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The map label for this gene is cysK [H]

Identifier: 114800279

GI number: 114800279

Start: 1449124

End: 1450131

Strand: Reverse

Name: cysK [H]

Synonym: HNE_1420

Alternate gene names: 114800279

Gene position: 1450131-1449124 (Counterclockwise)

Preceding gene: 114799535

Following gene: 114797517

Centisome position: 39.14

GC content: 63.99

Gene sequence:

>1008_bases
ATGACCATTCACAGGTCCGTTATCGACCTCATCGGCAATACGCCGCTGCTCCGGCTCAATCGTGTGTCAGATGAGACCGG
ATGCGAGATCCTGGGCAAGTGCGAGTTTCTCAATCCCGGCCAGTCGGTGAAGGATCGCCCGGCGCTGGGCATCATCCGTG
AGGCCGAAGAGTCCGGCGCGCTGAAGCCCGGCGGCACCATCGTGGAAGGCACCGCCGGCAATACCGGCATTGGCCTGGCG
CTGGTCGGCAAGGCGCTGGGTTACCGGGTGGTGATCGTCATGCCGCGCACACAGAGCCAGGAGAAGAAGGACGCGATCCG
CCTTCTGGGCGCTGAGCTGATCGAGGTGGACGCGGTGCCCTACGCCAACCCCAACAACTATGTGCGCTATTCCGGGCGCC
TGGCCGAGGAGCTGGCCGCGAGCGAGCCCAATGGCGCGATCTGGGCAAACCAGTTCGACAACCAGGCCAACCGCCGCGCG
CACTACAACACCACCGCGAAGGAAATCTGGGAGCAGACGAGCGGCAAGGTGGACGGGTTCATCTGCGCGGTGGGCTCCGG
CGGCACGCTGGGCGGGGTGGCGCTGGGCCTGAAGGAGCGCAACCCGAAGATCACCATCGGCCTGGCCGACCCCGGCGGCG
CGGCGCTCTATTCCTATTACACGACCGGTGAGCTGAAAGCCGAAGGCACTTCGATCACCGAGGGCATTGGCCAGGGGCGC
ATTACGGCAAACCTGGAAGGCATTCCGGTCGACAAGGCGTGGCGCATCAATGATGATGAGGCGCTGGGCTATATCTTCGG
CCTGGTCGAGGATGAGGGGCTGTGCCTTGGCGGATCATCGGGCGTGAATGTGGCGGGGGCTGTGCATCTCGCCCGTGAGC
TGGGGCCGGGGCACACGATCGTCACGATCCTCTGTGACTACGGCAACCGGTATCAGACGAAATTGTTCAACCCGGAATTC
CTGCGCTCCAAAGGCCTGCCGGTTCCGTCCTGGATGGAGGCGAAATAA

Upstream 100 bases:

>100_bases
GCCGGCCCGGTGGATCAGTTTGGAGGTGCTGACCGATTGAACCTGCCCGCGCGGGCGCGTAGCCTGAGACAAACGCACAA
CACCAGAATCGAGTTCCCTT

Downstream 100 bases:

>100_bases
TGAGCGAGAGCGGCGACCCGCTGGTCAGTGCAGACTGGCTGATGGCGAATATCAGCGCGCCGGATGTGCGCATTGTGGAC
GCGACCTGGTTTGCGCCCTG

Product: cysteine synthase A

Products: NA

Alternate protein names: CSase; O-acetylserine (thiol)-lyase; OAS-TL; O-acetylserine sulfhydrylase [H]

Number of amino acids: Translated: 335; Mature: 334

Protein sequence:

>335_residues
MTIHRSVIDLIGNTPLLRLNRVSDETGCEILGKCEFLNPGQSVKDRPALGIIREAEESGALKPGGTIVEGTAGNTGIGLA
LVGKALGYRVVIVMPRTQSQEKKDAIRLLGAELIEVDAVPYANPNNYVRYSGRLAEELAASEPNGAIWANQFDNQANRRA
HYNTTAKEIWEQTSGKVDGFICAVGSGGTLGGVALGLKERNPKITIGLADPGGAALYSYYTTGELKAEGTSITEGIGQGR
ITANLEGIPVDKAWRINDDEALGYIFGLVEDEGLCLGGSSGVNVAGAVHLARELGPGHTIVTILCDYGNRYQTKLFNPEF
LRSKGLPVPSWMEAK

Sequences:

>Translated_335_residues
MTIHRSVIDLIGNTPLLRLNRVSDETGCEILGKCEFLNPGQSVKDRPALGIIREAEESGALKPGGTIVEGTAGNTGIGLA
LVGKALGYRVVIVMPRTQSQEKKDAIRLLGAELIEVDAVPYANPNNYVRYSGRLAEELAASEPNGAIWANQFDNQANRRA
HYNTTAKEIWEQTSGKVDGFICAVGSGGTLGGVALGLKERNPKITIGLADPGGAALYSYYTTGELKAEGTSITEGIGQGR
ITANLEGIPVDKAWRINDDEALGYIFGLVEDEGLCLGGSSGVNVAGAVHLARELGPGHTIVTILCDYGNRYQTKLFNPEF
LRSKGLPVPSWMEAK
>Mature_334_residues
TIHRSVIDLIGNTPLLRLNRVSDETGCEILGKCEFLNPGQSVKDRPALGIIREAEESGALKPGGTIVEGTAGNTGIGLAL
VGKALGYRVVIVMPRTQSQEKKDAIRLLGAELIEVDAVPYANPNNYVRYSGRLAEELAASEPNGAIWANQFDNQANRRAH
YNTTAKEIWEQTSGKVDGFICAVGSGGTLGGVALGLKERNPKITIGLADPGGAALYSYYTTGELKAEGTSITEGIGQGRI
TANLEGIPVDKAWRINDDEALGYIFGLVEDEGLCLGGSSGVNVAGAVHLARELGPGHTIVTILCDYGNRYQTKLFNPEFL
RSKGLPVPSWMEAK

Specific function: Two Cysteine Synthase Enzymes Are Found. Both Catalyze The Same Reaction. Cysteine Synthase B Can Also Use Thiosulfate In Place Of Sulfide To Give Cysteine Thiosulfonate As A Product. [C]

COG id: COG0031

COG function: function code E; Cysteine synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the cysteine synthase/cystathionine beta- synthase family [H]

Homologues:

Organism=Homo sapiens, GI295821202, Length=323, Percent_Identity=42.4148606811146, Blast_Score=235, Evalue=5e-62,
Organism=Homo sapiens, GI295821200, Length=323, Percent_Identity=42.4148606811146, Blast_Score=235, Evalue=5e-62,
Organism=Homo sapiens, GI4557415, Length=323, Percent_Identity=42.4148606811146, Blast_Score=235, Evalue=5e-62,
Organism=Homo sapiens, GI11345492, Length=301, Percent_Identity=26.9102990033223, Blast_Score=74, Evalue=2e-13,
Organism=Escherichia coli, GI2367138, Length=313, Percent_Identity=37.6996805111821, Blast_Score=172, Evalue=3e-44,
Organism=Escherichia coli, GI1788754, Length=315, Percent_Identity=40.3174603174603, Blast_Score=166, Evalue=3e-42,
Organism=Caenorhabditis elegans, GI17535051, Length=314, Percent_Identity=39.8089171974522, Blast_Score=199, Evalue=1e-51,
Organism=Caenorhabditis elegans, GI17562970, Length=315, Percent_Identity=40.3174603174603, Blast_Score=189, Evalue=2e-48,
Organism=Caenorhabditis elegans, GI32566674, Length=305, Percent_Identity=40.9836065573771, Blast_Score=188, Evalue=3e-48,
Organism=Caenorhabditis elegans, GI115535073, Length=306, Percent_Identity=38.2352941176471, Blast_Score=162, Evalue=2e-40,
Organism=Caenorhabditis elegans, GI17534315, Length=331, Percent_Identity=35.6495468277946, Blast_Score=159, Evalue=2e-39,
Organism=Caenorhabditis elegans, GI17561720, Length=329, Percent_Identity=35.8662613981763, Blast_Score=156, Evalue=2e-38,
Organism=Caenorhabditis elegans, GI25147552, Length=330, Percent_Identity=32.1212121212121, Blast_Score=139, Evalue=2e-33,
Organism=Caenorhabditis elegans, GI32566672, Length=221, Percent_Identity=37.10407239819, Blast_Score=110, Evalue=1e-24,
Organism=Caenorhabditis elegans, GI71996324, Length=367, Percent_Identity=27.7929155313352, Blast_Score=79, Evalue=2e-15,
Organism=Saccharomyces cerevisiae, GI6321449, Length=329, Percent_Identity=41.3373860182371, Blast_Score=201, Evalue=1e-52,
Organism=Saccharomyces cerevisiae, GI6321594, Length=335, Percent_Identity=34.6268656716418, Blast_Score=179, Evalue=5e-46,
Organism=Drosophila melanogaster, GI24643623, Length=330, Percent_Identity=37.2727272727273, Blast_Score=179, Evalue=2e-45,
Organism=Drosophila melanogaster, GI20129101, Length=330, Percent_Identity=37.2727272727273, Blast_Score=179, Evalue=2e-45,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001216
- InterPro:   IPR005856
- InterPro:   IPR005859
- InterPro:   IPR001926 [H]

Pfam domain/function: PF00291 PALP [H]

EC number: =2.5.1.47 [H]

Molecular weight: Translated: 35653; Mature: 35522

Theoretical pI: Translated: 5.26; Mature: 5.26

Prosite motif: PS00901 CYS_SYNTHASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
0.6 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTIHRSVIDLIGNTPLLRLNRVSDETGCEILGKCEFLNPGQSVKDRPALGIIREAEESGA
CCCHHHHHHHHCCCCEEEEECCCCCCCCEEEEEEEECCCCCCCCCCCCCEEEEEHHHCCC
LKPGGTIVEGTAGNTGIGLALVGKALGYRVVIVMPRTQSQEKKDAIRLLGAELIEVDAVP
CCCCCEEEECCCCCCCCHHHHHHHHCCEEEEEEECCCCCHHHHHHHHHHCCHHEEECCCC
YANPNNYVRYSGRLAEELAASEPNGAIWANQFDNQANRRAHYNTTAKEIWEQTSGKVDGF
CCCCCCEEEECCHHHHHHHCCCCCCCEECCCCCCCCCCCCCCCCHHHHHHHHHCCCCCEE
ICAVGSGGTLGGVALGLKERNPKITIGLADPGGAALYSYYTTGELKAEGTSITEGIGQGR
EEEECCCCCCCEEEEEEECCCCEEEEEECCCCCCEEEEEEECCEEEECCCHHHHCCCCCE
ITANLEGIPVDKAWRINDDEALGYIFGLVEDEGLCLGGSSGVNVAGAVHLARELGPGHTI
EEEECCCCCCCCEEECCCCCCEEEEEEEECCCCEEECCCCCCCHHHHHHHHHHCCCCCEE
VTILCDYGNRYQTKLFNPEFLRSKGLPVPSWMEAK
EEEEECCCCCEEEEECCHHHHHHCCCCCCCCCCCC
>Mature Secondary Structure 
TIHRSVIDLIGNTPLLRLNRVSDETGCEILGKCEFLNPGQSVKDRPALGIIREAEESGA
CCHHHHHHHHCCCCEEEEECCCCCCCCEEEEEEEECCCCCCCCCCCCCEEEEEHHHCCC
LKPGGTIVEGTAGNTGIGLALVGKALGYRVVIVMPRTQSQEKKDAIRLLGAELIEVDAVP
CCCCCEEEECCCCCCCCHHHHHHHHCCEEEEEEECCCCCHHHHHHHHHHCCHHEEECCCC
YANPNNYVRYSGRLAEELAASEPNGAIWANQFDNQANRRAHYNTTAKEIWEQTSGKVDGF
CCCCCCEEEECCHHHHHHHCCCCCCCEECCCCCCCCCCCCCCCCHHHHHHHHHCCCCCEE
ICAVGSGGTLGGVALGLKERNPKITIGLADPGGAALYSYYTTGELKAEGTSITEGIGQGR
EEEECCCCCCCEEEEEEECCCCEEEEEECCCCCCEEEEEEECCEEEECCCHHHHCCCCCE
ITANLEGIPVDKAWRINDDEALGYIFGLVEDEGLCLGGSSGVNVAGAVHLARELGPGHTI
EEEECCCCCCCCEEECCCCCCEEEEEEEECCCCEEECCCCCCCHHHHHHHHHHCCCCCEE
VTILCDYGNRYQTKLFNPEFLRSKGLPVPSWMEAK
EEEEECCCCCEEEEECCHHHHHHCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA