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The map label for this gene is galE-1

Identifier: 11497973

GI number: 11497973

Start: 326924

End: 327841

Strand: Reverse

Name: galE-1

Synonym: AF0361

Alternate gene names: 11497973

Gene position: 327841-326924 (Counterclockwise)

Preceding gene: 11497977

Following gene: 11497970

Centisome position: 15.05

GC content: 49.46

Gene sequence:

>918_bases
ATGATTGTGGTGACGGGAGGAGCAGGATTTATAGGCAGCCATGTCGTCGATAAACTGTCAGAATCAAACGAAATAGTAGT
TATTGACAACCTCTCCAGCGGAAACGAGGAGTTTGTCAACGAGGCGGCAAGGCTCGTTAAAGCTGATTTGGCTGCTGATG
ACATCAAGGATTACCTGAAAGGTGCTGAAGAGGTCTGGCACATCGCCGCGAACCCAGATGTGAGAATTGGGGCTGAAAAT
CCCGATGAAATTTACAGAAACAACGTTCTCGCAACTTACAGACTGCTCGAGGCCATGAGAAAAGCGGGGGTGTCAAGGAT
AGTTTTCACCTCCACTTCGACCGTTTACGGTGAGGCTAAGGTGATTCCAACTCCCGAGGACTACCCCACGCACCCAATAA
GCCTTTACGGTGCTTCGAAGCTTGCCTGCGAAGCTCTGATCGAGTCCTACTGCCATACCTTTGACATGCAGGCGTGGATT
TACAGATTCGCCAATGTCATCGGGAGGAGGAGCACACACGGCGTGATATACGACTTCATAATGAAGCTGAAAAGGAATCC
GGAGGAGCTTGAAATTCTCGGTAATGGAGAGCAGAACAAATCCTACATCTACATTTCCGACTGCGTTGATGCGATGCTTT
TCGGTCTGAGGGGCGATGAGAGAGTCAACATATTCAACATAGGCAGCGAGGATCAGATTAAGGTGAAGAGAATTGCCGAA
ATAGTCTGCGAGGAGCTTGGACTGTCTCCCAGATTCAGATTCACGGGAGGAGATAGGGGGTGGAAGGGAGACGTGCCGGT
AATGCTCCTCAGCATTGAAAAGCTGAAAAGGCTGGGATGGAAGCCAAGATACAACAGCGAGGAAGCTGTGAGAATGGCCG
TGAGAGACCTCGTTGAAGATTTAGACGAACAGAACTGA

Upstream 100 bases:

>100_bases
TTTCCCACCATTGACTTTACCATCTGATTTGGAAGCACCATATCACCTCGCTGACCTGTGCAGAAAAAGTATATAACAAC
TCATTTTAAAATCTTTCCCA

Downstream 100 bases:

>100_bases
GAAGATTACCGCAAATATTCCGGTAAGGAAGATGCCGTCAAAGGTTCCAGCACCGCCAATGCTCACGACTCCCGAACCTA
TTTTGTTTAAATCCTTCAGA

Product: UDP-glucose 4-epimerase (galE-1)

Products: NA

Alternate protein names: Galactowaldenase; UDP-galactose 4-epimerase [H]

Number of amino acids: Translated: 305; Mature: 305

Protein sequence:

>305_residues
MIVVTGGAGFIGSHVVDKLSESNEIVVIDNLSSGNEEFVNEAARLVKADLAADDIKDYLKGAEEVWHIAANPDVRIGAEN
PDEIYRNNVLATYRLLEAMRKAGVSRIVFTSTSTVYGEAKVIPTPEDYPTHPISLYGASKLACEALIESYCHTFDMQAWI
YRFANVIGRRSTHGVIYDFIMKLKRNPEELEILGNGEQNKSYIYISDCVDAMLFGLRGDERVNIFNIGSEDQIKVKRIAE
IVCEELGLSPRFRFTGGDRGWKGDVPVMLLSIEKLKRLGWKPRYNSEEAVRMAVRDLVEDLDEQN

Sequences:

>Translated_305_residues
MIVVTGGAGFIGSHVVDKLSESNEIVVIDNLSSGNEEFVNEAARLVKADLAADDIKDYLKGAEEVWHIAANPDVRIGAEN
PDEIYRNNVLATYRLLEAMRKAGVSRIVFTSTSTVYGEAKVIPTPEDYPTHPISLYGASKLACEALIESYCHTFDMQAWI
YRFANVIGRRSTHGVIYDFIMKLKRNPEELEILGNGEQNKSYIYISDCVDAMLFGLRGDERVNIFNIGSEDQIKVKRIAE
IVCEELGLSPRFRFTGGDRGWKGDVPVMLLSIEKLKRLGWKPRYNSEEAVRMAVRDLVEDLDEQN
>Mature_305_residues
MIVVTGGAGFIGSHVVDKLSESNEIVVIDNLSSGNEEFVNEAARLVKADLAADDIKDYLKGAEEVWHIAANPDVRIGAEN
PDEIYRNNVLATYRLLEAMRKAGVSRIVFTSTSTVYGEAKVIPTPEDYPTHPISLYGASKLACEALIESYCHTFDMQAWI
YRFANVIGRRSTHGVIYDFIMKLKRNPEELEILGNGEQNKSYIYISDCVDAMLFGLRGDERVNIFNIGSEDQIKVKRIAE
IVCEELGLSPRFRFTGGDRGWKGDVPVMLLSIEKLKRLGWKPRYNSEEAVRMAVRDLVEDLDEQN

Specific function: Galactose metabolism; third step. [C]

COG id: COG0451

COG function: function code MG; Nucleoside-diphosphate-sugar epimerases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sugar epimerase family [H]

Homologues:

Organism=Homo sapiens, GI42516563, Length=314, Percent_Identity=26.7515923566879, Blast_Score=109, Evalue=3e-24,
Organism=Homo sapiens, GI7657641, Length=317, Percent_Identity=27.1293375394322, Blast_Score=103, Evalue=2e-22,
Organism=Homo sapiens, GI56237023, Length=278, Percent_Identity=26.6187050359712, Blast_Score=81, Evalue=1e-15,
Organism=Homo sapiens, GI56118217, Length=278, Percent_Identity=26.6187050359712, Blast_Score=81, Evalue=1e-15,
Organism=Homo sapiens, GI189083684, Length=278, Percent_Identity=26.6187050359712, Blast_Score=81, Evalue=1e-15,
Organism=Homo sapiens, GI193211614, Length=218, Percent_Identity=26.1467889908257, Blast_Score=69, Evalue=4e-12,
Organism=Homo sapiens, GI8393516, Length=218, Percent_Identity=26.1467889908257, Blast_Score=69, Evalue=4e-12,
Organism=Escherichia coli, GI1786974, Length=314, Percent_Identity=26.7515923566879, Blast_Score=94, Evalue=2e-20,
Organism=Escherichia coli, GI48994969, Length=328, Percent_Identity=26.219512195122, Blast_Score=84, Evalue=8e-18,
Organism=Escherichia coli, GI1788353, Length=334, Percent_Identity=26.0479041916168, Blast_Score=82, Evalue=5e-17,
Organism=Escherichia coli, GI1788366, Length=201, Percent_Identity=28.3582089552239, Blast_Score=64, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI17539532, Length=252, Percent_Identity=28.5714285714286, Blast_Score=106, Evalue=2e-23,
Organism=Caenorhabditis elegans, GI17568069, Length=267, Percent_Identity=27.7153558052434, Blast_Score=94, Evalue=8e-20,
Organism=Caenorhabditis elegans, GI115532424, Length=328, Percent_Identity=25.9146341463415, Blast_Score=82, Evalue=3e-16,
Organism=Saccharomyces cerevisiae, GI6319493, Length=336, Percent_Identity=29.4642857142857, Blast_Score=102, Evalue=5e-23,
Organism=Drosophila melanogaster, GI21356223, Length=256, Percent_Identity=30.859375, Blast_Score=115, Evalue=5e-26,
Organism=Drosophila melanogaster, GI19923002, Length=186, Percent_Identity=31.1827956989247, Blast_Score=79, Evalue=5e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001509
- InterPro:   IPR016040 [H]

Pfam domain/function: PF01370 Epimerase [H]

EC number: =5.1.3.2 [H]

Molecular weight: Translated: 34258; Mature: 34258

Theoretical pI: Translated: 4.79; Mature: 4.79

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIVVTGGAGFIGSHVVDKLSESNEIVVIDNLSSGNEEFVNEAARLVKADLAADDIKDYLK
CEEEECCCCHHHHHHHHHHCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHC
GAEEVWHIAANPDVRIGAENPDEIYRNNVLATYRLLEAMRKAGVSRIVFTSTSTVYGEAK
CHHHHEEEECCCCEEECCCCHHHHHHCCHHHHHHHHHHHHHCCCCEEEEECCCEEECCEE
VIPTPEDYPTHPISLYGASKLACEALIESYCHTFDMQAWIYRFANVIGRRSTHGVIYDFI
ECCCCCCCCCCCEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHH
MKLKRNPEELEILGNGEQNKSYIYISDCVDAMLFGLRGDERVNIFNIGSEDQIKVKRIAE
HHHHCCCCCEEEEECCCCCCCEEEHHHHHHHHHHCCCCCCEEEEEECCCCCCHHHHHHHH
IVCEELGLSPRFRFTGGDRGWKGDVPVMLLSIEKLKRLGWKPRYNSEEAVRMAVRDLVED
HHHHHHCCCCCEEECCCCCCCCCCCCEEEHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHH
LDEQN
HCCCC
>Mature Secondary Structure
MIVVTGGAGFIGSHVVDKLSESNEIVVIDNLSSGNEEFVNEAARLVKADLAADDIKDYLK
CEEEECCCCHHHHHHHHHHCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHC
GAEEVWHIAANPDVRIGAENPDEIYRNNVLATYRLLEAMRKAGVSRIVFTSTSTVYGEAK
CHHHHEEEECCCCEEECCCCHHHHHHCCHHHHHHHHHHHHHCCCCEEEEECCCEEECCEE
VIPTPEDYPTHPISLYGASKLACEALIESYCHTFDMQAWIYRFANVIGRRSTHGVIYDFI
ECCCCCCCCCCCEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHH
MKLKRNPEELEILGNGEQNKSYIYISDCVDAMLFGLRGDERVNIFNIGSEDQIKVKRIAE
HHHHCCCCCEEEEECCCCCCCEEEHHHHHHHHHHCCCCCCEEEEEECCCCCCHHHHHHHH
IVCEELGLSPRFRFTGGDRGWKGDVPVMLLSIEKLKRLGWKPRYNSEEAVRMAVRDLVED
HHHHHHCCCCCEEECCCCCCCCCCCCEEEHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHH
LDEQN
HCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]