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The map label for this gene is serS

Identifier: 114800440

GI number: 114800440

Start: 1999780

End: 2001078

Strand: Reverse

Name: serS

Synonym: HNE_1930

Alternate gene names: 114800440

Gene position: 2001078-1999780 (Counterclockwise)

Preceding gene: 114798916

Following gene: 114799382

Centisome position: 54.01

GC content: 61.74

Gene sequence:

>1299_bases
ATGTTCGACATCCGCGCCATCCGCGACAATCCCGACGCTTTCCGCAATGCCTGGAACCGGCGGAAGTCTGGATTGGGCTC
CGTGGTGGACGACATTCTGAAGCTGGATGCCCAATGGCGCGAGGCGACCACCGCCAAGCAGGACGCCGAAAGCGCCCGTA
ATGCCAATTCCAAGCTGATCGGTCAGGCGAAGGCCAAGAAGGACGAGGCGGAAGCCGCGCGCCTGATGGCGCTTGTCGCC
GAAGCGAAGACCACAATGGAACAGGCCGGTGAAGCCGAGGACAACGCCCGCAAGGCGCTGGACGATCTGCTGATGGGCCT
GCCGAACCTGCCGCTGGATGAAGTGCCCGAGGGCAGTGACGAGCATGGCAATGTTGAGCAGCACACATGGGGCGAGCCGA
AGCTCATCAATGATCCCAAGGACCATGCGGATCTGGGCGAAGCCCTGAAAGGGCAGGGCGGCTTCCCGATGATGGACTTT
GAAGCCGCCGCCCGGATGAGCGGCGCGCGCTTTGTGGCCCTACGCGGCAAGCTCACCCGGCTGGAGCGGGCGCTGGCGAA
CTTCATGCTTGACCTTCAGACAACGGAGCATGGGTATGAGGAGATGAGCGTGCCGGTGCTGGTGCGCGATCAGGCGCTCT
ATGGCACGGGGCAGTTGCCGAAGTTCGCGGAGGATTTGTTTCGCACGACTGTAGATCATTGGCTTACACCAACCGCAGAA
GTTTCTCTAACAAATCTCGTCCGTGAACAGATCCTAGATGCGGCACAACTCCCCCTCCGCTTCACCGCCCACACGCCCTG
CTTCCGCTCCGAAGCGGGCAGTGCGGGGCGCGATACCAAGGGCATGATCCGCCAGCACCAGTTCAACAAGGTGGAGCTGG
TCTCCATCGTGGCGAATGAGGCAGAGGGGCTGGCTGAGCTGGAGCGGATGACCGGCTGCGCTGAAGAAGTGCTCAAACGC
CTGGAACTGCCCTTCCGCCGCATGCTGCTCTGCACCGGCGATATGGGCGCTGGCGCGCGCAAGACCTATGATCTTGAAGT
CTGGCTGCCCTCGCAGAACACCTATCGCGAGATTTCGTCCTGCTCCTATTGCGGCGACTTCCAGGCCCGCCGCATGGATG
CGCGCTATCGGCCCGAACCCAAGGCCAAGCCCGAATATGTTCACACGCTGAACGGTTCGGGCCTCGCGGTGGGCCGCACG
CTGGTGGCGGTACTTGAAAATTATCAGAATGCGGACGGATCGATCACTGTGCCCAAGGCGCTGGTGCCCTATATGGGCGG
GGTTGAGGTTATAAACTAA

Upstream 100 bases:

>100_bases
CCGAGGTGGCCAACAGCCGGGCCTGACCTGTGGACAGGAGGGGGCGGCGCAGATTAGACGCTTCCCCGATACCCACTGAC
ACCAGAGCCTGAGGCTTCCC

Downstream 100 bases:

>100_bases
GTCCCTTCTTCCTTGGGGAGGGGGAACGAAAGGACGGATATGAGAATTCTCCTGACCAATGATGACGGCATCAACGCCCC
CGGCCTCTCCGTGCTGGAGG

Product: seryl-tRNA synthetase

Products: NA

Alternate protein names: Serine--tRNA ligase; SerRS; Seryl-tRNA(Ser/Sec) synthetase

Number of amino acids: Translated: 432; Mature: 432

Protein sequence:

>432_residues
MFDIRAIRDNPDAFRNAWNRRKSGLGSVVDDILKLDAQWREATTAKQDAESARNANSKLIGQAKAKKDEAEAARLMALVA
EAKTTMEQAGEAEDNARKALDDLLMGLPNLPLDEVPEGSDEHGNVEQHTWGEPKLINDPKDHADLGEALKGQGGFPMMDF
EAAARMSGARFVALRGKLTRLERALANFMLDLQTTEHGYEEMSVPVLVRDQALYGTGQLPKFAEDLFRTTVDHWLTPTAE
VSLTNLVREQILDAAQLPLRFTAHTPCFRSEAGSAGRDTKGMIRQHQFNKVELVSIVANEAEGLAELERMTGCAEEVLKR
LELPFRRMLLCTGDMGAGARKTYDLEVWLPSQNTYREISSCSYCGDFQARRMDARYRPEPKAKPEYVHTLNGSGLAVGRT
LVAVLENYQNADGSITVPKALVPYMGGVEVIN

Sequences:

>Translated_432_residues
MFDIRAIRDNPDAFRNAWNRRKSGLGSVVDDILKLDAQWREATTAKQDAESARNANSKLIGQAKAKKDEAEAARLMALVA
EAKTTMEQAGEAEDNARKALDDLLMGLPNLPLDEVPEGSDEHGNVEQHTWGEPKLINDPKDHADLGEALKGQGGFPMMDF
EAAARMSGARFVALRGKLTRLERALANFMLDLQTTEHGYEEMSVPVLVRDQALYGTGQLPKFAEDLFRTTVDHWLTPTAE
VSLTNLVREQILDAAQLPLRFTAHTPCFRSEAGSAGRDTKGMIRQHQFNKVELVSIVANEAEGLAELERMTGCAEEVLKR
LELPFRRMLLCTGDMGAGARKTYDLEVWLPSQNTYREISSCSYCGDFQARRMDARYRPEPKAKPEYVHTLNGSGLAVGRT
LVAVLENYQNADGSITVPKALVPYMGGVEVIN
>Mature_432_residues
MFDIRAIRDNPDAFRNAWNRRKSGLGSVVDDILKLDAQWREATTAKQDAESARNANSKLIGQAKAKKDEAEAARLMALVA
EAKTTMEQAGEAEDNARKALDDLLMGLPNLPLDEVPEGSDEHGNVEQHTWGEPKLINDPKDHADLGEALKGQGGFPMMDF
EAAARMSGARFVALRGKLTRLERALANFMLDLQTTEHGYEEMSVPVLVRDQALYGTGQLPKFAEDLFRTTVDHWLTPTAE
VSLTNLVREQILDAAQLPLRFTAHTPCFRSEAGSAGRDTKGMIRQHQFNKVELVSIVANEAEGLAELERMTGCAEEVLKR
LELPFRRMLLCTGDMGAGARKTYDLEVWLPSQNTYREISSCSYCGDFQARRMDARYRPEPKAKPEYVHTLNGSGLAVGRT
LVAVLENYQNADGSITVPKALVPYMGGVEVIN

Specific function: Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)

COG id: COG0172

COG function: function code J; Seryl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily

Homologues:

Organism=Homo sapiens, GI16306548, Length=456, Percent_Identity=29.8245614035088, Blast_Score=189, Evalue=6e-48,
Organism=Homo sapiens, GI225579074, Length=329, Percent_Identity=30.6990881458967, Blast_Score=157, Evalue=2e-38,
Organism=Homo sapiens, GI8923421, Length=329, Percent_Identity=30.6990881458967, Blast_Score=157, Evalue=2e-38,
Organism=Escherichia coli, GI1787120, Length=447, Percent_Identity=52.1252796420582, Blast_Score=434, Evalue=1e-123,
Organism=Caenorhabditis elegans, GI17539260, Length=459, Percent_Identity=29.6296296296296, Blast_Score=192, Evalue=3e-49,
Organism=Caenorhabditis elegans, GI17542084, Length=315, Percent_Identity=28.5714285714286, Blast_Score=135, Evalue=3e-32,
Organism=Saccharomyces cerevisiae, GI6320226, Length=456, Percent_Identity=28.5087719298246, Blast_Score=172, Evalue=1e-43,
Organism=Saccharomyces cerevisiae, GI6321799, Length=382, Percent_Identity=29.3193717277487, Blast_Score=162, Evalue=1e-40,
Organism=Drosophila melanogaster, GI24581334, Length=460, Percent_Identity=28.695652173913, Blast_Score=176, Evalue=2e-44,
Organism=Drosophila melanogaster, GI17737985, Length=267, Percent_Identity=34.8314606741573, Blast_Score=160, Evalue=2e-39,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): SYS_HYPNA (Q0C0W2)

Other databases:

- EMBL:   CP000158
- RefSeq:   YP_760631.1
- ProteinModelPortal:   Q0C0W2
- SMR:   Q0C0W2
- STRING:   Q0C0W2
- GeneID:   4288182
- GenomeReviews:   CP000158_GR
- KEGG:   hne:HNE_1930
- NMPDR:   fig|228405.5.peg.1858
- TIGR:   HNE_1930
- eggNOG:   COG0172
- HOGENOM:   HBG629391
- OMA:   AHWDLGP
- PhylomeDB:   Q0C0W2
- ProtClustDB:   PRK05431
- BioCyc:   HNEP81032:HNE_1930-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00176
- InterPro:   IPR002314
- InterPro:   IPR006195
- InterPro:   IPR002317
- InterPro:   IPR015866
- InterPro:   IPR010978
- Gene3D:   G3DSA:1.10.287.40
- PANTHER:   PTHR11778
- PIRSF:   PIRSF001529
- PRINTS:   PR00981
- TIGRFAMs:   TIGR00414

Pfam domain/function: PF02403 Seryl_tRNA_N; PF00587 tRNA-synt_2b; SSF46589 tRNA_binding_arm

EC number: =6.1.1.11

Molecular weight: Translated: 47837; Mature: 47837

Theoretical pI: Translated: 5.17; Mature: 5.17

Prosite motif: PS50862 AA_TRNA_LIGASE_II

Important sites: BINDING 292-292 BINDING 393-393

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFDIRAIRDNPDAFRNAWNRRKSGLGSVVDDILKLDAQWREATTAKQDAESARNANSKLI
CCCCEECCCCCHHHHHHHHHHHCCHHHHHHHHHHHCHHHHHHHHHHHHHHHHHCCCHHHH
GQAKAKKDEAEAARLMALVAEAKTTMEQAGEAEDNARKALDDLLMGLPNLPLDEVPEGSD
HHHHHCHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCCHHCCCCCCC
EHGNVEQHTWGEPKLINDPKDHADLGEALKGQGGFPMMDFEAAARMSGARFVALRGKLTR
CCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCHHHHHHCCCCEEEEEHHHHHH
LERALANFMLDLQTTEHGYEEMSVPVLVRDQALYGTGQLPKFAEDLFRTTVDHWLTPTAE
HHHHHHHHHHHHHHHHCCHHHCCCCEEEECCCCCCCCCCCHHHHHHHHHHHHHHCCCCHH
VSLTNLVREQILDAAQLPLRFTAHTPCFRSEAGSAGRDTKGMIRQHQFNKVELVSIVANE
HHHHHHHHHHHHHHHHCCEEEECCCCCHHCCCCCCCCCHHHHHHHHCCCHHHHHHHHHHH
AEGLAELERMTGCAEEVLKRLELPFRRMLLCTGDMGAGARKTYDLEVWLPSQNTYREISS
HHHHHHHHHHHHHHHHHHHHHCCCHHHHHHCCCCCCCCCCEEEEEEEEECCCHHHHHHHC
CSYCGDFQARRMDARYRPEPKAKPEYVHTLNGSGLAVGRTLVAVLENYQNADGSITVPKA
CCCCCCHHHHHCCCCCCCCCCCCCCEEEEECCCCHHHHHHHHHHHHHHCCCCCCEECHHH
LVPYMGGVEVIN
HHHHCCCEEECC
>Mature Secondary Structure
MFDIRAIRDNPDAFRNAWNRRKSGLGSVVDDILKLDAQWREATTAKQDAESARNANSKLI
CCCCEECCCCCHHHHHHHHHHHCCHHHHHHHHHHHCHHHHHHHHHHHHHHHHHCCCHHHH
GQAKAKKDEAEAARLMALVAEAKTTMEQAGEAEDNARKALDDLLMGLPNLPLDEVPEGSD
HHHHHCHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCCHHCCCCCCC
EHGNVEQHTWGEPKLINDPKDHADLGEALKGQGGFPMMDFEAAARMSGARFVALRGKLTR
CCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCHHHHHHCCCCEEEEEHHHHHH
LERALANFMLDLQTTEHGYEEMSVPVLVRDQALYGTGQLPKFAEDLFRTTVDHWLTPTAE
HHHHHHHHHHHHHHHHCCHHHCCCCEEEECCCCCCCCCCCHHHHHHHHHHHHHHCCCCHH
VSLTNLVREQILDAAQLPLRFTAHTPCFRSEAGSAGRDTKGMIRQHQFNKVELVSIVANE
HHHHHHHHHHHHHHHHCCEEEECCCCCHHCCCCCCCCCHHHHHHHHCCCHHHHHHHHHHH
AEGLAELERMTGCAEEVLKRLELPFRRMLLCTGDMGAGARKTYDLEVWLPSQNTYREISS
HHHHHHHHHHHHHHHHHHHHHCCCHHHHHHCCCCCCCCCCEEEEEEEEECCCHHHHHHHC
CSYCGDFQARRMDARYRPEPKAKPEYVHTLNGSGLAVGRTLVAVLENYQNADGSITVPKA
CCCCCCHHHHHCCCCCCCCCCCCCCEEEEECCCCHHHHHHHHHHHHHHCCCCCCEECHHH
LVPYMGGVEVIN
HHHHCCCEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA