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The map label for this gene is 114800376

Identifier: 114800376

GI number: 114800376

Start: 1802801

End: 1804498

Strand: Direct

Name: 114800376

Synonym: HNE_1761

Alternate gene names: NA

Gene position: 1802801-1804498 (Clockwise)

Preceding gene: 114799332

Following gene: 114797534

Centisome position: 48.66

GC content: 55.42

Gene sequence:

>1698_bases
TTGACACTGAAGGAGACCACAATCGATCAGTCCAAGGACGAGCTCGTATTTCTTCCCCTCGGCGGTTGCGGCGAGATCGG
AATGAACCTCAATGCCTATGGATATGGCCCGCCAAACGCGCGGCGATGGATCATCGTTGATGTGGGTGTCACATTTGGGA
ACTCGGATACGCCGGGAATTGACCTGATCTGTGCGGACCCAGATTATCTGATAGGGGAGCACATCGACGCAGTCTTCCTG
ACGCATGCTCATGAAGACCATATTGGGGCTGTTGGGCTTTTGTATCCGATGCTCAAGACGAAGGCGCCGATTTACGCAAC
GCCTTTTACATGTGAACTTGTTCGGTCCAAGATGGACGAGCGCGGCGTGGACCAAAAATGGCTGAAAACGATCTCGATGG
GTGGAACTGTCAAGGCGGGTCCTTTCGAGGTTACGTATGTTACCCTCACCCACTCGATACCTGAGCCCAACGCACTGGCC
ATCCGCACTCCAGCGGGGATAGTTCTTCATACGGGCGATTGGAAAATCGACCCGCAACCTCAAATCGGTTCGAGCACAGA
CATTAGTGGTCTTACAGCGCTAGGGGATGAAGGCGTGCTCGCGATGGTTTGCGACTCGACCAACGTGTTTGAAGGCGGCG
AAGCCGGGTCTGAAGAAACAGTGCGACAAGGGCTCATCGAGCTTATTGCCGAACAGACGCAGGCTGTGGCTGTCACAACT
TTTGCGTCCAATGTTGCGCGCGTTAAATCCATCATAGACGCTGCGAACCAGGCAGGCCGTAGCGTTTGTCTCGTGGGGCG
CAGTATGCACCGCGTGACAGCTGCGGCGAAAGCCGTGGGGATACTTCCGGCGCGCCTTGATTTTGTGGACGAGAGCGAAG
CGGGTTATTTGCCAGCGGAGAATATCCTTTATCTCTGTACAGGGAGCCAGGGAGAGGCCAACGCGGCGCTCTCGCGAATA
GCGCGCGGAGATCATCGTCATGTGGCGCTACGCGAGGGGGATAGTGTCATTTTTTCCTCTCGTCTGATCCCCGGCAATGA
AACCAGTGTCTACAGTTTGCAGAACACATTGGCGGAGAACGGAATAAAGGTAATCACTCCACGGATGGTTCCCCAGACGA
TCCATGTGTCTGGTCACCCCTGCCGTGATGAGCTGCGGCGAATGTATCAATGGGTCCGCCCCAGAATTTCTGTGCCGGTT
CATGGTGAGCGCCGGCATATTCTTGAACATGCATCCTATGCGCGATCCCTTCAGGTTCCTGAGGCAATCGCCCCCAGAAA
CGGAAGCCTCATCCGCCTCGCGCCAGGTGAGGCGGAGATACTCGATGAAGTGCCGGCAGGACGACTCTTTCTGGATGGCA
ATCGGCTGGTTCCAGAGGGCGCGCAGGGATTGGTTGAACGCAAACGGTTGCATAATAGCGGCGTAATATTCGCCACCGTC
AGTCTCGACCAGGCCGGACGGCCGGTCGACGGTCCCGTTGTTGTGGCTAAAGGACTTTCGGAAAAAGACGGAAGGGTCGC
TGAGGAAAGCCTCGAAATCCTTGATGAGGCGGCGGAAGCTGCCGTTGCTGGTTTATCAAAGAAAGATCGCAATGATGATG
AAGCGATCGAGCGATCAATAGGACGGGCTTTGCGTAAAGCGTGTGATGTCAATTTCGGCCTGAAGCCGGTGATTGAAGTG
GTTGTGCTGAGGAGCTGA

Upstream 100 bases:

>100_bases
GGGGCGTGGCGTCTCTCTTCGAAGGAGCAAGCGAAACCATCGATTACTACGATCAAGACATTCTTATCCGGGGGCTATTG
GAAGTCTGGAAGCGGAACCG

Downstream 100 bases:

>100_bases
GATAGCAATGAGCGAATTCAAGATCGGACCCCTGAATCATGTGGGGGTAGCTGTTCCCAATATTGAGCAAGCCTGTGAGA
CGTATCGCTCGCTTTACGGT

Product: metallo-beta-lactamase family protein

Products: NA

Alternate protein names: RNase J [H]

Number of amino acids: Translated: 565; Mature: 564

Protein sequence:

>565_residues
MTLKETTIDQSKDELVFLPLGGCGEIGMNLNAYGYGPPNARRWIIVDVGVTFGNSDTPGIDLICADPDYLIGEHIDAVFL
THAHEDHIGAVGLLYPMLKTKAPIYATPFTCELVRSKMDERGVDQKWLKTISMGGTVKAGPFEVTYVTLTHSIPEPNALA
IRTPAGIVLHTGDWKIDPQPQIGSSTDISGLTALGDEGVLAMVCDSTNVFEGGEAGSEETVRQGLIELIAEQTQAVAVTT
FASNVARVKSIIDAANQAGRSVCLVGRSMHRVTAAAKAVGILPARLDFVDESEAGYLPAENILYLCTGSQGEANAALSRI
ARGDHRHVALREGDSVIFSSRLIPGNETSVYSLQNTLAENGIKVITPRMVPQTIHVSGHPCRDELRRMYQWVRPRISVPV
HGERRHILEHASYARSLQVPEAIAPRNGSLIRLAPGEAEILDEVPAGRLFLDGNRLVPEGAQGLVERKRLHNSGVIFATV
SLDQAGRPVDGPVVVAKGLSEKDGRVAEESLEILDEAAEAAVAGLSKKDRNDDEAIERSIGRALRKACDVNFGLKPVIEV
VVLRS

Sequences:

>Translated_565_residues
MTLKETTIDQSKDELVFLPLGGCGEIGMNLNAYGYGPPNARRWIIVDVGVTFGNSDTPGIDLICADPDYLIGEHIDAVFL
THAHEDHIGAVGLLYPMLKTKAPIYATPFTCELVRSKMDERGVDQKWLKTISMGGTVKAGPFEVTYVTLTHSIPEPNALA
IRTPAGIVLHTGDWKIDPQPQIGSSTDISGLTALGDEGVLAMVCDSTNVFEGGEAGSEETVRQGLIELIAEQTQAVAVTT
FASNVARVKSIIDAANQAGRSVCLVGRSMHRVTAAAKAVGILPARLDFVDESEAGYLPAENILYLCTGSQGEANAALSRI
ARGDHRHVALREGDSVIFSSRLIPGNETSVYSLQNTLAENGIKVITPRMVPQTIHVSGHPCRDELRRMYQWVRPRISVPV
HGERRHILEHASYARSLQVPEAIAPRNGSLIRLAPGEAEILDEVPAGRLFLDGNRLVPEGAQGLVERKRLHNSGVIFATV
SLDQAGRPVDGPVVVAKGLSEKDGRVAEESLEILDEAAEAAVAGLSKKDRNDDEAIERSIGRALRKACDVNFGLKPVIEV
VVLRS
>Mature_564_residues
TLKETTIDQSKDELVFLPLGGCGEIGMNLNAYGYGPPNARRWIIVDVGVTFGNSDTPGIDLICADPDYLIGEHIDAVFLT
HAHEDHIGAVGLLYPMLKTKAPIYATPFTCELVRSKMDERGVDQKWLKTISMGGTVKAGPFEVTYVTLTHSIPEPNALAI
RTPAGIVLHTGDWKIDPQPQIGSSTDISGLTALGDEGVLAMVCDSTNVFEGGEAGSEETVRQGLIELIAEQTQAVAVTTF
ASNVARVKSIIDAANQAGRSVCLVGRSMHRVTAAAKAVGILPARLDFVDESEAGYLPAENILYLCTGSQGEANAALSRIA
RGDHRHVALREGDSVIFSSRLIPGNETSVYSLQNTLAENGIKVITPRMVPQTIHVSGHPCRDELRRMYQWVRPRISVPVH
GERRHILEHASYARSLQVPEAIAPRNGSLIRLAPGEAEILDEVPAGRLFLDGNRLVPEGAQGLVERKRLHNSGVIFATVS
LDQAGRPVDGPVVVAKGLSEKDGRVAEESLEILDEAAEAAVAGLSKKDRNDDEAIERSIGRALRKACDVNFGLKPVIEVV
VLRS

Specific function: Unknown

COG id: COG0595

COG function: function code R; Predicted hydrolase of the metallo-beta-lactamase superfamily

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family. RNase J subfamily [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001279
- InterPro:   IPR011108
- InterPro:   IPR001587 [H]

Pfam domain/function: PF00753 Lactamase_B; PF07521 RMMBL [H]

EC number: NA

Molecular weight: Translated: 60805; Mature: 60674

Theoretical pI: Translated: 5.50; Mature: 5.50

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTLKETTIDQSKDELVFLPLGGCGEIGMNLNAYGYGPPNARRWIIVDVGVTFGNSDTPGI
CCCCCCCCCCCCCCEEEEECCCCCCCCCCCEEEECCCCCCCEEEEEEEEEEECCCCCCCE
DLICADPDYLIGEHIDAVFLTHAHEDHIGAVGLLYPMLKTKAPIYATPFTCELVRSKMDE
EEEECCCCHHHHCCCCEEEEEECCCCCCCHHHHHHHHHHCCCCEEECCCHHHHHHHHHHH
RGVDQKWLKTISMGGTVKAGPFEVTYVTLTHSIPEPNALAIRTPAGIVLHTGDWKIDPQP
CCCCHHHHHHHHCCCCEECCCEEEEEEEEEECCCCCCEEEEECCCCEEEECCCEEECCCC
QIGSSTDISGLTALGDEGVLAMVCDSTNVFEGGEAGSEETVRQGLIELIAEQTQAVAVTT
CCCCCCCCCCEEEECCCCEEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHHEEEEEH
FASNVARVKSIIDAANQAGRSVCLVGRSMHRVTAAAKAVGILPARLDFVDESEAGYLPAE
HHHHHHHHHHHHHHHHHCCCEEEEECCHHHHHHHHHHHHHCCHHHCCCCCCCCCCCCCCC
NILYLCTGSQGEANAALSRIARGDHRHVALREGDSVIFSSRLIPGNETSVYSLQNTLAEN
CEEEEEECCCCCHHHHHHHHHCCCCCEEEEECCCCEEEEEECCCCCCCEEHHHHHHHHHC
GIKVITPRMVPQTIHVSGHPCRDELRRMYQWVRPRISVPVHGERRHILEHASYARSLQVP
CEEEEECCCCCEEEEECCCCHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHCCCC
EAIAPRNGSLIRLAPGEAEILDEVPAGRLFLDGNRLVPEGAQGLVERKRLHNSGVIFATV
HHCCCCCCCEEEECCCCHHHHHCCCCCEEEECCCEECCCHHHHHHHHHHHCCCCEEEEEE
SLDQAGRPVDGPVVVAKGLSEKDGRVAEESLEILDEAAEAAVAGLSKKDRNDDEAIERSI
EECCCCCCCCCCEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHH
GRALRKACDVNFGLKPVIEVVVLRS
HHHHHHHHCCCCCHHHHHHEEEECC
>Mature Secondary Structure 
TLKETTIDQSKDELVFLPLGGCGEIGMNLNAYGYGPPNARRWIIVDVGVTFGNSDTPGI
CCCCCCCCCCCCCEEEEECCCCCCCCCCCEEEECCCCCCCEEEEEEEEEEECCCCCCCE
DLICADPDYLIGEHIDAVFLTHAHEDHIGAVGLLYPMLKTKAPIYATPFTCELVRSKMDE
EEEECCCCHHHHCCCCEEEEEECCCCCCCHHHHHHHHHHCCCCEEECCCHHHHHHHHHHH
RGVDQKWLKTISMGGTVKAGPFEVTYVTLTHSIPEPNALAIRTPAGIVLHTGDWKIDPQP
CCCCHHHHHHHHCCCCEECCCEEEEEEEEEECCCCCCEEEEECCCCEEEECCCEEECCCC
QIGSSTDISGLTALGDEGVLAMVCDSTNVFEGGEAGSEETVRQGLIELIAEQTQAVAVTT
CCCCCCCCCCEEEECCCCEEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHHEEEEEH
FASNVARVKSIIDAANQAGRSVCLVGRSMHRVTAAAKAVGILPARLDFVDESEAGYLPAE
HHHHHHHHHHHHHHHHHCCCEEEEECCHHHHHHHHHHHHHCCHHHCCCCCCCCCCCCCCC
NILYLCTGSQGEANAALSRIARGDHRHVALREGDSVIFSSRLIPGNETSVYSLQNTLAEN
CEEEEEECCCCCHHHHHHHHHCCCCCEEEEECCCCEEEEEECCCCCCCEEHHHHHHHHHC
GIKVITPRMVPQTIHVSGHPCRDELRRMYQWVRPRISVPVHGERRHILEHASYARSLQVP
CEEEEECCCCCEEEEECCCCHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHCCCC
EAIAPRNGSLIRLAPGEAEILDEVPAGRLFLDGNRLVPEGAQGLVERKRLHNSGVIFATV
HHCCCCCCCEEEECCCCHHHHHCCCCCEEEECCCEECCCHHHHHHHHHHHCCCCEEEEEE
SLDQAGRPVDGPVVVAKGLSEKDGRVAEESLEILDEAAEAAVAGLSKKDRNDDEAIERSI
EECCCCCCCCCCEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHH
GRALRKACDVNFGLKPVIEVVVLRS
HHHHHHHHCCCCCHHHHHHEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12948626 [H]