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The map label for this gene is csd [H]

Identifier: 114800315

GI number: 114800315

Start: 2772051

End: 2773274

Strand: Reverse

Name: csd [H]

Synonym: HNE_2614

Alternate gene names: 114800315

Gene position: 2773274-2772051 (Counterclockwise)

Preceding gene: 114797340

Following gene: 114799313

Centisome position: 74.85

GC content: 64.13

Gene sequence:

>1224_bases
ATGCCACGCAAGCTCGACCTTCCCGCCATCCGTGCCGAATTCCCGATCCTCTCACGCGAAGTGAACGGGCATCCGCTGGT
TTACCTCGACAATGCCGCCAGCGCGCAGAAGTCCAACGCCGTCATCGACGCGCTCTCCGGCCAGATGCGGACCGCCTATG
CCAACGTCCATCGCGGCCTGCACACACTGGCGAACGAGACGACCGAGGCGTTCGAGGCGGCGCGCGAGACGGTGCGCGCG
TTTCTCAATGCGCCGTCCACGGATACTATCATCTTCACCAAGGGCTCGACCGAGGGGATAAACCTCGTCGCGTCTGCACT
TGCCGCGCGTATCCAGCCGGGCGACGAAATCGTGCTCTCCATCATGGAGCACCATTCCAACATCGTGCCCTGGCATTTCC
TGCGCGAACGCCATGGCGCGGTGCTGCGCTGGGTGGGGCTGACCGAAGACGGATCGCTGGATATGGACGCGATGGCCGCC
GCCATCGGCCCGAAGACGAAGCTGGTCGCCATCACCCATATGAGCAATGTGCTCGGCACGGTGGTCGACGTGGCCGCGGT
CGCAAAACTCGCTCATGACGCCGGCGCCGAAATCCTCATCGATGGCAGCCAGGCGGCGGTGCACCTGCCTGTCGATGTCC
AGGCCATTGGCTGCGACTGGTATGTGATTACCGCCCACAAGATCTATGGCCCGACCGGCATCGGCGCGCTTTACGGCACG
GCGCAGGCGCTTGACCGCGCGCGGCCCTATCAGGGCGGCGGCGAGATGATCGAGATCGTCGAGATGGACCGGATCACCTA
CAACTCGGCGCCTCACAAATTCGAAGCGGGCACGCCGCCGATTCTCGAAGCAATCGGCTTTGGCGCCGCCCTGCGCTGGC
TGGCTGAGTTCGACAAGGCGGAGGTCGCCGCCCATGAACACGGCCTCTATGAACGTGCCGCGAATGCCCTGCGCAGCGTG
AACGGCATCCGCATTCATGGCGAAGCGCCCGGAAAGGGCGCCGTGCTGGCCTTCAGCCTGGAAGGCGCCCACCCGCATGA
CATCGCCCAGATCGTCGATCGCTACGGCGTTGCCATCCGCGCGGGCCACCATTGTGCGCAGCCCTTAATGCAGCATTTAG
GCGTAACGGCTACGGCGAGGGCGAGTTTTGCCCTATATAACACTGAGGCTGAGGTGGACGCGCTGGCCGAGGCGCTCGCC
AAGGCACGCAAAATGCTGGTATAA

Upstream 100 bases:

>100_bases
CTGACCGAGGCTTTCATCGCTGAAGCCTTGGAAGATGCGGGCGTGCATGAAGATGCGCTGCGGGCGCAGGCGCAAGCCTG
GCTGTCAGAGGTCTGATGCC

Downstream 100 bases:

>100_bases
GTACGTATATGGCCGATGACATGACCTCCCAAGACCTGCTCGGCGTCCGCGATCCGGATGCTGTCTCCGCGATTCCGCAA
GATGAGCTGGATCGTTTGAC

Product: SufS family cysteine desulfurase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 407; Mature: 406

Protein sequence:

