Click here to switch to the map view.

The map label for this gene is acd-2

Identifier: 11498048

GI number: 11498048

Start: 393015

End: 394163

Strand: Reverse

Name: acd-2

Synonym: AF0436

Alternate gene names: 11498048

Gene position: 394163-393015 (Counterclockwise)

Preceding gene: 11498049

Following gene: 11498047

Centisome position: 18.09

GC content: 53.26

Gene sequence:

>1149_bases
ATGGATTTTAAGCTAACTCCTGAGCAGGAGGACATAAGGAGGGCTGCGAGAGAGTTTGCTGAGAAGGAGTTCACCCCCGA
AGTTATAGAGGAGTGCGATAGAGAGGAAAAGTATCCAATGGAAATCGTCAGGAAGGCGAGAGACCTTGGCTTCTCGACAG
TGAAGATTCCTGAGGAGTATGGGGGTATGGGGTTAAGTCTTTTTGAGGAAGCTCTGGTTACGGAGGAGTTCTACAGGGTT
AGTCCGGGGATAGGGAATGCTTGCCTTAGCTCAACCTTCGGCACTGAGCTTCTCATCCTGTTCGGCAGTGAGGAGCAGAA
GGAGAAGTATCTTAGATGGGTGACTGAGAGGCACGGGATTTCGGCAATGGCGACAACCGAGCCAGAGGCGGGAAGTGATG
TGGCTAACGTTAAGACCAAAATCGTCAAGGAGGGGGACGAGTGGGTCATAAACGGCACCAAGATGTTCATCACCAACGGC
ACTGTCTGCGATTTCGTTTTGGTTCTGGGTAGAACCTACGAGGGGGAGAAGAGGCACCACGGCCTCACCTTCGCCATTGT
GGAGAGCAAGAGTAAGGGGTTTAAGGCTACGAAGATAAAGAACAAGCTCGGCCTCAGGGCGAGTGATACAGCTGAGATTG
TGCTGAAAGATGTAAAGGTGCCGGAGGAGAACATTCTGGGCGAGCCGGGAAAGGGCTTCTACTACCTCATGGAGTTCTTC
AACCACACGAGACCGAGGGTGGCGGCTCAGGCTGTGGGGATAGCTCAGGGGGCTTTTGAGCTTGCTTTGAACTACGTTAA
GCAGAGGAAGCAGTTCGGGCAGCCGATTGCTGCATTTCAGCACACGCAATTCAAGATTGCCGAGATGGCGACGCGCATTC
AGGCTGCAAGGCTGCTGACGTGGCAGGCTGCTTGGCAGTGCAGCATCGGGCAGTCAAGGCCTGAGCTTTCCTCGATGGCC
AAGTGGTTTGCAGGGGAGACAGCTGTTTACGTCGCAGACTGGTGCGTGCAGCTTCATGGTGGCTACGGGTACATCGGCGA
GTATCCGGCAGAGCGCTACTACAGGGATGCGAAGCTGATGGAGATTTACGAGGGAACGAAAGAGGTTCAGAAGCAGATAA
TTGCGAGAAGGTTGATAGGAAAGCTTTGA

Upstream 100 bases:

>100_bases
GATGGGATGGGCGAAAGAGGTCAGGGTTGGCGACGTTGTGAGGTTAAAGCCGGGCAAGGACGAAACTGGAGTCTGGAAAG
TTTACTTCGAGGTGGTTTGA

Downstream 100 bases:

>100_bases
GGTGGGAGAATGGGAGAGAGAGTCAAGCTTGAGCTTGATGGTGAAATTGCTGTTGCAACCCTCAACAGACCAGAGAAGCT
AAACGCTCTTGACACCAAAA

Product: acyl-CoA dehydrogenase (acd-2)

Products: 2,3-dehydroacyl-CoA; reduced acceptor

Alternate protein names: NA

Number of amino acids: Translated: 382; Mature: 382

Protein sequence:

>382_residues
MDFKLTPEQEDIRRAAREFAEKEFTPEVIEECDREEKYPMEIVRKARDLGFSTVKIPEEYGGMGLSLFEEALVTEEFYRV
SPGIGNACLSSTFGTELLILFGSEEQKEKYLRWVTERHGISAMATTEPEAGSDVANVKTKIVKEGDEWVINGTKMFITNG
TVCDFVLVLGRTYEGEKRHHGLTFAIVESKSKGFKATKIKNKLGLRASDTAEIVLKDVKVPEENILGEPGKGFYYLMEFF
NHTRPRVAAQAVGIAQGAFELALNYVKQRKQFGQPIAAFQHTQFKIAEMATRIQAARLLTWQAAWQCSIGQSRPELSSMA
KWFAGETAVYVADWCVQLHGGYGYIGEYPAERYYRDAKLMEIYEGTKEVQKQIIARRLIGKL

Sequences:

>Translated_382_residues
MDFKLTPEQEDIRRAAREFAEKEFTPEVIEECDREEKYPMEIVRKARDLGFSTVKIPEEYGGMGLSLFEEALVTEEFYRV
SPGIGNACLSSTFGTELLILFGSEEQKEKYLRWVTERHGISAMATTEPEAGSDVANVKTKIVKEGDEWVINGTKMFITNG
TVCDFVLVLGRTYEGEKRHHGLTFAIVESKSKGFKATKIKNKLGLRASDTAEIVLKDVKVPEENILGEPGKGFYYLMEFF
NHTRPRVAAQAVGIAQGAFELALNYVKQRKQFGQPIAAFQHTQFKIAEMATRIQAARLLTWQAAWQCSIGQSRPELSSMA
KWFAGETAVYVADWCVQLHGGYGYIGEYPAERYYRDAKLMEIYEGTKEVQKQIIARRLIGKL
>Mature_382_residues
MDFKLTPEQEDIRRAAREFAEKEFTPEVIEECDREEKYPMEIVRKARDLGFSTVKIPEEYGGMGLSLFEEALVTEEFYRV
SPGIGNACLSSTFGTELLILFGSEEQKEKYLRWVTERHGISAMATTEPEAGSDVANVKTKIVKEGDEWVINGTKMFITNG
TVCDFVLVLGRTYEGEKRHHGLTFAIVESKSKGFKATKIKNKLGLRASDTAEIVLKDVKVPEENILGEPGKGFYYLMEFF
NHTRPRVAAQAVGIAQGAFELALNYVKQRKQFGQPIAAFQHTQFKIAEMATRIQAARLLTWQAAWQCSIGQSRPELSSMA
KWFAGETAVYVADWCVQLHGGYGYIGEYPAERYYRDAKLMEIYEGTKEVQKQIIARRLIGKL

Specific function: Involved in the degradation of long-chain fatty acids [H]

COG id: COG1960

COG function: function code I; Acyl-CoA dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the acyl-CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI4557231, Length=381, Percent_Identity=41.2073490813648, Blast_Score=283, Evalue=2e-76,
Organism=Homo sapiens, GI187960098, Length=381, Percent_Identity=41.2073490813648, Blast_Score=283, Evalue=2e-76,
Organism=Homo sapiens, GI4557233, Length=376, Percent_Identity=38.2978723404255, Blast_Score=259, Evalue=4e-69,
Organism=Homo sapiens, GI4501857, Length=377, Percent_Identity=37.1352785145889, Blast_Score=243, Evalue=2e-64,
Organism=Homo sapiens, GI4501859, Length=375, Percent_Identity=35.7333333333333, Blast_Score=241, Evalue=8e-64,
Organism=Homo sapiens, GI226958412, Length=382, Percent_Identity=35.6020942408377, Blast_Score=231, Evalue=7e-61,
Organism=Homo sapiens, GI7656849, Length=385, Percent_Identity=32.7272727272727, Blast_Score=225, Evalue=6e-59,
Organism=Homo sapiens, GI226958414, Length=344, Percent_Identity=36.9186046511628, Blast_Score=219, Evalue=3e-57,
Organism=Homo sapiens, GI21361497, Length=370, Percent_Identity=32.972972972973, Blast_Score=182, Evalue=3e-46,
Organism=Homo sapiens, GI4557235, Length=337, Percent_Identity=30.8605341246291, Blast_Score=170, Evalue=2e-42,
Organism=Homo sapiens, GI76496475, Length=337, Percent_Identity=30.8605341246291, Blast_Score=170, Evalue=2e-42,
Organism=Homo sapiens, GI4503943, Length=381, Percent_Identity=28.8713910761155, Blast_Score=147, Evalue=2e-35,
Organism=Homo sapiens, GI7669494, Length=365, Percent_Identity=28.7671232876712, Blast_Score=135, Evalue=8e-32,
Organism=Homo sapiens, GI211971008, Length=331, Percent_Identity=29.0030211480363, Blast_Score=122, Evalue=6e-28,
Organism=Homo sapiens, GI48976061, Length=331, Percent_Identity=29.0030211480363, Blast_Score=122, Evalue=7e-28,
Organism=Homo sapiens, GI38505218, Length=324, Percent_Identity=29.0123456790123, Blast_Score=116, Evalue=3e-26,
Organism=Escherichia coli, GI1786223, Length=380, Percent_Identity=32.6315789473684, Blast_Score=194, Evalue=1e-50,
Organism=Escherichia coli, GI87081958, Length=384, Percent_Identity=33.8541666666667, Blast_Score=192, Evalue=3e-50,
Organism=Caenorhabditis elegans, GI17570075, Length=384, Percent_Identity=39.0625, Blast_Score=286, Evalue=2e-77,
Organism=Caenorhabditis elegans, GI17534899, Length=380, Percent_Identity=41.0526315789474, Blast_Score=282, Evalue=2e-76,
Organism=Caenorhabditis elegans, GI17569725, Length=382, Percent_Identity=39.2670157068063, Blast_Score=269, Evalue=2e-72,
Organism=Caenorhabditis elegans, GI17508101, Length=375, Percent_Identity=37.3333333333333, Blast_Score=243, Evalue=1e-64,
Organism=Caenorhabditis elegans, GI17506239, Length=363, Percent_Identity=36.6391184573003, Blast_Score=237, Evalue=7e-63,
Organism=Caenorhabditis elegans, GI17538396, Length=385, Percent_Identity=35.0649350649351, Blast_Score=235, Evalue=3e-62,
Organism=Caenorhabditis elegans, GI17533517, Length=387, Percent_Identity=32.8165374677003, Blast_Score=225, Evalue=4e-59,
Organism=Caenorhabditis elegans, GI71990804, Length=293, Percent_Identity=38.2252559726962, Blast_Score=191, Evalue=5e-49,
Organism=Caenorhabditis elegans, GI17505929, Length=368, Percent_Identity=31.25, Blast_Score=182, Evalue=2e-46,
Organism=Caenorhabditis elegans, GI17551932, Length=362, Percent_Identity=31.2154696132597, Blast_Score=180, Evalue=1e-45,
Organism=Caenorhabditis elegans, GI71982178, Length=276, Percent_Identity=35.1449275362319, Blast_Score=171, Evalue=5e-43,
Organism=Caenorhabditis elegans, GI71985184, Length=351, Percent_Identity=29.0598290598291, Blast_Score=158, Evalue=5e-39,
Organism=Caenorhabditis elegans, GI32563615, Length=229, Percent_Identity=37.5545851528384, Blast_Score=157, Evalue=1e-38,
Organism=Caenorhabditis elegans, GI17534353, Length=384, Percent_Identity=30.46875, Blast_Score=154, Evalue=6e-38,
Organism=Caenorhabditis elegans, GI17531909, Length=234, Percent_Identity=33.3333333333333, Blast_Score=130, Evalue=1e-30,
Organism=Caenorhabditis elegans, GI71985192, Length=285, Percent_Identity=27.719298245614, Blast_Score=119, Evalue=2e-27,
Organism=Caenorhabditis elegans, GI17562446, Length=332, Percent_Identity=29.2168674698795, Blast_Score=116, Evalue=2e-26,
Organism=Caenorhabditis elegans, GI17531913, Length=176, Percent_Identity=32.9545454545455, Blast_Score=99, Evalue=4e-21,
Organism=Caenorhabditis elegans, GI86563383, Length=277, Percent_Identity=25.9927797833935, Blast_Score=80, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI86563381, Length=277, Percent_Identity=25.9927797833935, Blast_Score=80, Evalue=2e-15,
Organism=Drosophila melanogaster, GI24660351, Length=378, Percent_Identity=42.0634920634921, Blast_Score=279, Evalue=2e-75,
Organism=Drosophila melanogaster, GI21356377, Length=377, Percent_Identity=38.7267904509284, Blast_Score=269, Evalue=2e-72,
Organism=Drosophila melanogaster, GI24646207, Length=383, Percent_Identity=38.9033942558747, Blast_Score=262, Evalue=3e-70,
Organism=Drosophila melanogaster, GI24666513, Length=373, Percent_Identity=37.2654155495979, Blast_Score=249, Evalue=2e-66,
Organism=Drosophila melanogaster, GI21355753, Length=386, Percent_Identity=35.7512953367876, Blast_Score=233, Evalue=1e-61,
Organism=Drosophila melanogaster, GI281363737, Length=344, Percent_Identity=31.9767441860465, Blast_Score=176, Evalue=2e-44,
Organism=Drosophila melanogaster, GI19920834, Length=389, Percent_Identity=30.8483290488432, Blast_Score=153, Evalue=2e-37,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006089
- InterPro:   IPR006092
- InterPro:   IPR006090
- InterPro:   IPR006091
- InterPro:   IPR009075
- InterPro:   IPR013786
- InterPro:   IPR009100 [H]

Pfam domain/function: PF00441 Acyl-CoA_dh_1; PF02770 Acyl-CoA_dh_M; PF02771 Acyl-CoA_dh_N [H]

EC number: 1.3.99.3

Molecular weight: Translated: 43241; Mature: 43241

Theoretical pI: Translated: 6.53; Mature: 6.53

Prosite motif: PS00073 ACYL_COA_DH_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDFKLTPEQEDIRRAAREFAEKEFTPEVIEECDREEKYPMEIVRKARDLGFSTVKIPEEY
CCCCCCCCHHHHHHHHHHHHHHCCCHHHHHHCCCCCCCCHHHHHHHHHCCCCEEECCHHH
GGMGLSLFEEALVTEEFYRVSPGIGNACLSSTFGTELLILFGSEEQKEKYLRWVTERHGI
CCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHCCCCEEEEEECCCHHHHHHHHHHHHHCCC
SAMATTEPEAGSDVANVKTKIVKEGDEWVINGTKMFITNGTVCDFVLVLGRTYEGEKRHH
EEEECCCCCCCCHHHHHHHHHHCCCCEEEEECEEEEEECCHHHHHHHHHCCCCCCCHHHC
GLTFAIVESKSKGFKATKIKNKLGLRASDTAEIVLKDVKVPEENILGEPGKGFYYLMEFF
CEEEEEEECCCCCCCHHHHHHHHCCCCCCHHHHHHHHCCCCHHHCCCCCCCCHHHHHHHH
NHTRPRVAAQAVGIAQGAFELALNYVKQRKQFGQPIAAFQHTQFKIAEMATRIQAARLLT
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHH
WQAAWQCSIGQSRPELSSMAKWFAGETAVYVADWCVQLHGGYGYIGEYPAERYYRDAKLM
HHHHHEECCCCCCHHHHHHHHHHCCCCEEEHHHHHHHHCCCCCCCCCCCHHHHHHHHHHH
EIYEGTKEVQKQIIARRLIGKL
HHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MDFKLTPEQEDIRRAAREFAEKEFTPEVIEECDREEKYPMEIVRKARDLGFSTVKIPEEY
CCCCCCCCHHHHHHHHHHHHHHCCCHHHHHHCCCCCCCCHHHHHHHHHCCCCEEECCHHH
GGMGLSLFEEALVTEEFYRVSPGIGNACLSSTFGTELLILFGSEEQKEKYLRWVTERHGI
CCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHCCCCEEEEEECCCHHHHHHHHHHHHHCCC
SAMATTEPEAGSDVANVKTKIVKEGDEWVINGTKMFITNGTVCDFVLVLGRTYEGEKRHH
EEEECCCCCCCCHHHHHHHHHHCCCCEEEEECEEEEEECCHHHHHHHHHCCCCCCCHHHC
GLTFAIVESKSKGFKATKIKNKLGLRASDTAEIVLKDVKVPEENILGEPGKGFYYLMEFF
CEEEEEEECCCCCCCHHHHHHHHCCCCCCHHHHHHHHCCCCHHHCCCCCCCCHHHHHHHH
NHTRPRVAAQAVGIAQGAFELALNYVKQRKQFGQPIAAFQHTQFKIAEMATRIQAARLLT
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHH
WQAAWQCSIGQSRPELSSMAKWFAGETAVYVADWCVQLHGGYGYIGEYPAERYYRDAKLM
HHHHHEECCCCCCHHHHHHHHHHCCCCEEEHHHHHHHHCCCCCCCCCCCHHHHHHHHHHH
EIYEGTKEVQKQIIARRLIGKL
HHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: acyl-CoA; acceptor

Specific reaction: acyl-CoA + acceptor = 2,3-dehydroacyl-CoA + reduced acceptor

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9353933; 9384377 [H]