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The map label for this gene is cheA

Identifier: 11498645

GI number: 11498645

Start: 946246

End: 948216

Strand: Reverse

Name: cheA

Synonym: AF1040

Alternate gene names: 11498645

Gene position: 948216-946246 (Counterclockwise)

Preceding gene: 11498646

Following gene: 11498644

Centisome position: 43.53

GC content: 50.08

Gene sequence:

>1971_bases
ATGAGCGATGAAATGGAGGAGTACAAGCAGGAGTTCATACAGGAGGCCAGAGAGTACCTTGACGTGATGAATCAGAACTT
CATAAAGGTTGAGAAAGGGGACGTTGATGCAATTAACGAGATTTTCAGAGTGGCCCACACGATTAAGGGAATGGCAGGTT
TCATGGGCTACAAGAATCTTGAGGAACTCTGCCACAAGCTCGAGAGTGCGATGGGGAAAGTGAGGGATGGGGAGATAGAG
GTTACAGAAGAGCTCATCGACGTAATGCTGAAGGCTGTGGACGCAATAGGGGAGATGATAGACAGAATTGAGGATGAAGA
TAGCGACAGCGTTGATGTTAGGGACATTATTGAAGCTCTCACGATGTTTATGGAGAGCAGGGAAGAGGAGGAAGTTGCTG
ACAGGCATGAGCTTAAACCTGCAACTGCAAACCTCAGGGTTGATGTTTACATCAGCGAAGATTGCGTGATGAAGAGCGTT
AGGGCAGCACTCGTTGTTGAAGCTCTCAGCGAGGTTGCCGAAGTTGTTGGAGTAATCCCCGACGAGAGCGATATGGAGAA
GGAAACCTTCGACGGTCATTTCGTTGTTTACCTAAACGCTCCTGACGCTTCGGTTGTAGAAGATACTATCAGCAAGATTG
CGGAGATTGACAGGTTTGAAGTTAGCCCCGTTGACGGTGAAACAGTAGAGATGGGACAGGCTGTTAGCGAGGAGGAAGCT
GAGGAAAAAGCGGAAGGTGCTGCAAGGGCTGAAACCGAAGCGAAAGTTGAGAAGACGGAGAAGAGAGTGGATCCCGGCAG
GAAGGATAAGAAAAAGCTCGAAAGCATAAGGGTGAACATATCGCAGCTTGACACGATAATGAACCTCGTCGGGGAGCTTG
TGATAAGCAAGGGAAGGCTATTGCAGATTGCAAGCGAGTACGACATTCCTGAGCTGAAGGAAGCCGTTGCAATTATGGAT
AAGTCCATAACGAGCCTTCAGGACGAGATAATGCAGATAAGGATGGTGAGAGTTGAGAGGGTTTTCAGCAAGTTCCCGAG
GATGGTCAGAGACTTGGCGAGAAAGCTCGGCAAGAAGATTGACTTCACTATGGAGGGGCTTGAGACGGAGCTTGACAGAA
CAGTTCTCGATGAGATTAGCGACCCGCTGGTTCACCTTGTCAGGAACGCCGTTGACCACGGCATTGAAACTCCGGAAGAA
AGGGTGGCTGCAGGGAAGGATGAAGTGGGAAGAATTAAGCTCGCTGCCTGGAGGGAGAAGAACAACATCATTATCGAGCT
TGAGGATGACGGCAGAGGGCTTGACGTTGAGAAGATTAAGCAGAAGGCAATTGAGAAGGGGATAGTCTCTCCTGCCGAAG
CAGACTCGATGAGCGAGGACGAGATTAAGATGCTCATCTTCTCTCCTGGATTCTCGACCAAGGATGAGGCAACTGAGGTT
TCCGGAAGGGGCGTGGGGATGGATGTTGTAAAAACAACCGTTGAGAGGCTTGGCGGCAGTGTGAGGATATCTTCGGAGAA
GGGGAATGGGACGAGGATCAGAATACATCTCCCGCCAACAGTCGCGATCGTGAAGTCCCTGCTTGTGAAGGTGGCAAACG
AAACGTACGCAATACCGATTTCAAGCGTAGTAGAGGCTTTGTACGTCGGAGAGGATAACTGGAAGGTTATACACGGCAAC
CCGTTTTTGATCGTCCGTGGAAAGCTCGTTCCGGCCTTCAAGCTGAGGGAGCTGTTTAACGTGAGGAATGGGAGGCCTGA
GAGGGAAGTTGGTATTATCGTTGAGAAGGAGGGCGAGAAGTACGCCCTGATTGCAGACACCATAGCGGAGCAGCAGGAGA
TAGTTATAAAGCCCCTGACGGGGTATCTGGCCAAGATAAAGGGGTTTAGCGGAGTTACGATTTTGGGGGACGGGAGAGTT
GTGCCGATTCTTGACGTGTCAAGTTTGTTGGGAGGTGATAGGCTTGCATAG

Upstream 100 bases:

>100_bases
GGCATGCCGAAGGCGGCAATTGAGCTTGGCGGAATAACTTCGGTAAAGCCCGTTTTTGAGATTGCCGAGGAGATAGTCCG
GTTTTTGGAGGTGAAGCTTA

Downstream 100 bases:

>100_bases
CATTGAGGATTTTGGTGAGATGGAGCTTGATGCTTTGAAGGAGTTGGGGAACATCGGCGTGGGGAAGGCTGCCACTTCTC
TGTCCCAGATGCTCGGCAGA

Product: chemotaxis histidine kinase (cheA)

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 656; Mature: 655

Protein sequence:

>656_residues
MSDEMEEYKQEFIQEAREYLDVMNQNFIKVEKGDVDAINEIFRVAHTIKGMAGFMGYKNLEELCHKLESAMGKVRDGEIE
VTEELIDVMLKAVDAIGEMIDRIEDEDSDSVDVRDIIEALTMFMESREEEEVADRHELKPATANLRVDVYISEDCVMKSV
RAALVVEALSEVAEVVGVIPDESDMEKETFDGHFVVYLNAPDASVVEDTISKIAEIDRFEVSPVDGETVEMGQAVSEEEA
EEKAEGAARAETEAKVEKTEKRVDPGRKDKKKLESIRVNISQLDTIMNLVGELVISKGRLLQIASEYDIPELKEAVAIMD
KSITSLQDEIMQIRMVRVERVFSKFPRMVRDLARKLGKKIDFTMEGLETELDRTVLDEISDPLVHLVRNAVDHGIETPEE
RVAAGKDEVGRIKLAAWREKNNIIIELEDDGRGLDVEKIKQKAIEKGIVSPAEADSMSEDEIKMLIFSPGFSTKDEATEV
SGRGVGMDVVKTTVERLGGSVRISSEKGNGTRIRIHLPPTVAIVKSLLVKVANETYAIPISSVVEALYVGEDNWKVIHGN
PFLIVRGKLVPAFKLRELFNVRNGRPEREVGIIVEKEGEKYALIADTIAEQQEIVIKPLTGYLAKIKGFSGVTILGDGRV
VPILDVSSLLGGDRLA

Sequences:

