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The map label for this gene is noxA-2

Identifier: 11498007

GI number: 11498007

Start: 359369

End: 360679

Strand: Reverse

Name: noxA-2

Synonym: AF0395

Alternate gene names: 11498007

Gene position: 360679-359369 (Counterclockwise)

Preceding gene: 11498008

Following gene: 11498006

Centisome position: 16.56

GC content: 53.47

Gene sequence:

>1311_bases
ATGAGGGTAGTTGTTATCGGCGGTGGGGCAGCGGGAATGAGCGCTGCTTCGAGAGTTAAGGCTTTGCAGCCTGAGTGGGA
GGTTACGGTTTTTGAGGAGACCAACTTTGTCAGCCACGCTCCATGCGGGATTCCGTACGTTGTTGAAGGCTTGAGCGACC
CCTCACACCTGATGTACTACCCGCCGGAATTTTTCAGGGAGAAAAGGGGCATTGATTTGCACATCAACGCGAAGGTAGTT
GAGGCTGGAGACGGCTTTGTGAGAGTCATAGAGGACGGTCAGGAGAAAACCTACGAGTGGGATAAGCTTGTAATCGCCAC
CGGAGCACTTCCAAAAACCCCACCCTTCGAGGGCCTTGAGCTGGAAAACGTTTTCACCGTCAGACATCCTGTACAGGCGG
CTGAGCTGAGAGAGGCGGTTGAGAAGGCGGAGAACGTTGTAATCGTTGGTGCTGGCTACGTAGGAGTTGAGATGGCCGAA
GCTGCGGCAGCGAGAGGGAAGAAAGTAACGGTTGTGGAGTTTCTTGATCAACCACTCCCAAACCTCGACAGGGATGTTGC
GGACTTGGTGAAGCATAAGCTTGAGGAGAAGGTCAACCTGAGGCTGGGGGAGAAGGTAGAGGCTTTTGAGGGCGATGGAG
CGGTGAGGAAAGTGGTGACTGACAAAGGAGAGTATCCTGCAGATGTGGTTATAGTTGCAACGGGCGTGAAGGCCAACACT
GCCATTGCCGAGCAGATTGGCTGCAAGATTGGAGAGACTGGAGCAATCTGGACGGACAGCAGGATGCAGACAAGCGTTGA
GAATGTTTTTGCTGCTGGAGATTGCGCTGAAACAACCCACATGCTGACGAAAAAGAGAGTCTGGATTCCCTTAGCCCCGC
CGGGCAACAAGATGGGCTACGTTGCGGGAGTTAACGCCGCTGGCGGCAACATTGAGTTTCCCGGAGTGCTTGGAACTCAG
CTTACGAAGTTCTTCGACCTTGAAATTGGCGCCACGGGGCTGACGGAGAAGGCTGCGAAAGCTGAGGGATTTGAGGTTAA
AACAGCTGTCGTGAAAGCAAAAACCAGAGTTCACTACTACCCCGGGGCCAAGGACACCTTCCTAAAGGTTGTGGCGGATG
CAAGCACAAAGAGAATTCTGGGAGCGCAGGTTCTCGGGGCGGATGTGGCGATGAGGGTTAACGTCTTTGCTGCGATGATA
CAGGGCGGCTTCACGACGAAGGATGTTTTCTTCGCCGACCTCGGCTATGCTCCTCCATTCACACCCATCTGGGACCCGAT
TGTTGTTTCGGCAAGAATTCTTAAATTCTAA

Upstream 100 bases:

>100_bases
CATTTTGAAACTCAGAGCCTTTTCGCTCCTACAAAACCACAGATTACTCAACTTCCCAAAACCGCGAAAAGCATAAATTA
GTCTTGAACAATGATAAAGC

Downstream 100 bases:

>100_bases
ACTATTTTTTTCATGAGCTGGATTGATGAGCTTTCAAAAATTGTTGAGGTCTTTCCACCATCGGACGCTTATCGCTTCGA
TGAAACTCCACCTCTCGTTG

Product: NADH oxidase (noxA-2)

Products: NA

Alternate protein names: CoA-disulfide reductase; CoADR [H]

Number of amino acids: Translated: 436; Mature: 436

Protein sequence:

>436_residues
MRVVVIGGGAAGMSAASRVKALQPEWEVTVFEETNFVSHAPCGIPYVVEGLSDPSHLMYYPPEFFREKRGIDLHINAKVV
EAGDGFVRVIEDGQEKTYEWDKLVIATGALPKTPPFEGLELENVFTVRHPVQAAELREAVEKAENVVIVGAGYVGVEMAE
AAAARGKKVTVVEFLDQPLPNLDRDVADLVKHKLEEKVNLRLGEKVEAFEGDGAVRKVVTDKGEYPADVVIVATGVKANT
AIAEQIGCKIGETGAIWTDSRMQTSVENVFAAGDCAETTHMLTKKRVWIPLAPPGNKMGYVAGVNAAGGNIEFPGVLGTQ
LTKFFDLEIGATGLTEKAAKAEGFEVKTAVVKAKTRVHYYPGAKDTFLKVVADASTKRILGAQVLGADVAMRVNVFAAMI
QGGFTTKDVFFADLGYAPPFTPIWDPIVVSARILKF

Sequences:

>Translated_436_residues
MRVVVIGGGAAGMSAASRVKALQPEWEVTVFEETNFVSHAPCGIPYVVEGLSDPSHLMYYPPEFFREKRGIDLHINAKVV
EAGDGFVRVIEDGQEKTYEWDKLVIATGALPKTPPFEGLELENVFTVRHPVQAAELREAVEKAENVVIVGAGYVGVEMAE
AAAARGKKVTVVEFLDQPLPNLDRDVADLVKHKLEEKVNLRLGEKVEAFEGDGAVRKVVTDKGEYPADVVIVATGVKANT
AIAEQIGCKIGETGAIWTDSRMQTSVENVFAAGDCAETTHMLTKKRVWIPLAPPGNKMGYVAGVNAAGGNIEFPGVLGTQ
LTKFFDLEIGATGLTEKAAKAEGFEVKTAVVKAKTRVHYYPGAKDTFLKVVADASTKRILGAQVLGADVAMRVNVFAAMI
QGGFTTKDVFFADLGYAPPFTPIWDPIVVSARILKF
>Mature_436_residues
MRVVVIGGGAAGMSAASRVKALQPEWEVTVFEETNFVSHAPCGIPYVVEGLSDPSHLMYYPPEFFREKRGIDLHINAKVV
EAGDGFVRVIEDGQEKTYEWDKLVIATGALPKTPPFEGLELENVFTVRHPVQAAELREAVEKAENVVIVGAGYVGVEMAE
AAAARGKKVTVVEFLDQPLPNLDRDVADLVKHKLEEKVNLRLGEKVEAFEGDGAVRKVVTDKGEYPADVVIVATGVKANT
AIAEQIGCKIGETGAIWTDSRMQTSVENVFAAGDCAETTHMLTKKRVWIPLAPPGNKMGYVAGVNAAGGNIEFPGVLGTQ
LTKFFDLEIGATGLTEKAAKAEGFEVKTAVVKAKTRVHYYPGAKDTFLKVVADASTKRILGAQVLGADVAMRVNVFAAMI
QGGFTTKDVFFADLGYAPPFTPIWDPIVVSARILKF

Specific function: Unknown

COG id: COG0446

COG function: function code R; Uncharacterized NAD(FAD)-dependent dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-III pyridine nucleotide-disulfide oxidoreductase family [H]

Homologues:

Organism=Homo sapiens, GI226437568, Length=321, Percent_Identity=30.8411214953271, Blast_Score=107, Evalue=2e-23,
Organism=Homo sapiens, GI65787454, Length=321, Percent_Identity=30.8411214953271, Blast_Score=107, Evalue=2e-23,
Organism=Homo sapiens, GI21389617, Length=321, Percent_Identity=30.8411214953271, Blast_Score=107, Evalue=2e-23,
Organism=Homo sapiens, GI91199540, Length=351, Percent_Identity=26.7806267806268, Blast_Score=73, Evalue=4e-13,
Organism=Escherichia coli, GI1789065, Length=320, Percent_Identity=26.5625, Blast_Score=100, Evalue=3e-22,
Organism=Escherichia coli, GI1788892, Length=285, Percent_Identity=29.8245614035088, Blast_Score=92, Evalue=5e-20,
Organism=Escherichia coli, GI1786307, Length=320, Percent_Identity=28.125, Blast_Score=92, Evalue=7e-20,
Organism=Escherichia coli, GI1789765, Length=394, Percent_Identity=23.8578680203046, Blast_Score=76, Evalue=4e-15,
Organism=Escherichia coli, GI87081717, Length=427, Percent_Identity=24.5901639344262, Blast_Score=74, Evalue=2e-14,
Organism=Escherichia coli, GI87082354, Length=328, Percent_Identity=26.5243902439024, Blast_Score=68, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17559934, Length=214, Percent_Identity=30.3738317757009, Blast_Score=92, Evalue=5e-19,
Organism=Drosophila melanogaster, GI24585130, Length=312, Percent_Identity=27.2435897435897, Blast_Score=96, Evalue=6e-20,
Organism=Drosophila melanogaster, GI24639257, Length=320, Percent_Identity=25.3125, Blast_Score=88, Evalue=1e-17,
Organism=Drosophila melanogaster, GI281359715, Length=320, Percent_Identity=25.3125, Blast_Score=87, Evalue=2e-17,
Organism=Drosophila melanogaster, GI281359713, Length=320, Percent_Identity=25.3125, Blast_Score=87, Evalue=2e-17,
Organism=Drosophila melanogaster, GI24639250, Length=320, Percent_Identity=25.3125, Blast_Score=87, Evalue=2e-17,
Organism=Drosophila melanogaster, GI18543267, Length=320, Percent_Identity=25.3125, Blast_Score=87, Evalue=2e-17,
Organism=Drosophila melanogaster, GI24639252, Length=320, Percent_Identity=25.3125, Blast_Score=87, Evalue=2e-17,
Organism=Drosophila melanogaster, GI21358499, Length=348, Percent_Identity=26.4367816091954, Blast_Score=75, Evalue=9e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017758
- InterPro:   IPR016156
- InterPro:   IPR013027
- InterPro:   IPR004099
- InterPro:   IPR001327 [H]

Pfam domain/function: PF00070 Pyr_redox; PF07992 Pyr_redox_2; PF02852 Pyr_redox_dim [H]

EC number: =1.8.1.14 [H]

Molecular weight: Translated: 46964; Mature: 46964

Theoretical pI: Translated: 5.38; Mature: 5.38

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRVVVIGGGAAGMSAASRVKALQPEWEVTVFEETNFVSHAPCGIPYVVEGLSDPSHLMYY
CEEEEEECCCCCHHHHHHHHHCCCCCEEEEEECCCCCCCCCCCCCHHHHCCCCCCCEEEC
PPEFFREKRGIDLHINAKVVEAGDGFVRVIEDGQEKTYEWDKLVIATGALPKTPPFEGLE
CHHHHHHCCCCEEEEEEEEEECCCCEEEEEECCCCCCEEECEEEEEECCCCCCCCCCCCE
LENVFTVRHPVQAAELREAVEKAENVVIVGAGYVGVEMAEAAAARGKKVTVVEFLDQPLP
ECCEEEECCCCHHHHHHHHHHHHCCEEEEECCCHHHHHHHHHHHCCCEEEEHHHHCCCCC
NLDRDVADLVKHKLEEKVNLRLGEKVEAFEGDGAVRKVVTDKGEYPADVVIVATGVKANT
CCCHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCEEHHCCCCCCCCCEEEEEEECCCCCH
AIAEQIGCKIGETGAIWTDSRMQTSVENVFAAGDCAETTHMLTKKRVWIPLAPPGNKMGY
HHHHHHCCCCCCCCCEEECHHHHHHHHHHEECCCHHHHHHHHHHCEEEEEECCCCCCCEE
VAGVNAAGGNIEFPGVLGTQLTKFFDLEIGATGLTEKAAKAEGFEVKTAVVKAKTRVHYY
EEEECCCCCCEECCCCHHHHHHHEEEEEECCCCCCHHHHCCCCCEEEHEEEEEEEEEEEC
PGAKDTFLKVVADASTKRILGAQVLGADVAMRVNVFAAMIQGGFTTKDVFFADLGYAPPF
CCCCHHHHHEECCCCHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCHHEEEEECCCCCCC
TPIWDPIVVSARILKF
CCCCCHHHHHHHHHCC
>Mature Secondary Structure
MRVVVIGGGAAGMSAASRVKALQPEWEVTVFEETNFVSHAPCGIPYVVEGLSDPSHLMYY
CEEEEEECCCCCHHHHHHHHHCCCCCEEEEEECCCCCCCCCCCCCHHHHCCCCCCCEEEC
PPEFFREKRGIDLHINAKVVEAGDGFVRVIEDGQEKTYEWDKLVIATGALPKTPPFEGLE
CHHHHHHCCCCEEEEEEEEEECCCCEEEEEECCCCCCEEECEEEEEECCCCCCCCCCCCE
LENVFTVRHPVQAAELREAVEKAENVVIVGAGYVGVEMAEAAAARGKKVTVVEFLDQPLP
ECCEEEECCCCHHHHHHHHHHHHCCEEEEECCCHHHHHHHHHHHCCCEEEEHHHHCCCCC
NLDRDVADLVKHKLEEKVNLRLGEKVEAFEGDGAVRKVVTDKGEYPADVVIVATGVKANT
CCCHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCEEHHCCCCCCCCCEEEEEEECCCCCH
AIAEQIGCKIGETGAIWTDSRMQTSVENVFAAGDCAETTHMLTKKRVWIPLAPPGNKMGY
HHHHHHCCCCCCCCCEEECHHHHHHHHHHEECCCHHHHHHHHHHCEEEEEECCCCCCCEE
VAGVNAAGGNIEFPGVLGTQLTKFFDLEIGATGLTEKAAKAEGFEVKTAVVKAKTRVHYY
EEEECCCCCCEECCCCHHHHHHHEEEEEECCCCCCHHHHCCCCCEEEHEEEEEEEEEEEC
PGAKDTFLKVVADASTKRILGAQVLGADVAMRVNVFAAMIQGGFTTKDVFFADLGYAPPF
CCCCHHHHHEECCCCHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCHHEEEEECCCCCCC
TPIWDPIVVSARILKF
CCCCCHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA