Click here to switch to the map view.

The map label for this gene is fadA-1

Identifier: 11498633

GI number: 11498633

Start: 930225

End: 931415

Strand: Reverse

Name: fadA-1

Synonym: AF1028

Alternate gene names: 11498633

Gene position: 931415-930225 (Counterclockwise)

Preceding gene: 11498634

Following gene: 11498632

Centisome position: 42.76

GC content: 55.33

Gene sequence:

>1191_bases
GTGGAAGAAGTGTATATTGTAGAGTATGCAAGAACGCCCTTTTCGAGAAGCAGGCCGAAGAAGCCCGAAAGGGACGTGTT
CCACAAGATTAGAGGAGACGAGCTAATGGCGTTGGTTCTGGAAAAGCTGCCTGAGAGGGCGGGGATTGAGAAGAAGGAAG
TTGGGAGGATTTTACTCGGATGCGCCTTTCCGGTGTCGGAGAACTGGCCTTACGGAGGGAAGATGGCGTCGCTGCTGGCA
AAGTACCCTCCCGAAACCTCAGCAAGCCACGTGGACATGCAGTGCGGGTCGTCCCTTGCAACAACCGCCTACGCGTATCT
GGAAATTGCAAGCGGAAACGAGGACATGATGATTTCCGGCGGTTACGAGCACATGACGAGGGTGCCGATGGGTGCCGACA
ATCCGCACGTTGACCGCCATCCGAAGTTGCTCACGGAGGAGTACAAGGACTACAGAATGGACATCGGGTTTGTCATGGGC
TTGACTGCGGAAACGCTCTTTGAGATGGCGGGCTACCTGACCAAAGAGGACCTCGACAGGTGGTCTCTGAGGAGCCACCA
GCTTGCTGCCAAGGCCCTCAAAGATGGTTACTTCAAGGGGGAGATAATCCCCGTTGAAGCCCCGCAGGCTGATGGTAGTG
TGATAACCGTGGATTCGGATCAGTCAATAAGGCCAGACACATCCCTTGAGCAGATAGCCTCTCTGCCACCAGCCTTTAAG
CCTGGAGGGGTGATTACAGCCGGAAACTCCTCTCCTCTCAACGCTGGAGCTTCAGGCCTGCTGCTTGCCTCTAAAAAGAA
GGTTCAGGAGCTTGGACTTGAGCCAATCGCCAAAATCATCGGATACGGCACAGCGGGAGTGCCTCCTTACATAATGGGAG
CAGGGCCGGTTCCTGCAAGCAGAAAGGCTCTGGAAAAAACTGGCTTGAAGGTGAGCGACATAGACTACTGGGAGATTAAC
GAGGCCTTTGCGATAGTCCCGCTTTACGCCATCCACGAGCTCGGAATTGAGCCGGAGAGGGTGAATATACATGGTGGTGC
AGTTGCCATCGGTCATCCTCTGGCAGCGAGCGGTGCGAGGCTGATTGGCACGCTGGCAAGAATCCTTCAGGAGAACAATG
GCGATTACGGCGTGGCAACCGCCTGCGTCGGCGGCGGACAGGGCGCGGCGGTTGTAATTGAGAGAGTTTAA

Upstream 100 bases:

>100_bases
ATTGTTGAATTCAGGGATGAGCTCCCCAAGTCCGCTGCTGGGAAGTATTTGAGGAGAATTTTGAGAGAGGAGGAATTGAA
GAAGATGAAGAGGTGATTTC

Downstream 100 bases:

>100_bases
TTTTTTTAAAAAATATTTTTAAAAATTAATTGTGTTGGTGATGTTATGAGAACATCGGAGGAATACAGGCAGGATTTGTA
TAAGCTGAAGCCGAATGTTT

Product: acetyl-CoA acetyltransferase

Products: NA

Alternate protein names: Acetyl-CoA acyltransferase; Beta-ketothiolase; Fatty acid oxidation complex subunit beta [H]

Number of amino acids: Translated: 396; Mature: 396

Protein sequence:

>396_residues
MEEVYIVEYARTPFSRSRPKKPERDVFHKIRGDELMALVLEKLPERAGIEKKEVGRILLGCAFPVSENWPYGGKMASLLA
KYPPETSASHVDMQCGSSLATTAYAYLEIASGNEDMMISGGYEHMTRVPMGADNPHVDRHPKLLTEEYKDYRMDIGFVMG
LTAETLFEMAGYLTKEDLDRWSLRSHQLAAKALKDGYFKGEIIPVEAPQADGSVITVDSDQSIRPDTSLEQIASLPPAFK
PGGVITAGNSSPLNAGASGLLLASKKKVQELGLEPIAKIIGYGTAGVPPYIMGAGPVPASRKALEKTGLKVSDIDYWEIN
EAFAIVPLYAIHELGIEPERVNIHGGAVAIGHPLAASGARLIGTLARILQENNGDYGVATACVGGGQGAAVVIERV

