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The map label for this gene is aphA

Identifier: 11497747

GI number: 11497747

Start: 118313

End: 119392

Strand: Reverse

Name: aphA

Synonym: AF0130

Alternate gene names: NA

Gene position: 119392-118313 (Counterclockwise)

Preceding gene: 11497749

Following gene: 11497746

Centisome position: 5.48

GC content: 53.06

Gene sequence:

>1080_bases
ATGGTTACCGGCATTGTCTTTCATGAGGAGTATCTGAAGCACGAGCAGAGCCCAACTCATCCCGAAAGGCGTGAGAGGCT
TGCTTACACAATGGACCAGCTGAGGGAGGAGGGGATATTCGAGAGCGAGCGTATTGTTCTTCTTGAGCCCTTCAAAGCAT
CGCTTGAGGATGTTCTTGAGGTGCACACTGAGGAGTATGTAAGATTCCTTGAGATGGAGAGCAAGAAGGGCGGAATTATT
GACTTTGACACCAACATTCCTGTAGGGGTTTTTGACAGGGCCCTGTTGGCGGCTGGTGGAGCGATAAGGGCTGCTCAGGC
CGTGCTAAACAAGGAGTGCGAGAACGCTTTTGCGATGATTCGCCCTCCGGGGCACCATGCGAAGCCCTACATCGGGGCTG
GTTTTTGCTACCTCAACAACATGGCGATAATGGTGAAGTGGCTGCTGAAGCAGGGCTTTGAAAGGATTGCCATTCTGGAC
TGGGACGCTCACCACGGCGACGGCACTCAGGAGATTTTCTACAACGACGACAGAGTTCTTTTCATATCAACCCACCAGAT
GCCCCTCTACCCCGGAACGGGCTATCCTGAGGAGTGCGGAACTGGCAAGGGCGAGGGCTACACGGTAAACATCCCTCTCC
CTCCCGGAACGGGAGATGAGGGCTACATGATGGTCATTGACGAGATAATTGAGCCAGTTGTCAATGAATTTAAGCCGCAG
TTCATTGCTATCTCTGCCGGACAGGACAACCACTTCACGGACCCAATTACAAGCCTGGCTTTGACTGCAAGGGGATATGC
GGAGATGATGCGGAGGGCTGTTGCAATGGCTGAAAAGCACTGCGACGGAAGACTTGTTGCCGTTCTTGAGGGAGGTTACA
GCGTTGAAGGGGCCCTGCCTTACACAAACCTCGGGATAATTGCGGCGATGGCGGGCTTTGACCTGTCAGCCATAAGGGAG
CCCGAAAACTACCTCCCCGAGCTGCTCTGGCGGAAGAGGGATTCGGCATTGGTGAAGCTGAAGCACAACATAGAGGATGT
GAAGAGGGTTCACTCAAAATACTGGAAGTGCTTCAAATGA

Upstream 100 bases:

>100_bases
CATGCTCGACACACTCAAGAAGCTCCATAAAAATTAAAAATTAAGTTCAGTTAAAAGCTTTTTGAAAAGAGCTTTATATT
CACACGGTAATTTGTTTTAG

Downstream 100 bases:

>100_bases
ATCTCGAAGAGCTGAGGAGGATACAGGAGGAGATGTCCAGAAGTGTGGTTCTCGAAGACTTAATCCCTCTTGAAGAGCTT
GAGTACGTTGTGGGTGTTGA

Product: acetylpolyamine aminohydrolase (aphA)

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 359; Mature: 359

Protein sequence:

>359_residues
MVTGIVFHEEYLKHEQSPTHPERRERLAYTMDQLREEGIFESERIVLLEPFKASLEDVLEVHTEEYVRFLEMESKKGGII
DFDTNIPVGVFDRALLAAGGAIRAAQAVLNKECENAFAMIRPPGHHAKPYIGAGFCYLNNMAIMVKWLLKQGFERIAILD
WDAHHGDGTQEIFYNDDRVLFISTHQMPLYPGTGYPEECGTGKGEGYTVNIPLPPGTGDEGYMMVIDEIIEPVVNEFKPQ
FIAISAGQDNHFTDPITSLALTARGYAEMMRRAVAMAEKHCDGRLVAVLEGGYSVEGALPYTNLGIIAAMAGFDLSAIRE
PENYLPELLWRKRDSALVKLKHNIEDVKRVHSKYWKCFK

Sequences:

>Translated_359_residues
MVTGIVFHEEYLKHEQSPTHPERRERLAYTMDQLREEGIFESERIVLLEPFKASLEDVLEVHTEEYVRFLEMESKKGGII
DFDTNIPVGVFDRALLAAGGAIRAAQAVLNKECENAFAMIRPPGHHAKPYIGAGFCYLNNMAIMVKWLLKQGFERIAILD
WDAHHGDGTQEIFYNDDRVLFISTHQMPLYPGTGYPEECGTGKGEGYTVNIPLPPGTGDEGYMMVIDEIIEPVVNEFKPQ
FIAISAGQDNHFTDPITSLALTARGYAEMMRRAVAMAEKHCDGRLVAVLEGGYSVEGALPYTNLGIIAAMAGFDLSAIRE
PENYLPELLWRKRDSALVKLKHNIEDVKRVHSKYWKCFK
>Mature_359_residues
MVTGIVFHEEYLKHEQSPTHPERRERLAYTMDQLREEGIFESERIVLLEPFKASLEDVLEVHTEEYVRFLEMESKKGGII
DFDTNIPVGVFDRALLAAGGAIRAAQAVLNKECENAFAMIRPPGHHAKPYIGAGFCYLNNMAIMVKWLLKQGFERIAILD
WDAHHGDGTQEIFYNDDRVLFISTHQMPLYPGTGYPEECGTGKGEGYTVNIPLPPGTGDEGYMMVIDEIIEPVVNEFKPQ
FIAISAGQDNHFTDPITSLALTARGYAEMMRRAVAMAEKHCDGRLVAVLEGGYSVEGALPYTNLGIIAAMAGFDLSAIRE
PENYLPELLWRKRDSALVKLKHNIEDVKRVHSKYWKCFK

Specific function: Putative deacetylase

COG id: COG0123

COG function: function code BQ; Deacetylases, including yeast histone deacetylase and acetoin utilization protein

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the histone deacetylase family

Homologues:

Organism=Homo sapiens, GI30795202, Length=399, Percent_Identity=32.8320802005013, Blast_Score=189, Evalue=5e-48,
Organism=Homo sapiens, GI30795204, Length=399, Percent_Identity=32.8320802005013, Blast_Score=188, Evalue=5e-48,
Organism=Homo sapiens, GI153085395, Length=396, Percent_Identity=31.3131313131313, Blast_Score=183, Evalue=2e-46,
Organism=Homo sapiens, GI17158039, Length=359, Percent_Identity=33.7047353760446, Blast_Score=181, Evalue=8e-46,
Organism=Homo sapiens, GI148539870, Length=397, Percent_Identity=31.4861460957179, Blast_Score=176, Evalue=3e-44,
Organism=Homo sapiens, GI169234807, Length=397, Percent_Identity=31.4861460957179, Blast_Score=176, Evalue=3e-44,
Organism=Homo sapiens, GI13128864, Length=374, Percent_Identity=30.4812834224599, Blast_Score=162, Evalue=3e-40,
Organism=Homo sapiens, GI62750347, Length=405, Percent_Identity=32.0987654320988, Blast_Score=159, Evalue=4e-39,
Organism=Homo sapiens, GI62750349, Length=405, Percent_Identity=32.0987654320988, Blast_Score=159, Evalue=4e-39,
Organism=Homo sapiens, GI20070354, Length=319, Percent_Identity=33.5423197492163, Blast_Score=157, Evalue=2e-38,
Organism=Homo sapiens, GI13128862, Length=290, Percent_Identity=31.7241379310345, Blast_Score=140, Evalue=2e-33,
Organism=Homo sapiens, GI13128860, Length=262, Percent_Identity=31.6793893129771, Blast_Score=138, Evalue=8e-33,
Organism=Homo sapiens, GI293336691, Length=262, Percent_Identity=31.6793893129771, Blast_Score=137, Evalue=2e-32,
Organism=Homo sapiens, GI8923769, Length=284, Percent_Identity=29.9295774647887, Blast_Score=135, Evalue=4e-32,
Organism=Homo sapiens, GI226529806, Length=319, Percent_Identity=31.3479623824451, Blast_Score=129, Evalue=5e-30,
Organism=Homo sapiens, GI262073092, Length=248, Percent_Identity=31.0483870967742, Blast_Score=114, Evalue=1e-25,
Organism=Homo sapiens, GI262073088, Length=142, Percent_Identity=34.5070422535211, Blast_Score=102, Evalue=7e-22,
Organism=Homo sapiens, GI217272877, Length=292, Percent_Identity=26.7123287671233, Blast_Score=82, Evalue=6e-16,
Organism=Homo sapiens, GI209862883, Length=285, Percent_Identity=25.6140350877193, Blast_Score=79, Evalue=5e-15,
Organism=Caenorhabditis elegans, GI193206283, Length=312, Percent_Identity=34.2948717948718, Blast_Score=165, Evalue=3e-41,
Organism=Caenorhabditis elegans, GI17540334, Length=310, Percent_Identity=34.5161290322581, Blast_Score=165, Evalue=3e-41,
Organism=Caenorhabditis elegans, GI17540332, Length=310, Percent_Identity=34.5161290322581, Blast_Score=165, Evalue=4e-41,
Organism=Caenorhabditis elegans, GI193209491, Length=332, Percent_Identity=33.1325301204819, Blast_Score=147, Evalue=8e-36,
Organism=Caenorhabditis elegans, GI17561978, Length=263, Percent_Identity=31.5589353612167, Blast_Score=132, Evalue=4e-31,
Organism=Caenorhabditis elegans, GI17537347, Length=329, Percent_Identity=30.6990881458967, Blast_Score=131, Evalue=6e-31,
Organism=Caenorhabditis elegans, GI17534739, Length=299, Percent_Identity=30.1003344481605, Blast_Score=130, Evalue=8e-31,
Organism=Caenorhabditis elegans, GI17508561, Length=288, Percent_Identity=30.2083333333333, Blast_Score=127, Evalue=9e-30,
Organism=Caenorhabditis elegans, GI25154020, Length=204, Percent_Identity=31.8627450980392, Blast_Score=116, Evalue=1e-26,
Organism=Caenorhabditis elegans, GI25154022, Length=204, Percent_Identity=30.8823529411765, Blast_Score=111, Evalue=6e-25,
Organism=Saccharomyces cerevisiae, GI6324307, Length=370, Percent_Identity=35.1351351351351, Blast_Score=205, Evalue=7e-54,
Organism=Saccharomyces cerevisiae, GI6321244, Length=267, Percent_Identity=31.0861423220974, Blast_Score=128, Evalue=2e-30,
Organism=Saccharomyces cerevisiae, GI6323999, Length=265, Percent_Identity=28.6792452830189, Blast_Score=124, Evalue=2e-29,
Organism=Saccharomyces cerevisiae, GI6325325, Length=148, Percent_Identity=30.4054054054054, Blast_Score=87, Evalue=6e-18,
Organism=Drosophila melanogaster, GI24642142, Length=294, Percent_Identity=35.0340136054422, Blast_Score=166, Evalue=2e-41,
Organism=Drosophila melanogaster, GI24642144, Length=294, Percent_Identity=35.0340136054422, Blast_Score=166, Evalue=2e-41,
Organism=Drosophila melanogaster, GI24642146, Length=294, Percent_Identity=35.0340136054422, Blast_Score=166, Evalue=3e-41,
Organism=Drosophila melanogaster, GI281360899, Length=294, Percent_Identity=35.0340136054422, Blast_Score=165, Evalue=4e-41,
Organism=Drosophila melanogaster, GI24641720, Length=331, Percent_Identity=31.7220543806647, Blast_Score=155, Evalue=6e-38,
Organism=Drosophila melanogaster, GI281360799, Length=331, Percent_Identity=31.7220543806647, Blast_Score=155, Evalue=6e-38,
Organism=Drosophila melanogaster, GI281360801, Length=331, Percent_Identity=31.7220543806647, Blast_Score=155, Evalue=6e-38,
Organism=Drosophila melanogaster, GI24657891, Length=287, Percent_Identity=32.0557491289199, Blast_Score=139, Evalue=2e-33,
Organism=Drosophila melanogaster, GI24644244, Length=268, Percent_Identity=31.3432835820896, Blast_Score=137, Evalue=1e-32,
Organism=Drosophila melanogaster, GI24649807, Length=256, Percent_Identity=25.78125, Blast_Score=71, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): Y130_ARCFU (O30107)

Other databases:

- EMBL:   AE000782
- PIR:   B69266
- RefSeq:   NP_068969.1
- ProteinModelPortal:   O30107
- SMR:   O30107
- GeneID:   1483341
- GenomeReviews:   AE000782_GR
- KEGG:   afu:AF0130
- NMPDR:   fig|224325.1.peg.128
- TIGR:   AF_0130
- HOGENOM:   HBG713516
- OMA:   GHHAWAD
- ProtClustDB:   CLSK541334
- BioCyc:   AFUL224325:AF_0130-MONOMER
- InterPro:   IPR000286
- InterPro:   IPR003084
- Gene3D:   G3DSA:3.40.800.20
- PANTHER:   PTHR10625
- PRINTS:   PR01270
- PRINTS:   PR01271

Pfam domain/function: PF00850 Hist_deacetyl

EC number: NA

Molecular weight: Translated: 40469; Mature: 40469

Theoretical pI: Translated: 5.18; Mature: 5.18

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVTGIVFHEEYLKHEQSPTHPERRERLAYTMDQLREEGIFESERIVLLEPFKASLEDVLE
CCEEEEEHHHHHHCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCEEEECCHHHHHHHHHH
VHTEEYVRFLEMESKKGGIIDFDTNIPVGVFDRALLAAGGAIRAAQAVLNKECENAFAMI
HHHHHHHHHHHHHCCCCCEEEECCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHCCEEEE
RPPGHHAKPYIGAGFCYLNNMAIMVKWLLKQGFERIAILDWDAHHGDGTQEIFYNDDRVL
CCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCEEEECCCEEE
FISTHQMPLYPGTGYPEECGTGKGEGYTVNIPLPPGTGDEGYMMVIDEIIEPVVNEFKPQ
EEEECCCCCCCCCCCCHHCCCCCCCCEEEEEECCCCCCCCCHHHHHHHHHHHHHHHCCCC
FIAISAGQDNHFTDPITSLALTARGYAEMMRRAVAMAEKHCDGRLVAVLEGGYSVEGALP
EEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCEEECCCCC
YTNLGIIAAMAGFDLSAIREPENYLPELLWRKRDSALVKLKHNIEDVKRVHSKYWKCFK
CCHHHHHHHHHCCCHHHHCCCHHHHHHHHHCCCCCCEEEEHHCHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MVTGIVFHEEYLKHEQSPTHPERRERLAYTMDQLREEGIFESERIVLLEPFKASLEDVLE
CCEEEEEHHHHHHCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCEEEECCHHHHHHHHHH
VHTEEYVRFLEMESKKGGIIDFDTNIPVGVFDRALLAAGGAIRAAQAVLNKECENAFAMI
HHHHHHHHHHHHHCCCCCEEEECCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHCCEEEE
RPPGHHAKPYIGAGFCYLNNMAIMVKWLLKQGFERIAILDWDAHHGDGTQEIFYNDDRVL
CCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCEEEECCCEEE
FISTHQMPLYPGTGYPEECGTGKGEGYTVNIPLPPGTGDEGYMMVIDEIIEPVVNEFKPQ
EEEECCCCCCCCCCCCHHCCCCCCCCEEEEEECCCCCCCCCHHHHHHHHHHHHHHHCCCC
FIAISAGQDNHFTDPITSLALTARGYAEMMRRAVAMAEKHCDGRLVAVLEGGYSVEGALP
EEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCEEECCCCC
YTNLGIIAAMAGFDLSAIREPENYLPELLWRKRDSALVKLKHNIEDVKRVHSKYWKCFK
CCHHHHHHHHHCCCHHHHCCCHHHHHHHHHCCCCCCEEEEHHCHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9389475