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The map label for this gene is ppiB [C]

Identifier: 114800546

GI number: 114800546

Start: 2917718

End: 2918701

Strand: Reverse

Name: ppiB [C]

Synonym: HNE_2758

Alternate gene names: 114800546

Gene position: 2918701-2917718 (Counterclockwise)

Preceding gene: 114799402

Following gene: 114797801

Centisome position: 78.78

GC content: 62.8

Gene sequence:

>984_bases
ATGAAAATTCGTGGCTTTGCAGCGGTCGTGGCTCTGGCGGGATGTCTCCTGCCGGCCTGCGCCGATACCACCGATGGCGG
CTGGTCGTTCGAGACGCCTGAAGATGTCGCTGCAAGCCCCGGAACCTGGCGCCCGGTTGATCCCGAGCGCCTGTTCATCT
TCCAGACTAATAAAGGCCGCGTCCTGATCGAGGCGTTCCCGGATGTGGCGCCCAACCATTTTGCCCATTTCACCTCTGTC
ACGCGGTCGGGCGATTATGACGGCACCAGCTTTCACCGTGTCATCGACGATTTCATGGCCCAGGGCGGCGACATTCAGGC
CCTCAAGGGCCGCCCGTCGGCAGAGCCGGACGTGAAGGGCGAATTCACCTTCCGCCGCGATGTCACCAAGATGCCGCTGC
AGGCCACCATCGGCCCGGAAGACAGCGCCAAGCATGGCTATTTCAACGGCTTCCCGATCCAGACCCAGCCATCCTTCTTC
GCTGAAATGTCGGTCGATGGCCTGGTCGAAAGCCATATCCCCCATTGCGCCAGCGTCGTCTCCACCGCGCGCACCAGCGA
TCCGGACTCGGCCAATGGCCAGTTCTTCCTGATGCGCGGCTACTCGGCCCATCTCGACCGTCTTTATACGTCCTGGGGCC
GCGTCATCGGAGGCCAGGATGTCGTGCTCTCGCTGAAGTCCGGCTCGCCCCAGAATAACGGCTCGGTCACCAATCCCGAC
ATCCTCACCTCGGCGAAAATCGCCGCAGACCTTCCGGAGGCGGAACGTCCGCGCGCCTATGTCCTGCGCACCGACAGCGA
GGCCTTTAAGACCGCGCTGGAAGCCAAGGGCGAGCCCAATATCTGCGATCTGGCGCCGGTGCCGGCCATCATCATCGATC
CAGCTGGCACAGGCGCAGAAGCCCCCGAAGCTGACGACGAAGCCGCTGATGACGCTGCTCCAGAATCCGCCCCCGAATCC
AACTCTGAAACCACCGGGGAATAG

Upstream 100 bases:

>100_bases
TGGCTTCGCGTCTGGTCAAGGAGATCGCGAGCCTCGGCGGCGACATCACGCCGTTCGTAACACCGTCGGTGAAAAAGGCT
CTGCTGGAGAAGTATAAACA

Downstream 100 bases:

>100_bases
GGGGCATCGCCGGCCTGATCCGGTGACCGTACATGGACCTCTCGGTATTCCAGTTTGATCTGCCTGAAGATCTCATCGCC
CTGCGGCCCGCCCAGCCGCA

Product: cyclophilin-type peptidyl-prolyl cis-trans isomerase

Products: Peptidylproline (omega = 0) [C]

Alternate protein names: Peptidyl-Prolyl Cis-Trans Isomerase; Peptidyl-Prolyl Cis-Trans Isomerase Cyclophilin-Type; Peptidylprolyl Isomerase; Peptidyl-Prolyl Cis-Trans Isomerase B; Peptidyl Prolyl Cis-Trans Isomerase; Cyclophilin-Type Peptidyl-Prolyl Cis-Trans Isomerase; Peptidyl Prolyl Cis-Trans Isomerase B; Peptidyl-Prolyl Cis-Trans Isomerase A; Peptidyl-Prolyl Cis-Trans Isomerase Family Protein

Number of amino acids: Translated: 327; Mature: 327

Protein sequence:

>327_residues
MKIRGFAAVVALAGCLLPACADTTDGGWSFETPEDVAASPGTWRPVDPERLFIFQTNKGRVLIEAFPDVAPNHFAHFTSV
TRSGDYDGTSFHRVIDDFMAQGGDIQALKGRPSAEPDVKGEFTFRRDVTKMPLQATIGPEDSAKHGYFNGFPIQTQPSFF
AEMSVDGLVESHIPHCASVVSTARTSDPDSANGQFFLMRGYSAHLDRLYTSWGRVIGGQDVVLSLKSGSPQNNGSVTNPD
ILTSAKIAADLPEAERPRAYVLRTDSEAFKTALEAKGEPNICDLAPVPAIIIDPAGTGAEAPEADDEAADDAAPESAPES
NSETTGE

Sequences:

>Translated_327_residues
MKIRGFAAVVALAGCLLPACADTTDGGWSFETPEDVAASPGTWRPVDPERLFIFQTNKGRVLIEAFPDVAPNHFAHFTSV
TRSGDYDGTSFHRVIDDFMAQGGDIQALKGRPSAEPDVKGEFTFRRDVTKMPLQATIGPEDSAKHGYFNGFPIQTQPSFF
AEMSVDGLVESHIPHCASVVSTARTSDPDSANGQFFLMRGYSAHLDRLYTSWGRVIGGQDVVLSLKSGSPQNNGSVTNPD
ILTSAKIAADLPEAERPRAYVLRTDSEAFKTALEAKGEPNICDLAPVPAIIIDPAGTGAEAPEADDEAADDAAPESAPES
NSETTGE
>Mature_327_residues
MKIRGFAAVVALAGCLLPACADTTDGGWSFETPEDVAASPGTWRPVDPERLFIFQTNKGRVLIEAFPDVAPNHFAHFTSV
TRSGDYDGTSFHRVIDDFMAQGGDIQALKGRPSAEPDVKGEFTFRRDVTKMPLQATIGPEDSAKHGYFNGFPIQTQPSFF
AEMSVDGLVESHIPHCASVVSTARTSDPDSANGQFFLMRGYSAHLDRLYTSWGRVIGGQDVVLSLKSGSPQNNGSVTNPD
ILTSAKIAADLPEAERPRAYVLRTDSEAFKTALEAKGEPNICDLAPVPAIIIDPAGTGAEAPEADDEAADDAAPESAPES
NSETTGE

Specific function: Ppiases Accelerate The Folding Of Proteins. It Catalyzes The Cis-Trans Isomerization Of Proline Imidic Peptide Bonds In Oligopeptides. [C]

COG id: COG0652

COG function: function code O; Peptidyl-prolyl cis-trans isomerase (rotamase) - cyclophilin family

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

None

Paralogues:

None

Copy number: 780 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 60 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

NA

Pfam domain/function: NA

EC number: 5.2.1.8 [C]

Molecular weight: Translated: 34877; Mature: 34877

Theoretical pI: Translated: 4.34; Mature: 4.34

Prosite motif: PS00013 PROKAR_LIPOPROTEIN ; PS00170 CSA_PPIASE_1 ; PS50072 CSA_PPIASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKIRGFAAVVALAGCLLPACADTTDGGWSFETPEDVAASPGTWRPVDPERLFIFQTNKGR
CCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHCCCCCCCCCCCCCEEEEEECCCCE
VLIEAFPDVAPNHFAHFTSVTRSGDYDGTSFHRVIDDFMAQGGDIQALKGRPSAEPDVKG
EEEEECCCCCCCHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCEEEECCCCCCCCCCCC
EFTFRRDVTKMPLQATIGPEDSAKHGYFNGFPIQTQPSFFAEMSVDGLVESHIPHCASVV
CEEECCCCCCCCEEEECCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCHHHHHHH
STARTSDPDSANGQFFLMRGYSAHLDRLYTSWGRVIGGQDVVLSLKSGSPQNNGSVTNPD
HHHCCCCCCCCCCCEEEEECCHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCCCCC
ILTSAKIAADLPEAERPRAYVLRTDSEAFKTALEAKGEPNICDLAPVPAIIIDPAGTGAE
HHHHHHHHHCCCCCCCCCEEEEECCHHHHHHHHHCCCCCCCCCCCCCCEEEECCCCCCCC
APEADDEAADDAAPESAPESNSETTGE
CCCCCCCCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MKIRGFAAVVALAGCLLPACADTTDGGWSFETPEDVAASPGTWRPVDPERLFIFQTNKGR
CCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHCCCCCCCCCCCCCEEEEEECCCCE
VLIEAFPDVAPNHFAHFTSVTRSGDYDGTSFHRVIDDFMAQGGDIQALKGRPSAEPDVKG
EEEEECCCCCCCHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCEEEECCCCCCCCCCCC
EFTFRRDVTKMPLQATIGPEDSAKHGYFNGFPIQTQPSFFAEMSVDGLVESHIPHCASVV
CEEECCCCCCCCEEEECCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCHHHHHHH
STARTSDPDSANGQFFLMRGYSAHLDRLYTSWGRVIGGQDVVLSLKSGSPQNNGSVTNPD
HHHCCCCCCCCCCCEEEEECCHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCCCCC
ILTSAKIAADLPEAERPRAYVLRTDSEAFKTALEAKGEPNICDLAPVPAIIIDPAGTGAE
HHHHHHHHHCCCCCCCCCEEEEECCHHHHHHHHHCCCCCCCCCCCCCCEEEECCCCCCCC
APEADDEAADDAAPESAPESNSETTGE
CCCCCCCCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Peptidoproline (omega = 180) [C]

Specific reaction: Peptidoproline (omega = 180) = Peptidylproline (omega = 0) [C]

General reaction: Rotation (single bond) [C]

Inhibitor: cyclosporins [C]

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA