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The map label for this gene is hrcA [H]

Identifier: 114800305

GI number: 114800305

Start: 3470977

End: 3472065

Strand: Direct

Name: hrcA [H]

Synonym: HNE_3317

Alternate gene names: 114800305

Gene position: 3470977-3472065 (Clockwise)

Preceding gene: 114799647

Following gene: 114797336

Centisome position: 93.68

GC content: 66.76

Gene sequence:

>1089_bases
ATGGCGGACAATTCAGAAATCCTGAGCCTGATGCAGCGCCTCGACCAGCGCTCCCGGAACATCTTCCGGGAAATCGTCGA
GGGCTATCTGGCCACCGGAGAGCCGGTCGGCTCGCGCACGCTGTCAAAGGCGGGCATTGCCCTCTCCCCGGCCTCCATCC
GCAATGTGATGGCCGACCTGACAGAGCTTGGCCTGCTGGACGCGCCGCACATCTCGGCCGGCCGCGCCCCCACCCATAAG
GGCCTGCGCCTCTTCGTCGACGGCTTTCTGGAATACGGCGACCCCTCGCGGGAAGACAAGCGACAGATCGACGACCGCCT
CGCCGCGGCCGGCACCGAGATCGAAGCGGTCCTGGGCGAGGCGTCCGACATCCTCTCCGGCCTCGCCGGCGGGGCCGGCC
TCGTCGCCTCCCCGGCGCGTGACGCCGCCGTGCGCCATGTCGAATTTGTGCCCCTGGCAGGGGGCGACGCCCTCTGCGTT
CTCGTCACCGAAGACGGCGACGTTGAAAACCGCATCCTGAAGGTGCCCGACGGCCTGCCCGCCACCTCCCTGATTGAAGC
GGGCAACTACCTCTCCACCCGCCTCAAGGGCCGGACGCTGGCCGAGGCCTCCGCCGAAGTGCGCGCCGAGTTGCAGGAGC
GCCGCGCCATGCTGGATGCGGCCACCACGGCCCTTGTTGAGGCCGGCCTTGCCGATTGGGGCGGCGACGCGCCCGGCCGG
GGCCGCAGCCTGATCGTGCGCGGACGCGCCAATCTGCTGGAAGACGCCAAGGCCGCCCAGGATCTCGACCGGGTGCGGCA
ATTGTTCAATGAGCTGGAACGCCAGCAAAGCCTGCTTGAAATTCTCGACACAACGCGCGAAGCGGGCGGCGTGCGCTTGT
TCATCGGGTCGGAAAACAGGCTTTTTCCGCTCTCTGGTTCAAGTGTGATTGTGGCACCCTATATGGGCGGCACGAAACAA
GTGATCGGGGCGCTGGGCGTGATCGGGCCAACCCGGCTCAACTACGCCAGGGTCATTCCGATGGTCGATTATACCGCCAA
GGTCGTGGGGGACATCCTCTCACACCGGCGCGGAAAGGATGGGAAGTGA

Upstream 100 bases:

>100_bases
CGCCGCCGAGCACATCCACCTCAACCGCCAGGGCCAGATCGAGGGGTTGAACTAGCCCATGCCTATTGTGCCGGGGATGT
ACCGCCCTTAATCCAGTAAC

Downstream 100 bases:

>100_bases
TGAGCGACGAAAACAAACCGGGTGAGGCCGCTGAACTCGACGCCGGCGTAGCCCCTGAGGCCCAGCCCGAGACGGAACTG
ACCGTTGAGGAGCTGATTAT

Product: heat-inducible transcription repressor

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 362; Mature: 361

Protein sequence:

>362_residues
MADNSEILSLMQRLDQRSRNIFREIVEGYLATGEPVGSRTLSKAGIALSPASIRNVMADLTELGLLDAPHISAGRAPTHK
GLRLFVDGFLEYGDPSREDKRQIDDRLAAAGTEIEAVLGEASDILSGLAGGAGLVASPARDAAVRHVEFVPLAGGDALCV
LVTEDGDVENRILKVPDGLPATSLIEAGNYLSTRLKGRTLAEASAEVRAELQERRAMLDAATTALVEAGLADWGGDAPGR
GRSLIVRGRANLLEDAKAAQDLDRVRQLFNELERQQSLLEILDTTREAGGVRLFIGSENRLFPLSGSSVIVAPYMGGTKQ
VIGALGVIGPTRLNYARVIPMVDYTAKVVGDILSHRRGKDGK

Sequences:

>Translated_362_residues
MADNSEILSLMQRLDQRSRNIFREIVEGYLATGEPVGSRTLSKAGIALSPASIRNVMADLTELGLLDAPHISAGRAPTHK
GLRLFVDGFLEYGDPSREDKRQIDDRLAAAGTEIEAVLGEASDILSGLAGGAGLVASPARDAAVRHVEFVPLAGGDALCV
LVTEDGDVENRILKVPDGLPATSLIEAGNYLSTRLKGRTLAEASAEVRAELQERRAMLDAATTALVEAGLADWGGDAPGR
GRSLIVRGRANLLEDAKAAQDLDRVRQLFNELERQQSLLEILDTTREAGGVRLFIGSENRLFPLSGSSVIVAPYMGGTKQ
VIGALGVIGPTRLNYARVIPMVDYTAKVVGDILSHRRGKDGK
>Mature_361_residues
ADNSEILSLMQRLDQRSRNIFREIVEGYLATGEPVGSRTLSKAGIALSPASIRNVMADLTELGLLDAPHISAGRAPTHKG
LRLFVDGFLEYGDPSREDKRQIDDRLAAAGTEIEAVLGEASDILSGLAGGAGLVASPARDAAVRHVEFVPLAGGDALCVL
VTEDGDVENRILKVPDGLPATSLIEAGNYLSTRLKGRTLAEASAEVRAELQERRAMLDAATTALVEAGLADWGGDAPGRG
RSLIVRGRANLLEDAKAAQDLDRVRQLFNELERQQSLLEILDTTREAGGVRLFIGSENRLFPLSGSSVIVAPYMGGTKQV
IGALGVIGPTRLNYARVIPMVDYTAKVVGDILSHRRGKDGK

Specific function: Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons [H]

COG id: COG1420

COG function: function code K; Transcriptional regulator of heat shock gene

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the hrcA family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002571
- InterPro:   IPR021153
- InterPro:   IPR011991 [H]

Pfam domain/function: PF01628 HrcA [H]

EC number: NA

Molecular weight: Translated: 38552; Mature: 38421

Theoretical pI: Translated: 5.18; Mature: 5.18

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MADNSEILSLMQRLDQRSRNIFREIVEGYLATGEPVGSRTLSKAGIALSPASIRNVMADL
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHCCCEECHHHHHHHHHHH
TELGLLDAPHISAGRAPTHKGLRLFVDGFLEYGDPSREDKRQIDDRLAAAGTEIEAVLGE
HHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCHHHHHHHH
ASDILSGLAGGAGLVASPARDAAVRHVEFVPLAGGDALCVLVTEDGDVENRILKVPDGLP
HHHHHHHHCCCCCCCCCCHHHHHHHEEEEEEECCCCEEEEEEECCCCCCCCEEECCCCCC
ATSLIEAGNYLSTRLKGRTLAEASAEVRAELQERRAMLDAATTALVEAGLADWGGDAPGR
HHHHHHCCCHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
GRSLIVRGRANLLEDAKAAQDLDRVRQLFNELERQQSLLEILDTTREAGGVRLFIGSENR
CCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCE
LFPLSGSSVIVAPYMGGTKQVIGALGVIGPTRLNYARVIPMVDYTAKVVGDILSHRRGKD
EEEECCCCEEEEECCCCHHHHHHHHHCCCCCCCCHHHCCHHHHHHHHHHHHHHHHCCCCC
GK
CC
>Mature Secondary Structure 
ADNSEILSLMQRLDQRSRNIFREIVEGYLATGEPVGSRTLSKAGIALSPASIRNVMADL
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHCCCEECHHHHHHHHHHH
TELGLLDAPHISAGRAPTHKGLRLFVDGFLEYGDPSREDKRQIDDRLAAAGTEIEAVLGE
HHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCHHHHHHHH
ASDILSGLAGGAGLVASPARDAAVRHVEFVPLAGGDALCVLVTEDGDVENRILKVPDGLP
HHHHHHHHCCCCCCCCCCHHHHHHHEEEEEEECCCCEEEEEEECCCCCCCCEEECCCCCC
ATSLIEAGNYLSTRLKGRTLAEASAEVRAELQERRAMLDAATTALVEAGLADWGGDAPGR
HHHHHHCCCHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
GRSLIVRGRANLLEDAKAAQDLDRVRQLFNELERQQSLLEILDTTREAGGVRLFIGSENR
CCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCE
LFPLSGSSVIVAPYMGGTKQVIGALGVIGPTRLNYARVIPMVDYTAKVVGDILSHRRGKD
EEEECCCCEEEEECCCCHHHHHHHHHCCCCCCCCHHHCCHHHHHHHHHHHHHHHHCCCCC
GK
CC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8606155 [H]