>Translated_656_residues
MSDEMEEYKQEFIQEAREYLDVMNQNFIKVEKGDVDAINEIFRVAHTIKGMAGFMGYKNLEELCHKLESAMGKVRDGEIE
VTEELIDVMLKAVDAIGEMIDRIEDEDSDSVDVRDIIEALTMFMESREEEEVADRHELKPATANLRVDVYISEDCVMKSV
RAALVVEALSEVAEVVGVIPDESDMEKETFDGHFVVYLNAPDASVVEDTISKIAEIDRFEVSPVDGETVEMGQAVSEEEA
EEKAEGAARAETEAKVEKTEKRVDPGRKDKKKLESIRVNISQLDTIMNLVGELVISKGRLLQIASEYDIPELKEAVAIMD
KSITSLQDEIMQIRMVRVERVFSKFPRMVRDLARKLGKKIDFTMEGLETELDRTVLDEISDPLVHLVRNAVDHGIETPEE
RVAAGKDEVGRIKLAAWREKNNIIIELEDDGRGLDVEKIKQKAIEKGIVSPAEADSMSEDEIKMLIFSPGFSTKDEATEV
SGRGVGMDVVKTTVERLGGSVRISSEKGNGTRIRIHLPPTVAIVKSLLVKVANETYAIPISSVVEALYVGEDNWKVIHGN
PFLIVRGKLVPAFKLRELFNVRNGRPEREVGIIVEKEGEKYALIADTIAEQQEIVIKPLTGYLAKIKGFSGVTILGDGRV
VPILDVSSLLGGDRLA
>Mature_655_residues
SDEMEEYKQEFIQEAREYLDVMNQNFIKVEKGDVDAINEIFRVAHTIKGMAGFMGYKNLEELCHKLESAMGKVRDGEIEV
TEELIDVMLKAVDAIGEMIDRIEDEDSDSVDVRDIIEALTMFMESREEEEVADRHELKPATANLRVDVYISEDCVMKSVR
AALVVEALSEVAEVVGVIPDESDMEKETFDGHFVVYLNAPDASVVEDTISKIAEIDRFEVSPVDGETVEMGQAVSEEEAE
EKAEGAARAETEAKVEKTEKRVDPGRKDKKKLESIRVNISQLDTIMNLVGELVISKGRLLQIASEYDIPELKEAVAIMDK
SITSLQDEIMQIRMVRVERVFSKFPRMVRDLARKLGKKIDFTMEGLETELDRTVLDEISDPLVHLVRNAVDHGIETPEER
VAAGKDEVGRIKLAAWREKNNIIIELEDDGRGLDVEKIKQKAIEKGIVSPAEADSMSEDEIKMLIFSPGFSTKDEATEVS
GRGVGMDVVKTTVERLGGSVRISSEKGNGTRIRIHLPPTVAIVKSLLVKVANETYAIPISSVVEALYVGEDNWKVIHGNP
FLIVRGKLVPAFKLRELFNVRNGRPEREVGIIVEKEGEKYALIADTIAEQQEIVIKPLTGYLAKIKGFSGVTILGDGRVV
PILDVSSLLGGDRLA

Specific function: Involved in the transmission of sensory signals from the chemoreceptors to the flagellar motors. CheA is autophosphorylated; it can transfer its phosphate group to either CheB or CheY [H]

COG id: COG0643

COG function: function code NT; Chemotaxis protein histidine kinase and related kinases

Gene ontology:

Cell location: Membrane (Potential). Note=It is not known whether CheA is actually membrane bound although CheA has two regions at the C-terminal end with the potential to be transmembrane regions [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HPt domain [H]

Homologues:

Organism=Escherichia coli, GI1788197, Length=676, Percent_Identity=35.9467455621302, Blast_Score=379, Evalue=1e-106,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR002545
- InterPro:   IPR004358
- InterPro:   IPR008207
- InterPro:   IPR004105
- InterPro:   IPR005467
- InterPro:   IPR009082
- InterPro:   IPR010808 [H]

Pfam domain/function: PF01584 CheW; PF02895 H-kinase_dim; PF02518 HATPase_c; PF01627 Hpt; PF07194 P2 [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 73043; Mature: 72912

Theoretical pI: Translated: 4.43; Mature: 4.43

Prosite motif: PS50851 CHEW ; PS50894 HPT ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDEMEEYKQEFIQEAREYLDVMNQNFIKVEKGDVDAINEIFRVAHTIKGMAGFMGYKNL
CCCHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHCHHHH
EELCHKLESAMGKVRDGEIEVTEELIDVMLKAVDAIGEMIDRIEDEDSDSVDVRDIIEAL
HHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHH
TMFMESREEEEVADRHELKPATANLRVDVYISEDCVMKSVRAALVVEALSEVAEVVGVIP
HHHHHCCCHHHHHHHHHCCCCCCCEEEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHCCC
DESDMEKETFDGHFVVYLNAPDASVVEDTISKIAEIDRFEVSPVDGETVEMGQAVSEEEA
CCCCCCHHHCCCEEEEEEECCCHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHH
EEKAEGAARAETEAKVEKTEKRVDPGRKDKKKLESIRVNISQLDTIMNLVGELVISKGRL
HHHHHCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCE
LQIASEYDIPELKEAVAIMDKSITSLQDEIMQIRMVRVERVFSKFPRMVRDLARKLGKKI
EEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
DFTMEGLETELDRTVLDEISDPLVHLVRNAVDHGIETPEERVAAGKDEVGRIKLAAWREK
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHCCCCCCCEEEEEEEECC
NNIIIELEDDGRGLDVEKIKQKAIEKGIVSPAEADSMSEDEIKMLIFSPGFSTKDEATEV
CCEEEEECCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCEEEEEECCCCCCCCHHHHC
SGRGVGMDVVKTTVERLGGSVRISSEKGNGTRIRIHLPPTVAIVKSLLVKVANETYAIPI
CCCCCCHHHHHHHHHHCCCCEEEECCCCCCCEEEEECCCHHHHHHHHHHHHHCCCEEEEH
SSVVEALYVGEDNWKVIHGNPFLIVRGKLVPAFKLRELFNVRNGRPEREVGIIVEKEGEK
HHHHHHHHCCCCCCEEEECCEEEEEECCCCCHHHHHHHHHHCCCCCCCCEEEEEECCCCE
YALIADTIAEQQEIVIKPLTGYLAKIKGFSGVTILGDGRVVPILDVSSLLGGDRLA
EEEEHHHHHCCHHEEEEHHHHHHHHHCCCCCEEEEECCEEEEEEEHHHHCCCCCCC
>Mature Secondary Structure 
SDEMEEYKQEFIQEAREYLDVMNQNFIKVEKGDVDAINEIFRVAHTIKGMAGFMGYKNL
CCHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHCHHHH
EELCHKLESAMGKVRDGEIEVTEELIDVMLKAVDAIGEMIDRIEDEDSDSVDVRDIIEAL
HHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHH
TMFMESREEEEVADRHELKPATANLRVDVYISEDCVMKSVRAALVVEALSEVAEVVGVIP
HHHHHCCCHHHHHHHHHCCCCCCCEEEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHCCC
DESDMEKETFDGHFVVYLNAPDASVVEDTISKIAEIDRFEVSPVDGETVEMGQAVSEEEA
CCCCCCHHHCCCEEEEEEECCCHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHH
EEKAEGAARAETEAKVEKTEKRVDPGRKDKKKLESIRVNISQLDTIMNLVGELVISKGRL
HHHHHCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCE
LQIASEYDIPELKEAVAIMDKSITSLQDEIMQIRMVRVERVFSKFPRMVRDLARKLGKKI
EEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
DFTMEGLETELDRTVLDEISDPLVHLVRNAVDHGIETPEERVAAGKDEVGRIKLAAWREK
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHCCCCCCCEEEEEEEECC
NNIIIELEDDGRGLDVEKIKQKAIEKGIVSPAEADSMSEDEIKMLIFSPGFSTKDEATEV
CCEEEEECCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCEEEEEECCCCCCCCHHHHC
SGRGVGMDVVKTTVERLGGSVRISSEKGNGTRIRIHLPPTVAIVKSLLVKVANETYAIPI
CCCCCCHHHHHHHHHHCCCCEEEECCCCCCCEEEEECCCHHHHHHHHHHHHHCCCEEEEH
SSVVEALYVGEDNWKVIHGNPFLIVRGKLVPAFKLRELFNVRNGRPEREVGIIVEKEGEK
HHHHHHHHCCCCCCEEEECCEEEEEECCCCCHHHHHHHHHHCCCCCCCCEEEEEECCCCE
YALIADTIAEQQEIVIKPLTGYLAKIKGFSGVTILGDGRVVPILDVSSLLGGDRLA
EEEEHHHHHCCHHEEEEHHHHHHHHHCCCCCEEEEECCEEEEEEEHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 1938941; 9384377 [H]