>407_residues
MPRKLDLPAIRAEFPILSREVNGHPLVYLDNAASAQKSNAVIDALSGQMRTAYANVHRGLHTLANETTEAFEAARETVRA
FLNAPSTDTIIFTKGSTEGINLVASALAARIQPGDEIVLSIMEHHSNIVPWHFLRERHGAVLRWVGLTEDGSLDMDAMAA
AIGPKTKLVAITHMSNVLGTVVDVAAVAKLAHDAGAEILIDGSQAAVHLPVDVQAIGCDWYVITAHKIYGPTGIGALYGT
AQALDRARPYQGGGEMIEIVEMDRITYNSAPHKFEAGTPPILEAIGFGAALRWLAEFDKAEVAAHEHGLYERAANALRSV
NGIRIHGEAPGKGAVLAFSLEGAHPHDIAQIVDRYGVAIRAGHHCAQPLMQHLGVTATARASFALYNTEAEVDALAEALA
KARKMLV

Sequences:

>Translated_407_residues
MPRKLDLPAIRAEFPILSREVNGHPLVYLDNAASAQKSNAVIDALSGQMRTAYANVHRGLHTLANETTEAFEAARETVRA
FLNAPSTDTIIFTKGSTEGINLVASALAARIQPGDEIVLSIMEHHSNIVPWHFLRERHGAVLRWVGLTEDGSLDMDAMAA
AIGPKTKLVAITHMSNVLGTVVDVAAVAKLAHDAGAEILIDGSQAAVHLPVDVQAIGCDWYVITAHKIYGPTGIGALYGT
AQALDRARPYQGGGEMIEIVEMDRITYNSAPHKFEAGTPPILEAIGFGAALRWLAEFDKAEVAAHEHGLYERAANALRSV
NGIRIHGEAPGKGAVLAFSLEGAHPHDIAQIVDRYGVAIRAGHHCAQPLMQHLGVTATARASFALYNTEAEVDALAEALA
KARKMLV
>Mature_406_residues
PRKLDLPAIRAEFPILSREVNGHPLVYLDNAASAQKSNAVIDALSGQMRTAYANVHRGLHTLANETTEAFEAARETVRAF
LNAPSTDTIIFTKGSTEGINLVASALAARIQPGDEIVLSIMEHHSNIVPWHFLRERHGAVLRWVGLTEDGSLDMDAMAAA
IGPKTKLVAITHMSNVLGTVVDVAAVAKLAHDAGAEILIDGSQAAVHLPVDVQAIGCDWYVITAHKIYGPTGIGALYGTA
QALDRARPYQGGGEMIEIVEMDRITYNSAPHKFEAGTPPILEAIGFGAALRWLAEFDKAEVAAHEHGLYERAANALRSVN
GIRIHGEAPGKGAVLAFSLEGAHPHDIAQIVDRYGVAIRAGHHCAQPLMQHLGVTATARASFALYNTEAEVDALAEALAK
ARKMLV

Specific function: Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine [H]

COG id: COG0520

COG function: function code E; Selenocysteine lyase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. Csd subfamily [H]

Homologues:

Organism=Homo sapiens, GI32307132, Length=398, Percent_Identity=23.8693467336683, Blast_Score=108, Evalue=8e-24,
Organism=Homo sapiens, GI156713448, Length=241, Percent_Identity=28.6307053941909, Blast_Score=77, Evalue=2e-14,
Organism=Escherichia coli, GI1787970, Length=399, Percent_Identity=47.3684210526316, Blast_Score=369, Evalue=1e-103,
Organism=Escherichia coli, GI1789175, Length=399, Percent_Identity=43.3583959899749, Blast_Score=327, Evalue=7e-91,
Organism=Escherichia coli, GI48994898, Length=391, Percent_Identity=25.8312020460358, Blast_Score=113, Evalue=3e-26,
Organism=Caenorhabditis elegans, GI25143064, Length=229, Percent_Identity=31.0043668122271, Blast_Score=113, Evalue=2e-25,
Organism=Caenorhabditis elegans, GI193211090, Length=371, Percent_Identity=23.1805929919137, Blast_Score=89, Evalue=5e-18,
Organism=Saccharomyces cerevisiae, GI6319831, Length=398, Percent_Identity=25.1256281407035, Blast_Score=108, Evalue=1e-24,
Organism=Drosophila melanogaster, GI20129463, Length=311, Percent_Identity=29.5819935691318, Blast_Score=121, Evalue=9e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000192
- InterPro:   IPR020578
- InterPro:   IPR010970
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00266 Aminotran_5 [H]

EC number: =2.8.1.7 [H]

Molecular weight: Translated: 43482; Mature: 43351

Theoretical pI: Translated: 6.43; Mature: 6.43

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPRKLDLPAIRAEFPILSREVNGHPLVYLDNAASAQKSNAVIDALSGQMRTAYANVHRGL
CCCCCCCCHHHHCCCHHEEECCCCCEEEECCCCCCCCCCHHHHHHCCHHHHHHHHHHHHH
HTLANETTEAFEAARETVRAFLNAPSTDTIIFTKGSTEGINLVASALAARIQPGDEIVLS
HHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCHHHHHHHHHHHHCCCCHHHHHH
IMEHHSNIVPWHFLRERHGAVLRWVGLTEDGSLDMDAMAAAIGPKTKLVAITHMSNVLGT
HHHHCCCCCCHHHHHHHCCCEEEEEECCCCCCCCHHHHHHHCCCCCEEEEEEHHHHHHHH
VVDVAAVAKLAHDAGAEILIDGSQAAVHLPVDVQAIGCDWYVITAHKIYGPTGIGALYGT
HHHHHHHHHHHHCCCCEEEEECCCCEEECCEEEEEECCCEEEEEEEEECCCCCHHHHHHH
AQALDRARPYQGGGEMIEIVEMDRITYNSAPHKFEAGTPPILEAIGFGAALRWLAEFDKA
HHHHHHCCCCCCCCCEEEEEEECCEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHH
EVAAHEHGLYERAANALRSVNGIRIHGEAPGKGAVLAFSLEGAHPHDIAQIVDRYGVAIR
HHHHHHHHHHHHHHHHHHHCCCEEEECCCCCCCEEEEEEECCCCHHHHHHHHHHHCCEEE
AGHHCAQPLMQHLGVTATARASFALYNTEAEVDALAEALAKARKMLV
CCHHHHHHHHHHCCCEEECCCEEEEECCCHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
PRKLDLPAIRAEFPILSREVNGHPLVYLDNAASAQKSNAVIDALSGQMRTAYANVHRGL
CCCCCCCHHHHCCCHHEEECCCCCEEEECCCCCCCCCCHHHHHHCCHHHHHHHHHHHHH
HTLANETTEAFEAARETVRAFLNAPSTDTIIFTKGSTEGINLVASALAARIQPGDEIVLS
HHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCHHHHHHHHHHHHCCCCHHHHHH
IMEHHSNIVPWHFLRERHGAVLRWVGLTEDGSLDMDAMAAAIGPKTKLVAITHMSNVLGT
HHHHCCCCCCHHHHHHHCCCEEEEEECCCCCCCCHHHHHHHCCCCCEEEEEEHHHHHHHH
VVDVAAVAKLAHDAGAEILIDGSQAAVHLPVDVQAIGCDWYVITAHKIYGPTGIGALYGT
HHHHHHHHHHHHCCCCEEEEECCCCEEECCEEEEEECCCEEEEEEEEECCCCCHHHHHHH
AQALDRARPYQGGGEMIEIVEMDRITYNSAPHKFEAGTPPILEAIGFGAALRWLAEFDKA
HHHHHHCCCCCCCCCEEEEEEECCEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHH
EVAAHEHGLYERAANALRSVNGIRIHGEAPGKGAVLAFSLEGAHPHDIAQIVDRYGVAIR
HHHHHHHHHHHHHHHHHHHCCCEEEECCCCCCCEEEEEEECCCCHHHHHHHHHHHCCEEE
AGHHCAQPLMQHLGVTATARASFALYNTEAEVDALAEALAKARKMLV
CCHHHHHHHHHHCCCEEECCCEEEEECCCHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]