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The map label for this gene is glmS [H]

Identifier: 114800082

GI number: 114800082

Start: 789693

End: 791519

Strand: Direct

Name: glmS [H]

Synonym: HNE_0778

Alternate gene names: 114800082

Gene position: 789693-791519 (Clockwise)

Preceding gene: 114798294

Following gene: 114799033

Centisome position: 21.31

GC content: 63.49

Gene sequence:

>1827_bases
ATGTGTGGCATCGTCGCAATTGCAGGGAAAGATGAAGTCGCTGGCCGCCTGGTCGATGGCCTCAAGCGGCTCGAGTATCG
CGGATATGACAGCGCAGGCATCGCGGTCGCTGCCGAAGGCGGCGTCGAGCGCCGCCGGGCCAAGGGCAAGATCGTCAACT
TGCAGGAGCGCCTGACGGAAAACCCCCTGAAAGGGCTCACCGGAATCGCCCACACCCGCTGGGCCACACATGGCGCGCCA
AACGAGACAAATGCCCACCCGCATATGTCAGGCTCGGTCGCCATCGTGCACAACGGCATCATCGAGAATTACCGCGAGCT
GCGCGAGGACCTTGAGGGGCGGGGCCGCAAATTCGAGTCTGAAACCGACAGCGAAGTCATCGCCCAGCTGATCGATGCCT
ATATGGAAGAGGGCAAAGACCCGGTTGCCGCCTTTGAAGAGGCGCTGAAGCATTTCCATGGCGCATTCGCCATTGCCGCC
ATTTTCTCGAATGACCCGGAGCTGGTGATCGGCGCCCGCAAGGGCTCGCCCCTGGTGCTCGGCTATGGCGAGGACGAGAT
GTATCTCGGCTCCGACGCCATCGCGCTGGCCCCGCTGACGCGGGACGTTACCTATCTGGAGGAGGGCGACTGGGTTGTCC
TTCGCCGCAACAGCTTTGACATCCGCAATGTGCGCGGCGAGCGGGTCAACCGCGCGCGCGTGACGTCGGCGGTCAATGAT
GCCCTGATCGAGCGCGGCGAGTATGATCACTTCATGCTCAAGGAAATCCATGAGCAGTCTGAATCGCTGGCGCGTTCGAT
TATGCCTTACATCAATCAGGCGACCCAGACAGTCAGCGTGCCCGAGGCAGCCGAGACGCTGTTTGCCGACGCTGACCGCG
CCGTGGCCATTGCCTGCGGCACGGCATTCTATGCGGCCTTCACGGCGAAATACTGGTTTGAGCAGATCGCGCGCCTGGCC
TTCGAGCCCGACATTGCCTCGGAGTTCCGCTATCGCCGCCCGGTGTTGCCGCAGAAGGGGTTTTCCCTGTTTGTCAGCCA
GTCCGGCGAGACGGCCGATACGCTGGCCGCGCTGCGCTATTGCCGGGAAAACCGCACGCCGGCGATTGCGGTCGTGAACG
TGCCGGAAAGCTCGATTGCGCGGGAAGCCGCCTCCATCGTGCCCACCCATGCCGGGCCGGAGATCGGCGTGGCCTCGACC
AAGGCCTTTACCGCGCAATTGTCCGTACTCGCCGTTCTGGCGCTGTCGGCTGCCAAGGCGCGCGGGCATCTGCTGCCGGG
TGACGAGATGAACTATGTCCGCAGCCTGCTGGCCCTGCCGCGCAAGGTGACCGAGGCGCTCGAATGCGCCGGTCAGGTCA
GGGAGATTGCCAGGCATATCGCCGGCAAGCGCGACGTGCTGTTCCTGGGCCGGGGCCGGTATTATCCCCTCGCGCTGGAA
GGCGCGCTGAAGCTGAAGGAAGTCTCCTATATCCATGCCGAAGGCTATGCGGCGGGCGAGCTGAAGCATGGCCCCATCGC
GCTGATCGAGAAGGGGCTTCCGGTCGTCGTGGTGGCGCCGAAGGATGAGCTGTTCGAGAAGACGATTTCCAATGTCGAGG
AAGTGCGCGCGCGCGGCGCAGAGATCATCCTGATCTCCGACGCGGCGGGCATCAAGGCGGCAGGCAAGCGGGCCGATCAT
GTGATCCTGCTGCCGGATGGCGACGATATTTCCCTGCCGATCCTTTCGGCCGTGCCGCTGCAATTGCTGGCCTATTATGT
GGCCCTGACACGCGGAACCGATGTCGACCAGCCGCGCAATCTGGCCAAATCGGTGACGGTGGAATAG

