAAAATCACAGAAATCTACGAGGGGGCGAAGGAGA
TAGAGAAGCTAATAATCGCAAGGAATCTTCTCGGATTCCGTTAA

Upstream 100 bases:

>100_bases
AAATAGACACCCCTGCGGACTTGATGAAGGCCAGATACGAAATCTACCCCAAAATCCAGTTTTGAGAAAAAGAAATATAG
ACCCATTTTTTACTTGAAGC

Downstream 100 bases:

>100_bases
ATTCTTCTCAATTTTTCAAAGAGTGCTGTCATAGCGAGAAGGGTGAGAACGGACGAGATTATATCGGCTACGGGCTGGGA
CAAAATAAACCTCGGCGATA

Product: acyl-CoA dehydrogenase (acd-8)

Products: 2,3-dehydroacyl-CoA; reduced acceptor

Alternate protein names: NA

Number of amino acids: Translated: 387; Mature: 386

Protein sequence:

>387_residues
MAIGFTFTEEQEDIRRAAREFAEKEFTPELARECDREEKFPYELWKKCAKLGFHAVDIPEEYGGGGYGPIEKMIVMEEFS
AVNPGLGLACLLPTFGFEILVLHGSEEQKEKWLTKLARGDVIMGMANTEPDAGSDAANIKTRAVKEGDEWVINGTKQFIS
NGSIADFLLVTARTREMDPKAKHRGISYFIVETNREGYKANKIKGKMGIRATDTAEISFSNVRVPAENLVGEEGKGFYYM
MEFFDMSRVWVGAQAVGIAKGALKLVIDYVKQRKAFNVPLATFQYIQFKIAELATKIEAARTLVYRAAAVQVEQGKPDNT
LSSMAKWYAGEVAVETANWALQFHGGYGYIDEYAINQFYRDAKITEIYEGAKEIEKLIIARNLLGFR

Sequences:

>Translated_387_residues
MAIGFTFTEEQEDIRRAAREFAEKEFTPELARECDREEKFPYELWKKCAKLGFHAVDIPEEYGGGGYGPIEKMIVMEEFS
AVNPGLGLACLLPTFGFEILVLHGSEEQKEKWLTKLARGDVIMGMANTEPDAGSDAANIKTRAVKEGDEWVINGTKQFIS
NGSIADFLLVTARTREMDPKAKHRGISYFIVETNREGYKANKIKGKMGIRATDTAEISFSNVRVPAENLVGEEGKGFYYM
MEFFDMSRVWVGAQAVGIAKGALKLVIDYVKQRKAFNVPLATFQYIQFKIAELATKIEAARTLVYRAAAVQVEQGKPDNT
LSSMAKWYAGEVAVETANWALQFHGGYGYIDEYAINQFYRDAKITEIYEGAKEIEKLIIARNLLGFR
>Mature_386_residues
AIGFTFTEEQEDIRRAAREFAEKEFTPELARECDREEKFPYELWKKCAKLGFHAVDIPEEYGGGGYGPIEKMIVMEEFSA
VNPGLGLACLLPTFGFEILVLHGSEEQKEKWLTKLARGDVIMGMANTEPDAGSDAANIKTRAVKEGDEWVINGTKQFISN
GSIADFLLVTARTREMDPKAKHRGISYFIVETNREGYKANKIKGKMGIRATDTAEISFSNVRVPAENLVGEEGKGFYYMM
EFFDMSRVWVGAQAVGIAKGALKLVIDYVKQRKAFNVPLATFQYIQFKIAELATKIEAARTLVYRAAAVQVEQGKPDNTL
SSMAKWYAGEVAVETANWALQFHGGYGYIDEYAINQFYRDAKITEIYEGAKEIEKLIIARNLLGFR

Specific function: Involved in the degradation of long-chain fatty acids [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the acyl-CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI4557233, Length=388, Percent_Identity=40.2061855670103, Blast_Score=268, Evalue=5e-72,
Organism=Homo sapiens, GI187960098, Length=382, Percent_Identity=37.9581151832461, Blast_Score=251, Evalue=7e-67,
Organism=Homo sapiens, GI4557231, Length=382, Percent_Identity=37.9581151832461, Blast_Score=251, Evalue=1e-66,
Organism=Homo sapiens, GI4501857, Length=384, Percent_Identity=37.5, Blast_Score=246, Evalue=3e-65,
Organism=Homo sapiens, GI226958412, Length=378, Percent_Identity=35.1851851851852, Blast_Score=244, Evalue=1e-64,
Organism=Homo sapiens, GI4501859, Length=379, Percent_Identity=35.3562005277045, Blast_Score=244, Evalue=1e-64,
Organism=Homo sapiens, GI7656849, Length=378, Percent_Identity=34.3915343915344, Blast_Score=238, Evalue=6e-63,
Organism=Homo sapiens, GI226958414, Length=340, Percent_Identity=35.8823529411765, Blast_Score=228, Evalue=9e-60,
Organism=Homo sapiens, GI21361497, Length=389, Percent_Identity=34.9614395886889, Blast_Score=216, Evalue=3e-56,
Organism=Homo sapiens, GI76496475, Length=342, Percent_Identity=32.7485380116959, Blast_Score=186, Evalue=3e-47,
Organism=Homo sapiens, GI4557235, Length=342, Percent_Identity=32.7485380116959, Blast_Score=186, Evalue=4e-47,
Organism=Homo sapiens, GI4503943, Length=389, Percent_Identity=28.2776349614396, Blast_Score=137, Evalue=2e-32,
Organism=Homo sapiens, GI7669494, Length=371, Percent_Identity=28.0323450134771, Blast_Score=124, Evalue=1e-28,
Organism=Homo sapiens, GI38505218, Length=301, Percent_Identity=31.5614617940199, Blast_Score=123, Evalue=3e-28,
Organism=Homo sapiens, GI211971008, Length=304, Percent_Identity=31.5789473684211, Blast_Score=119, Evalue=6e-27,
Organism=Homo sapiens, GI48976061, Length=304, Percent_Identity=31.5789473684211, Blast_Score=119, Evalue=7e-27,
Organism=Escherichia coli, GI87081958, Length=385, Percent_Identity=32.987012987013, Blast_Score=188, Evalue=5e-49,
Organism=Escherichia coli, GI1786223, Length=382, Percent_Identity=28.7958115183246, Blast_Score=169, Evalue=3e-43,
Organism=Escherichia coli, GI87082384, Length=274, Percent_Identity=25.1824817518248, Blast_Score=81, Evalue=9e-17,
Organism=Escherichia coli, GI87081702, Length=405, Percent_Identity=24.4444444444444, Blast_Score=81, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI17534899, Length=382, Percent_Identity=37.696335078534, Blast_Score=263, Evalue=2e-70,
Organism=Caenorhabditis elegans, GI17569725, Length=386, Percent_Identity=37.3056994818653, Blast_Score=256, Evalue=2e-68,
Organism=Caenorhabditis elegans, GI17570075, Length=381, Percent_Identity=36.745406824147, Blast_Score=253, Evalue=1e-67,
Organism=Caenorhabditis elegans, GI17506239, Length=376, Percent_Identity=37.5, Blast_Score=241, Evalue=3e-64,
Organism=Caenorhabditis elegans, GI17508101, Length=376, Percent_Identity=36.1702127659575, Blast_Score=236, Evalue=1e-62,
Organism=Caenorhabditis elegans, GI17538396, Length=382, Percent_Identity=34.5549738219895, Blast_Score=234, Evalue=5e-62,
Organism=Caenorhabditis elegans, GI17533517, Length=382, Percent_Identity=34.2931937172775, Blast_Score=232, Evalue=3e-61,
Organism=Caenorhabditis elegans, GI71990804, Length=296, Percent_Identity=36.8243243243243, Blast_Score=189, Evalue=2e-48,
Organism=Caenorhabditis elegans, GI71985184, Length=352, Percent_Identity=32.9545454545455, Blast_Score=186, Evalue=1e-47,
Organism=Caenorhabditis elegans, GI17551932, Length=378, Percent_Identity=29.6296296296296, Blast_Score=174, Evalue=5e-44,
Organism=Caenorhabditis elegans, GI71982178, Length=278, Percent_Identity=36.3309352517986, Blast_Score=174, Evalue=8e-44,
Organism=Caenorhabditis elegans, GI17505929, Length=371, Percent_Identity=30.188679245283, Blast_Score=171, Evalue=8e-43,
Organism=Caenorhabditis elegans, GI32563615, Length=232, Percent_Identity=38.3620689655172, Blast_Score=166, Evalue=2e-41,
Organism=Caenorhabditis elegans, GI71985192, Length=280, Percent_Identity=33.2142857142857, Blast_Score=153, Evalue=2e-37,
Organism=Caenorhabditis elegans, GI17534353, Length=383, Percent_Identity=27.9373368146214, Blast_Score=150, Evalue=1e-36,
Organism=Caenorhabditis elegans, GI17531909, Length=243, Percent_Identity=35.8024691358025, Blast_Score=148, Evalue=6e-36,
Organism=Caenorhabditis elegans, GI17562446, Length=303, Percent_Identity=32.013201320132, Blast_Score=123, Evalue=2e-28,
Organism=Caenorhabditis elegans, GI17531913, Length=175, Percent_Identity=34.8571428571429, Blast_Score=102, Evalue=3e-22,
Organism=Caenorhabditis elegans, GI86563383, Length=276, Percent_Identity=26.0869565217391, Blast_Score=83, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI86563381, Length=276, Percent_Identity=26.0869565217391, Blast_Score=83, Evalue=2e-16,
Organism=Drosophila melanogaster, GI24660351, Length=380, Percent_Identity=38.6842105263158, Blast_Score=259, Evalue=3e-69,
Organism=Drosophila melanogaster, GI21356377, Length=388, Percent_Identity=37.3711340206186, Blast_Score=250, Evalue=1e-66,
Organism=Drosophila melanogaster, GI24646207, Length=378, Percent_Identity=37.037037037037, Blast_Score=248, Evalue=5e-66,
Organism=Drosophila melanogaster, GI24666513, Length=378, Percent_Identity=36.7724867724868, Blast_Score=241, Evalue=4e-64,
Organism=Drosophila melanogaster, GI21355753, Length=382, Percent_Identity=36.9109947643979, Blast_Score=241, Evalue=7e-64,
Organism=Drosophila melanogaster, GI281363737, Length=380, Percent_Identity=32.6315789473684, Blast_Score=187, Evalue=1e-47,
Organism=Drosophila melanogaster, GI19920834, Length=385, Percent_Identity=27.5324675324675, Blast_Score=133, Evalue=2e-31,
Organism=Drosophila melanogaster, GI24652780, Length=285, Percent_Identity=23.859649122807, Blast_Score=73, Evalue=4e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006089
- InterPro:   IPR006092
- InterPro:   IPR006090
- InterPro:   IPR006091
- InterPro:   IPR009075
- InterPro:   IPR013786
- InterPro:   IPR009100 [H]

Pfam domain/function: PF00441 Acyl-CoA_dh_1; PF02770 Acyl-CoA_dh_M; PF02771 Acyl-CoA_dh_N [H]

EC number: 1.3.99.3

Molecular weight: Translated: 43460; Mature: 43329

Theoretical pI: Translated: 5.42; Mature: 5.42

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAIGFTFTEEQEDIRRAAREFAEKEFTPELARECDREEKFPYELWKKCAKLGFHAVDIPE
CEECCCCCCCHHHHHHHHHHHHHHCCCHHHHHHCCCCCCCCHHHHHHHHHCCCEEEECCH
EYGGGGYGPIEKMIVMEEFSAVNPGLGLACLLPTFGFEILVLHGSEEQKEKWLTKLARGD
HHCCCCCCHHHHHHHHHHHHCCCCCCCHHHHHHHCCEEEEEEECCCHHHHHHHHHHHCCC
VIMGMANTEPDAGSDAANIKTRAVKEGDEWVINGTKQFISNGSIADFLLVTARTREMDPK
EEEEECCCCCCCCCCCCCCHHHHCCCCCCEEECCHHHHHCCCCHHHHHEEEHHCCCCCCH
AKHRGISYFIVETNREGYKANKIKGKMGIRATDTAEISFSNVRVPAENLVGEEGKGFYYM
HHHCCEEEEEEECCCCCCCCCCCCCCCCCEECCCCEEEECCEECCHHHHCCCCCCCEEEH
MEFFDMSRVWVGAQAVGIAKGALKLVIDYVKQRKAFNVPLATFQYIQFKIAELATKIEAA
HHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHH
RTLVYRAAAVQVEQGKPDNTLSSMAKWYAGEVAVETANWALQFHGGYGYIDEYAINQFYR
HHHHHHHHHEEEECCCCCHHHHHHHHHHCCCEEEEEEEEEEEECCCCCCHHHHHHHHHHH
DAKITEIYEGAKEIEKLIIARNLLGFR
CCHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
AIGFTFTEEQEDIRRAAREFAEKEFTPELARECDREEKFPYELWKKCAKLGFHAVDIPE
EECCCCCCCHHHHHHHHHHHHHHCCCHHHHHHCCCCCCCCHHHHHHHHHCCCEEEECCH
EYGGGGYGPIEKMIVMEEFSAVNPGLGLACLLPTFGFEILVLHGSEEQKEKWLTKLARGD
HHCCCCCCHHHHHHHHHHHHCCCCCCCHHHHHHHCCEEEEEEECCCHHHHHHHHHHHCCC
VIMGMANTEPDAGSDAANIKTRAVKEGDEWVINGTKQFISNGSIADFLLVTARTREMDPK
EEEEECCCCCCCCCCCCCCHHHHCCCCCCEEECCHHHHHCCCCHHHHHEEEHHCCCCCCH
AKHRGISYFIVETNREGYKANKIKGKMGIRATDTAEISFSNVRVPAENLVGEEGKGFYYM
HHHCCEEEEEEECCCCCCCCCCCCCCCCCEECCCCEEEECCEECCHHHHCCCCCCCEEEH
MEFFDMSRVWVGAQAVGIAKGALKLVIDYVKQRKAFNVPLATFQYIQFKIAELATKIEAA
HHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHH
RTLVYRAAAVQVEQGKPDNTLSSMAKWYAGEVAVETANWALQFHGGYGYIDEYAINQFYR
HHHHHHHHHEEEECCCCCHHHHHHHHHHCCCEEEEEEEEEEEECCCCCCHHHHHHHHHHH
DAKITEIYEGAKEIEKLIIARNLLGFR
CCHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: acyl-CoA; acceptor

Specific reaction: acyl-CoA + acceptor = 2,3-dehydroacyl-CoA + reduced acceptor

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9353933; 9384377 [H]