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The map label for this gene is hbd-4

Identifier: 11498630

GI number: 11498630

Start: 926228

End: 927349

Strand: Reverse

Name: hbd-4

Synonym: AF1025

Alternate gene names: 11498630

Gene position: 927349-926228 (Counterclockwise)

Preceding gene: 11498632

Following gene: 11498628

Centisome position: 42.57

GC content: 50.09

Gene sequence:

>1122_bases
ATGGAGATAAAAACCGTTGCAGTTCTCGGTGCCGGGCTGATGGGACACGGAATTGCTGAAGTCTGCGCGATGGCGGGCTA
CAACGTGACAATGAGGGACATCAAGCAGGAGTTTGTTGACAGAGGAATGAACATGATAAAGGAGAGCCTTGCGAAGCTCG
AGCAGAAGGGCAAAATAAAGAGCGCCGAAGAAGTCCTTTCCAGAATAAAGCCAACAGTAGATCTGGAGGAGGCTGTTAAG
GATGCCGACTTGGTTATAGAGGCAGTTCCAGAAGTGGTTGAAATCAAGAAGCAGGTCTGGGAGGAGGTTGACAAGCTGGC
AAAGCCGGACTGCATCTTCACCTCCAACACCTCAACAATGAGAATAACCATGCTCGCAGACTTCACCTCAAGGCCTGAGA
AGTTTGCAGGCCTGCACTTCTTCAACCCGCCAGTCTTGATGAGGCTGGTTGAGGTTATAAGGGGAGAGAAGACCAGCGAC
GAGGTAATGGACTTGCTTGTTGAGTTCGTGAAGAGCATCGGCAAAACGCCGGTGAGAGTGGAGAAGGACGTGCCGGGGTT
CATTGCCAATAGAGTTGTTGCACCAAGAGGCGTTTTGCTTCATGCAGTGGTTGAGGCCGAGAATTTAACGCCTGAGGAAG
TTGATGCAGCTTTCAGAAAAGCGGGTTATCCTATGGGTCCCTTTGAGCTTGCAGATTACGTTGGGATAGATGTCAATTAC
AATGCTGCCAGATACTTTGCCAGAGCAGTTAGCCCCGAATACGAACCGCCCGAAAGGGTTAGGAAAATGGTTGAGGAAGG
CAGGCTTGGAAGAAAAACGGGCAGGGGGTGGTACGACTGGAGTGGTGGTAAGCCAAAAATTGACCTGAGCAAGGCAACAG
GCAAAATCAACGTCGAGGATTTTCTGATGGTCGAAATAAACGAAGCGGTTAAGCTCGTTGAAATGGGAGTGGCGAAGCCT
GAAGACATCGACATCGCTCTGAAGCTTGGATACGGCAGGCAGAAAGGACCGTTTGAGCTCCTTGAAGAGTTTGGAAAGGA
GAGGGTTGCAAGGAGGCTCGAGGAGCTGGCGAAAAAATATGGAAAGAAGATTTTTGAGCCAGCGGAATCTCTCAGAACCT
AA

Upstream 100 bases:

>100_bases
TTAAGATTTTGATTTGACATACTTTGAAATTTATTTGAAAAAATTTCGTAAAAATAGTAAGAATTATAAAGGAGGATTCC
AAATATGAGTGGTGGTAAAA

Downstream 100 bases:

>100_bases
TCTATACTTTTTATCTCCGCATACAGGTCTTCCAGAGCTTTGAGGTAGTCAAGCTCTCCGCGCTCGATTGCATCCATTCT
GCTTTCCAAGTCTCTTGTTC

Product: 3-hydroxyacyl-CoA dehydrogenase (hbd-4)

Products: NA

Alternate protein names: Beta-hydroxybutyryl-CoA dehydrogenase; BHBD [H]

Number of amino acids: Translated: 373; Mature: 373

Protein sequence:

>373_residues
MEIKTVAVLGAGLMGHGIAEVCAMAGYNVTMRDIKQEFVDRGMNMIKESLAKLEQKGKIKSAEEVLSRIKPTVDLEEAVK
DADLVIEAVPEVVEIKKQVWEEVDKLAKPDCIFTSNTSTMRITMLADFTSRPEKFAGLHFFNPPVLMRLVEVIRGEKTSD
EVMDLLVEFVKSIGKTPVRVEKDVPGFIANRVVAPRGVLLHAVVEAENLTPEEVDAAFRKAGYPMGPFELADYVGIDVNY
NAARYFARAVSPEYEPPERVRKMVEEGRLGRKTGRGWYDWSGGKPKIDLSKATGKINVEDFLMVEINEAVKLVEMGVAKP
EDIDIALKLGYGRQKGPFELLEEFGKERVARRLEELAKKYGKKIFEPAESLRT

