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The map label for this gene is acad8 [H]

Identifier: 114800043

GI number: 114800043

Start: 918103

End: 919242

Strand: Direct

Name: acad8 [H]

Synonym: HNE_0900

Alternate gene names: 114800043

Gene position: 918103-919242 (Clockwise)

Preceding gene: 114797691

Following gene: 114798042

Centisome position: 24.78

GC content: 63.25

Gene sequence:

>1140_bases
ATGAGCCTCATCTTCACGCAAGAACAAGAGATGATCGCCGACATGGCGGCCAAATTCGCCGCCGACAAGCTCGCCCCCCA
TTCGGAGGCCTGGGACCGTGACAGCCATTTCCCCGTTGATGTCATCCGCTCCACCGCCGAACTCGGCTTTGCCGGCATCT
ATGTCAAAGAGGACGTTGGCGGCTCGGGCCTCACGCGCACAGACGCGGCCCTGATCTTTGAACAGCTCTCCTATGGCGAC
GTCTCCACCGCCGCCTTCATCTCCATCCACAATATGGCGAGCTGGATGATCGATACCTTTGGGTCAGAGGAGCAGCGCGC
TGCCTGGGTGCCCCGGCTCACCTCGATGGAGCTGATCGCCTCCTACTGCCTGACGGAGCCGGGCTCCGGGTCTGATGCCG
CCAGCCTGAAAACCAAAGCCGTGAAAGAGGGCGACGATTACGTCATCACCGGCACCAAACAGTTCATCTCCGGCGCGGGC
ACATCGGACGTCTACGTCCTCATGGCGCGCACGTCCGATGATGGCGCCAAAGGCGTCTCCGCCTTCATCATCGAGAAAGA
TACGCCGGGTCTGTCGTTTGGCGCCAATGAGCGCAAGATGGGCTGGAAATCCCAGCCCACCCGGCAGGTCATCCTCGACG
GCGTCCGCGTGCCTGCCGCAAACCGCATCGGCGAAGAAGGCCACGGCTTCCGCTTCGCCATGGCGGGTCTTGATGGCGGC
CGCCTCAACATCGCCGCCTGCGCCCTGGGCGGCGCGCAGCTCGCCCTCGACAAGGCCGTCGTCTACGCCAAAGAGCGCCG
GCAATTCGGCAAGGCCCTCGCCGAGTTCCAGAACACCCAGTTCAAGCTTGCCGATATGGAAACCGAACTGCAGGCGGCCC
GCGTCATGCTCTACGAAGCCGCTGGCCGGCTCGACCGCAAAGCCCCCGACGCCACCCGCTGGTGCGCCATGGCCAAACGC
TTCGTCACCGACACCGCCTTCAAGGTCGCCAACGACGCCCTGCAGATCCATGGCGGCTACGGCTACCTCGCCGACTACCA
TGTCGAACGCATCGTCCGTGACTTGAGGGTCCACCAGATCCTCGAAGGCACCAACGAAGTGATGCGGGTGATTATCTCGC
GCGATATGCTGAAGGGGTAG

Upstream 100 bases:

>100_bases
CCGGTAATCACATACCCGGCAGGAGGGCGTCGGATTGACATGGTGTAAGCCTCAAACGACAAGCGGCCCAAAGACTTAAG
CCAATCCGGGAGCCCCGCCA

Downstream 100 bases:

>100_bases
GGAGAGGGACTCAGTACCGGGGCACCCGGTCCCGTATCCGGTCAAACCCCTCCTTGATCGCCGCAAACCTCGCCTCAATG
TGCGGCTCAAACTGCATGTC

Product: acyl-CoA dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 379; Mature: 378

Protein sequence:

>379_residues
MSLIFTQEQEMIADMAAKFAADKLAPHSEAWDRDSHFPVDVIRSTAELGFAGIYVKEDVGGSGLTRTDAALIFEQLSYGD
VSTAAFISIHNMASWMIDTFGSEEQRAAWVPRLTSMELIASYCLTEPGSGSDAASLKTKAVKEGDDYVITGTKQFISGAG
TSDVYVLMARTSDDGAKGVSAFIIEKDTPGLSFGANERKMGWKSQPTRQVILDGVRVPAANRIGEEGHGFRFAMAGLDGG
RLNIAACALGGAQLALDKAVVYAKERRQFGKALAEFQNTQFKLADMETELQAARVMLYEAAGRLDRKAPDATRWCAMAKR
FVTDTAFKVANDALQIHGGYGYLADYHVERIVRDLRVHQILEGTNEVMRVIISRDMLKG

Sequences:

>Translated_379_residues
MSLIFTQEQEMIADMAAKFAADKLAPHSEAWDRDSHFPVDVIRSTAELGFAGIYVKEDVGGSGLTRTDAALIFEQLSYGD
VSTAAFISIHNMASWMIDTFGSEEQRAAWVPRLTSMELIASYCLTEPGSGSDAASLKTKAVKEGDDYVITGTKQFISGAG
TSDVYVLMARTSDDGAKGVSAFIIEKDTPGLSFGANERKMGWKSQPTRQVILDGVRVPAANRIGEEGHGFRFAMAGLDGG
RLNIAACALGGAQLALDKAVVYAKERRQFGKALAEFQNTQFKLADMETELQAARVMLYEAAGRLDRKAPDATRWCAMAKR
FVTDTAFKVANDALQIHGGYGYLADYHVERIVRDLRVHQILEGTNEVMRVIISRDMLKG
>Mature_378_residues
SLIFTQEQEMIADMAAKFAADKLAPHSEAWDRDSHFPVDVIRSTAELGFAGIYVKEDVGGSGLTRTDAALIFEQLSYGDV
STAAFISIHNMASWMIDTFGSEEQRAAWVPRLTSMELIASYCLTEPGSGSDAASLKTKAVKEGDDYVITGTKQFISGAGT
SDVYVLMARTSDDGAKGVSAFIIEKDTPGLSFGANERKMGWKSQPTRQVILDGVRVPAANRIGEEGHGFRFAMAGLDGGR
LNIAACALGGAQLALDKAVVYAKERRQFGKALAEFQNTQFKLADMETELQAARVMLYEAAGRLDRKAPDATRWCAMAKRF
VTDTAFKVANDALQIHGGYGYLADYHVERIVRDLRVHQILEGTNEVMRVIISRDMLKG

Specific function: Unknown

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the acyl-CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI7656849, Length=377, Percent_Identity=56.2334217506631, Blast_Score=448, Evalue=1e-126,
Organism=Homo sapiens, GI187960098, Length=381, Percent_Identity=38.3202099737533, Blast_Score=278, Evalue=5e-75,
Organism=Homo sapiens, GI4557231, Length=381, Percent_Identity=38.3202099737533, Blast_Score=278, Evalue=6e-75,
Organism=Homo sapiens, GI4501859, Length=374, Percent_Identity=37.7005347593583, Blast_Score=265, Evalue=4e-71,
Organism=Homo sapiens, GI4557233, Length=381, Percent_Identity=38.8451443569554, Blast_Score=254, Evalue=1e-67,
Organism=Homo sapiens, GI4501857, Length=378, Percent_Identity=33.0687830687831, Blast_Score=230, Evalue=1e-60,
Organism=Homo sapiens, GI76496475, Length=336, Percent_Identity=37.5, Blast_Score=224, Evalue=1e-58,
Organism=Homo sapiens, GI4557235, Length=336, Percent_Identity=37.5, Blast_Score=224, Evalue=1e-58,
Organism=Homo sapiens, GI21361497, Length=354, Percent_Identity=35.5932203389831, Blast_Score=217, Evalue=1e-56,
Organism=Homo sapiens, GI226958412, Length=376, Percent_Identity=33.5106382978723, Blast_Score=215, Evalue=7e-56,
Organism=Homo sapiens, GI226958414, Length=336, Percent_Identity=34.2261904761905, Blast_Score=199, Evalue=4e-51,
Organism=Homo sapiens, GI4503943, Length=374, Percent_Identity=31.283422459893, Blast_Score=161, Evalue=1e-39,
Organism=Homo sapiens, GI7669494, Length=355, Percent_Identity=31.5492957746479, Blast_Score=151, Evalue=9e-37,
Organism=Homo sapiens, GI38505218, Length=324, Percent_Identity=28.0864197530864, Blast_Score=107, Evalue=2e-23,
Organism=Homo sapiens, GI211971008, Length=330, Percent_Identity=26.969696969697, Blast_Score=98, Evalue=2e-20,
Organism=Homo sapiens, GI48976061, Length=330, Percent_Identity=26.969696969697, Blast_Score=97, Evalue=2e-20,
Organism=Escherichia coli, GI87081958, Length=385, Percent_Identity=30.9090909090909, Blast_Score=156, Evalue=2e-39,
Organism=Escherichia coli, GI1786223, Length=386, Percent_Identity=28.4974093264249, Blast_Score=151, Evalue=9e-38,
Organism=Escherichia coli, GI87082384, Length=277, Percent_Identity=26.7148014440433, Blast_Score=74, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI17533517, Length=370, Percent_Identity=51.6216216216216, Blast_Score=405, Evalue=1e-113,
Organism=Caenorhabditis elegans, GI17534899, Length=382, Percent_Identity=38.7434554973822, Blast_Score=284, Evalue=5e-77,
Organism=Caenorhabditis elegans, GI17569725, Length=381, Percent_Identity=38.5826771653543, Blast_Score=282, Evalue=2e-76,
Organism=Caenorhabditis elegans, GI17570075, Length=381, Percent_Identity=34.3832020997375, Blast_Score=247, Evalue=8e-66,
Organism=Caenorhabditis elegans, GI17506239, Length=373, Percent_Identity=35.1206434316354, Blast_Score=238, Evalue=3e-63,
Organism=Caenorhabditis elegans, GI17508101, Length=372, Percent_Identity=34.4086021505376, Blast_Score=236, Evalue=1e-62,
Organism=Caenorhabditis elegans, GI71985184, Length=350, Percent_Identity=34.8571428571429, Blast_Score=216, Evalue=2e-56,
Organism=Caenorhabditis elegans, GI17538396, Length=367, Percent_Identity=35.4223433242507, Blast_Score=206, Evalue=2e-53,
Organism=Caenorhabditis elegans, GI71990804, Length=294, Percent_Identity=39.1156462585034, Blast_Score=205, Evalue=2e-53,
Organism=Caenorhabditis elegans, GI32563615, Length=228, Percent_Identity=39.4736842105263, Blast_Score=173, Evalue=1e-43,
Organism=Caenorhabditis elegans, GI17551932, Length=383, Percent_Identity=31.0704960835509, Blast_Score=166, Evalue=2e-41,
Organism=Caenorhabditis elegans, GI17505929, Length=387, Percent_Identity=30.749354005168, Blast_Score=164, Evalue=1e-40,
Organism=Caenorhabditis elegans, GI71985192, Length=296, Percent_Identity=33.7837837837838, Blast_Score=163, Evalue=1e-40,
Organism=Caenorhabditis elegans, GI71982178, Length=274, Percent_Identity=29.5620437956204, Blast_Score=152, Evalue=3e-37,
Organism=Caenorhabditis elegans, GI17534353, Length=373, Percent_Identity=28.4182305630027, Blast_Score=145, Evalue=3e-35,
Organism=Caenorhabditis elegans, GI17531909, Length=240, Percent_Identity=28.75, Blast_Score=112, Evalue=3e-25,
Organism=Caenorhabditis elegans, GI17562446, Length=336, Percent_Identity=27.3809523809524, Blast_Score=107, Evalue=1e-23,
Organism=Caenorhabditis elegans, GI86563381, Length=307, Percent_Identity=28.3387622149837, Blast_Score=92, Evalue=3e-19,
Organism=Caenorhabditis elegans, GI86563383, Length=307, Percent_Identity=28.3387622149837, Blast_Score=92, Evalue=4e-19,
Organism=Caenorhabditis elegans, GI17531913, Length=192, Percent_Identity=27.6041666666667, Blast_Score=73, Evalue=2e-13,
Organism=Drosophila melanogaster, GI24660351, Length=379, Percent_Identity=36.1477572559367, Blast_Score=262, Evalue=3e-70,
Organism=Drosophila melanogaster, GI24666513, Length=377, Percent_Identity=36.3395225464191, Blast_Score=252, Evalue=2e-67,
Organism=Drosophila melanogaster, GI21356377, Length=376, Percent_Identity=36.436170212766, Blast_Score=250, Evalue=1e-66,
Organism=Drosophila melanogaster, GI24646207, Length=376, Percent_Identity=37.5, Blast_Score=246, Evalue=2e-65,
Organism=Drosophila melanogaster, GI281363737, Length=357, Percent_Identity=33.6134453781513, Blast_Score=209, Evalue=2e-54,
Organism=Drosophila melanogaster, GI21355753, Length=378, Percent_Identity=33.5978835978836, Blast_Score=207, Evalue=7e-54,
Organism=Drosophila melanogaster, GI19920834, Length=375, Percent_Identity=28.8, Blast_Score=143, Evalue=2e-34,
Organism=Drosophila melanogaster, GI24652780, Length=318, Percent_Identity=22.6415094339623, Blast_Score=74, Evalue=2e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006089
- InterPro:   IPR006092
- InterPro:   IPR006090
- InterPro:   IPR006091
- InterPro:   IPR009075
- InterPro:   IPR013786
- InterPro:   IPR009100 [H]

Pfam domain/function: PF00441 Acyl-CoA_dh_1; PF02770 Acyl-CoA_dh_M; PF02771 Acyl-CoA_dh_N [H]

EC number: NA

Molecular weight: Translated: 41347; Mature: 41216

Theoretical pI: Translated: 5.71; Mature: 5.71

Prosite motif: PS00072 ACYL_COA_DH_1 ; PS00073 ACYL_COA_DH_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSLIFTQEQEMIADMAAKFAADKLAPHSEAWDRDSHFPVDVIRSTAELGFAGIYVKEDVG
CCEEECCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHCCEEEEEEEECCC
GSGLTRTDAALIFEQLSYGDVSTAAFISIHNMASWMIDTFGSEEQRAAWVPRLTSMELIA
CCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHCCCHHHHHHHH
SYCLTEPGSGSDAASLKTKAVKEGDDYVITGTKQFISGAGTSDVYVLMARTSDDGAKGVS
HHHCCCCCCCCCHHHHHHHHHCCCCCEEEECCHHHHCCCCCCCEEEEEEECCCCCCCCEE
AFIIEKDTPGLSFGANERKMGWKSQPTRQVILDGVRVPAANRIGEEGHGFRFAMAGLDGG
EEEEECCCCCCCCCCCCCCCCCCCCCHHHHHHCCCCCCCHHHCCCCCCCEEEEEECCCCC
RLNIAACALGGAQLALDKAVVYAKERRQFGKALAEFQNTQFKLADMETELQAARVMLYEA
CEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECHHHHHHHHHHHHHHH
AGRLDRKAPDATRWCAMAKRFVTDTAFKVANDALQIHGGYGYLADYHVERIVRDLRVHQI
HHHHCCCCCCHHHHHHHHHHHHHHHHHHHHCCEEEEECCCCCHHHHHHHHHHHHHHHHHH
LEGTNEVMRVIISRDMLKG
HHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
SLIFTQEQEMIADMAAKFAADKLAPHSEAWDRDSHFPVDVIRSTAELGFAGIYVKEDVG
CEEECCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHCCEEEEEEEECCC
GSGLTRTDAALIFEQLSYGDVSTAAFISIHNMASWMIDTFGSEEQRAAWVPRLTSMELIA
CCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHCCCHHHHHHHH
SYCLTEPGSGSDAASLKTKAVKEGDDYVITGTKQFISGAGTSDVYVLMARTSDDGAKGVS
HHHCCCCCCCCCHHHHHHHHHCCCCCEEEECCHHHHCCCCCCCEEEEEEECCCCCCCCEE
AFIIEKDTPGLSFGANERKMGWKSQPTRQVILDGVRVPAANRIGEEGHGFRFAMAGLDGG
EEEEECCCCCCCCCCCCCCCCCCCCCHHHHHHCCCCCCCHHHCCCCCCCEEEEEECCCCC
RLNIAACALGGAQLALDKAVVYAKERRQFGKALAEFQNTQFKLADMETELQAARVMLYEA
CEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECHHHHHHHHHHHHHHH
AGRLDRKAPDATRWCAMAKRFVTDTAFKVANDALQIHGGYGYLADYHVERIVRDLRVHQI
HHHHCCCCCCHHHHHHHHHHHHHHHHHHHHCCEEEEECCCCCHHHHHHHHHHHHHHHHHH
LEGTNEVMRVIISRDMLKG
HHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8759838; 8969508; 9384377 [H]