Sequences:

>Translated_396_residues
MEEVYIVEYARTPFSRSRPKKPERDVFHKIRGDELMALVLEKLPERAGIEKKEVGRILLGCAFPVSENWPYGGKMASLLA
KYPPETSASHVDMQCGSSLATTAYAYLEIASGNEDMMISGGYEHMTRVPMGADNPHVDRHPKLLTEEYKDYRMDIGFVMG
LTAETLFEMAGYLTKEDLDRWSLRSHQLAAKALKDGYFKGEIIPVEAPQADGSVITVDSDQSIRPDTSLEQIASLPPAFK
PGGVITAGNSSPLNAGASGLLLASKKKVQELGLEPIAKIIGYGTAGVPPYIMGAGPVPASRKALEKTGLKVSDIDYWEIN
EAFAIVPLYAIHELGIEPERVNIHGGAVAIGHPLAASGARLIGTLARILQENNGDYGVATACVGGGQGAAVVIERV
>Mature_396_residues
MEEVYIVEYARTPFSRSRPKKPERDVFHKIRGDELMALVLEKLPERAGIEKKEVGRILLGCAFPVSENWPYGGKMASLLA
KYPPETSASHVDMQCGSSLATTAYAYLEIASGNEDMMISGGYEHMTRVPMGADNPHVDRHPKLLTEEYKDYRMDIGFVMG
LTAETLFEMAGYLTKEDLDRWSLRSHQLAAKALKDGYFKGEIIPVEAPQADGSVITVDSDQSIRPDTSLEQIASLPPAFK
PGGVITAGNSSPLNAGASGLLLASKKKVQELGLEPIAKIIGYGTAGVPPYIMGAGPVPASRKALEKTGLKVSDIDYWEIN
EAFAIVPLYAIHELGIEPERVNIHGGAVAIGHPLAASGARLIGTLARILQENNGDYGVATACVGGGQGAAVVIERV

Specific function: Catalyzes the final step of fatty acid oxidation in which acetyl-CoA is released and the CoA ester of a fatty acid two carbons shorter is formed [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thiolase family [H]

Homologues:

Organism=Homo sapiens, GI4501853, Length=403, Percent_Identity=36.9727047146402, Blast_Score=221, Evalue=1e-57,
Organism=Homo sapiens, GI167614485, Length=402, Percent_Identity=32.3383084577114, Blast_Score=216, Evalue=4e-56,
Organism=Homo sapiens, GI148539872, Length=405, Percent_Identity=33.3333333333333, Blast_Score=204, Evalue=2e-52,
Organism=Homo sapiens, GI4557237, Length=400, Percent_Identity=30.75, Blast_Score=177, Evalue=1e-44,
Organism=Homo sapiens, GI4504327, Length=438, Percent_Identity=30.8219178082192, Blast_Score=159, Evalue=3e-39,
Organism=Homo sapiens, GI194353979, Length=397, Percent_Identity=27.2040302267003, Blast_Score=114, Evalue=2e-25,
Organism=Escherichia coli, GI48994986, Length=401, Percent_Identity=40.8977556109726, Blast_Score=261, Evalue=6e-71,
Organism=Escherichia coli, GI1787663, Length=408, Percent_Identity=37.7450980392157, Blast_Score=258, Evalue=4e-70,
Organism=Escherichia coli, GI87082165, Length=407, Percent_Identity=34.8894348894349, Blast_Score=218, Evalue=6e-58,
Organism=Escherichia coli, GI1788554, Length=371, Percent_Identity=36.1185983827493, Blast_Score=205, Evalue=4e-54,
Organism=Escherichia coli, GI1788683, Length=433, Percent_Identity=29.3302540415704, Blast_Score=140, Evalue=2e-34,
Organism=Caenorhabditis elegans, GI133906874, Length=402, Percent_Identity=33.8308457711443, Blast_Score=210, Evalue=8e-55,
Organism=Caenorhabditis elegans, GI25147385, Length=403, Percent_Identity=32.5062034739454, Blast_Score=197, Evalue=7e-51,
Organism=Caenorhabditis elegans, GI17535921, Length=402, Percent_Identity=33.5820895522388, Blast_Score=186, Evalue=2e-47,
Organism=Caenorhabditis elegans, GI17551802, Length=439, Percent_Identity=29.6127562642369, Blast_Score=142, Evalue=3e-34,
Organism=Caenorhabditis elegans, GI17535917, Length=398, Percent_Identity=27.1356783919598, Blast_Score=133, Evalue=2e-31,
Organism=Saccharomyces cerevisiae, GI6322031, Length=326, Percent_Identity=38.0368098159509, Blast_Score=197, Evalue=3e-51,
Organism=Saccharomyces cerevisiae, GI6325229, Length=406, Percent_Identity=33.4975369458128, Blast_Score=182, Evalue=8e-47,
Organism=Drosophila melanogaster, GI24655093, Length=403, Percent_Identity=35.4838709677419, Blast_Score=245, Evalue=4e-65,
Organism=Drosophila melanogaster, GI17648125, Length=405, Percent_Identity=31.8518518518519, Blast_Score=201, Evalue=6e-52,
Organism=Drosophila melanogaster, GI24640423, Length=404, Percent_Identity=29.7029702970297, Blast_Score=177, Evalue=9e-45,
Organism=Drosophila melanogaster, GI17137578, Length=438, Percent_Identity=31.2785388127854, Blast_Score=158, Evalue=6e-39,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012805
- InterPro:   IPR002155
- InterPro:   IPR016039
- InterPro:   IPR016038
- InterPro:   IPR020615
- InterPro:   IPR020610
- InterPro:   IPR020617
- InterPro:   IPR020613
- InterPro:   IPR020616 [H]

