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The map label for this gene is hbd-3

Identifier: 11498046

GI number: 11498046

Start: 391316

End: 392230

Strand: Reverse

Name: hbd-3

Synonym: AF0434

Alternate gene names: 11498046

Gene position: 392230-391316 (Counterclockwise)

Preceding gene: 11498047

Following gene: 11498045

Centisome position: 18.01

GC content: 53.66

Gene sequence:

>915_bases
ATGTTCGAGAAGATTGGAGTTGTCGGATTCGGCCTGATGGGCACCCAGATAACCCAATTTTTTGCCCAGCAGGGTTTGGA
GGTTGTTGCGATTGACGTTAGCGAGGAAAGGCTGAGGAAGGGAATGGAGGCGATAAAAGCCGGCAGATTTGGACTGCAGA
GGCTTGTGGAAAAAGGAAAAATCACGGAGGAGGAGATGAACGCTGTGCTGAGCAGAATATCCACCAGCACATCTCACAGC
GCTTTAAAGGACTGTGATCTGGTAATAGAGGCCGTTTTCGAGGACGTTAACCTGAAGCTGAAGGTTCTGAGGGAGATTGA
TGCTGTTACGGATGCGGTCATAGGCTCAAACACCTCCTCAATAAGCATAACCAAGCTCTCCTCCGCCGTCAGCAACCCAG
AGAGGTTTCTGGGCATTCACTTCTTCAACCCAGCGCAGATTCAGAAGCTTGTTGAGCTTGTAAAGGGCTTGCTGAGCGAC
GAGAAGCTTGTTAACGGCATCAGAGACTGGTTCCTCAAGCTGGGAAAAGTGCCCATCGTCGTCAATGACTCCCCCGGCTT
TGCTACCTCCCGCCTTGGCCTTGTTCTTGGCAAGGAGGCCTTGCTGATGGTTCAGGAAGGTGTTGCGACACCGCAGGACA
TCGACATCGGCATGATGCTCGGCTACGGCTACTCTATGGGCCCCATTGAGACGGGAGATTTGGTCGGCCTCGACACGAGG
CTCAGAATCTACGAGGCGATGTTCGAGGCAACGAAAGACCCCAAGTGGGCACCTCCAAAGCTACTCGTCCAGCTTGTGGA
TGCTGGCTATCTGGGCGACCCATCGTTAAAGCCGGGCAGCAAGGGAGGTGTTTACGAGTACTTCGGGCAGGAGAGGGCTA
CTGAGGTGCTGAGGAGGTTGGGGGTTCGTAAGTGA

Upstream 100 bases:

>100_bases
GCAAGCCTCTTCGCCCTGCTCTTCTCCAGCGAGGATGCTAAGGAGGGGATGAGGGCGTTTCTGGAGAAGAGGAAGCCTGA
GTTTAGGGGAAGGTGATGGC

Downstream 100 bases:

>100_bases
TTTTCTTTCAATTTTTCTTCTCATAAATTTACTGTTCTTTGTAACCTTTGGTAACACCAAAAACCAAAATTTTAATCTTC
AGTCTGCCATTAGCACAGTT

Product: 3-hydroxyacyl-CoA dehydrogenase (hbd-3)

Products: NA

Alternate protein names: Beta-hydroxybutyryl-CoA dehydrogenase; BHBD [H]

Number of amino acids: Translated: 304; Mature: 304

Protein sequence:

>304_residues
MFEKIGVVGFGLMGTQITQFFAQQGLEVVAIDVSEERLRKGMEAIKAGRFGLQRLVEKGKITEEEMNAVLSRISTSTSHS
ALKDCDLVIEAVFEDVNLKLKVLREIDAVTDAVIGSNTSSISITKLSSAVSNPERFLGIHFFNPAQIQKLVELVKGLLSD
EKLVNGIRDWFLKLGKVPIVVNDSPGFATSRLGLVLGKEALLMVQEGVATPQDIDIGMMLGYGYSMGPIETGDLVGLDTR
LRIYEAMFEATKDPKWAPPKLLVQLVDAGYLGDPSLKPGSKGGVYEYFGQERATEVLRRLGVRK

