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The map label for this gene is hisA-1

Identifier: 11498320

GI number: 11498320

Start: 643324

End: 643995

Strand: Reverse

Name: hisA-1

Synonym: AF0713

Alternate gene names: NA

Gene position: 643995-643324 (Counterclockwise)

Preceding gene: 11498327

Following gene: 11498317

Centisome position: 29.56

GC content: 47.77

Gene sequence:

>672_bases
ATGAAGGTATTTTTTGTGGTTGATATAAAAAGCGGTAAGGTAGTTGCGGGAAAGGGAGGGGAGAGGGAAAGCTACCCTCC
CATAACCGCCATCAGCAGGCTTGTGTCATCTGATGATGCCTTGAAGGTGATTGAGGAGATTAAGCCAAGATTTTTGTATG
CTGCAGACCTCGACAGGATTGTGGGATTGGGTGACAACTTTTCCCTGCTATCGAAGCTATCAAAGAGGGTTGAAGAGCTC
ATAGCTGACTGCGGTTTCAGAAGCCCCGAAGAGCTTGAAAAATTGCCCTTCACTCCTGTGGTTGGAACGGAAACCTTCGA
CATAACTCAGCTTGACAGGAAATGCTACGTCAGCCTCGATTTCAAGGAGAAATTTCTGGATGCATCTGGAAAGTTCGAAA
GCTGGGAGGAGGTGGTTAAATTCCTTAACTCCTTCGACCTCTACGGGCTGATAGTCCTGCCGATACATGCTGTTGGAGCT
ATGAAGCCCGACCTCTCCGTTTTAACTAAAACTCTCGAACTTTCCGAACATCCAGTCATGCTTGGAGGGGGGATTTCGGG
AGTTGAAGATTTGGAAAGGCTCAAGGAAATGGGGTGCAGCGGTGTTCTGGTTGCCACGGCGGTGCATAAAGGCAAAATAC
CGCTTGATGTAGTAAGGAAGGGGAAATTTTAG

Upstream 100 bases:

>100_bases
CTTCAAAACACCAACTTTCACAACCATTTTTATCACCTGCTGGCTGTATGCTTCAGTTTATTTAACATTTCCTTTTTAAT
CTCATTGCTGATATGGGAGC

Downstream 100 bases:

>100_bases
CCGTAAAGCTTCTCGGATATCGCTACAACCACAATCCCTATCCCGTAGGCTGTGAAGCAGTATGGGCAGAAGTAGCCGTG
CAGAACCGCGTACGTTCCGA

Product: phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase (hisA-1)

Products: 5-[(5-phospho-1-deoxyribulos-1-ylamino)methylideneamino]-1-(5-; $phosphoribosyl)imidazole-4-carboxamide

Alternate protein names: NA

Number of amino acids: Translated: 223; Mature: 223

Protein sequence:

>223_residues
MKVFFVVDIKSGKVVAGKGGERESYPPITAISRLVSSDDALKVIEEIKPRFLYAADLDRIVGLGDNFSLLSKLSKRVEEL
IADCGFRSPEELEKLPFTPVVGTETFDITQLDRKCYVSLDFKEKFLDASGKFESWEEVVKFLNSFDLYGLIVLPIHAVGA
MKPDLSVLTKTLELSEHPVMLGGGISGVEDLERLKEMGCSGVLVATAVHKGKIPLDVVRKGKF

Sequences:

>Translated_223_residues
MKVFFVVDIKSGKVVAGKGGERESYPPITAISRLVSSDDALKVIEEIKPRFLYAADLDRIVGLGDNFSLLSKLSKRVEEL
IADCGFRSPEELEKLPFTPVVGTETFDITQLDRKCYVSLDFKEKFLDASGKFESWEEVVKFLNSFDLYGLIVLPIHAVGA
MKPDLSVLTKTLELSEHPVMLGGGISGVEDLERLKEMGCSGVLVATAVHKGKIPLDVVRKGKF
>Mature_223_residues
MKVFFVVDIKSGKVVAGKGGERESYPPITAISRLVSSDDALKVIEEIKPRFLYAADLDRIVGLGDNFSLLSKLSKRVEEL
IADCGFRSPEELEKLPFTPVVGTETFDITQLDRKCYVSLDFKEKFLDASGKFESWEEVVKFLNSFDLYGLIVLPIHAVGA
MKPDLSVLTKTLELSEHPVMLGGGISGVEDLERLKEMGCSGVLVATAVHKGKIPLDVVRKGKF

Specific function: Unknown

COG id: COG1411

COG function: function code R; Uncharacterized protein related to proFAR isomerase (HisA)

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the hisA/hisF family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR006062
- InterPro:   IPR004650
- InterPro:   IPR011060 [H]

Pfam domain/function: PF00977 His_biosynth [H]

EC number: 5.3.1.16

Molecular weight: Translated: 24568; Mature: 24568

Theoretical pI: Translated: 5.45; Mature: 5.45

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKVFFVVDIKSGKVVAGKGGERESYPPITAISRLVSSDDALKVIEEIKPRFLYAADLDRI
CEEEEEEEECCCEEEECCCCCCCCCCCHHHHHHHHCCCHHHHHHHHHCCCEEEHHCHHHH
VGLGDNFSLLSKLSKRVEELIADCGFRSPEELEKLPFTPVVGTETFDITQLDRKCYVSLD
HCCCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHCCCCCCCCCCCCCCEECCCEEEEEEC
FKEKFLDASGKFESWEEVVKFLNSFDLYGLIVLPIHAVGAMKPDLSVLTKTLELSEHPVM
HHHHHHCCCCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCEE
LGGGISGVEDLERLKEMGCSGVLVATAVHKGKIPLDVVRKGKF
EECCCCCHHHHHHHHHCCCCCEEEEEEHHCCCCCHHHHCCCCC
>Mature Secondary Structure
MKVFFVVDIKSGKVVAGKGGERESYPPITAISRLVSSDDALKVIEEIKPRFLYAADLDRI
CEEEEEEEECCCEEEECCCCCCCCCCCHHHHHHHHCCCHHHHHHHHHCCCEEEHHCHHHH
VGLGDNFSLLSKLSKRVEELIADCGFRSPEELEKLPFTPVVGTETFDITQLDRKCYVSLD
HCCCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHCCCCCCCCCCCCCCEECCCEEEEEEC
FKEKFLDASGKFESWEEVVKFLNSFDLYGLIVLPIHAVGAMKPDLSVLTKTLELSEHPVM
HHHHHHCCCCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCEE
LGGGISGVEDLERLKEMGCSGVLVATAVHKGKIPLDVVRKGKF
EECCCCCHHHHHHHHHCCCCCEEEEEEHHCCCCCHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: 1-(5-phosphoribosyl)-5-[(5-; $phosphoribosylamino)methylideneamino]imidazole-4-carboxamide

Specific reaction: 1-(5-phosphoribosyl)-5-[(5- $phosphoribosylamino)methylideneamino]imidazole-4-carboxamide = 5- $[(5-phospho-1-deoxyribulos-1-ylamino)methylideneamino]-1-(5- $phosphoribosyl)imidazole-4-carboxamide

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]