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The map label for this gene is proC [H]

Identifier: 114799869

GI number: 114799869

Start: 1416416

End: 1417222

Strand: Direct

Name: proC [H]

Synonym: HNE_1387

Alternate gene names: 114799869

Gene position: 1416416-1417222 (Clockwise)

Preceding gene: 114798921

Following gene: 114797672

Centisome position: 38.23

GC content: 67.29

Gene sequence:

>807_bases
ATGAAGCCAGCAGCGTCCCTGACCCTTGTCGGCGCGGGCCGAATGGGCTCCGCGCTGCTGCATGGCTGGCTGAAGGGTCC
CGAGCGCGAAATTTCGGTGATTGAACCTTCGCCGCGTCCCGAGATACGGGCGTTGGCGGAGGAGGGGCGTATCCAGCTCA
ATCCGGCGCCGTCTGAAAGCAGCATCATTGTGCTGGCGGTAAAGCCTCAGCAGTTTGCGGCGGTCTCCGAGCAGGCCAAA
GCCTTCGTCGGCCCTAAATCGGTTGCCATCTCGATCATGGCGGGTGTGCGCCTGGCGCAGCTTTCGCGGCGGCTCGGCAC
GGAGCGGGTGATCCGCTCCATGCCGAACACGCCCGGCGCTATCGGGCAGGGCGTTACCGTTTTCACCGCGCCCGAAGGGG
CCAAGCGCACCGATCTGTCTGCCGCGCGCGAGCTGCTCGCGCCGCTGGGCGAGGTGCATGGGCCGGTGGACGAGGCCATG
ATGTCGGCGGTCACGGCGCTGTCGGGCTCTGGCCCGGCTTATATTTTCCTGTTGGCCGAGGTGATGGCGGAAGCCGGCGT
GGCGCAGGGCCTGCCGCGCGATCTTGCGCTTAGTCTCGCCCGGCGCACTGTCGAAGGCGCCGCCGCCCTGATGGGCGAGA
GTGGCGACAGCCCCGAAGCGCTTCGCAAAGCCGTGACTTCACCCGGCGGAACCACCCAGGCGGCACTTGACATCCTTATG
GACACGGGTGGGATGCCCGCCTTGTTCAGGAACGCTCTCAGCGCCGCTGCCAACCGCGACCGGCAGCTGTCCCAAGAGGC
GGACTGA

Upstream 100 bases:

>100_bases
TATCCCGGCGTTCAATTTCCTTGTCTGGGCTGGCAAGTCTCCGCGCGATGCGATCGACGCGGTGATGTTTGAAACCCACG
GCGAAGCCTGAGCTGACCCG

Downstream 100 bases:

>100_bases
CCTCACAGGAGGTAGTTCTGGTGGCCGTCACCAATACAGTCATAGAAGCCGGGCTGCTCGCAGCGCTGGAGCTTGCGGCT
GAGAAACCCTGGCCGGAGAT

Product: pyrroline-5-carboxylate reductase

Products: NA

Alternate protein names: P5C reductase; P5CR [H]

Number of amino acids: Translated: 268; Mature: 268

Protein sequence:

>268_residues
MKPAASLTLVGAGRMGSALLHGWLKGPEREISVIEPSPRPEIRALAEEGRIQLNPAPSESSIIVLAVKPQQFAAVSEQAK
AFVGPKSVAISIMAGVRLAQLSRRLGTERVIRSMPNTPGAIGQGVTVFTAPEGAKRTDLSAARELLAPLGEVHGPVDEAM
MSAVTALSGSGPAYIFLLAEVMAEAGVAQGLPRDLALSLARRTVEGAAALMGESGDSPEALRKAVTSPGGTTQAALDILM
DTGGMPALFRNALSAAANRDRQLSQEAD

Sequences:

>Translated_268_residues
MKPAASLTLVGAGRMGSALLHGWLKGPEREISVIEPSPRPEIRALAEEGRIQLNPAPSESSIIVLAVKPQQFAAVSEQAK
AFVGPKSVAISIMAGVRLAQLSRRLGTERVIRSMPNTPGAIGQGVTVFTAPEGAKRTDLSAARELLAPLGEVHGPVDEAM
MSAVTALSGSGPAYIFLLAEVMAEAGVAQGLPRDLALSLARRTVEGAAALMGESGDSPEALRKAVTSPGGTTQAALDILM
DTGGMPALFRNALSAAANRDRQLSQEAD
>Mature_268_residues
MKPAASLTLVGAGRMGSALLHGWLKGPEREISVIEPSPRPEIRALAEEGRIQLNPAPSESSIIVLAVKPQQFAAVSEQAK
AFVGPKSVAISIMAGVRLAQLSRRLGTERVIRSMPNTPGAIGQGVTVFTAPEGAKRTDLSAARELLAPLGEVHGPVDEAM
MSAVTALSGSGPAYIFLLAEVMAEAGVAQGLPRDLALSLARRTVEGAAALMGESGDSPEALRKAVTSPGGTTQAALDILM
DTGGMPALFRNALSAAANRDRQLSQEAD

Specific function: Proline biosynthesis; third (last) step. [C]

COG id: COG0345

COG function: function code E; Pyrroline-5-carboxylate reductase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the pyrroline-5-carboxylate reductase family [H]

Homologues:

Organism=Homo sapiens, GI24797095, Length=275, Percent_Identity=34.1818181818182, Blast_Score=130, Evalue=1e-30,
Organism=Homo sapiens, GI24797097, Length=275, Percent_Identity=34.1818181818182, Blast_Score=130, Evalue=1e-30,
Organism=Homo sapiens, GI21361454, Length=275, Percent_Identity=34.1818181818182, Blast_Score=130, Evalue=2e-30,
Organism=Homo sapiens, GI198041662, Length=265, Percent_Identity=30.9433962264151, Blast_Score=104, Evalue=7e-23,
Organism=Escherichia coli, GI1786585, Length=265, Percent_Identity=34.3396226415094, Blast_Score=129, Evalue=3e-31,
Organism=Caenorhabditis elegans, GI17569021, Length=267, Percent_Identity=32.9588014981273, Blast_Score=127, Evalue=8e-30,
Organism=Caenorhabditis elegans, GI17540664, Length=216, Percent_Identity=32.8703703703704, Blast_Score=85, Evalue=4e-17,
Organism=Saccharomyces cerevisiae, GI6320861, Length=211, Percent_Identity=33.175355450237, Blast_Score=101, Evalue=1e-22,
Organism=Drosophila melanogaster, GI21358587, Length=272, Percent_Identity=34.9264705882353, Blast_Score=140, Evalue=6e-34,
Organism=Drosophila melanogaster, GI24647700, Length=171, Percent_Identity=42.1052631578947, Blast_Score=118, Evalue=4e-27,
Organism=Drosophila melanogaster, GI24648116, Length=218, Percent_Identity=33.0275229357798, Blast_Score=114, Evalue=8e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR016040
- InterPro:   IPR004455
- InterPro:   IPR000304 [H]

Pfam domain/function: PF03807 F420_oxidored [H]

EC number: =1.5.1.2 [H]

Molecular weight: Translated: 27675; Mature: 27675

Theoretical pI: Translated: 6.56; Mature: 6.56

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKPAASLTLVGAGRMGSALLHGWLKGPEREISVIEPSPRPEIRALAEEGRIQLNPAPSES
CCCCCCEEEEECCCHHHHHHHHHHCCCCCCEEEECCCCCHHHHHHHHCCCEEECCCCCCC
SIIVLAVKPQQFAAVSEQAKAFVGPKSVAISIMAGVRLAQLSRRLGTERVIRSMPNTPGA
CEEEEEECCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCHHHHHHHCCCCCCC
IGQGVTVFTAPEGAKRTDLSAARELLAPLGEVHGPVDEAMMSAVTALSGSGPAYIFLLAE
CCCCEEEEECCCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCHHHHHHHH
VMAEAGVAQGLPRDLALSLARRTVEGAAALMGESGDSPEALRKAVTSPGGTTQAALDILM
HHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCCHHHHHHHHHH
DTGGMPALFRNALSAAANRDRQLSQEAD
CCCCCHHHHHHHHHHHHCCHHHHHCCCC
>Mature Secondary Structure
MKPAASLTLVGAGRMGSALLHGWLKGPEREISVIEPSPRPEIRALAEEGRIQLNPAPSES
CCCCCCEEEEECCCHHHHHHHHHHCCCCCCEEEECCCCCHHHHHHHHCCCEEECCCCCCC
SIIVLAVKPQQFAAVSEQAKAFVGPKSVAISIMAGVRLAQLSRRLGTERVIRSMPNTPGA
CEEEEEECCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCHHHHHHHCCCCCCC
IGQGVTVFTAPEGAKRTDLSAARELLAPLGEVHGPVDEAMMSAVTALSGSGPAYIFLLAE
CCCCEEEEECCCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCHHHHHHHH
VMAEAGVAQGLPRDLALSLARRTVEGAAALMGESGDSPEALRKAVTSPGGTTQAALDILM
HHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCCHHHHHHHHHH
DTGGMPALFRNALSAAANRDRQLSQEAD
CCCCCHHHHHHHHHHHHCCHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11844777; 11932238 [H]