Sequences:

>Translated_304_residues
MFEKIGVVGFGLMGTQITQFFAQQGLEVVAIDVSEERLRKGMEAIKAGRFGLQRLVEKGKITEEEMNAVLSRISTSTSHS
ALKDCDLVIEAVFEDVNLKLKVLREIDAVTDAVIGSNTSSISITKLSSAVSNPERFLGIHFFNPAQIQKLVELVKGLLSD
EKLVNGIRDWFLKLGKVPIVVNDSPGFATSRLGLVLGKEALLMVQEGVATPQDIDIGMMLGYGYSMGPIETGDLVGLDTR
LRIYEAMFEATKDPKWAPPKLLVQLVDAGYLGDPSLKPGSKGGVYEYFGQERATEVLRRLGVRK
>Mature_304_residues
MFEKIGVVGFGLMGTQITQFFAQQGLEVVAIDVSEERLRKGMEAIKAGRFGLQRLVEKGKITEEEMNAVLSRISTSTSHS
ALKDCDLVIEAVFEDVNLKLKVLREIDAVTDAVIGSNTSSISITKLSSAVSNPERFLGIHFFNPAQIQKLVELVKGLLSD
EKLVNGIRDWFLKLGKVPIVVNDSPGFATSRLGLVLGKEALLMVQEGVATPQDIDIGMMLGYGYSMGPIETGDLVGLDTR
LRIYEAMFEATKDPKWAPPKLLVQLVDAGYLGDPSLKPGSKGGVYEYFGQERATEVLRRLGVRK

Specific function: Butyrate/butanol-producing pathway. Phenylacetic acid aerobic catabolism. [C]

COG id: COG1250

COG function: function code I; 3-hydroxyacyl-CoA dehydrogenase

Gene ontology:

Cell location: Mitochondria or Peroxisomes [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 3-hydroxyacyl-CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI296179429, Length=291, Percent_Identity=35.7388316151203, Blast_Score=166, Evalue=2e-41,
Organism=Homo sapiens, GI296179427, Length=308, Percent_Identity=33.7662337662338, Blast_Score=155, Evalue=3e-38,
Organism=Homo sapiens, GI20127408, Length=288, Percent_Identity=30.9027777777778, Blast_Score=134, Evalue=1e-31,
Organism=Homo sapiens, GI261878539, Length=236, Percent_Identity=30.5084745762712, Blast_Score=117, Evalue=1e-26,
Organism=Homo sapiens, GI68989263, Length=236, Percent_Identity=30.5084745762712, Blast_Score=117, Evalue=1e-26,
Organism=Homo sapiens, GI115430219, Length=235, Percent_Identity=28.0851063829787, Blast_Score=89, Evalue=4e-18,
Organism=Escherichia coli, GI1787661, Length=294, Percent_Identity=35.0340136054422, Blast_Score=164, Evalue=5e-42,
Organism=Escherichia coli, GI1790281, Length=221, Percent_Identity=36.6515837104072, Blast_Score=132, Evalue=3e-32,
Organism=Escherichia coli, GI1788682, Length=210, Percent_Identity=30.4761904761905, Blast_Score=103, Evalue=1e-23,
Organism=Caenorhabditis elegans, GI17549919, Length=291, Percent_Identity=33.6769759450172, Blast_Score=156, Evalue=1e-38,
Organism=Caenorhabditis elegans, GI17563036, Length=297, Percent_Identity=32.3232323232323, Blast_Score=144, Evalue=6e-35,
Organism=Caenorhabditis elegans, GI17553560, Length=296, Percent_Identity=33.445945945946, Blast_Score=143, Evalue=1e-34,
Organism=Caenorhabditis elegans, GI17508953, Length=274, Percent_Identity=31.3868613138686, Blast_Score=132, Evalue=2e-31,
Organism=Caenorhabditis elegans, GI25144276, Length=274, Percent_Identity=31.3868613138686, Blast_Score=132, Evalue=2e-31,
Organism=Caenorhabditis elegans, GI17508951, Length=274, Percent_Identity=31.3868613138686, Blast_Score=132, Evalue=2e-31,
Organism=Caenorhabditis elegans, GI17558304, Length=289, Percent_Identity=29.757785467128, Blast_Score=125, Evalue=2e-29,
Organism=Caenorhabditis elegans, GI71985923, Length=242, Percent_Identity=29.7520661157025, Blast_Score=125, Evalue=3e-29,
Organism=Caenorhabditis elegans, GI71985930, Length=236, Percent_Identity=29.6610169491525, Blast_Score=117, Evalue=6e-27,
Organism=Caenorhabditis elegans, GI193203623, Length=221, Percent_Identity=28.9592760180996, Blast_Score=77, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI115533614, Length=221, Percent_Identity=28.9592760180996, Blast_Score=77, Evalue=2e-14,
Organism=Drosophila melanogaster, GI19921000, Length=294, Percent_Identity=34.3537414965986, Blast_Score=151, Evalue=6e-37,
Organism=Drosophila melanogaster, GI24583077, Length=294, Percent_Identity=34.3537414965986, Blast_Score=150, Evalue=7e-37,
Organism=Drosophila melanogaster, GI24583079, Length=294, Percent_Identity=34.3537414965986, Blast_Score=150, Evalue=7e-37,
Organism=Drosophila melanogaster, GI45549573, Length=242, Percent_Identity=29.7520661157025, Blast_Score=87, Evalue=2e-17,
Organism=Drosophila melanogaster, GI20129993, Length=242, Percent_Identity=27.6859504132231, Blast_Score=77, Evalue=1e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR022694
- InterPro:   IPR006180
- InterPro:   IPR006176
- InterPro:   IPR006108
- InterPro:   IPR008927
- InterPro:   IPR013328
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00725 3HCDH; PF02737 3HCDH_N [H]

EC number: =1.1.1.157 [H]

Molecular weight: Translated: 33251; Mature: 33251

Theoretical pI: Translated: 5.53; Mature: 5.53

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFEKIGVVGFGLMGTQITQFFAQQGLEVVAIDVSEERLRKGMEAIKAGRFGLQRLVEKGK
CCCCCCHHCCHHHHHHHHHHHHHCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHCC
ITEEEMNAVLSRISTSTSHSALKDCDLVIEAVFEDVNLKLKVLREIDAVTDAVIGSNTSS
CCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCE
ISITKLSSAVSNPERFLGIHFFNPAQIQKLVELVKGLLSDEKLVNGIRDWFLKLGKVPIV
EEEHHHHHHHCCCCCEEEEEECCHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHCCCCEE
VNDSPGFATSRLGLVLGKEALLMVQEGVATPQDIDIGMMLGYGYSMGPIETGDLVGLDTR
EECCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEECCCCCCCCCCCCCEECCCHH
LRIYEAMFEATKDPKWAPPKLLVQLVDAGYLGDPSLKPGSKGGVYEYFGQERATEVLRRL
HHHHHHHHHHCCCCCCCCHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHH
GVRK
CCCC
>Mature Secondary Structure
MFEKIGVVGFGLMGTQITQFFAQQGLEVVAIDVSEERLRKGMEAIKAGRFGLQRLVEKGK
CCCCCCHHCCHHHHHHHHHHHHHCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHCC
ITEEEMNAVLSRISTSTSHSALKDCDLVIEAVFEDVNLKLKVLREIDAVTDAVIGSNTSS
CCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCE
ISITKLSSAVSNPERFLGIHFFNPAQIQKLVELVKGLLSDEKLVNGIRDWFLKLGKVPIV
EEEHHHHHHHCCCCCEEEEEECCHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHCCCCEE
VNDSPGFATSRLGLVLGKEALLMVQEGVATPQDIDIGMMLGYGYSMGPIETGDLVGLDTR
EECCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEECCCCCCCCCCCCCEECCCHH
LRIYEAMFEATKDPKWAPPKLLVQLVDAGYLGDPSLKPGSKGGVYEYFGQERATEVLRRL
HHHHHHHHHHCCCCCCCCHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHH
GVRK
CCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA