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The map label for this gene is acaB-3

Identifier: 11497750

GI number: 11497750

Start: 120644

End: 121879

Strand: Reverse

Name: acaB-3

Synonym: AF0133

Alternate gene names: NA

Gene position: 121879-120644 (Counterclockwise)

Preceding gene: 11497751

Following gene: 11497749

Centisome position: 5.59

GC content: 55.02

Gene sequence:

>1236_bases
ATGAGGAGAGTTGCGATTATTGGTTGCGGGCAGTCGAAGCATGGTAGAAGGACTGATGTTAGCCAAGCTGAGCTTGTTGC
AGAAGCCGTTTGGGCGGCGATAGAAGATGCAAGCATCGCTCCCGAAGACATTGAGGCTTACGCTGTTGGAAACATGCAGG
GGTTTGGTGGGATCTGCCAGCCCGATTTGGTGTTTGCCGACTACATCGCTGCAGGGGGTAAAGCGATGCAGAGAGTTGCC
ACAGGAGGGACGGTTGGTGGCTCCACCGCCCACCTCGGCTACTACGAGGTCGCTTCAGGGATGTACGATGTTGTTCTGGC
TGTGAGCTGGGAGAAGCACAGCGACAGCGCAGAGCCGGGTGCGACAACAGGCTTACTCCACGTAGCCTTCGCCAATTTAA
GCTACATGATGAAAATTGGCATGGACATGAGGAGCTTCGCAATTATGGGCCTTGCCGGTGCTGCTGCTGGCATATCAGCC
TATCAGGCTGCCTTCTACATGGCCAGATCAGGATGCAGCATCGAGCACTTCGACATGGTTGCAGCCAAGGCAAGGAGAAA
TGCTGCAAAGAACAAGTACGCCCACCTTAAGTGGCCCAACTGCACTCCTGAAGACATAGCAAAGACCGAGATGCTGATAT
GGCCCATGCGCTTCGGCCACGTCTGCCCTGCAAGTGATGGTGCGTCATGCGTTATTTACGCCAGCGAGGATGCGGTGAAG
AGGCTTGGAATCAAGGAGGTGGCGTGGGTAAAGGGTGTTGCAGCCTACGCTGACGAGGAGGCTGATCAGGGAGAGAGCTA
TCAGGGGACAGCAGTTGTTGACTACTCCGACCAGACAGGGGCAATTCTCTCTGCCAGAAAGGCCTACGAAAGGGCGGGGA
TTAAGGATCCAAGGAAGGAGATAGATGTTGCTGAGATTTACGCCCCCTTCCCCCATCAAGAGCTGATGTTCAGCGAGAGA
CTTGGTTTCTTCGATGATGGCACCGCATGGAAAGCTGTGGAAGAGGGAGTAACAGAAATTGACGGCGACTTCCCCATCTG
CCCCTCAGGAGGGGTTAACGCAACAAACGCCATTGGCTCTTCTGGCATGCAGAGGGTTGTGGAGGCAGCACTGCAGATAA
TGGGGAAGGCTGAGGAGCATCAGGTTCCAAAGGACGTGAGAAATGCAGTTGCTCACGCGTGGGGGGGACAGGTGCAGTTC
AACACGGTAATGGTGCTTGGAGACAGGCCGAGGTGA

Upstream 100 bases:

>100_bases
AGGCAGAGAATCAGGTCGAAGATTGCAGAACTGCTTTGGCTCATGCTCAGTGGGGGTTGTGTGCTCAGAAGAATCTTGTT
TTTGTGCTGGGTGATAGGCC

Downstream 100 bases:

>100_bases
TGGAAATGGGGCTTATTAAGGAAAAATTCGAAAAAACCATGCAGGTAGAGGGAGAGTGGAACTGGGAGCCTACAGGTGGA
AGGCTCCGGTGGGCTATCTG

Product: acetyl-CoA acetyltransferase

Products: CoA; 3-oxoacyl-CoA

Alternate protein names: NA

Number of amino acids: Translated: 411; Mature: 411

Protein sequence:

>411_residues
MRRVAIIGCGQSKHGRRTDVSQAELVAEAVWAAIEDASIAPEDIEAYAVGNMQGFGGICQPDLVFADYIAAGGKAMQRVA
TGGTVGGSTAHLGYYEVASGMYDVVLAVSWEKHSDSAEPGATTGLLHVAFANLSYMMKIGMDMRSFAIMGLAGAAAGISA
YQAAFYMARSGCSIEHFDMVAAKARRNAAKNKYAHLKWPNCTPEDIAKTEMLIWPMRFGHVCPASDGASCVIYASEDAVK
RLGIKEVAWVKGVAAYADEEADQGESYQGTAVVDYSDQTGAILSARKAYERAGIKDPRKEIDVAEIYAPFPHQELMFSER
LGFFDDGTAWKAVEEGVTEIDGDFPICPSGGVNATNAIGSSGMQRVVEAALQIMGKAEEHQVPKDVRNAVAHAWGGQVQF
NTVMVLGDRPR

Sequences:

>Translated_411_residues
MRRVAIIGCGQSKHGRRTDVSQAELVAEAVWAAIEDASIAPEDIEAYAVGNMQGFGGICQPDLVFADYIAAGGKAMQRVA
TGGTVGGSTAHLGYYEVASGMYDVVLAVSWEKHSDSAEPGATTGLLHVAFANLSYMMKIGMDMRSFAIMGLAGAAAGISA
YQAAFYMARSGCSIEHFDMVAAKARRNAAKNKYAHLKWPNCTPEDIAKTEMLIWPMRFGHVCPASDGASCVIYASEDAVK
RLGIKEVAWVKGVAAYADEEADQGESYQGTAVVDYSDQTGAILSARKAYERAGIKDPRKEIDVAEIYAPFPHQELMFSER
LGFFDDGTAWKAVEEGVTEIDGDFPICPSGGVNATNAIGSSGMQRVVEAALQIMGKAEEHQVPKDVRNAVAHAWGGQVQF
NTVMVLGDRPR
>Mature_411_residues
MRRVAIIGCGQSKHGRRTDVSQAELVAEAVWAAIEDASIAPEDIEAYAVGNMQGFGGICQPDLVFADYIAAGGKAMQRVA
TGGTVGGSTAHLGYYEVASGMYDVVLAVSWEKHSDSAEPGATTGLLHVAFANLSYMMKIGMDMRSFAIMGLAGAAAGISA
YQAAFYMARSGCSIEHFDMVAAKARRNAAKNKYAHLKWPNCTPEDIAKTEMLIWPMRFGHVCPASDGASCVIYASEDAVK
RLGIKEVAWVKGVAAYADEEADQGESYQGTAVVDYSDQTGAILSARKAYERAGIKDPRKEIDVAEIYAPFPHQELMFSER
LGFFDDGTAWKAVEEGVTEIDGDFPICPSGGVNATNAIGSSGMQRVVEAALQIMGKAEEHQVPKDVRNAVAHAWGGQVQF
NTVMVLGDRPR

Specific function: Unknown

COG id: COG0183

COG function: function code I; Acetyl-CoA acetyltransferase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI19923233, Length=402, Percent_Identity=25.6218905472637, Blast_Score=97, Evalue=4e-20,
Organism=Homo sapiens, GI302344760, Length=314, Percent_Identity=27.3885350318471, Blast_Score=86, Evalue=8e-17,
Organism=Homo sapiens, GI302344767, Length=314, Percent_Identity=27.3885350318471, Blast_Score=86, Evalue=9e-17,
Organism=Homo sapiens, GI302344762, Length=300, Percent_Identity=27.3333333333333, Blast_Score=85, Evalue=2e-16,
Organism=Homo sapiens, GI55956775, Length=267, Percent_Identity=26.9662921348315, Blast_Score=71, Evalue=2e-12,
Organism=Drosophila melanogaster, GI24585051, Length=399, Percent_Identity=25.8145363408521, Blast_Score=114, Evalue=8e-26,
Organism=Drosophila melanogaster, GI19921506, Length=399, Percent_Identity=25.8145363408521, Blast_Score=113, Evalue=3e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002155
- InterPro:   IPR016039
- InterPro:   IPR016038
- InterPro:   IPR020617
- InterPro:   IPR020616 [H]