Pfam domain/function: PF02803 Thiolase_C; PF00108 Thiolase_N [H]

EC number: =2.3.1.16 [H]

Molecular weight: Translated: 42591; Mature: 42591

Theoretical pI: Translated: 5.47; Mature: 5.47

Prosite motif: PS00737 THIOLASE_2 ; PS00099 THIOLASE_3 ; PS00178 AA_TRNA_LIGASE_I

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEEVYIVEYARTPFSRSRPKKPERDVFHKIRGDELMALVLEKLPERAGIEKKEVGRILLG
CCCEEEEEEECCCCCCCCCCCCHHHHHHHHCCHHHHHHHHHHHHHHHCCCHHHHCEEEEE
CAFPVSENWPYGGKMASLLAKYPPETSASHVDMQCGSSLATTAYAYLEIASGNEDMMISG
EECCCCCCCCCCHHHHHHHHHCCCCCCCCEEEHHCCCHHHHHEEEEEEEECCCCCEEEEC
GYEHMTRVPMGADNPHVDRHPKLLTEEYKDYRMDIGFVMGLTAETLFEMAGYLTKEDLDR
CHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHCHHHHHH
WSLRSHQLAAKALKDGYFKGEIIPVEAPQADGSVITVDSDQSIRPDTSLEQIASLPPAFK
HHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCEEEECCCCCCCCCCCHHHHHCCCCCCC
PGGVITAGNSSPLNAGASGLLLASKKKVQELGLEPIAKIIGYGTAGVPPYIMGAGPVPAS
CCCEEECCCCCCCCCCCCCEEEHHHHHHHHCCHHHHHHHHCCCCCCCCCEEEECCCCCHH
RKALEKTGLKVSDIDYWEINEAFAIVPLYAIHELGIEPERVNIHGGAVAIGHPLAASGAR
HHHHHHHCCEEECCCEEECCCCEEEHHHHHHHHCCCCCCEEEECCCEEEECCCCHHCHHH
LIGTLARILQENNGDYGVATACVGGGQGAAVVIERV
HHHHHHHHHHHCCCCEEEEEEEECCCCCEEEEEEEC
>Mature Secondary Structure
MEEVYIVEYARTPFSRSRPKKPERDVFHKIRGDELMALVLEKLPERAGIEKKEVGRILLG
CCCEEEEEEECCCCCCCCCCCCHHHHHHHHCCHHHHHHHHHHHHHHHCCCHHHHCEEEEE
CAFPVSENWPYGGKMASLLAKYPPETSASHVDMQCGSSLATTAYAYLEIASGNEDMMISG
EECCCCCCCCCCHHHHHHHHHCCCCCCCCEEEHHCCCHHHHHEEEEEEEECCCCCEEEEC
GYEHMTRVPMGADNPHVDRHPKLLTEEYKDYRMDIGFVMGLTAETLFEMAGYLTKEDLDR
CHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHCHHHHHH
WSLRSHQLAAKALKDGYFKGEIIPVEAPQADGSVITVDSDQSIRPDTSLEQIASLPPAFK
HHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCEEEECCCCCCCCCCCHHHHHCCCCCCC
PGGVITAGNSSPLNAGASGLLLASKKKVQELGLEPIAKIIGYGTAGVPPYIMGAGPVPAS
CCCEEECCCCCCCCCCCCCEEEHHHHHHHHCCHHHHHHHHCCCCCCCCCEEEECCCCCHH
RKALEKTGLKVSDIDYWEINEAFAIVPLYAIHELGIEPERVNIHGGAVAIGHPLAASGAR
HHHHHHHCCEEECCCEEECCCCEEEHHHHHHHHCCCCCCEEEECCCEEEECCCCHHCHHH
LIGTLARILQENNGDYGVATACVGGGQGAAVVIERV
HHHHHHHHHHHCCCCEEEEEEEECCCCCEEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA