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The map label for this gene is proW-2

Identifier: 11498585

GI number: 11498585

Start: 882018

End: 882674

Strand: Reverse

Name: proW-2

Synonym: AF0980

Alternate gene names: 11498585

Gene position: 882674-882018 (Counterclockwise)

Preceding gene: 11498586

Following gene: 11498584

Centisome position: 40.52

GC content: 50.08

Gene sequence:

>657_bases
ATGACCGACGGCAGCTTTTTAACCACCCTTATTGAAATCTGGGAGCTTCACAGGCTTACGGAGAGAACTCTCGAACACCT
CTACATGTTTTCAGTCTCCCTCGCAGTGTCAGTCATTGTGGGAGTGCTCCTCGGCGTTTTGATTTACAGGCACCGCAAGA
TTGAGAGCCTCACCTTCAACGCTCTGAATGTCATCGAAACGATTCCCACTCTTGCTCTGCTGGTCCTCCTACTCCCAATT
CTCGGTTTGGGAATGGTTCCAACAATTGCAGCATGTATACTCTACTCCATTCTCCCCATAGCAAGGAACACTTACACAGG
CCTTGTTACAGTCAGCGAGGAGTACATCGAGATTGCGAGGGCAATAGGGATGTCTGAGAGGGAAATTCTGCTGAAGGTGA
GATTCCCCTTGGCTCTTCCCCTAATCATGGGAGGAATCAGGATTGCGGTGGTTTTCACGATGGGTGTGGTTACTCTGGGA
GGGTTAATTGCTGCAGGTGGGCTTGGAGCACCACTTCAGACGGGGATTCATCTCTACGACAAGCTCCTCATACTCGTTGC
GGGTTTATGGGTTGGGATTCTTGCTGTATTGCTCGACGCCTTTGCCGGGGCTGTTGAGAGAGTTTTGAGCAGAAAATTCA
GGGGAGAGTATGATTGA

Upstream 100 bases:

>100_bases
TGCTTGAGCTGAGGGAGAGCGGTGAGTTCGTGGGTGTGGTTGAGGAAAAGGGAGAGGTGGCAGGAGTTCTGCTCTCAAAC
GAGATTTTGATGAGGCTGAT

Downstream 100 bases:

>100_bases
GCTGCTGAAGGTTCTCGCTGCCACCTACGAGCACCTCCTTCTAACCTATGGGGCGCTGGCCGTAAGCATAGCCCTTGCCA
TCCCCCTCGCCATCGCCTCG

Product: osmoprotection protein (proW-2)

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 218; Mature: 217

Protein sequence:

>218_residues
MTDGSFLTTLIEIWELHRLTERTLEHLYMFSVSLAVSVIVGVLLGVLIYRHRKIESLTFNALNVIETIPTLALLVLLLPI
LGLGMVPTIAACILYSILPIARNTYTGLVTVSEEYIEIARAIGMSEREILLKVRFPLALPLIMGGIRIAVVFTMGVVTLG
GLIAAGGLGAPLQTGIHLYDKLLILVAGLWVGILAVLLDAFAGAVERVLSRKFRGEYD

Sequences:

>Translated_218_residues
MTDGSFLTTLIEIWELHRLTERTLEHLYMFSVSLAVSVIVGVLLGVLIYRHRKIESLTFNALNVIETIPTLALLVLLLPI
LGLGMVPTIAACILYSILPIARNTYTGLVTVSEEYIEIARAIGMSEREILLKVRFPLALPLIMGGIRIAVVFTMGVVTLG
GLIAAGGLGAPLQTGIHLYDKLLILVAGLWVGILAVLLDAFAGAVERVLSRKFRGEYD
>Mature_217_residues
TDGSFLTTLIEIWELHRLTERTLEHLYMFSVSLAVSVIVGVLLGVLIYRHRKIESLTFNALNVIETIPTLALLVLLLPIL
GLGMVPTIAACILYSILPIARNTYTGLVTVSEEYIEIARAIGMSEREILLKVRFPLALPLIMGGIRIAVVFTMGVVTLGG
LIAAGGLGAPLQTGIHLYDKLLILVAGLWVGILAVLLDAFAGAVERVLSRKFRGEYD

Specific function: Involved in a high affinity multicomponent binding- protein-dependent transport system for glycine betaine, carnitine and choline; probably responsible for the translocation of the substrate across the membrane [H]

COG id: COG1174

COG function: function code E; ABC-type proline/glycine betaine transport systems, permease component

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ABC transmembrane type-1 domain [H]

Homologues:

Organism=Escherichia coli, GI1788451, Length=192, Percent_Identity=34.8958333333333, Blast_Score=99, Evalue=2e-22,
Organism=Escherichia coli, GI1788449, Length=190, Percent_Identity=28.9473684210526, Blast_Score=99, Evalue=3e-22,
Organism=Escherichia coli, GI1789033, Length=179, Percent_Identity=32.9608938547486, Blast_Score=98, Evalue=5e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000515 [H]

Pfam domain/function: PF00528 BPD_transp_1 [H]

EC number: NA

Molecular weight: Translated: 23723; Mature: 23592

Theoretical pI: Translated: 6.96; Mature: 6.96

Prosite motif: PS50928 ABC_TM1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTDGSFLTTLIEIWELHRLTERTLEHLYMFSVSLAVSVIVGVLLGVLIYRHRKIESLTFN
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ALNVIETIPTLALLVLLLPILGLGMVPTIAACILYSILPIARNTYTGLVTVSEEYIEIAR
HHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCHHHHEEHHHHHHHHHH
AIGMSEREILLKVRFPLALPLIMGGIRIAVVFTMGVVTLGGLIAAGGLGAPLQTGIHLYD
HHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHH
KLLILVAGLWVGILAVLLDAFAGAVERVLSRKFRGEYD
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure 
TDGSFLTTLIEIWELHRLTERTLEHLYMFSVSLAVSVIVGVLLGVLIYRHRKIESLTFN
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ALNVIETIPTLALLVLLLPILGLGMVPTIAACILYSILPIARNTYTGLVTVSEEYIEIAR
HHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCHHHHEEHHHHHHHHHH
AIGMSEREILLKVRFPLALPLIMGGIRIAVVFTMGVVTLGGLIAAGGLGAPLQTGIHLYD
HHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHH
KLLILVAGLWVGILAVLLDAFAGAVERVLSRKFRGEYD
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 10216873; 9384377 [H]