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The map label for this gene is acaB-4

Identifier: 11497751

GI number: 11497751

Start: 121876

End: 123072

Strand: Reverse

Name: acaB-4

Synonym: AF0134

Alternate gene names: NA

Gene position: 123072-121876 (Counterclockwise)

Preceding gene: 11497752

Following gene: 11497750

Centisome position: 5.65

GC content: 51.96

Gene sequence:

>1197_bases
GTGGGCGGAGAAGACCGAGGGGAAGCCCTCAGACCTTATTGGCTTCAGGGTGATAGAATGAGGGTGGCGATTATTGGCTA
TGCAGTAAGCAAGCTGGAGTGGGATGCAGAGAAGACGAGGGAGGAGGCAGTTTTTGAGGTTACGAGGGAAGCGATGAGAA
GGGCTGGGGTTGAGAGGGAGGATGTTGGGACGGTAATAAGTGCATCAACGGACTTCCTTGATGGGAGAACGATTTCAAAC
TGCATGCTGATTGGGGCCAGCGGGGCCTATCTGAAGGATGAGAGCAAGGCTGAGGAGGATGGCATGTATGCTGCACTCTA
CGCTGCCCAGAGAATAATGAGCGGTGTTCATGATGTTGCTTTAGCTATCTCCCACACTCACAGCTGGATTTTCAACCCCC
ATCAGGTTTCGCAGTACATGCTTGAGCCGTGGTTCGACAGGCAGAATGAATTGCTGAATGGAATTACGCTCGCAGCTTTA
CAGGCGAGGCTTTACATGAGCAGGAGTGGGGTGGATGAGGGGCATCTGGCAGAGGTTTGCGTTAAAAACCTGAGGAATGC
TGCAAAGGTTCCCTATGCCTTCAGAAAAATGGCTGATGTAACTGTTGAAGAGGTGCTGGAATCAAAGCTATACTCCTCTC
CGCTTACAGAGCTTATGATTGCCCCTCCATGCGACGGTGCTGCTGCTGTTGTCCTTGCCAGCGAGGAGGTGGCAAAAGAG
CTTTGCGATGAACCAGTTTGGATTAAGGGCATTGGCAATTCCTGCGACAGATACTTGAGGGACAGAGACTTGGGAAGGCT
TGAGTCGTTGAGGCTTGCTGCTGAGAAAGCGTACAGAATGGCGGGTATTGAAGAGCCCTTCAGGCAGATTGATGTTGCTG
AGATTTCGGAGAGGTTTGCCCACCATGAGCTAATGGCCTACGAGGCCCTTGGTTTCTGCAGAGATGGAATGGGGAAGGTT
CTGATTGAGGAGGGAATTACGGAGGTTTACGGAGACATGCCCGTCAATCCCAGCGGTGGAGCTTTGGCTGGTGATGCGAT
TTGCGCAACGGGAATGATAAGGCTGATTGAGGCTGCAAGGCAGGTCAGGGGTGAGGCAGAGAATCAGGTCGAAGATTGCA
GAACTGCTTTGGCTCATGCTCAGTGGGGGTTGTGTGCTCAGAAGAATCTTGTTTTTGTGCTGGGTGATAGGCCATGA

Upstream 100 bases:

>100_bases
AGCCCGAGGTTCTTGCCGCCATAAAGCTTGATGGAGCCAGCTCCACAATTTTTGCAAGAGTTGAGGGAGATGTGAAGCTC
GGCTCCAAGGTTGAGCCTGT

Downstream 100 bases:

>100_bases
GGAGAGTTGCGATTATTGGTTGCGGGCAGTCGAAGCATGGTAGAAGGACTGATGTTAGCCAAGCTGAGCTTGTTGCAGAA
GCCGTTTGGGCGGCGATAGA

Product: 3-ketoacyl-CoA thiolase (acaB-4)

Products: CoA; 3-oxoacyl-CoA

Alternate protein names: NA

Number of amino acids: Translated: 398; Mature: 397

Protein sequence:

>398_residues
MGGEDRGEALRPYWLQGDRMRVAIIGYAVSKLEWDAEKTREEAVFEVTREAMRRAGVEREDVGTVISASTDFLDGRTISN
CMLIGASGAYLKDESKAEEDGMYAALYAAQRIMSGVHDVALAISHTHSWIFNPHQVSQYMLEPWFDRQNELLNGITLAAL
QARLYMSRSGVDEGHLAEVCVKNLRNAAKVPYAFRKMADVTVEEVLESKLYSSPLTELMIAPPCDGAAAVVLASEEVAKE
LCDEPVWIKGIGNSCDRYLRDRDLGRLESLRLAAEKAYRMAGIEEPFRQIDVAEISERFAHHELMAYEALGFCRDGMGKV
LIEEGITEVYGDMPVNPSGGALAGDAICATGMIRLIEAARQVRGEAENQVEDCRTALAHAQWGLCAQKNLVFVLGDRP

Sequences:

>Translated_398_residues
MGGEDRGEALRPYWLQGDRMRVAIIGYAVSKLEWDAEKTREEAVFEVTREAMRRAGVEREDVGTVISASTDFLDGRTISN
CMLIGASGAYLKDESKAEEDGMYAALYAAQRIMSGVHDVALAISHTHSWIFNPHQVSQYMLEPWFDRQNELLNGITLAAL
QARLYMSRSGVDEGHLAEVCVKNLRNAAKVPYAFRKMADVTVEEVLESKLYSSPLTELMIAPPCDGAAAVVLASEEVAKE
LCDEPVWIKGIGNSCDRYLRDRDLGRLESLRLAAEKAYRMAGIEEPFRQIDVAEISERFAHHELMAYEALGFCRDGMGKV
LIEEGITEVYGDMPVNPSGGALAGDAICATGMIRLIEAARQVRGEAENQVEDCRTALAHAQWGLCAQKNLVFVLGDRP
>Mature_397_residues
GGEDRGEALRPYWLQGDRMRVAIIGYAVSKLEWDAEKTREEAVFEVTREAMRRAGVEREDVGTVISASTDFLDGRTISNC
MLIGASGAYLKDESKAEEDGMYAALYAAQRIMSGVHDVALAISHTHSWIFNPHQVSQYMLEPWFDRQNELLNGITLAALQ
ARLYMSRSGVDEGHLAEVCVKNLRNAAKVPYAFRKMADVTVEEVLESKLYSSPLTELMIAPPCDGAAAVVLASEEVAKEL
CDEPVWIKGIGNSCDRYLRDRDLGRLESLRLAAEKAYRMAGIEEPFRQIDVAEISERFAHHELMAYEALGFCRDGMGKVL
IEEGITEVYGDMPVNPSGGALAGDAICATGMIRLIEAARQVRGEAENQVEDCRTALAHAQWGLCAQKNLVFVLGDRP

Specific function: Unknown

COG id: COG0183

COG function: function code I; Acetyl-CoA acetyltransferase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI19923233, Length=416, Percent_Identity=25.9615384615385, Blast_Score=86, Evalue=5e-17,
Organism=Homo sapiens, GI302344760, Length=238, Percent_Identity=28.9915966386555, Blast_Score=84, Evalue=2e-16,
Organism=Homo sapiens, GI302344762, Length=238, Percent_Identity=28.9915966386555, Blast_Score=84, Evalue=2e-16,
Organism=Homo sapiens, GI302344767, Length=238, Percent_Identity=28.9915966386555, Blast_Score=84, Evalue=2e-16,
Organism=Homo sapiens, GI55956775, Length=209, Percent_Identity=27.7511961722488, Blast_Score=69, Evalue=8e-12,
Organism=Caenorhabditis elegans, GI17537653, Length=238, Percent_Identity=28.1512605042017, Blast_Score=79, Evalue=3e-15,
Organism=Drosophila melanogaster, GI24585051, Length=396, Percent_Identity=27.5252525252525, Blast_Score=102, Evalue=4e-22,
Organism=Drosophila melanogaster, GI19921506, Length=398, Percent_Identity=27.3869346733668, Blast_Score=102, Evalue=5e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002155
- InterPro:   IPR016039
- InterPro:   IPR016038
- InterPro:   IPR020617
- InterPro:   IPR020616 [H]

Pfam domain/function: PF02803 Thiolase_C; PF00108 Thiolase_N [H]

EC number: 2.3.1.16

Molecular weight: Translated: 44001; Mature: 43869

Theoretical pI: Translated: 4.66; Mature: 4.66

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.3 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
6.0 %Cys+Met (Translated Protein)
2.3 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
5.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGGEDRGEALRPYWLQGDRMRVAIIGYAVSKLEWDAEKTREEAVFEVTREAMRRAGVERE
CCCCCCCCCCCCEEECCCCEEEEEEHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCHH
DVGTVISASTDFLDGRTISNCMLIGASGAYLKDESKAEEDGMYAALYAAQRIMSGVHDVA
HHCCCCCCCCCCCCCCCCCCEEEEECCCCCCCCCCCHHHCCHHHHHHHHHHHHHHHHHHH
LAISHTHSWIFNPHQVSQYMLEPWFDRQNELLNGITLAALQARLYMSRSGVDEGHLAEVC
HHHHHHHHHCCCHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHH
VKNLRNAAKVPYAFRKMADVTVEEVLESKLYSSPLTELMIAPPCDGAAAVVLASEEVAKE
HHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCHHHEEECCCCCCCEEEEEECHHHHHH
LCDEPVWIKGIGNSCDRYLRDRDLGRLESLRLAAEKAYRMAGIEEPFRQIDVAEISERFA
HCCCCEEEEECCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCHHHHHHCCHHHHHHHHH
HHELMAYEALGFCRDGMGKVLIEEGITEVYGDMPVNPSGGALAGDAICATGMIRLIEAAR
HHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHH
QVRGEAENQVEDCRTALAHAQWGLCAQKNLVFVLGDRP
HHHCCHHHHHHHHHHHHHHHHCCCEECCCEEEEECCCC
>Mature Secondary Structure 
GGEDRGEALRPYWLQGDRMRVAIIGYAVSKLEWDAEKTREEAVFEVTREAMRRAGVERE
CCCCCCCCCCCEEECCCCEEEEEEHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCHH
DVGTVISASTDFLDGRTISNCMLIGASGAYLKDESKAEEDGMYAALYAAQRIMSGVHDVA
HHCCCCCCCCCCCCCCCCCCEEEEECCCCCCCCCCCHHHCCHHHHHHHHHHHHHHHHHHH
LAISHTHSWIFNPHQVSQYMLEPWFDRQNELLNGITLAALQARLYMSRSGVDEGHLAEVC
HHHHHHHHHCCCHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHH
VKNLRNAAKVPYAFRKMADVTVEEVLESKLYSSPLTELMIAPPCDGAAAVVLASEEVAKE
HHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCHHHEEECCCCCCCEEEEEECHHHHHH
LCDEPVWIKGIGNSCDRYLRDRDLGRLESLRLAAEKAYRMAGIEEPFRQIDVAEISERFA
HCCCCEEEEECCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCHHHHHHCCHHHHHHHHH
HHELMAYEALGFCRDGMGKVLIEEGITEVYGDMPVNPSGGALAGDAICATGMIRLIEAAR
HHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHH
QVRGEAENQVEDCRTALAHAQWGLCAQKNLVFVLGDRP
HHHCCHHHHHHHHHHHHHHHHCCCEECCCEEEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: acyl-CoA; acetyl-CoA

Specific reaction: acyl-CoA + acetyl-CoA = CoA + 3-oxoacyl-CoA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9371463 [H]