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The map label for this gene is kefBC [H]

Identifier: 114800280

GI number: 114800280

Start: 2938870

End: 2940606

Strand: Reverse

Name: kefBC [H]

Synonym: HNE_2775

Alternate gene names: 114800280

Gene position: 2940606-2938870 (Counterclockwise)

Preceding gene: 114798136

Following gene: 114797831

Centisome position: 79.37

GC content: 65.23

Gene sequence:

>1737_bases
ATGGAGCATGCCGCGCACGGGCCAAGCCCGACCCTGATCAAGGATCTGCTGGTTTTCCTCATCGCCGCGGGCATTCTTGT
TCCTGCCATGCGCTGGCTGAAGATGCCGACCATCATCGCGTTCATGCTGGCTGGGGTCGGGCTTGGCCCTTACGCGCTGG
GCCATTTTGCCGAAGACTATCCTGTCCTCACTTTCTTCTCGATTACCGAACCGGAAGCGGCCTTGCCGCTGGCCGAATTG
GGCGTGCTGTTCCTGCTCTTTCTGCTGGGGGTGGAGTTTTCCTTCCAGCGGCTCTGGGCCTTGCGCAAGGTCGTGCTGGG
CGCGGGCGGGATGCAGACGCTGCTCAGCGCAGCGGTGATCGCGGTGGCGGGCTGGGCGCTCGGGCTTGATCCGGCGGTAT
CGCTGATCCTTGGCCTCGCGCTGGCGCTGTCTTCCACGGCTATCGTGATGCAGGTGCTGGTGGAGGAAAAGCGCGCGGCC
CAGCCGGTGGGGCGCACTTCGCTGGGTGTGTTGCTGTTTCAGGACATCATGGTTGCGCCGATCCTGATCTTTGTCGGCTT
TGTCGGCCTCAAGAGCGACGCCAATCTGGGCGGCGTGCTGCTGGACGCGCTGATCCGGGGACTGATTGCCATTGCGGTGA
TCTGGGTGATCGGCAACTTCCTGCTGGGCCGGGTTTTCCGGCTGGCGGCGGCGAGCGGGGGCCGCGACTTCCTGATGGCG
CTGACGCTGCTGACGGTCGTGGGCGCGGCGGCCATCACCTACAGCGCGGGTCTGTCGGTTGCGCTGGGCGCGTTCCTGGC
CGGGCTGCTGGTGGGGGAGACGGAGTTCAAACACCAGACGGAAGTAGACCTTGAACCGTTCAAGGGGCTGTTGCTGGGCC
TCTTCTTCATGACGGTCGGCATGAGCCTCGACCTGCCGGCCATCGCCGGTCAGCTTGGCCCGATCCTCGCCGTGCTGGCG
GGGCTGATCGTGGCCAAGGTGGGGATTGCCTATCTTGCCTGCCGCCTGTTTGCCGGGGGGCATCCGATCTCGATCGAGGC
AGCGCTGCTGCTGGCGCCGGCCGGGGAGTTTGCCTTCATCATTCTGACGGCGGCGCAGGCGGGCAATGCCGTGACACGGG
AAGTGGCGACCTTTGCCGCGGCGGTGGCGGGACTGTCGATGTTGCTGACGCCGCTGCTGGGCCAGCTTGGCCGAAAGCTC
GCGGCGCGGCGTCCGGCAAAGGTGGACCCCGAAGGCATGCAGCTGACCGATCCGTCAGAGATGGAAAACCATGTCGTGCT
GGCCGGCTATGGCCGGGTTGGCCGGGCTGTCGCGCGGGTGCTCAAGGATGAGGAAGTGTCCATTCTGGCGATCGACCGGG
ACCCGGAGAAAGTTCATCAGGCGCGCCTCGATGGGCTGACAGCCTATGTCGGCGATGCGGCGCGGCCGGAAATCCTCACC
CTGACGGGCATTGCGAAAGCCGAGCAGTTCATCGTCACGGTGGATGATCCGAACCGGGCCAGAGATATGGTGAGCAGCGC
GCGCAGTCTGCATCGCGACATTCTGATCCTTGCCCGCGCCCATGACGGCGAACATGCCGCCGAGCTTGAAAAAGCCGGCG
CCGCGCATGTGGTGCCCGAAGCGGTCGAGTCCGGGTTGCAGATGGCTGGGATGGCGCTGGAAGGCTTCGGCTATGAAACC
GAAACCGTGCGGGACATTCTCGCGGTTGTGCGGGACGAGGAATACCGGCGCGCCTGA

Upstream 100 bases:

>100_bases
GGCCGACCTGCTCCGGGACTTCTTCCGCACCCGCCGGGGCTGACAAAGCCGTAATCAGGCTGCATGACTGGTCTTCACAT
CTGAAGGGGACGATTTGCCC

Downstream 100 bases:

>100_bases
TGCATTGCTGATGCGTGCACAGATTAAAGCGTGACGGAGACATCCCGGATAAGCCCGCGCAGCCACATCAGGGCCGGGTC
CTGTGCATATTCGCGATGCC

Product: glutathione-regulated potassium-efflux system protein

Products: Proton [Cytoplasm]; K (I) [Periplasm] [C]

Alternate protein names: K(+)/H(+) antiporter [H]

Number of amino acids: Translated: 578; Mature: 578

Protein sequence:

>578_residues
MEHAAHGPSPTLIKDLLVFLIAAGILVPAMRWLKMPTIIAFMLAGVGLGPYALGHFAEDYPVLTFFSITEPEAALPLAEL
GVLFLLFLLGVEFSFQRLWALRKVVLGAGGMQTLLSAAVIAVAGWALGLDPAVSLILGLALALSSTAIVMQVLVEEKRAA
QPVGRTSLGVLLFQDIMVAPILIFVGFVGLKSDANLGGVLLDALIRGLIAIAVIWVIGNFLLGRVFRLAAASGGRDFLMA
LTLLTVVGAAAITYSAGLSVALGAFLAGLLVGETEFKHQTEVDLEPFKGLLLGLFFMTVGMSLDLPAIAGQLGPILAVLA
GLIVAKVGIAYLACRLFAGGHPISIEAALLLAPAGEFAFIILTAAQAGNAVTREVATFAAAVAGLSMLLTPLLGQLGRKL
AARRPAKVDPEGMQLTDPSEMENHVVLAGYGRVGRAVARVLKDEEVSILAIDRDPEKVHQARLDGLTAYVGDAARPEILT
LTGIAKAEQFIVTVDDPNRARDMVSSARSLHRDILILARAHDGEHAAELEKAGAAHVVPEAVESGLQMAGMALEGFGYET
ETVRDILAVVRDEEYRRA

Sequences:

>Translated_578_residues
MEHAAHGPSPTLIKDLLVFLIAAGILVPAMRWLKMPTIIAFMLAGVGLGPYALGHFAEDYPVLTFFSITEPEAALPLAEL
GVLFLLFLLGVEFSFQRLWALRKVVLGAGGMQTLLSAAVIAVAGWALGLDPAVSLILGLALALSSTAIVMQVLVEEKRAA
QPVGRTSLGVLLFQDIMVAPILIFVGFVGLKSDANLGGVLLDALIRGLIAIAVIWVIGNFLLGRVFRLAAASGGRDFLMA
LTLLTVVGAAAITYSAGLSVALGAFLAGLLVGETEFKHQTEVDLEPFKGLLLGLFFMTVGMSLDLPAIAGQLGPILAVLA
GLIVAKVGIAYLACRLFAGGHPISIEAALLLAPAGEFAFIILTAAQAGNAVTREVATFAAAVAGLSMLLTPLLGQLGRKL
AARRPAKVDPEGMQLTDPSEMENHVVLAGYGRVGRAVARVLKDEEVSILAIDRDPEKVHQARLDGLTAYVGDAARPEILT
LTGIAKAEQFIVTVDDPNRARDMVSSARSLHRDILILARAHDGEHAAELEKAGAAHVVPEAVESGLQMAGMALEGFGYET
ETVRDILAVVRDEEYRRA
>Mature_578_residues
MEHAAHGPSPTLIKDLLVFLIAAGILVPAMRWLKMPTIIAFMLAGVGLGPYALGHFAEDYPVLTFFSITEPEAALPLAEL
GVLFLLFLLGVEFSFQRLWALRKVVLGAGGMQTLLSAAVIAVAGWALGLDPAVSLILGLALALSSTAIVMQVLVEEKRAA
QPVGRTSLGVLLFQDIMVAPILIFVGFVGLKSDANLGGVLLDALIRGLIAIAVIWVIGNFLLGRVFRLAAASGGRDFLMA
LTLLTVVGAAAITYSAGLSVALGAFLAGLLVGETEFKHQTEVDLEPFKGLLLGLFFMTVGMSLDLPAIAGQLGPILAVLA
GLIVAKVGIAYLACRLFAGGHPISIEAALLLAPAGEFAFIILTAAQAGNAVTREVATFAAAVAGLSMLLTPLLGQLGRKL
AARRPAKVDPEGMQLTDPSEMENHVVLAGYGRVGRAVARVLKDEEVSILAIDRDPEKVHQARLDGLTAYVGDAARPEILT
LTGIAKAEQFIVTVDDPNRARDMVSSARSLHRDILILARAHDGEHAAELEKAGAAHVVPEAVESGLQMAGMALEGFGYET
ETVRDILAVVRDEEYRRA

Specific function: Transport system that facilitate potassium-efflux, possibly by potassium-proton antiport [H]

COG id: COG0475

COG function: function code P; Kef-type K+ transport systems, membrane components

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 RCK N-terminal domain [H]

Homologues:

Organism=Homo sapiens, GI157388921, Length=427, Percent_Identity=26.463700234192, Blast_Score=86, Evalue=1e-16,
Organism=Escherichia coli, GI1786232, Length=562, Percent_Identity=32.3843416370107, Blast_Score=279, Evalue=4e-76,
Organism=Escherichia coli, GI1789749, Length=546, Percent_Identity=32.6007326007326, Blast_Score=248, Evalue=1e-66,
Organism=Escherichia coli, GI1786685, Length=554, Percent_Identity=30.5054151624549, Blast_Score=178, Evalue=7e-46,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006153
- InterPro:   IPR004771
- InterPro:   IPR016040
- InterPro:   IPR003148 [H]

Pfam domain/function: PF00999 Na_H_Exchanger; PF02254 TrkA_N [H]

EC number: NA

Molecular weight: Translated: 60822; Mature: 60822

Theoretical pI: Translated: 5.33; Mature: 5.33

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEHAAHGPSPTLIKDLLVFLIAAGILVPAMRWLKMPTIIAFMLAGVGLGPYALGHFAEDY
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHCCCCC
PVLTFFSITEPEAALPLAELGVLFLLFLLGVEFSFQRLWALRKVVLGAGGMQTLLSAAVI
CEEEEEEECCCHHHCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHH
AVAGWALGLDPAVSLILGLALALSSTAIVMQVLVEEKRAAQPVGRTSLGVLLFQDIMVAP
HHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHH
ILIFVGFVGLKSDANLGGVLLDALIRGLIAIAVIWVIGNFLLGRVFRLAAASGGRDFLMA
HHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHH
LTLLTVVGAAAITYSAGLSVALGAFLAGLLVGETEFKHQTEVDLEPFKGLLLGLFFMTVG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHCCCCCCCHHHHHHHHHHHHHHHHC
MSLDLPAIAGQLGPILAVLAGLIVAKVGIAYLACRLFAGGHPISIEAALLLAPAGEFAFI
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEEEECCCCEEEE
ILTAAQAGNAVTREVATFAAAVAGLSMLLTPLLGQLGRKLAARRPAKVDPEGMQLTDPSE
EEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHH
MENHVVLAGYGRVGRAVARVLKDEEVSILAIDRDPEKVHQARLDGLTAYVGDAARPEILT
HCCCEEEEECCHHHHHHHHHHCCCCEEEEEECCCHHHHHHHHHHHHHHHHCCCCCCCEEE
LTGIAKAEQFIVTVDDPNRARDMVSSARSLHRDILILARAHDGEHAAELEKAGAAHVVPE
EECHHCCCEEEEEECCCHHHHHHHHHHHHHHHHHEEEEECCCCHHHHHHHHCCCCCCCHH
AVESGLQMAGMALEGFGYETETVRDILAVVRDEEYRRA
HHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCHHHCCC
>Mature Secondary Structure
MEHAAHGPSPTLIKDLLVFLIAAGILVPAMRWLKMPTIIAFMLAGVGLGPYALGHFAEDY
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHCCCCC
PVLTFFSITEPEAALPLAELGVLFLLFLLGVEFSFQRLWALRKVVLGAGGMQTLLSAAVI
CEEEEEEECCCHHHCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHH
AVAGWALGLDPAVSLILGLALALSSTAIVMQVLVEEKRAAQPVGRTSLGVLLFQDIMVAP
HHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHH
ILIFVGFVGLKSDANLGGVLLDALIRGLIAIAVIWVIGNFLLGRVFRLAAASGGRDFLMA
HHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHH
LTLLTVVGAAAITYSAGLSVALGAFLAGLLVGETEFKHQTEVDLEPFKGLLLGLFFMTVG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHCCCCCCCHHHHHHHHHHHHHHHHC
MSLDLPAIAGQLGPILAVLAGLIVAKVGIAYLACRLFAGGHPISIEAALLLAPAGEFAFI
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEEEECCCCEEEE
ILTAAQAGNAVTREVATFAAAVAGLSMLLTPLLGQLGRKLAARRPAKVDPEGMQLTDPSE
EEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHH
MENHVVLAGYGRVGRAVARVLKDEEVSILAIDRDPEKVHQARLDGLTAYVGDAARPEILT
HCCCEEEEECCHHHHHHHHHHCCCCEEEEEECCCHHHHHHHHHHHHHHHHCCCCCCCEEE
LTGIAKAEQFIVTVDDPNRARDMVSSARSLHRDILILARAHDGEHAAELEKAGAAHVVPE
EECHHCCCEEEEEECCCHHHHHHHHHHHHHHHHHEEEEECCCCHHHHHHHHCCCCCCCHH
AVESGLQMAGMALEGFGYETETVRDILAVVRDEEYRRA
HHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; K (I) [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + K (I) [Cytoplasm] = Proton [Cytoplasm] + K (I) [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]