Pfam domain/function: PF02803 Thiolase_C; PF00108 Thiolase_N [H]

EC number: 2.3.1.16

Molecular weight: Translated: 43985; Mature: 43985

Theoretical pI: Translated: 5.05; Mature: 5.05

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
4.1 %Met     (Translated Protein)
5.8 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
4.1 %Met     (Mature Protein)
5.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRRVAIIGCGQSKHGRRTDVSQAELVAEAVWAAIEDASIAPEDIEAYAVGNMQGFGGICQ
CCEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCEEEECCCCCCCCCCC
PDLVFADYIAAGGKAMQRVATGGTVGGSTAHLGYYEVASGMYDVVLAVSWEKHSDSAEPG
CHHHHHHHHHCCHHHHHHHHCCCCCCCCCEECCHHHHHCCCEEEEEEEEECCCCCCCCCC
ATTGLLHVAFANLSYMMKIGMDMRSFAIMGLAGAAAGISAYQAAFYMARSGCSIEHFDMV
CHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHH
AAKARRNAAKNKYAHLKWPNCTPEDIAKTEMLIWPMRFGHVCPASDGASCVIYASEDAVK
HHHHHHHHHCCCEEEEECCCCCHHHHHCHHEEEEEHHHCCCCCCCCCCEEEEEECHHHHH
RLGIKEVAWVKGVAAYADEEADQGESYQGTAVVDYSDQTGAILSARKAYERAGIKDPRKE
HCCCHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEECCCCCHHHHHHHHHHHCCCCCCHHH
IDVAEIYAPFPHQELMFSERLGFFDDGTAWKAVEEGVTEIDGDFPICPSGGVNATNAIGS
CCHHHHCCCCCHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHH
SGMQRVVEAALQIMGKAEEHQVPKDVRNAVAHAWGGQVQFNTVMVLGDRPR
HHHHHHHHHHHHHHCCCHHCCCCHHHHHHHHHHCCCEEEEEEEEEECCCCC
>Mature Secondary Structure
MRRVAIIGCGQSKHGRRTDVSQAELVAEAVWAAIEDASIAPEDIEAYAVGNMQGFGGICQ
CCEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCEEEECCCCCCCCCCC
PDLVFADYIAAGGKAMQRVATGGTVGGSTAHLGYYEVASGMYDVVLAVSWEKHSDSAEPG
CHHHHHHHHHCCHHHHHHHHCCCCCCCCCEECCHHHHHCCCEEEEEEEEECCCCCCCCCC
ATTGLLHVAFANLSYMMKIGMDMRSFAIMGLAGAAAGISAYQAAFYMARSGCSIEHFDMV
CHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHH
AAKARRNAAKNKYAHLKWPNCTPEDIAKTEMLIWPMRFGHVCPASDGASCVIYASEDAVK
HHHHHHHHHCCCEEEEECCCCCHHHHHCHHEEEEEHHHCCCCCCCCCCEEEEEECHHHHH
RLGIKEVAWVKGVAAYADEEADQGESYQGTAVVDYSDQTGAILSARKAYERAGIKDPRKE
HCCCHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEECCCCCHHHHHHHHHHHCCCCCCHHH
IDVAEIYAPFPHQELMFSERLGFFDDGTAWKAVEEGVTEIDGDFPICPSGGVNATNAIGS
CCHHHHCCCCCHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHH
SGMQRVVEAALQIMGKAEEHQVPKDVRNAVAHAWGGQVQFNTVMVLGDRPR
HHHHHHHHHHHHHHCCCHHCCCCHHHHHHHHHHCCCEEEEEEEEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: acyl-CoA; acetyl-CoA

Specific reaction: acyl-CoA + acetyl-CoA = CoA + 3-oxoacyl-CoA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9371463 [H]