Click here to switch to the map view.

The map label for this gene is dld

Identifier: 11498006

GI number: 11498006

Start: 358025

End: 359356

Strand: Reverse

Name: dld

Synonym: AF0394

Alternate gene names: 11498006

Gene position: 359356-358025 (Counterclockwise)

Preceding gene: 11498007

Following gene: 11498005

Centisome position: 16.5

GC content: 53.15

Gene sequence:

>1332_bases
ATGAGCTGGATTGATGAGCTTTCAAAAATTGTTGAGGTCTTTCCACCATCGGACGCTTATCGCTTCGATGAAACTCCACC
TCTCGTTGCTCCCAGAGCAGCTGAAAATTTCGTTGTGGTGAAGCCCAGCAACAGCGAGGAGGTCTCGGCGATTTTGAAGT
TCGCCAACGAAAAAAGTATACCAGTTTTCATGAGGGGCGGTGGGACTGGGCTTAGCGGCGGGGCTGTGCCGACTGAGGAG
GGCATTGTACTCTCAACTGAAAAAATGACAGAGCTTGAGGTTGATGCCGACAACAGAGTTGCTATTTGCGGTGCGGGAGT
TACTTTGAAGCAGCTTGACGATGCAGCCTTCAGGCACGGCTTGAGCTTCCCGCCCCATCCCGGAGCTGAAACCGCAACAG
TCGGAGGGATGATTGCAACCAACGCTGGGGGAGTGAGGGCTTTGAAGTACGGAACCATGAGGAACTACGTTCTCAGCCTC
GAAGCTGTTCTTGCCGACGGCAGGATAATCAATGTTGGCGGGAAAACGATAAAGAACTCCTCGGGCTACTCTCTCCTTCA
CCTTCTTGTGGGGAGTGAGGGGACGCTTGCAGTGATAACTAAGGCAACAATTCGCCTTTTCCCGCAGATGAGGGACATGA
CTGTCCTCGCCATCCCCTTTCCGACGATGGAGGATGCTATGAACTGCGTTGTTGAGGTTGCGAGAAAAATGCTCCCCATG
GCCCTCGAATTCATGGAAAAGAGGGCAGTTGAGATTGGGGAGAAGGTTAGCGGGGAGAGGTGGGTGAGCAGGGAGGGGGA
GGCACACCTCCTGATGGTCTTCGAGAGCTTTGATGAGGCCGAGGAGGCTGCAAAAATTGCCCAGTCGCTTGGAGCGATTG
ACGTTTACGCAGCAACCACAAAGAAGGATCAGGACAGGCTGCTGAAAGTGAGGGGAATGATTTACGAGGGGCTGAGAAAG
GAGGTCATTGAGGTTCTCGACGCCTGCGTTCCTCCAGCTAAAATTGCCGAGTACTGGAGAAGGAGCAACGAGCTTGCTGA
AGAATATGGCATCGAGCTAATAACCTACGGCCATGCTGGAGATGGCAACGTCCACCAGCACCCGCTGGTTTACGAGGGAT
GGGAGAAAAGCTACTTTGAGTTCAGAAAGTCCCTCCTCAGCCTCGCTGTCAGCCTTGGCGGTGTGATCAGCGGCGAGCAC
GGTATAGGGGCGGTTAAGCTTTCGGAGCTAGAGGAGCTGTTTCCAGAGCAGTTCGAGCTGATGAGACAAATCAAGCTCCT
CTTCGACCCAAAAAACATCCTCAACCCCGGCAAGGTTGTTCGCAAACTATAA

Upstream 100 bases:

>100_bases
TGTTTTCTTCGCCGACCTCGGCTATGCTCCTCCATTCACACCCATCTGGGACCCGATTGTTGTTTCGGCAAGAATTCTTA
AATTCTAAACTATTTTTTTC

Downstream 100 bases:

>100_bases
ATATGCTACAGCACACCACTTGACGTGATAGAGGTTAACAACCTGACGGTGAGGTATGGAAAAACGACGGCTGTCAGCAA
TGTTGGATTCACAGTTGAGA

Product: D-lactate dehydrogenase, cytochrome-type (dld)

Products: pyruvate; ferrocytochrome c

Alternate protein names: NA

Number of amino acids: Translated: 443; Mature: 442

Protein sequence:

>443_residues
MSWIDELSKIVEVFPPSDAYRFDETPPLVAPRAAENFVVVKPSNSEEVSAILKFANEKSIPVFMRGGGTGLSGGAVPTEE
GIVLSTEKMTELEVDADNRVAICGAGVTLKQLDDAAFRHGLSFPPHPGAETATVGGMIATNAGGVRALKYGTMRNYVLSL
EAVLADGRIINVGGKTIKNSSGYSLLHLLVGSEGTLAVITKATIRLFPQMRDMTVLAIPFPTMEDAMNCVVEVARKMLPM
ALEFMEKRAVEIGEKVSGERWVSREGEAHLLMVFESFDEAEEAAKIAQSLGAIDVYAATTKKDQDRLLKVRGMIYEGLRK
EVIEVLDACVPPAKIAEYWRRSNELAEEYGIELITYGHAGDGNVHQHPLVYEGWEKSYFEFRKSLLSLAVSLGGVISGEH
GIGAVKLSELEELFPEQFELMRQIKLLFDPKNILNPGKVVRKL

Sequences:

>Translated_443_residues
MSWIDELSKIVEVFPPSDAYRFDETPPLVAPRAAENFVVVKPSNSEEVSAILKFANEKSIPVFMRGGGTGLSGGAVPTEE
GIVLSTEKMTELEVDADNRVAICGAGVTLKQLDDAAFRHGLSFPPHPGAETATVGGMIATNAGGVRALKYGTMRNYVLSL
EAVLADGRIINVGGKTIKNSSGYSLLHLLVGSEGTLAVITKATIRLFPQMRDMTVLAIPFPTMEDAMNCVVEVARKMLPM
ALEFMEKRAVEIGEKVSGERWVSREGEAHLLMVFESFDEAEEAAKIAQSLGAIDVYAATTKKDQDRLLKVRGMIYEGLRK
EVIEVLDACVPPAKIAEYWRRSNELAEEYGIELITYGHAGDGNVHQHPLVYEGWEKSYFEFRKSLLSLAVSLGGVISGEH
GIGAVKLSELEELFPEQFELMRQIKLLFDPKNILNPGKVVRKL
>Mature_442_residues
SWIDELSKIVEVFPPSDAYRFDETPPLVAPRAAENFVVVKPSNSEEVSAILKFANEKSIPVFMRGGGTGLSGGAVPTEEG
IVLSTEKMTELEVDADNRVAICGAGVTLKQLDDAAFRHGLSFPPHPGAETATVGGMIATNAGGVRALKYGTMRNYVLSLE
AVLADGRIINVGGKTIKNSSGYSLLHLLVGSEGTLAVITKATIRLFPQMRDMTVLAIPFPTMEDAMNCVVEVARKMLPMA
LEFMEKRAVEIGEKVSGERWVSREGEAHLLMVFESFDEAEEAAKIAQSLGAIDVYAATTKKDQDRLLKVRGMIYEGLRKE
VIEVLDACVPPAKIAEYWRRSNELAEEYGIELITYGHAGDGNVHQHPLVYEGWEKSYFEFRKSLLSLAVSLGGVISGEHG
IGAVKLSELEELFPEQFELMRQIKLLFDPKNILNPGKVVRKL

Specific function: Unknown

COG id: COG0277

COG function: function code C; FAD/FMN-containing dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 FAD-binding PCMH-type domain [H]

Homologues:

Organism=Homo sapiens, GI37595756, Length=423, Percent_Identity=33.096926713948, Blast_Score=189, Evalue=3e-48,
Organism=Homo sapiens, GI37595754, Length=446, Percent_Identity=31.390134529148, Blast_Score=181, Evalue=1e-45,
Organism=Homo sapiens, GI119964728, Length=418, Percent_Identity=30.3827751196172, Blast_Score=171, Evalue=1e-42,
Organism=Homo sapiens, GI4501993, Length=294, Percent_Identity=27.2108843537415, Blast_Score=100, Evalue=3e-21,
Organism=Escherichia coli, GI1789351, Length=423, Percent_Identity=31.6784869976359, Blast_Score=185, Evalue=5e-48,
Organism=Escherichia coli, GI1787977, Length=498, Percent_Identity=25.9036144578313, Blast_Score=100, Evalue=3e-22,
Organism=Escherichia coli, GI48994907, Length=175, Percent_Identity=33.7142857142857, Blast_Score=84, Evalue=1e-17,
Organism=Escherichia coli, GI48994914, Length=155, Percent_Identity=33.5483870967742, Blast_Score=73, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI71992373, Length=441, Percent_Identity=36.281179138322, Blast_Score=217, Evalue=1e-56,
Organism=Caenorhabditis elegans, GI71992381, Length=444, Percent_Identity=35.1351351351351, Blast_Score=197, Evalue=9e-51,
Organism=Caenorhabditis elegans, GI71992392, Length=388, Percent_Identity=34.2783505154639, Blast_Score=175, Evalue=5e-44,
Organism=Caenorhabditis elegans, GI17534361, Length=431, Percent_Identity=29.0023201856148, Blast_Score=153, Evalue=1e-37,
Organism=Caenorhabditis elegans, GI17556096, Length=459, Percent_Identity=23.7472766884532, Blast_Score=92, Evalue=8e-19,
Organism=Saccharomyces cerevisiae, GI6320027, Length=465, Percent_Identity=29.4623655913978, Blast_Score=167, Evalue=2e-42,
Organism=Saccharomyces cerevisiae, GI6320023, Length=430, Percent_Identity=29.5348837209302, Blast_Score=167, Evalue=3e-42,
Organism=Saccharomyces cerevisiae, GI6320764, Length=433, Percent_Identity=27.2517321016166, Blast_Score=147, Evalue=3e-36,
Organism=Drosophila melanogaster, GI18921117, Length=427, Percent_Identity=31.1475409836066, Blast_Score=176, Evalue=2e-44,
Organism=Drosophila melanogaster, GI24639277, Length=427, Percent_Identity=31.1475409836066, Blast_Score=176, Evalue=2e-44,
Organism=Drosophila melanogaster, GI24639275, Length=427, Percent_Identity=31.1475409836066, Blast_Score=176, Evalue=2e-44,
Organism=Drosophila melanogaster, GI24653753, Length=237, Percent_Identity=28.6919831223629, Blast_Score=84, Evalue=2e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016166
- InterPro:   IPR016167
- InterPro:   IPR016164
- InterPro:   IPR016168
- InterPro:   IPR004113
- InterPro:   IPR004490
- InterPro:   IPR006094
- InterPro:   IPR016171 [H]

Pfam domain/function: PF02913 FAD-oxidase_C; PF01565 FAD_binding_4 [H]

EC number: 1.1.2.4

Molecular weight: Translated: 48488; Mature: 48356

Theoretical pI: Translated: 5.01; Mature: 5.01

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSWIDELSKIVEVFPPSDAYRFDETPPLVAPRAAENFVVVKPSNSEEVSAILKFANEKSI
CCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCEEEECCCCCHHHHHHHHHHCCCCC
PVFMRGGGTGLSGGAVPTEEGIVLSTEKMTELEVDADNRVAICGAGVTLKQLDDAAFRHG
EEEEECCCCCCCCCCCCCCCCEEEECCCCEEEEECCCCEEEEEECCCCHHHHHHHHHHCC
LSFPPHPGAETATVGGMIATNAGGVRALKYGTMRNYVLSLEAVLADGRIINVGGKTIKNS
CCCCCCCCCCCEEECCEEEECCCCEEEEEHHHHHHHHHHHHHHHCCCEEEECCCCEEECC
SGYSLLHLLVGSEGTLAVITKATIRLFPQMRDMTVLAIPFPTMEDAMNCVVEVARKMLPM
CCCEEEEEEECCCCCEEEEEHHHHHHCCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHH
ALEFMEKRAVEIGEKVSGERWVSREGEAHLLMVFESFDEAEEAAKIAQSLGAIDVYAATT
HHHHHHHHHHHHHHHCCCCHHHCCCCCEEEEEEEHHHCHHHHHHHHHHHCCCEEEEEECC
KKDQDRLLKVRGMIYEGLRKEVIEVLDACVPPAKIAEYWRRSNELAEEYGIELITYGHAG
CCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCEEEEECCCC
DGNVHQHPLVYEGWEKSYFEFRKSLLSLAVSLGGVISGEHGIGAVKLSELEELFPEQFEL
CCCCCCCCCEECCCHHHHHHHHHHHHHHHHHHCCEEECCCCCCEEEHHHHHHHCHHHHHH
MRQIKLLFDPKNILNPGKVVRKL
HHHHHHHCCCHHHCCHHHHHHCC
>Mature Secondary Structure 
SWIDELSKIVEVFPPSDAYRFDETPPLVAPRAAENFVVVKPSNSEEVSAILKFANEKSI
CHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCEEEECCCCCHHHHHHHHHHCCCCC
PVFMRGGGTGLSGGAVPTEEGIVLSTEKMTELEVDADNRVAICGAGVTLKQLDDAAFRHG
EEEEECCCCCCCCCCCCCCCCEEEECCCCEEEEECCCCEEEEEECCCCHHHHHHHHHHCC
LSFPPHPGAETATVGGMIATNAGGVRALKYGTMRNYVLSLEAVLADGRIINVGGKTIKNS
CCCCCCCCCCCEEECCEEEECCCCEEEEEHHHHHHHHHHHHHHHCCCEEEECCCCEEECC
SGYSLLHLLVGSEGTLAVITKATIRLFPQMRDMTVLAIPFPTMEDAMNCVVEVARKMLPM
CCCEEEEEEECCCCCEEEEEHHHHHHCCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHH
ALEFMEKRAVEIGEKVSGERWVSREGEAHLLMVFESFDEAEEAAKIAQSLGAIDVYAATT
HHHHHHHHHHHHHHHCCCCHHHCCCCCEEEEEEEHHHCHHHHHHHHHHHCCCEEEEEECC
KKDQDRLLKVRGMIYEGLRKEVIEVLDACVPPAKIAEYWRRSNELAEEYGIELITYGHAG
CCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCEEEEECCCC
DGNVHQHPLVYEGWEKSYFEFRKSLLSLAVSLGGVISGEHGIGAVKLSELEELFPEQFEL
CCCCCCCCCEECCCHHHHHHHHHHHHHHHHHHCCEEECCCCCCEEEHHHHHHHCHHHHHH
MRQIKLLFDPKNILNPGKVVRKL
HHHHHHHCCCHHHCCHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: (R)-lactate; ferricytochrome c

Specific reaction: (R)-lactate + 2 ferricytochrome c = pyruvate + 2 ferrocytochrome c

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8969504; 9384377 [H]