Sequences:

>Translated_373_residues
MEIKTVAVLGAGLMGHGIAEVCAMAGYNVTMRDIKQEFVDRGMNMIKESLAKLEQKGKIKSAEEVLSRIKPTVDLEEAVK
DADLVIEAVPEVVEIKKQVWEEVDKLAKPDCIFTSNTSTMRITMLADFTSRPEKFAGLHFFNPPVLMRLVEVIRGEKTSD
EVMDLLVEFVKSIGKTPVRVEKDVPGFIANRVVAPRGVLLHAVVEAENLTPEEVDAAFRKAGYPMGPFELADYVGIDVNY
NAARYFARAVSPEYEPPERVRKMVEEGRLGRKTGRGWYDWSGGKPKIDLSKATGKINVEDFLMVEINEAVKLVEMGVAKP
EDIDIALKLGYGRQKGPFELLEEFGKERVARRLEELAKKYGKKIFEPAESLRT
>Mature_373_residues
MEIKTVAVLGAGLMGHGIAEVCAMAGYNVTMRDIKQEFVDRGMNMIKESLAKLEQKGKIKSAEEVLSRIKPTVDLEEAVK
DADLVIEAVPEVVEIKKQVWEEVDKLAKPDCIFTSNTSTMRITMLADFTSRPEKFAGLHFFNPPVLMRLVEVIRGEKTSD
EVMDLLVEFVKSIGKTPVRVEKDVPGFIANRVVAPRGVLLHAVVEAENLTPEEVDAAFRKAGYPMGPFELADYVGIDVNY
NAARYFARAVSPEYEPPERVRKMVEEGRLGRKTGRGWYDWSGGKPKIDLSKATGKINVEDFLMVEINEAVKLVEMGVAKP
EDIDIALKLGYGRQKGPFELLEEFGKERVARRLEELAKKYGKKIFEPAESLRT

Specific function: Butyrate/butanol-producing pathway. Phenylacetic acid aerobic catabolism. [C]

COG id: COG1250

COG function: function code I; 3-hydroxyacyl-CoA dehydrogenase

Gene ontology:

Cell location: Mitochondria or Peroxisomes [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 3-hydroxyacyl-CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI296179429, Length=288, Percent_Identity=39.5833333333333, Blast_Score=210, Evalue=2e-54,
Organism=Homo sapiens, GI296179427, Length=307, Percent_Identity=37.785016286645, Blast_Score=203, Evalue=3e-52,
Organism=Homo sapiens, GI20127408, Length=397, Percent_Identity=32.7455919395466, Blast_Score=182, Evalue=5e-46,
Organism=Homo sapiens, GI68989263, Length=413, Percent_Identity=31.7191283292978, Blast_Score=150, Evalue=2e-36,
Organism=Homo sapiens, GI261878539, Length=413, Percent_Identity=31.7191283292978, Blast_Score=150, Evalue=2e-36,
Organism=Homo sapiens, GI115430219, Length=191, Percent_Identity=31.9371727748691, Blast_Score=105, Evalue=5e-23,
Organism=Escherichia coli, GI1787661, Length=340, Percent_Identity=37.3529411764706, Blast_Score=208, Evalue=5e-55,
Organism=Escherichia coli, GI1790281, Length=383, Percent_Identity=33.1592689295039, Blast_Score=165, Evalue=4e-42,
Organism=Escherichia coli, GI1788682, Length=370, Percent_Identity=32.4324324324324, Blast_Score=158, Evalue=6e-40,
Organism=Caenorhabditis elegans, GI17553560, Length=294, Percent_Identity=39.7959183673469, Blast_Score=211, Evalue=5e-55,
Organism=Caenorhabditis elegans, GI17549919, Length=293, Percent_Identity=39.2491467576792, Blast_Score=207, Evalue=5e-54,
Organism=Caenorhabditis elegans, GI17508953, Length=404, Percent_Identity=32.1782178217822, Blast_Score=191, Evalue=7e-49,
Organism=Caenorhabditis elegans, GI17508951, Length=404, Percent_Identity=32.1782178217822, Blast_Score=191, Evalue=7e-49,
Organism=Caenorhabditis elegans, GI17563036, Length=288, Percent_Identity=36.4583333333333, Blast_Score=189, Evalue=2e-48,
Organism=Caenorhabditis elegans, GI17558304, Length=407, Percent_Identity=31.2039312039312, Blast_Score=179, Evalue=3e-45,
Organism=Caenorhabditis elegans, GI25144276, Length=318, Percent_Identity=33.9622641509434, Blast_Score=167, Evalue=7e-42,
Organism=Caenorhabditis elegans, GI71985923, Length=381, Percent_Identity=28.8713910761155, Blast_Score=153, Evalue=1e-37,
Organism=Caenorhabditis elegans, GI71985930, Length=398, Percent_Identity=26.3819095477387, Blast_Score=132, Evalue=3e-31,
Organism=Caenorhabditis elegans, GI193203623, Length=165, Percent_Identity=29.6969696969697, Blast_Score=87, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI115533614, Length=165, Percent_Identity=29.6969696969697, Blast_Score=87, Evalue=2e-17,
Organism=Drosophila melanogaster, GI24583077, Length=404, Percent_Identity=30.9405940594059, Blast_Score=177, Evalue=8e-45,
Organism=Drosophila melanogaster, GI24583079, Length=404, Percent_Identity=30.9405940594059, Blast_Score=177, Evalue=8e-45,
Organism=Drosophila melanogaster, GI19921000, Length=404, Percent_Identity=30.9405940594059, Blast_Score=177, Evalue=9e-45,
Organism=Drosophila melanogaster, GI45549573, Length=260, Percent_Identity=29.2307692307692, Blast_Score=102, Evalue=3e-22,
Organism=Drosophila melanogaster, GI20129993, Length=196, Percent_Identity=28.0612244897959, Blast_Score=102, Evalue=4e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR022694
- InterPro:   IPR006180
- InterPro:   IPR006176
- InterPro:   IPR006108
- InterPro:   IPR008927
- InterPro:   IPR013328
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00725 3HCDH; PF02737 3HCDH_N [H]

EC number: =1.1.1.157 [H]

Molecular weight: Translated: 41738; Mature: 41738

Theoretical pI: Translated: 5.47; Mature: 5.47

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEIKTVAVLGAGLMGHGIAEVCAMAGYNVTMRDIKQEFVDRGMNMIKESLAKLEQKGKIK
CCCEEEHHHHCCHHHCCHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
SAEEVLSRIKPTVDLEEAVKDADLVIEAVPEVVEIKKQVWEEVDKLAKPDCIFTSNTSTM
CHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCEE
RITMLADFTSRPEKFAGLHFFNPPVLMRLVEVIRGEKTSDEVMDLLVEFVKSIGKTPVRV
EEEEEECCCCCHHHHCCCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCEEE
EKDVPGFIANRVVAPRGVLLHAVVEAENLTPEEVDAAFRKAGYPMGPFELADYVGIDVNY
CCCCCHHHHHCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCHHHHHHHCCCCCCC
NAARYFARAVSPEYEPPERVRKMVEEGRLGRKTGRGWYDWSGGKPKIDLSKATGKINVED
HHHHHHHHHCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCEEEECCCCEECCCC
FLMVEINEAVKLVEMGVAKPEDIDIALKLGYGRQKGPFELLEEFGKERVARRLEELAKKY
EEEEEHHHHHHHHHHCCCCCCCCEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
GKKIFEPAESLRT
HHHHHHHHHHHCC
>Mature Secondary Structure
MEIKTVAVLGAGLMGHGIAEVCAMAGYNVTMRDIKQEFVDRGMNMIKESLAKLEQKGKIK
CCCEEEHHHHCCHHHCCHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
SAEEVLSRIKPTVDLEEAVKDADLVIEAVPEVVEIKKQVWEEVDKLAKPDCIFTSNTSTM
CHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCEE
RITMLADFTSRPEKFAGLHFFNPPVLMRLVEVIRGEKTSDEVMDLLVEFVKSIGKTPVRV
EEEEEECCCCCHHHHCCCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCEEE
EKDVPGFIANRVVAPRGVLLHAVVEAENLTPEEVDAAFRKAGYPMGPFELADYVGIDVNY
CCCCCHHHHHCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCHHHHHHHCCCCCCC
NAARYFARAVSPEYEPPERVRKMVEEGRLGRKTGRGWYDWSGGKPKIDLSKATGKINVED
HHHHHHHHHCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCEEEECCCCEECCCC
FLMVEINEAVKLVEMGVAKPEDIDIALKLGYGRQKGPFELLEEFGKERVARRLEELAKKY
EEEEEHHHHHHHHHHCCCCCCCCEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
GKKIFEPAESLRT
HHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8655474; 11466286 [H]