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The map label for this gene is serA

Identifier: 11498419

GI number: 11498419

Start: 723653

End: 725236

Strand: Reverse

Name: serA

Synonym: AF0813

Alternate gene names: 11498419

Gene position: 725236-723653 (Counterclockwise)

Preceding gene: 11498422

Following gene: 11498413

Centisome position: 33.29

GC content: 51.45

Gene sequence:

>1584_bases
ATGAAAGTGCTTGTTGCAGAGCCAATCAGTGAAGAGGCCATCGACTATATGCGCAAAAACGGATTAGAGGTTGAAGTAAA
AACAGGAATGTCGAGAGAGGAGCTTATTCGGGAAGTGCCCAAGTATGAGGCCATCGTCGTTAGAAGCCAGACCAAGGTGG
ATGCTGAAGTCATTCAGGCAGCTAAGAACCTCAAGATTATCGGAAGAGCAGGAGTTGGAGTGGACAACATAGACATCAAC
GCCGCAACGCAGAGGGGAATAGTTGTTGTTAACGCTCCGGGAGGAAACACGATCTCAACCGCTGAACATGCAATCGCCCT
AATGCTCGCCGCTGCCAGGAAAATCCCGCAGGCTGACAGAAGCGTCAAGGAGGGGAAGTGGGAGAGGAAGAAATTCATGG
GAATTGAGCTTAGGGGGAAGACTGCTGGAGTCATCGGGCTTGGCAGAGTTGGTTTTGAAGTAGCAAAGCGCTGCAAGGCC
CTAGAGATGAACGTTTTAGCCTACGACCCCTTCGTGTCCAAGGAGAGGGCCGAGCAGATTGGGGTTAAGCTTGTTGACTT
TGACACTCTCTTGGCATCATCGGATGTCATAACTGTCCACGTTCCGAGAACGAAGGAAACCATCGGTCTGATTGGAAAGG
GGCAGTTTGAAAAGATGAAGGACGGTGTGATAGTCGTCAACGCTGCCAGAGGTGGAATTGTCGATGAAGCAGCGCTTTAC
GAGGCGATAAAGGCGGGAAAAGTTGCGGCTGCTGCCCTCGACGTTTACGAAAAGGAGCCGCCATCTCCAGACAACCCGCT
TCTCAAGCTGGATAATGTGGTCACAACTCCTCACATCGCCGCATCAACAAGAGAGGCTCAGCTCAACGTGGGGATGATAA
TTGCGGAGGACATCGTGAACATGGCGAAGGGTCTGCCTGTTAGAAATGCAGTCAACCTGCCCTCCATTGAGCCCTCCGAT
TTCGAATTTATGATGCCTTTCCTGACGCTGGCCGAGAAAATGGGGAAGATTGCGAGCGTGAGGCTTGGGGGAGCAATAAG
AAAAGTCAAGGTGACCTGCAGCGGAAAGCTTGCAACCAAGAATACCGAATTCGTTACGAGAGCGCTCCTCAAAGGTCTTT
TCGAGCCTATTCTCAGCAATGAGATAAATCTGGTTTCAGCGAAGCCGGTAGCAGTTGAGAGGGGGATAACCATTGAGGAA
AGCAAGGTTGAGAGTGTGGAGCACTACGAGAGCTTGCTGGAGGTTTGGGTTGAGAGCAACGGAAAGGAGATGTATCTCGC
AGGCACATGCTTCGGCAACGAGTACAGAATCCTGAAAATTGACGTTTACAATGTCAACTTCGTCCCGAAGGGCCACTACA
TCATCTCCCTGCACGAAGACAAGCCCGGTGTCATCGGCAGAGTGGGGACGCTGTTCGGCAGGAACAACATCAACATAGCG
GGGATGATTGTTGGGAGGAGCGGAGACAAGCCGGGAGGAATTCAGCTTATGCTCCTGCTCGTAGATGATCCGCCAACGCC
AGAGGTGCTTGAGGAGATGACGAAGCTTGATGGAATAATCGACGCAACCTACGTCGAGCTTTAG

Upstream 100 bases:

>100_bases
CCGGTCTTCCGGTGACCGCAACTTTCACAGCCTGAAATTGGTGGACGAGTAAAAGTTTTTATCGTAAAAGTTTTTAGCTC
TGCCCCTGAGCGTGAGAGGT

Downstream 100 bases:

>100_bases
CTTTTTTAAAAAATTTAGAGGCACCAGCTTCTCGCCACCAGGACCTGCCTTTCAGTCCTCATTCCTGCGGGATGGTAGGC
TATCACAGGAACGCACCCTC

Product: D-3-phosphoglycerate dehydrogenase

Products: NA

Alternate protein names: PGDH

Number of amino acids: Translated: 527; Mature: 527

Protein sequence:

>527_residues
MKVLVAEPISEEAIDYMRKNGLEVEVKTGMSREELIREVPKYEAIVVRSQTKVDAEVIQAAKNLKIIGRAGVGVDNIDIN
AATQRGIVVVNAPGGNTISTAEHAIALMLAAARKIPQADRSVKEGKWERKKFMGIELRGKTAGVIGLGRVGFEVAKRCKA
LEMNVLAYDPFVSKERAEQIGVKLVDFDTLLASSDVITVHVPRTKETIGLIGKGQFEKMKDGVIVVNAARGGIVDEAALY
EAIKAGKVAAAALDVYEKEPPSPDNPLLKLDNVVTTPHIAASTREAQLNVGMIIAEDIVNMAKGLPVRNAVNLPSIEPSD
FEFMMPFLTLAEKMGKIASVRLGGAIRKVKVTCSGKLATKNTEFVTRALLKGLFEPILSNEINLVSAKPVAVERGITIEE
SKVESVEHYESLLEVWVESNGKEMYLAGTCFGNEYRILKIDVYNVNFVPKGHYIISLHEDKPGVIGRVGTLFGRNNINIA
GMIVGRSGDKPGGIQLMLLLVDDPPTPEVLEEMTKLDGIIDATYVEL

Sequences:

>Translated_527_residues
MKVLVAEPISEEAIDYMRKNGLEVEVKTGMSREELIREVPKYEAIVVRSQTKVDAEVIQAAKNLKIIGRAGVGVDNIDIN
AATQRGIVVVNAPGGNTISTAEHAIALMLAAARKIPQADRSVKEGKWERKKFMGIELRGKTAGVIGLGRVGFEVAKRCKA
LEMNVLAYDPFVSKERAEQIGVKLVDFDTLLASSDVITVHVPRTKETIGLIGKGQFEKMKDGVIVVNAARGGIVDEAALY
EAIKAGKVAAAALDVYEKEPPSPDNPLLKLDNVVTTPHIAASTREAQLNVGMIIAEDIVNMAKGLPVRNAVNLPSIEPSD
FEFMMPFLTLAEKMGKIASVRLGGAIRKVKVTCSGKLATKNTEFVTRALLKGLFEPILSNEINLVSAKPVAVERGITIEE
SKVESVEHYESLLEVWVESNGKEMYLAGTCFGNEYRILKIDVYNVNFVPKGHYIISLHEDKPGVIGRVGTLFGRNNINIA
GMIVGRSGDKPGGIQLMLLLVDDPPTPEVLEEMTKLDGIIDATYVEL
>Mature_527_residues
MKVLVAEPISEEAIDYMRKNGLEVEVKTGMSREELIREVPKYEAIVVRSQTKVDAEVIQAAKNLKIIGRAGVGVDNIDIN
AATQRGIVVVNAPGGNTISTAEHAIALMLAAARKIPQADRSVKEGKWERKKFMGIELRGKTAGVIGLGRVGFEVAKRCKA
LEMNVLAYDPFVSKERAEQIGVKLVDFDTLLASSDVITVHVPRTKETIGLIGKGQFEKMKDGVIVVNAARGGIVDEAALY
EAIKAGKVAAAALDVYEKEPPSPDNPLLKLDNVVTTPHIAASTREAQLNVGMIIAEDIVNMAKGLPVRNAVNLPSIEPSD
FEFMMPFLTLAEKMGKIASVRLGGAIRKVKVTCSGKLATKNTEFVTRALLKGLFEPILSNEINLVSAKPVAVERGITIEE
SKVESVEHYESLLEVWVESNGKEMYLAGTCFGNEYRILKIDVYNVNFVPKGHYIISLHEDKPGVIGRVGTLFGRNNINIA
GMIVGRSGDKPGGIQLMLLLVDDPPTPEVLEEMTKLDGIIDATYVEL

Specific function: Serine biosynthesis; first step. [C]

COG id: COG0111

COG function: function code HE; Phosphoglycerate dehydrogenase and related dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ACT domain

Homologues:

Organism=Homo sapiens, GI23308577, Length=401, Percent_Identity=41.645885286783, Blast_Score=314, Evalue=1e-85,
Organism=Homo sapiens, GI6912396, Length=322, Percent_Identity=33.5403726708075, Blast_Score=162, Evalue=1e-39,
Organism=Homo sapiens, GI61743967, Length=273, Percent_Identity=36.2637362637363, Blast_Score=152, Evalue=1e-36,
Organism=Homo sapiens, GI4557497, Length=273, Percent_Identity=36.2637362637363, Blast_Score=152, Evalue=1e-36,
Organism=Homo sapiens, GI145580578, Length=273, Percent_Identity=35.5311355311355, Blast_Score=147, Evalue=2e-35,
Organism=Homo sapiens, GI4557499, Length=273, Percent_Identity=35.5311355311355, Blast_Score=147, Evalue=2e-35,
Organism=Homo sapiens, GI145580575, Length=273, Percent_Identity=35.5311355311355, Blast_Score=144, Evalue=2e-34,
Organism=Escherichia coli, GI1789279, Length=322, Percent_Identity=33.5403726708075, Blast_Score=181, Evalue=1e-46,
Organism=Escherichia coli, GI87082289, Length=268, Percent_Identity=35.4477611940299, Blast_Score=176, Evalue=3e-45,
Organism=Escherichia coli, GI1787645, Length=299, Percent_Identity=32.1070234113712, Blast_Score=160, Evalue=1e-40,
Organism=Escherichia coli, GI87081824, Length=255, Percent_Identity=27.843137254902, Blast_Score=94, Evalue=2e-20,
Organism=Escherichia coli, GI1788660, Length=291, Percent_Identity=31.2714776632302, Blast_Score=92, Evalue=9e-20,
Organism=Caenorhabditis elegans, GI17532191, Length=316, Percent_Identity=47.1518987341772, Blast_Score=280, Evalue=2e-75,
Organism=Caenorhabditis elegans, GI25147481, Length=348, Percent_Identity=29.0229885057471, Blast_Score=140, Evalue=1e-33,
Organism=Saccharomyces cerevisiae, GI6320925, Length=333, Percent_Identity=37.2372372372372, Blast_Score=209, Evalue=9e-55,
Organism=Saccharomyces cerevisiae, GI6322116, Length=340, Percent_Identity=34.4117647058824, Blast_Score=197, Evalue=4e-51,
Organism=Saccharomyces cerevisiae, GI6324055, Length=301, Percent_Identity=30.2325581395349, Blast_Score=141, Evalue=2e-34,
Organism=Saccharomyces cerevisiae, GI6324964, Length=279, Percent_Identity=30.8243727598566, Blast_Score=124, Evalue=4e-29,
Organism=Saccharomyces cerevisiae, GI6324980, Length=181, Percent_Identity=30.3867403314917, Blast_Score=82, Evalue=2e-16,
Organism=Saccharomyces cerevisiae, GI6325144, Length=169, Percent_Identity=26.0355029585799, Blast_Score=70, Evalue=8e-13,
Organism=Drosophila melanogaster, GI19921140, Length=303, Percent_Identity=43.5643564356436, Blast_Score=251, Evalue=1e-66,
Organism=Drosophila melanogaster, GI28574284, Length=315, Percent_Identity=33.968253968254, Blast_Score=182, Evalue=5e-46,
Organism=Drosophila melanogaster, GI45552429, Length=315, Percent_Identity=33.968253968254, Blast_Score=182, Evalue=5e-46,
Organism=Drosophila melanogaster, GI24585514, Length=315, Percent_Identity=33.968253968254, Blast_Score=182, Evalue=5e-46,
Organism=Drosophila melanogaster, GI28574282, Length=315, Percent_Identity=33.968253968254, Blast_Score=182, Evalue=5e-46,
Organism=Drosophila melanogaster, GI45551003, Length=315, Percent_Identity=33.968253968254, Blast_Score=182, Evalue=5e-46,
Organism=Drosophila melanogaster, GI28574286, Length=316, Percent_Identity=32.2784810126582, Blast_Score=174, Evalue=9e-44,
Organism=Drosophila melanogaster, GI28571528, Length=314, Percent_Identity=36.9426751592357, Blast_Score=160, Evalue=2e-39,
Organism=Drosophila melanogaster, GI24585516, Length=314, Percent_Identity=30.2547770700637, Blast_Score=156, Evalue=3e-38,
Organism=Drosophila melanogaster, GI24646446, Length=278, Percent_Identity=35.9712230215827, Blast_Score=144, Evalue=2e-34,
Organism=Drosophila melanogaster, GI24646448, Length=278, Percent_Identity=35.9712230215827, Blast_Score=144, Evalue=2e-34,
Organism=Drosophila melanogaster, GI24646452, Length=278, Percent_Identity=35.9712230215827, Blast_Score=144, Evalue=2e-34,
Organism=Drosophila melanogaster, GI24646450, Length=278, Percent_Identity=35.9712230215827, Blast_Score=144, Evalue=2e-34,
Organism=Drosophila melanogaster, GI62472511, Length=278, Percent_Identity=35.9712230215827, Blast_Score=143, Evalue=3e-34,

Paralogues:

None

Copy number: 380 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): SERA_ARCFU (O29445)

Other databases:

- EMBL:   AE000782
- PIR:   E69351
- RefSeq:   NP_069647.1
- ProteinModelPortal:   O29445
- SMR:   O29445
- GeneID:   1484032
- GenomeReviews:   AE000782_GR
- KEGG:   afu:AF0813
- NMPDR:   fig|224325.1.peg.806
- TIGR:   AF_0813
- HOGENOM:   HBG731446
- OMA:   KSFKGME
- ProtClustDB:   PRK13581
- BioCyc:   AFUL224325:AF_0813-MONOMER
- BRENDA:   1.1.1.95
- InterPro:   IPR002912
- InterPro:   IPR006236
- InterPro:   IPR006139
- InterPro:   IPR006140
- InterPro:   IPR015508
- InterPro:   IPR016040
- Gene3D:   G3DSA:3.40.50.720
- PANTHER:   PTHR10996:SF20
- TIGRFAMs:   TIGR01327

Pfam domain/function: PF00389 2-Hacid_dh; PF02826 2-Hacid_dh_C; PF01842 ACT

EC number: =1.1.1.95

Molecular weight: Translated: 57204; Mature: 57204

Theoretical pI: Translated: 6.31; Mature: 6.31

Prosite motif: PS00065 D_2_HYDROXYACID_DH_1; PS00670 D_2_HYDROXYACID_DH_2; PS00671 D_2_HYDROXYACID_DH_3

Important sites: ACT_SITE 230-230 ACT_SITE 259-259 ACT_SITE 278-278 BINDING 169-169 BINDING 254-254

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKVLVAEPISEEAIDYMRKNGLEVEVKTGMSREELIREVPKYEAIVVRSQTKVDAEVIQA
CEEEEECCCCHHHHHHHHHCCCEEEEECCCCHHHHHHHCCCCEEEEEECCCCHHHHHHHH
AKNLKIIGRAGVGVDNIDINAATQRGIVVVNAPGGNTISTAEHAIALMLAAARKIPQADR
HCCEEEEEECCCCCCCEEEECCCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHCCCCCC
SVKEGKWERKKFMGIELRGKTAGVIGLGRVGFEVAKRCKALEMNVLAYDPFVSKERAEQI
HHHCCCHHHHHEEEEEEECCCCCEEEECHHHHHHHHHHHHHEEEEEEECCCCCHHHHHHH
GVKLVDFDTLLASSDVITVHVPRTKETIGLIGKGQFEKMKDGVIVVNAARGGIVDEAALY
CEEEEEHHHHHCCCCEEEEEECCCCHHHEECCCCCHHHCCCCEEEEECCCCCCCHHHHHH
EAIKAGKVAAAALDVYEKEPPSPDNPLLKLDNVVTTPHIAASTREAQLNVGMIIAEDIVN
HHHHCCCHHHHHHHHHHCCCCCCCCCCEEECCEECCCCCCCCCCCCEEEEEEEEHHHHHH
MAKGLPVRNAVNLPSIEPSDFEFMMPFLTLAEKMGKIASVRLGGAIRKVKVTCSGKLATK
HHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCEEEEECCCEEEEEEEECCEEECC
NTEFVTRALLKGLFEPILSNEINLVSAKPVAVERGITIEESKVESVEHYESLLEVWVESN
CHHHHHHHHHHHHHHHHHCCCCEEEECCCEEEECCCEECHHHHHHHHHHHHHHHHHHCCC
GKEMYLAGTCFGNEYRILKIDVYNVNFVPKGHYIISLHEDKPGVIGRVGTLFGRNNINIA
CCEEEEEEEEECCCEEEEEEEEEEEEEEECCCEEEEEECCCCCCEEEHHHHCCCCCCEEE
GMIVGRSGDKPGGIQLMLLLVDDPPTPEVLEEMTKLDGIIDATYVEL
EEEEECCCCCCCCEEEEEEEECCCCCHHHHHHHHHHCCCCCEEEECC
>Mature Secondary Structure
MKVLVAEPISEEAIDYMRKNGLEVEVKTGMSREELIREVPKYEAIVVRSQTKVDAEVIQA
CEEEEECCCCHHHHHHHHHCCCEEEEECCCCHHHHHHHCCCCEEEEEECCCCHHHHHHHH
AKNLKIIGRAGVGVDNIDINAATQRGIVVVNAPGGNTISTAEHAIALMLAAARKIPQADR
HCCEEEEEECCCCCCCEEEECCCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHCCCCCC
SVKEGKWERKKFMGIELRGKTAGVIGLGRVGFEVAKRCKALEMNVLAYDPFVSKERAEQI
HHHCCCHHHHHEEEEEEECCCCCEEEECHHHHHHHHHHHHHEEEEEEECCCCCHHHHHHH
GVKLVDFDTLLASSDVITVHVPRTKETIGLIGKGQFEKMKDGVIVVNAARGGIVDEAALY
CEEEEEHHHHHCCCCEEEEEECCCCHHHEECCCCCHHHCCCCEEEEECCCCCCCHHHHHH
EAIKAGKVAAAALDVYEKEPPSPDNPLLKLDNVVTTPHIAASTREAQLNVGMIIAEDIVN
HHHHCCCHHHHHHHHHHCCCCCCCCCCEEECCEECCCCCCCCCCCCEEEEEEEEHHHHHH
MAKGLPVRNAVNLPSIEPSDFEFMMPFLTLAEKMGKIASVRLGGAIRKVKVTCSGKLATK
HHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCEEEEECCCEEEEEEEECCEEECC
NTEFVTRALLKGLFEPILSNEINLVSAKPVAVERGITIEESKVESVEHYESLLEVWVESN
CHHHHHHHHHHHHHHHHHCCCCEEEECCCEEEECCCEECHHHHHHHHHHHHHHHHHHCCC
GKEMYLAGTCFGNEYRILKIDVYNVNFVPKGHYIISLHEDKPGVIGRVGTLFGRNNINIA
CCEEEEEEEEECCCEEEEEEEEEEEEEEECCCEEEEEECCCCCCEEEHHHHCCCCCCEEE
GMIVGRSGDKPGGIQLMLLLVDDPPTPEVLEEMTKLDGIIDATYVEL
EEEEECCCCCCCCEEEEEEEECCCCCHHHHHHHHHHCCCCCEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9389475