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The map label for this gene is fhs

Identifier: 114799647

GI number: 114799647

Start: 3469261

End: 3470931

Strand: Direct

Name: fhs

Synonym: HNE_3316

Alternate gene names: 114799647

Gene position: 3469261-3470931 (Clockwise)

Preceding gene: 114800112

Following gene: 114800305

Centisome position: 93.64

GC content: 64.33

Gene sequence:

>1671_bases
ATGGCCAGTGACATCGAGATTGCGCGGGGCGCAAAGAAAAAGCCGATCCAGGAGGTCGCCGCCAGGGCGGGCGTGAGCCC
TGAAAACCTGATCCCCTACGGCCACGACAAGGCCAAGATCTCGGCCGCCCATCTGGCTGGCCTCGCCCACAATGCCACCG
GCAAGCTGATCCTCGTCACCGCCATCAACCCGACCCCTGCGGGCGAAGGCAAGACCACCACCTCTATCGGCCTCGCCGAC
GCTATGAACCGCATCGGCGCAAACACCCTCCTCTGCCTGCGCGAGCCTTCGCTGGGCCCCTGCTTCGGCATGAAGGGCGG
CGCTACAGGCGGCGGCCTTGCCCAGATCGTGCCGATGGAAGACATCAACCTGCATTTCACCGGCGACTTCCACGCCATCA
CCTCGGCGCACAATCTCCTCTCCACCATGATCGACAATCACATCCATTGGGGCGGCGAGCCAAAGCTTGAAGCCGTGCGC
ACCAGCTGGCGCCGCGTGATGGACATGAACGACCGTAGCCTGAGGAATATTGTTTCCGGCCTCGGCGGCCCCGGCAATGG
CAGCCCTTCGGAGACCGGCTTTGACATCACCGTCGCCTCCGAAGTCATGGCCATTCTCTGCCTCGCCACGGACGCTGAAG
ATCTCGAGGCCCGCCTCGCCCGCATCATCGTCGGCTACACAAGCGAGAAGGAAGCCGTCACCGCCGCAGACATCAAGGCC
ACCGGCGCAATGATGGCCCTGCTGCGCGATGCCATGCTGCCAAACCTTGTACAGACGCTGGAAAACAATCCCTGCCTGGT
GCATGGCGGCCCCTTCGCCAACATCGCCCATGGCTGCAACTCGGTCATGGCCACAAGCGCGGCCCTGAAGATGGCAGACT
ATGTCGTCACCGAAGCAGGTTTTGGCGCAGACCTTGGCGCCGAGAAATTCCTCAACATCAAATGCCGCCAGGCCGGCCTT
GCGCCCGACGCCGTCGTTCTGGTCGCAACCATCCGGGCCCTGAAGATGCATGGCGGCCTCGGCAAGAATGATCTGGGCAA
GGTCAGCTATGAGGCGCTGGAAAGCGGCCTTGAAAATCTCGGGCGCCATATCGGGAACCTGCGCAGCTTCGGCCTGCCGG
TCATCGTCGCCATCAACCGCTTCACCACCGACACCGAAGGTGAAGTCCACGCCCTTCAGGCCTATTGCGAAAAGCTCGGC
GTGCCCGTCTCCCTCTGCACCCATTGGGCAGAAGGGGGCAAAGGCACCGAAGACCTCGCCCGCGGCGTCACCGCGCTCAT
CGAAAAGGGAGAGGCAGACTTCAAACCCCTTTATCCCGATGACATGCCGCTGCTGGAAAAGATCGAGACGGTCGCCAAGT
CGATCTACCGGGCCGGAAGGGTGGAAACCACCCGCGCCGTCCGCAACCAGCTCGCCGCCTGGGAGAAGGCGGGCTTCGGC
CACCTGCCCGTCTGCATGGCCAAGACCCAGTACAGCTTCTCCACCGATCCGGCCCTGCTGGGCGCGCCCGAAGGCCATGT
CGTGCGCCTGCGCGAAGTACGCCTCGCGGCCGGGGCCGGCTTCGTGGTCGCCATCTGCGGCGACATCATGACGATGCCCG
GCCTCCCCCGCCGCCCCGCCGCCGAGCACATCCACCTCAACCGCCAGGGCCAGATCGAGGGGTTGAACTAG

Upstream 100 bases:

>100_bases
GATTTGGCATCCGGGGGAATCCTTCTAGCTGAAGGCCTGATTTGCGGGTTTTGCGGCGCCTGTCTACACCAAGGCTGCGC
GCGAAAGGAAAGTACCGAAT

Downstream 100 bases:

>100_bases
CCCATGCCTATTGTGCCGGGGATGTACCGCCCTTAATCCAGTAACATGGCGGACAATTCAGAAATCCTGAGCCTGATGCA
GCGCCTCGACCAGCGCTCCC

Product: formate--tetrahydrofolate ligase

Products: NA

Alternate protein names: Formyltetrahydrofolate synthetase; FHS; FTHFS

Number of amino acids: Translated: 556; Mature: 555

Protein sequence:

>556_residues
MASDIEIARGAKKKPIQEVAARAGVSPENLIPYGHDKAKISAAHLAGLAHNATGKLILVTAINPTPAGEGKTTTSIGLAD
AMNRIGANTLLCLREPSLGPCFGMKGGATGGGLAQIVPMEDINLHFTGDFHAITSAHNLLSTMIDNHIHWGGEPKLEAVR
TSWRRVMDMNDRSLRNIVSGLGGPGNGSPSETGFDITVASEVMAILCLATDAEDLEARLARIIVGYTSEKEAVTAADIKA
TGAMMALLRDAMLPNLVQTLENNPCLVHGGPFANIAHGCNSVMATSAALKMADYVVTEAGFGADLGAEKFLNIKCRQAGL
APDAVVLVATIRALKMHGGLGKNDLGKVSYEALESGLENLGRHIGNLRSFGLPVIVAINRFTTDTEGEVHALQAYCEKLG
VPVSLCTHWAEGGKGTEDLARGVTALIEKGEADFKPLYPDDMPLLEKIETVAKSIYRAGRVETTRAVRNQLAAWEKAGFG
HLPVCMAKTQYSFSTDPALLGAPEGHVVRLREVRLAAGAGFVVAICGDIMTMPGLPRRPAAEHIHLNRQGQIEGLN

Sequences:

>Translated_556_residues
MASDIEIARGAKKKPIQEVAARAGVSPENLIPYGHDKAKISAAHLAGLAHNATGKLILVTAINPTPAGEGKTTTSIGLAD
AMNRIGANTLLCLREPSLGPCFGMKGGATGGGLAQIVPMEDINLHFTGDFHAITSAHNLLSTMIDNHIHWGGEPKLEAVR
TSWRRVMDMNDRSLRNIVSGLGGPGNGSPSETGFDITVASEVMAILCLATDAEDLEARLARIIVGYTSEKEAVTAADIKA
TGAMMALLRDAMLPNLVQTLENNPCLVHGGPFANIAHGCNSVMATSAALKMADYVVTEAGFGADLGAEKFLNIKCRQAGL
APDAVVLVATIRALKMHGGLGKNDLGKVSYEALESGLENLGRHIGNLRSFGLPVIVAINRFTTDTEGEVHALQAYCEKLG
VPVSLCTHWAEGGKGTEDLARGVTALIEKGEADFKPLYPDDMPLLEKIETVAKSIYRAGRVETTRAVRNQLAAWEKAGFG
HLPVCMAKTQYSFSTDPALLGAPEGHVVRLREVRLAAGAGFVVAICGDIMTMPGLPRRPAAEHIHLNRQGQIEGLN
>Mature_555_residues
ASDIEIARGAKKKPIQEVAARAGVSPENLIPYGHDKAKISAAHLAGLAHNATGKLILVTAINPTPAGEGKTTTSIGLADA
MNRIGANTLLCLREPSLGPCFGMKGGATGGGLAQIVPMEDINLHFTGDFHAITSAHNLLSTMIDNHIHWGGEPKLEAVRT
SWRRVMDMNDRSLRNIVSGLGGPGNGSPSETGFDITVASEVMAILCLATDAEDLEARLARIIVGYTSEKEAVTAADIKAT
GAMMALLRDAMLPNLVQTLENNPCLVHGGPFANIAHGCNSVMATSAALKMADYVVTEAGFGADLGAEKFLNIKCRQAGLA
PDAVVLVATIRALKMHGGLGKNDLGKVSYEALESGLENLGRHIGNLRSFGLPVIVAINRFTTDTEGEVHALQAYCEKLGV
PVSLCTHWAEGGKGTEDLARGVTALIEKGEADFKPLYPDDMPLLEKIETVAKSIYRAGRVETTRAVRNQLAAWEKAGFGH
LPVCMAKTQYSFSTDPALLGAPEGHVVRLREVRLAAGAGFVVAICGDIMTMPGLPRRPAAEHIHLNRQGQIEGLN

