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The map label for this gene is bioA [H]

Identifier: 114800419

GI number: 114800419

Start: 1270852

End: 1272129

Strand: Reverse

Name: bioA [H]

Synonym: HNE_1247

Alternate gene names: 114800419

Gene position: 1272129-1270852 (Counterclockwise)

Preceding gene: 114798275

Following gene: 114798344

Centisome position: 34.34

GC content: 64.55

Gene sequence:

>1278_bases
ATGGCAGACCCGAAAGACTGGTTCACCGCGGGCCTGGAACACATCTGGCTGCCCTACGCCCAGATGCGCACCCTGCCCGC
TCCGGTTGCCATCGCGCGCACCGAAGGCTCCCGGCTTTACCTCGCCGATGGCCGCGAGCTGGTAGACGGTGTCGGCAGCT
GGTGGACCAGCATCCACGGCTATAACCGCCCCGAGCTTCTGGACGCCGCCCGCGACCAGATGGCGAAGATGCCCCACATC
ATGCTCGGCGGCCTCGCCCATGAACCGGCCTACCGGCTGGCCACGCGCCTCGCCGAAATCACCCCCGGCGATCTTTCCCG
CGTCTTCTTCACCGAGTCCGGCTCGGTCGCCGTCGAAGTCGCGATGAAAATCGCCATCCAGTATTTCCGCAACACGGCCG
GTGTCACGCGCACCAAATTCGTCTCCTTCCTCGGCGGCTATCATGGCGACACGCTGGCCACCATGTCGGTCTGCGATCCC
GATGAAGGCATGCACCACATGTTCCGCGGCGCCCTGGCCGAACAATATGTCGTCGCCTTGCCCGAAACGCGCGACCAGAT
CCGCGCGCTGGAAACCCTTCTGTCTACGGACAAGAAAATCGCCGCCGTGATGATCGAGCCGCTGATCCAGGGCGCCGGCG
GCATGCGCATGCACAGCCCCCAGGTCCTTAAGACGCTCCGCCGCCTCTGCGATCAGGCCGGCGTCCTCCTCATCTTCGAT
GAAATCTTTACCGGCTTTGGCCGCACCGGCGAAATGTTCGCCGCCGCCCGCGCCGGCGTCACGCCCGACATCATGTGCCT
GGGCAAAGCCATCACCGGCGGCATCACCCCGCTCGCCGCGACGCTGGCCTCCTCGAAAGTCTACGCCGCCTTCCATTCGG
AAAATCCGGATCACGCCCTGATGCACGGACCCACCTATACCGGCCACGCCCTCGCCTGCGCCGTCGCCAATGCGGGCCTC
GATCTTTTTGCCGATGGCAGCCTCATCAAGCGCGTCAAGAAACTCGAAGCCAGCCTCACCAGCGCGCTCGCCCCGGCAAA
GGATATGGATAGCGTCGTCGATGTCCGCGTCCTCGGCGCCGTCGCTGCCGTGGAACTGGCAGATCCCTTCCCCATCGAGG
CAGCCCGCAAATGGTTCATCGATGAAGGCACCTTCATCCGCCCTCTCGGCCGCACGGTCTACCTCTCCCCCGCCTACGGC
ATCAGCGACGATGACCTGGCCCGGCTCACCGGCGCCATCCTGAAATTTGCAAAAACGGGAATATCCGACATCGGATAA

Upstream 100 bases:

>100_bases
CAATCCTCTGGCCGTTGCGCCGCGCCTGTCCTAGGGGATGCACGCGGGGCATGCCAAGCGTCGAATGCCCGCAGCAACGG
ACCCTTTAGGAGCGCTGAAC

Downstream 100 bases:

>100_bases
TCAGCGGCAGGGCGCCCCAGCCTCGGCCTCTTCATAATCCGCCAGAATCCAGGGCTGCATGTCTCCGGCTTTCATCGCCT
CGACCGCAGGCCGCAGGAGC

Product: adenosylmethionine--8-amino-7-oxononanoate transaminase

Products: NA

Alternate protein names: 7,8-diamino-pelargonic acid aminotransferase; DAPA AT; DAPA aminotransferase; Diaminopelargonic acid synthase [H]

Number of amino acids: Translated: 425; Mature: 424

Protein sequence:

>425_residues
MADPKDWFTAGLEHIWLPYAQMRTLPAPVAIARTEGSRLYLADGRELVDGVGSWWTSIHGYNRPELLDAARDQMAKMPHI
MLGGLAHEPAYRLATRLAEITPGDLSRVFFTESGSVAVEVAMKIAIQYFRNTAGVTRTKFVSFLGGYHGDTLATMSVCDP
DEGMHHMFRGALAEQYVVALPETRDQIRALETLLSTDKKIAAVMIEPLIQGAGGMRMHSPQVLKTLRRLCDQAGVLLIFD
EIFTGFGRTGEMFAAARAGVTPDIMCLGKAITGGITPLAATLASSKVYAAFHSENPDHALMHGPTYTGHALACAVANAGL
DLFADGSLIKRVKKLEASLTSALAPAKDMDSVVDVRVLGAVAAVELADPFPIEAARKWFIDEGTFIRPLGRTVYLSPAYG
ISDDDLARLTGAILKFAKTGISDIG

Sequences:

>Translated_425_residues
MADPKDWFTAGLEHIWLPYAQMRTLPAPVAIARTEGSRLYLADGRELVDGVGSWWTSIHGYNRPELLDAARDQMAKMPHI
MLGGLAHEPAYRLATRLAEITPGDLSRVFFTESGSVAVEVAMKIAIQYFRNTAGVTRTKFVSFLGGYHGDTLATMSVCDP
DEGMHHMFRGALAEQYVVALPETRDQIRALETLLSTDKKIAAVMIEPLIQGAGGMRMHSPQVLKTLRRLCDQAGVLLIFD
EIFTGFGRTGEMFAAARAGVTPDIMCLGKAITGGITPLAATLASSKVYAAFHSENPDHALMHGPTYTGHALACAVANAGL
DLFADGSLIKRVKKLEASLTSALAPAKDMDSVVDVRVLGAVAAVELADPFPIEAARKWFIDEGTFIRPLGRTVYLSPAYG
ISDDDLARLTGAILKFAKTGISDIG
>Mature_424_residues
ADPKDWFTAGLEHIWLPYAQMRTLPAPVAIARTEGSRLYLADGRELVDGVGSWWTSIHGYNRPELLDAARDQMAKMPHIM
LGGLAHEPAYRLATRLAEITPGDLSRVFFTESGSVAVEVAMKIAIQYFRNTAGVTRTKFVSFLGGYHGDTLATMSVCDPD
EGMHHMFRGALAEQYVVALPETRDQIRALETLLSTDKKIAAVMIEPLIQGAGGMRMHSPQVLKTLRRLCDQAGVLLIFDE
IFTGFGRTGEMFAAARAGVTPDIMCLGKAITGGITPLAATLASSKVYAAFHSENPDHALMHGPTYTGHALACAVANAGLD
LFADGSLIKRVKKLEASLTSALAPAKDMDSVVDVRVLGAVAAVELADPFPIEAARKWFIDEGTFIRPLGRTVYLSPAYGI
SDDDLARLTGAILKFAKTGISDIG

Specific function: Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor [H]

COG id: COG0161

COG function: function code H; Adenosylmethionine-8-amino-7-oxononanoate aminotransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. BioA subfamily [H]

Homologues:

Organism=Homo sapiens, GI4557809, Length=402, Percent_Identity=29.3532338308458, Blast_Score=122, Evalue=5e-28,
Organism=Homo sapiens, GI284507298, Length=306, Percent_Identity=31.0457516339869, Blast_Score=104, Evalue=1e-22,
Organism=Homo sapiens, GI13994255, Length=415, Percent_Identity=25.5421686746988, Blast_Score=100, Evalue=3e-21,
Organism=Homo sapiens, GI37574042, Length=358, Percent_Identity=24.8603351955307, Blast_Score=96, Evalue=9e-20,
Organism=Homo sapiens, GI226442705, Length=358, Percent_Identity=24.8603351955307, Blast_Score=92, Evalue=1e-18,
Organism=Homo sapiens, GI226442709, Length=326, Percent_Identity=25.7668711656442, Blast_Score=88, Evalue=1e-17,
Organism=Escherichia coli, GI1786991, Length=409, Percent_Identity=47.6772616136919, Blast_Score=371, Evalue=1e-104,
Organism=Escherichia coli, GI1789759, Length=342, Percent_Identity=33.0409356725146, Blast_Score=167, Evalue=2e-42,
Organism=Escherichia coli, GI145693181, Length=370, Percent_Identity=31.8918918918919, Blast_Score=165, Evalue=6e-42,
Organism=Escherichia coli, GI1788044, Length=413, Percent_Identity=31.9612590799031, Blast_Score=158, Evalue=8e-40,
Organism=Escherichia coli, GI1789016, Length=352, Percent_Identity=33.5227272727273, Blast_Score=156, Evalue=3e-39,
Organism=Escherichia coli, GI1787560, Length=347, Percent_Identity=31.4121037463977, Blast_Score=137, Evalue=1e-33,
Organism=Escherichia coli, GI1786349, Length=403, Percent_Identity=26.5508684863524, Blast_Score=98, Evalue=1e-21,
Organism=Caenorhabditis elegans, GI25144271, Length=339, Percent_Identity=28.3185840707965, Blast_Score=117, Evalue=9e-27,
Organism=Caenorhabditis elegans, GI25144274, Length=170, Percent_Identity=36.4705882352941, Blast_Score=100, Evalue=2e-21,
Organism=Caenorhabditis elegans, GI71992977, Length=368, Percent_Identity=23.0978260869565, Blast_Score=72, Evalue=4e-13,
Organism=Saccharomyces cerevisiae, GI6324386, Length=453, Percent_Identity=36.644591611479, Blast_Score=283, Evalue=4e-77,
Organism=Saccharomyces cerevisiae, GI6324432, Length=394, Percent_Identity=29.4416243654822, Blast_Score=130, Evalue=4e-31,
Organism=Saccharomyces cerevisiae, GI6323470, Length=419, Percent_Identity=26.7303102625298, Blast_Score=124, Evalue=3e-29,
Organism=Drosophila melanogaster, GI21357415, Length=391, Percent_Identity=27.8772378516624, Blast_Score=114, Evalue=1e-25,
Organism=Drosophila melanogaster, GI28574759, Length=375, Percent_Identity=28, Blast_Score=91, Evalue=1e-18,
Organism=Drosophila melanogaster, GI161085790, Length=375, Percent_Identity=27.7333333333333, Blast_Score=91, Evalue=1e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005814
- InterPro:   IPR005815
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00202 Aminotran_3 [H]

EC number: =2.6.1.62 [H]

Molecular weight: Translated: 45806; Mature: 45675

Theoretical pI: Translated: 6.51; Mature: 6.51

Prosite motif: PS00600 AA_TRANSFER_CLASS_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MADPKDWFTAGLEHIWLPYAQMRTLPAPVAIARTEGSRLYLADGRELVDGVGSWWTSIHG
CCCCHHHHHHHHHHHHCCHHHHHCCCCCEEEEECCCCEEEEECCHHHHHHHHHHHHHHCC
YNRPELLDAARDQMAKMPHIMLGGLAHEPAYRLATRLAEITPGDLSRVFFTESGSVAVEV
CCCHHHHHHHHHHHHHCCHHHHCCCCCCHHHHHHHHHHHCCCCCCCEEEEECCCCHHHHH
AMKIAIQYFRNTAGVTRTKFVSFLGGYHGDTLATMSVCDPDEGMHHMFRGALAEQYVVAL
HHHHHHHHHHHCCCCHHHHHHHHHCCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHEEEC
PETRDQIRALETLLSTDKKIAAVMIEPLIQGAGGMRMHSPQVLKTLRRLCDQAGVLLIFD
CCCHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHCCEEEEEH
EIFTGFGRTGEMFAAARAGVTPDIMCLGKAITGGITPLAATLASSKVYAAFHSENPDHAL
HHHHCCCCCCHHHHHHHCCCCHHHHHHHHHHHCCHHHHHHHHHCCCEEEEECCCCCCCEE
MHGPTYTGHALACAVANAGLDLFADGSLIKRVKKLEASLTSALAPAKDMDSVVDVRVLGA
ECCCCCCCHHHHHHHHHCCCCEEECCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHH
VAAVELADPFPIEAARKWFIDEGTFIRPLGRTVYLSPAYGISDDDLARLTGAILKFAKTG
HHHHHCCCCCCHHHHHHHHCCCCCEEEECCCEEEECCCCCCCCHHHHHHHHHHHHHHHHC
ISDIG
CCCCC
>Mature Secondary Structure 
ADPKDWFTAGLEHIWLPYAQMRTLPAPVAIARTEGSRLYLADGRELVDGVGSWWTSIHG
CCCHHHHHHHHHHHHCCHHHHHCCCCCEEEEECCCCEEEEECCHHHHHHHHHHHHHHCC
YNRPELLDAARDQMAKMPHIMLGGLAHEPAYRLATRLAEITPGDLSRVFFTESGSVAVEV
CCCHHHHHHHHHHHHHCCHHHHCCCCCCHHHHHHHHHHHCCCCCCCEEEEECCCCHHHHH
AMKIAIQYFRNTAGVTRTKFVSFLGGYHGDTLATMSVCDPDEGMHHMFRGALAEQYVVAL
HHHHHHHHHHHCCCCHHHHHHHHHCCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHEEEC
PETRDQIRALETLLSTDKKIAAVMIEPLIQGAGGMRMHSPQVLKTLRRLCDQAGVLLIFD
CCCHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHCCEEEEEH
EIFTGFGRTGEMFAAARAGVTPDIMCLGKAITGGITPLAATLASSKVYAAFHSENPDHAL
HHHHCCCCCCHHHHHHHCCCCHHHHHHHHHHHCCHHHHHHHHHCCCEEEEECCCCCCCEE
MHGPTYTGHALACAVANAGLDLFADGSLIKRVKKLEASLTSALAPAKDMDSVVDVRVLGA
ECCCCCCCHHHHHHHHHCCCCEEECCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHH
VAAVELADPFPIEAARKWFIDEGTFIRPLGRTVYLSPAYGISDDDLARLTGAILKFAKTG
HHHHHCCCCCCHHHHHHHHCCCCCEEEECCCEEEECCCCCCCCHHHHHHHHHHHHHHHHC
ISDIG
CCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8890743 [H]