Upstream 100 bases:

>100_bases
TCACAAATGCACATAAATCGTCATTGTGCAGCCTGACTCGCGAGGTTTATGGAGACGATCAGATTGTTGGCTGGGGCCAG
AGAACCGGAGCACCGTTTAA

Downstream 100 bases:

>100_bases
GGCTCGCTCCGCATTGAAGGCTTGCTGCGCTATGATATAGCGCAGCAATGACCTTGATTGTGACATCCGACGATGCACTT
CCCGAAGTGCTCCATGTGCT

Product: glucosamine--fructose-6-phosphate aminotransferase, isomerizing

Products: NA

Alternate protein names: D-fructose-6-phosphate amidotransferase; GFAT; Glucosamine-6-phosphate synthase; Hexosephosphate aminotransferase; L-glutamine-D-fructose-6-phosphate amidotransferase [H]

Number of amino acids: Translated: 608; Mature: 608

Protein sequence:

>608_residues
MCGIVAIAGKDEVAGRLVDGLKRLEYRGYDSAGIAVAAEGGVERRRAKGKIVNLQERLTENPLKGLTGIAHTRWATHGAP
NETNAHPHMSGSVAIVHNGIIENYRELREDLEGRGRKFESETDSEVIAQLIDAYMEEGKDPVAAFEEALKHFHGAFAIAA
IFSNDPELVIGARKGSPLVLGYGEDEMYLGSDAIALAPLTRDVTYLEEGDWVVLRRNSFDIRNVRGERVNRARVTSAVND
ALIERGEYDHFMLKEIHEQSESLARSIMPYINQATQTVSVPEAAETLFADADRAVAIACGTAFYAAFTAKYWFEQIARLA
FEPDIASEFRYRRPVLPQKGFSLFVSQSGETADTLAALRYCRENRTPAIAVVNVPESSIAREAASIVPTHAGPEIGVAST
KAFTAQLSVLAVLALSAAKARGHLLPGDEMNYVRSLLALPRKVTEALECAGQVREIARHIAGKRDVLFLGRGRYYPLALE
GALKLKEVSYIHAEGYAAGELKHGPIALIEKGLPVVVVAPKDELFEKTISNVEEVRARGAEIILISDAAGIKAAGKRADH
VILLPDGDDISLPILSAVPLQLLAYYVALTRGTDVDQPRNLAKSVTVE

Sequences:

>Translated_608_residues
MCGIVAIAGKDEVAGRLVDGLKRLEYRGYDSAGIAVAAEGGVERRRAKGKIVNLQERLTENPLKGLTGIAHTRWATHGAP
NETNAHPHMSGSVAIVHNGIIENYRELREDLEGRGRKFESETDSEVIAQLIDAYMEEGKDPVAAFEEALKHFHGAFAIAA
IFSNDPELVIGARKGSPLVLGYGEDEMYLGSDAIALAPLTRDVTYLEEGDWVVLRRNSFDIRNVRGERVNRARVTSAVND
ALIERGEYDHFMLKEIHEQSESLARSIMPYINQATQTVSVPEAAETLFADADRAVAIACGTAFYAAFTAKYWFEQIARLA
FEPDIASEFRYRRPVLPQKGFSLFVSQSGETADTLAALRYCRENRTPAIAVVNVPESSIAREAASIVPTHAGPEIGVAST
KAFTAQLSVLAVLALSAAKARGHLLPGDEMNYVRSLLALPRKVTEALECAGQVREIARHIAGKRDVLFLGRGRYYPLALE
GALKLKEVSYIHAEGYAAGELKHGPIALIEKGLPVVVVAPKDELFEKTISNVEEVRARGAEIILISDAAGIKAAGKRADH
VILLPDGDDISLPILSAVPLQLLAYYVALTRGTDVDQPRNLAKSVTVE
>Mature_608_residues
MCGIVAIAGKDEVAGRLVDGLKRLEYRGYDSAGIAVAAEGGVERRRAKGKIVNLQERLTENPLKGLTGIAHTRWATHGAP
NETNAHPHMSGSVAIVHNGIIENYRELREDLEGRGRKFESETDSEVIAQLIDAYMEEGKDPVAAFEEALKHFHGAFAIAA
IFSNDPELVIGARKGSPLVLGYGEDEMYLGSDAIALAPLTRDVTYLEEGDWVVLRRNSFDIRNVRGERVNRARVTSAVND
ALIERGEYDHFMLKEIHEQSESLARSIMPYINQATQTVSVPEAAETLFADADRAVAIACGTAFYAAFTAKYWFEQIARLA
FEPDIASEFRYRRPVLPQKGFSLFVSQSGETADTLAALRYCRENRTPAIAVVNVPESSIAREAASIVPTHAGPEIGVAST
KAFTAQLSVLAVLALSAAKARGHLLPGDEMNYVRSLLALPRKVTEALECAGQVREIARHIAGKRDVLFLGRGRYYPLALE
GALKLKEVSYIHAEGYAAGELKHGPIALIEKGLPVVVVAPKDELFEKTISNVEEVRARGAEIILISDAAGIKAAGKRADH
VILLPDGDDISLPILSAVPLQLLAYYVALTRGTDVDQPRNLAKSVTVE

Specific function: Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source [H]

COG id: COG0449

COG function: function code M; Glucosamine 6-phosphate synthetase, contains amidotransferase and phosphosugar isomerase domains

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 SIS domains [H]

Homologues:

Organism=Homo sapiens, GI4826742, Length=685, Percent_Identity=36.3503649635037, Blast_Score=389, Evalue=1e-108,
Organism=Homo sapiens, GI205277386, Length=686, Percent_Identity=35.131195335277, Blast_Score=380, Evalue=1e-105,
Organism=Escherichia coli, GI1790167, Length=612, Percent_Identity=47.2222222222222, Blast_Score=539, Evalue=1e-154,
Organism=Escherichia coli, GI1788651, Length=220, Percent_Identity=30, Blast_Score=81, Evalue=2e-16,
Organism=Escherichia coli, GI87082251, Length=364, Percent_Identity=22.8021978021978, Blast_Score=65, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17539970, Length=432, Percent_Identity=36.5740740740741, Blast_Score=262, Evalue=5e-70,
Organism=Caenorhabditis elegans, GI17532899, Length=432, Percent_Identity=35.1851851851852, Blast_Score=259, Evalue=4e-69,
Organism=Caenorhabditis elegans, GI17532897, Length=432, Percent_Identity=35.1851851851852, Blast_Score=258, Evalue=5e-69,
Organism=Saccharomyces cerevisiae, GI6322745, Length=477, Percent_Identity=35.6394129979036, Blast_Score=268, Evalue=2e-72,
Organism=Saccharomyces cerevisiae, GI6323731, Length=430, Percent_Identity=32.093023255814, Blast_Score=197, Evalue=4e-51,
Organism=Saccharomyces cerevisiae, GI6323730, Length=204, Percent_Identity=36.2745098039216, Blast_Score=115, Evalue=2e-26,
Organism=Drosophila melanogaster, GI21357745, Length=691, Percent_Identity=35.6005788712012, Blast_Score=390, Evalue=1e-108,
Organism=Drosophila melanogaster, GI24659598, Length=141, Percent_Identity=34.7517730496454, Blast_Score=68, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000583
- InterPro:   IPR017932
- InterPro:   IPR005855
- InterPro:   IPR001347 [H]

Pfam domain/function: PF00310 GATase_2; PF01380 SIS [H]

EC number: =2.6.1.16 [H]

Molecular weight: Translated: 66108; Mature: 66108

Theoretical pI: Translated: 5.91; Mature: 5.91

Prosite motif: PS00443 GATASE_TYPE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MCGIVAIAGKDEVAGRLVDGLKRLEYRGYDSAGIAVAAEGGVERRRAKGKIVNLQERLTE
CCCEEEECCCHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCHHHHHHCCCEECHHHHHCC
NPLKGLTGIAHTRWATHGAPNETNAHPHMSGSVAIVHNGIIENYRELREDLEGRGRKFES
CHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCEEEEECHHHHHHHHHHHHHHHCCCCCCC
ETDSEVIAQLIDAYMEEGKDPVAAFEEALKHFHGAFAIAAIFSNDPELVIGARKGSPLVL
CCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHEEEEEECCCCCEEEEECCCCEEEE
GYGEDEMYLGSDAIALAPLTRDVTYLEEGDWVVLRRNSFDIRNVRGERVNRARVTSAVND
EECCCCEEECCCCEEEEECCCCCEEEECCCEEEEECCCCCCCCCCCCHHHHHHHHHHHHH
ALIERGEYDHFMLKEIHEQSESLARSIMPYINQATQTVSVPEAAETLFADADRAVAIACG
HHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCEEEEEEH
TAFYAAFTAKYWFEQIARLAFEPDIASEFRYRRPVLPQKGFSLFVSQSGETADTLAALRY
HHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHCCCCCCCCCCEEEEECCCCHHHHHHHHHH
CRENRTPAIAVVNVPESSIAREAASIVPTHAGPEIGVASTKAFTAQLSVLAVLALSAAKA
HHCCCCCEEEEEECCHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHH
RGHLLPGDEMNYVRSLLALPRKVTEALECAGQVREIARHIAGKRDVLFLGRGRYYPLALE
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCEEEEEEC
GALKLKEVSYIHAEGYAAGELKHGPIALIEKGLPVVVVAPKDELFEKTISNVEEVRARGA
CCEEHHHEEEEEECCCCCCCCCCCCHHHEECCCCEEEECCCHHHHHHHHHHHHHHHHCCC
EIILISDAAGIKAAGKRADHVILLPDGDDISLPILSAVPLQLLAYYVALTRGTDVDQPRN
EEEEEECCCCCCCCCCCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCHHH
LAKSVTVE
HHHHCCCC
>Mature Secondary Structure
MCGIVAIAGKDEVAGRLVDGLKRLEYRGYDSAGIAVAAEGGVERRRAKGKIVNLQERLTE
CCCEEEECCCHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCHHHHHHCCCEECHHHHHCC
NPLKGLTGIAHTRWATHGAPNETNAHPHMSGSVAIVHNGIIENYRELREDLEGRGRKFES
CHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCEEEEECHHHHHHHHHHHHHHHCCCCCCC
ETDSEVIAQLIDAYMEEGKDPVAAFEEALKHFHGAFAIAAIFSNDPELVIGARKGSPLVL
CCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHEEEEEECCCCCEEEEECCCCEEEE
GYGEDEMYLGSDAIALAPLTRDVTYLEEGDWVVLRRNSFDIRNVRGERVNRARVTSAVND
EECCCCEEECCCCEEEEECCCCCEEEECCCEEEEECCCCCCCCCCCCHHHHHHHHHHHHH
ALIERGEYDHFMLKEIHEQSESLARSIMPYINQATQTVSVPEAAETLFADADRAVAIACG
HHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCEEEEEEH
TAFYAAFTAKYWFEQIARLAFEPDIASEFRYRRPVLPQKGFSLFVSQSGETADTLAALRY
HHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHCCCCCCCCCCEEEEECCCCHHHHHHHHHH
CRENRTPAIAVVNVPESSIAREAASIVPTHAGPEIGVASTKAFTAQLSVLAVLALSAAKA
HHCCCCCEEEEEECCHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHH
RGHLLPGDEMNYVRSLLALPRKVTEALECAGQVREIARHIAGKRDVLFLGRGRYYPLALE
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCEEEEEEC
GALKLKEVSYIHAEGYAAGELKHGPIALIEKGLPVVVVAPKDELFEKTISNVEEVRARGA
CCEEHHHEEEEEECCCCCCCCCCCCHHHEECCCCEEEECCCHHHHHHHHHHHHHHHHCCC
EIILISDAAGIKAAGKRADHVILLPDGDDISLPILSAVPLQLLAYYVALTRGTDVDQPRN
EEEEEECCCCCCCCCCCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCHHH
LAKSVTVE
HHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12597275 [H]