Specific function: Unknown

COG id: COG2759

COG function: function code F; Formyltetrahydrofolate synthetase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the formate--tetrahydrofolate ligase family

Homologues:

Organism=Homo sapiens, GI222136639, Length=621, Percent_Identity=41.5458937198068, Blast_Score=445, Evalue=1e-125,
Organism=Homo sapiens, GI36796743, Length=621, Percent_Identity=41.5458937198068, Blast_Score=434, Evalue=1e-121,
Organism=Homo sapiens, GI310124614, Length=105, Percent_Identity=31.4285714285714, Blast_Score=72, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17568737, Length=617, Percent_Identity=41.0048622366288, Blast_Score=427, Evalue=1e-120,
Organism=Caenorhabditis elegans, GI17568739, Length=617, Percent_Identity=41.0048622366288, Blast_Score=427, Evalue=1e-120,
Organism=Saccharomyces cerevisiae, GI6319558, Length=632, Percent_Identity=39.2405063291139, Blast_Score=419, Evalue=1e-118,
Organism=Saccharomyces cerevisiae, GI6321643, Length=627, Percent_Identity=39.5534290271132, Blast_Score=414, Evalue=1e-116,
Organism=Drosophila melanogaster, GI24645718, Length=623, Percent_Identity=42.215088282504, Blast_Score=442, Evalue=1e-124,
Organism=Drosophila melanogaster, GI17137370, Length=623, Percent_Identity=42.215088282504, Blast_Score=442, Evalue=1e-124,
Organism=Drosophila melanogaster, GI62472483, Length=623, Percent_Identity=42.215088282504, Blast_Score=437, Evalue=1e-123,
Organism=Drosophila melanogaster, GI45551871, Length=623, Percent_Identity=42.215088282504, Blast_Score=437, Evalue=1e-123,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): FTHS_HYPNA (Q0BX04)

Other databases:

- EMBL:   CP000158
- RefSeq:   YP_761989.1
- ProteinModelPortal:   Q0BX04
- SMR:   Q0BX04
- STRING:   Q0BX04
- GeneID:   4290287
- GenomeReviews:   CP000158_GR
- KEGG:   hne:HNE_3316
- NMPDR:   fig|228405.5.peg.3176
- TIGR:   HNE_3316
- eggNOG:   COG2759
- HOGENOM:   HBG677721
- OMA:   EIMAVLC
- PhylomeDB:   Q0BX04
- BioCyc:   HNEP81032:HNE_3316-MONOMER
- HAMAP:   MF_01543
- InterPro:   IPR000559
- InterPro:   IPR020628

Pfam domain/function: PF01268 FTHFS

EC number: =6.3.4.3

Molecular weight: Translated: 58754; Mature: 58623

Theoretical pI: Translated: 6.79; Mature: 6.79

Prosite motif: PS00721 FTHFS_1; PS00722 FTHFS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MASDIEIARGAKKKPIQEVAARAGVSPENLIPYGHDKAKISAAHLAGLAHNATGKLILVT
CCCCCCHHCCCCCCCHHHHHHHCCCCHHHCCCCCCCHHHHHHHHHHHHHCCCCCCEEEEE
AINPTPAGEGKTTTSIGLADAMNRIGANTLLCLREPSLGPCFGMKGGATGGGLAQIVPME
EECCCCCCCCCCCHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCCCCCCCCCEEEEEEC
DINLHFTGDFHAITSAHNLLSTMIDNHIHWGGEPKLEAVRTSWRRVMDMNDRSLRNIVSG
CCEEEECCCHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHH
LGGPGNGSPSETGFDITVASEVMAILCLATDAEDLEARLARIIVGYTSEKEAVTAADIKA
CCCCCCCCCCCCCCEEEEHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCCCEEHHHHHH
TGAMMALLRDAMLPNLVQTLENNPCLVHGGPFANIAHGCNSVMATSAALKMADYVVTEAG
HHHHHHHHHHHHHHHHHHHHCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
FGADLGAEKFLNIKCRQAGLAPDAVVLVATIRALKMHGGLGKNDLGKVSYEALESGLENL
CCCCCCCHHHEEEEECCCCCCCHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHH
GRHIGNLRSFGLPVIVAINRFTTDTEGEVHALQAYCEKLGVPVSLCTHWAEGGKGTEDLA
HHHHHHHHHCCCEEEEEEECCCCCCCCHHHHHHHHHHHHCCCHHHHHHHHCCCCCHHHHH
RGVTALIEKGEADFKPLYPDDMPLLEKIETVAKSIYRAGRVETTRAVRNQLAAWEKAGFG
HHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCC
HLPVCMAKTQYSFSTDPALLGAPEGHVVRLREVRLAAGAGFVVAICGDIMTMPGLPRRPA
CCCEEEEECCCCCCCCCCEEECCCCCEEEEEEEHHHCCCCCHHHHHHHHHHCCCCCCCCC
AEHIHLNRQGQIEGLN
HHHEECCCCCCCCCCC
>Mature Secondary Structure 
ASDIEIARGAKKKPIQEVAARAGVSPENLIPYGHDKAKISAAHLAGLAHNATGKLILVT
CCCCCHHCCCCCCCHHHHHHHCCCCHHHCCCCCCCHHHHHHHHHHHHHCCCCCCEEEEE
AINPTPAGEGKTTTSIGLADAMNRIGANTLLCLREPSLGPCFGMKGGATGGGLAQIVPME
EECCCCCCCCCCCHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCCCCCCCCCEEEEEEC
DINLHFTGDFHAITSAHNLLSTMIDNHIHWGGEPKLEAVRTSWRRVMDMNDRSLRNIVSG
CCEEEECCCHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHH
LGGPGNGSPSETGFDITVASEVMAILCLATDAEDLEARLARIIVGYTSEKEAVTAADIKA
CCCCCCCCCCCCCCEEEEHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCCCEEHHHHHH
TGAMMALLRDAMLPNLVQTLENNPCLVHGGPFANIAHGCNSVMATSAALKMADYVVTEAG
HHHHHHHHHHHHHHHHHHHHCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
FGADLGAEKFLNIKCRQAGLAPDAVVLVATIRALKMHGGLGKNDLGKVSYEALESGLENL
CCCCCCCHHHEEEEECCCCCCCHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHH
GRHIGNLRSFGLPVIVAINRFTTDTEGEVHALQAYCEKLGVPVSLCTHWAEGGKGTEDLA
HHHHHHHHHCCCEEEEEEECCCCCCCCHHHHHHHHHHHHCCCHHHHHHHHCCCCCHHHHH
RGVTALIEKGEADFKPLYPDDMPLLEKIETVAKSIYRAGRVETTRAVRNQLAAWEKAGFG
HHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCC
HLPVCMAKTQYSFSTDPALLGAPEGHVVRLREVRLAAGAGFVVAICGDIMTMPGLPRRPA
CCCEEEEECCCCCCCCCCEEECCCCCEEEEEEEHHHCCCCCHHHHHHHHHHCCCCCCCCC
AEHIHLNRQGQIEGLN
HHHEECCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA