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The map label for this gene is ribAB [H]

Identifier: 114799819

GI number: 114799819

Start: 2130518

End: 2131645

Strand: Reverse

Name: ribAB [H]

Synonym: HNE_2056

Alternate gene names: 114799819

Gene position: 2131645-2130518 (Counterclockwise)

Preceding gene: 114798806

Following gene: 114799272

Centisome position: 57.53

GC content: 63.39

Gene sequence:

>1128_bases
ATGAGCAGCGAGTTCACCGCCGCCATCTCCTCGATTGAGGAAATAATCGAAGACGCCCGCAACGGGCGCATGTTCATCCT
GGTGGATGCCGAAGACCGTGAGAATGAGGGCGACCTCATCATCCCGGCCACCTTCGCCACGCCCGAGGCGGTGAACTTCA
TGGCCAAGCATGGCCGGGGCCTCATCTGCCTCGCCATGACGCAGGAGCGCGGCCACACGCTGCGCCTCGACATGATGACC
CGCAACAACCGCGAAAGCATGCAGACGGCGTTCACCGTCTCCATCGAAGCGAAAGAGGGCGTCACCACCGGCATCTCCGC
CCATGACCGTTCCCGGACAATTGCCGTGGCCATCGATCCGACCAAGGACGATGACGACATCGTCAGCCCAGGGCATATCT
TCCCGCTGATCGCCAAGGAAGGCGGCACGCTCGTCCGCGCTGGCCATACTGAAGCAGCGGTCGACATTTCCCGCATGGCC
GGGCTCTATCCCGCCGGCGTGATCTGCGAAATCATGAATGATGACGGCTCCATGGCCCGCTTGCCGGAGCTCGTCGCCTT
TGCCCAGCTTCACAATCTGAAAATCGGCACCATTGCCGACCTGATCGCCTGGCGCCGCCAGAACGACCGGTTCCTGGAGC
GCCGCATTGAGACGGCGCTGGAATCTGACTATGGCAGCGGCTTCCGCACGGTCTGTTTCCGCAACACGATGGACAATTCC
GAACACATCGCCATCGTCCACGGAGACATCACGCCCGACGCGACAACCCTTGTCCGCGTCCACCGTACAGACATCCTTTC
CGACATCCTCGGCGAGAAGGGCCCGCGCTCTGGCCTGGTCGCCCGCGCCATGCGCCTGATCGCCAAAGCGCCCGAGCCCG
GCGTCGTTGTGTTCGTTAACGCGATGCAGCCCGGCTCCATCGCAGAGCGCCTGGGCCTCAAATCCGGCGCCGCGCGCGAC
CCCTCCGCGCCCATCCGCGAATACGGCATCGGCGCGCAGATCCTGCGGGAACTGGGCGTGCGCAGCATGATTTACCTGTC
CGATACGCAGCCCACCCGCCTTGCGGGGCTTGACGGATACGGTTTGACAATAGAGGGCTGGCGCCACCTGAGCGAGGAGA
ATACTTAA

Upstream 100 bases:

>100_bases
CGCGTTGAAGCCCGGCACAAAGGTAAACCTCGAAATTGATATGCTTGCGCGCTATGTGGCGCGGATGATCGGTGCGGACG
CGCCACAAGGGAGTTAGATA

Downstream 100 bases:

>100_bases
GATGGCTGACCGCGTTTTGATCGCGATTTCGCGCTATTACAAACACATCAGCGACGAGCTGGAAGCAGGCGCGCTCGAAG
TGCTCGAAGCTGCCGGCGCC

Product: riboflavin biosynthesis protein RibA

Products: NA

Alternate protein names: DHBP synthase [H]

Number of amino acids: Translated: 375; Mature: 374

Protein sequence:

>375_residues
MSSEFTAAISSIEEIIEDARNGRMFILVDAEDRENEGDLIIPATFATPEAVNFMAKHGRGLICLAMTQERGHTLRLDMMT
RNNRESMQTAFTVSIEAKEGVTTGISAHDRSRTIAVAIDPTKDDDDIVSPGHIFPLIAKEGGTLVRAGHTEAAVDISRMA
GLYPAGVICEIMNDDGSMARLPELVAFAQLHNLKIGTIADLIAWRRQNDRFLERRIETALESDYGSGFRTVCFRNTMDNS
EHIAIVHGDITPDATTLVRVHRTDILSDILGEKGPRSGLVARAMRLIAKAPEPGVVVFVNAMQPGSIAERLGLKSGAARD
PSAPIREYGIGAQILRELGVRSMIYLSDTQPTRLAGLDGYGLTIEGWRHLSEENT

Sequences:

>Translated_375_residues
MSSEFTAAISSIEEIIEDARNGRMFILVDAEDRENEGDLIIPATFATPEAVNFMAKHGRGLICLAMTQERGHTLRLDMMT
RNNRESMQTAFTVSIEAKEGVTTGISAHDRSRTIAVAIDPTKDDDDIVSPGHIFPLIAKEGGTLVRAGHTEAAVDISRMA
GLYPAGVICEIMNDDGSMARLPELVAFAQLHNLKIGTIADLIAWRRQNDRFLERRIETALESDYGSGFRTVCFRNTMDNS
EHIAIVHGDITPDATTLVRVHRTDILSDILGEKGPRSGLVARAMRLIAKAPEPGVVVFVNAMQPGSIAERLGLKSGAARD
PSAPIREYGIGAQILRELGVRSMIYLSDTQPTRLAGLDGYGLTIEGWRHLSEENT
>Mature_374_residues
SSEFTAAISSIEEIIEDARNGRMFILVDAEDRENEGDLIIPATFATPEAVNFMAKHGRGLICLAMTQERGHTLRLDMMTR
NNRESMQTAFTVSIEAKEGVTTGISAHDRSRTIAVAIDPTKDDDDIVSPGHIFPLIAKEGGTLVRAGHTEAAVDISRMAG
LYPAGVICEIMNDDGSMARLPELVAFAQLHNLKIGTIADLIAWRRQNDRFLERRIETALESDYGSGFRTVCFRNTMDNSE
HIAIVHGDITPDATTLVRVHRTDILSDILGEKGPRSGLVARAMRLIAKAPEPGVVVFVNAMQPGSIAERLGLKSGAARDP
SAPIREYGIGAQILRELGVRSMIYLSDTQPTRLAGLDGYGLTIEGWRHLSEENT

Specific function: Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate [H]

COG id: COG0108

COG function: function code H; 3,4-dihydroxy-2-butanone 4-phosphate synthase

Gene ontology:

Cell location: Membrane-Associated [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the GTP cyclohydrolase II family [H]

Homologues:

Organism=Escherichia coli, GI1789420, Length=208, Percent_Identity=47.5961538461538, Blast_Score=206, Evalue=3e-54,
Organism=Saccharomyces cerevisiae, GI6320695, Length=207, Percent_Identity=36.7149758454106, Blast_Score=144, Evalue=2e-35,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017945
- InterPro:   IPR000422
- InterPro:   IPR000926
- InterPro:   IPR016299 [H]

Pfam domain/function: PF00926 DHBP_synthase; PF00925 GTP_cyclohydro2 [H]

EC number: =4.1.99.12 [H]

Molecular weight: Translated: 40949; Mature: 40818

Theoretical pI: Translated: 5.18; Mature: 5.18

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSSEFTAAISSIEEIIEDARNGRMFILVDAEDRENEGDLIIPATFATPEAVNFMAKHGRG
CCCHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCEEEEECCCCHHHHHHHHHCCCC
LICLAMTQERGHTLRLDMMTRNNRESMQTAFTVSIEAKEGVTTGISAHDRSRTIAVAIDP
EEEEEEECCCCCEEEEEEEECCCHHHCEEEEEEEEECCCCCCCCCCCCCCCCEEEEEECC
TKDDDDIVSPGHIFPLIAKEGGTLVRAGHTEAAVDISRMAGLYPAGVICEIMNDDGSMAR
CCCCCCCCCCCCEEEEEECCCCEEEEECCCHHHHHHHHHHCCCCCCEEEEEECCCCCHHH
LPELVAFAQLHNLKIGTIADLIAWRRQNDRFLERRIETALESDYGSGFRTVCFRNTMDNS
HHHHHHHHHHHCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCEEEEEEECCCCCC
EHIAIVHGDITPDATTLVRVHRTDILSDILGEKGPRSGLVARAMRLIAKAPEPGVVVFVN
CEEEEEECCCCCCHHHEEEEHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCCCEEEEEE
AMQPGSIAERLGLKSGAARDPSAPIREYGIGAQILRELGVRSMIYLSDTQPTRLAGLDGY
CCCCCHHHHHHCCCCCCCCCCCCCHHHHCCHHHHHHHCCCCEEEEEECCCCCEEECCCCC
GLTIEGWRHLSEENT
CEEEHHHHHHCCCCC
>Mature Secondary Structure 
SSEFTAAISSIEEIIEDARNGRMFILVDAEDRENEGDLIIPATFATPEAVNFMAKHGRG
CCHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCEEEEECCCCHHHHHHHHHCCCC
LICLAMTQERGHTLRLDMMTRNNRESMQTAFTVSIEAKEGVTTGISAHDRSRTIAVAIDP
EEEEEEECCCCCEEEEEEEECCCHHHCEEEEEEEEECCCCCCCCCCCCCCCCEEEEEECC
TKDDDDIVSPGHIFPLIAKEGGTLVRAGHTEAAVDISRMAGLYPAGVICEIMNDDGSMAR
CCCCCCCCCCCCEEEEEECCCCEEEEECCCHHHHHHHHHHCCCCCCEEEEEECCCCCHHH
LPELVAFAQLHNLKIGTIADLIAWRRQNDRFLERRIETALESDYGSGFRTVCFRNTMDNS
HHHHHHHHHHHCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCEEEEEEECCCCCC
EHIAIVHGDITPDATTLVRVHRTDILSDILGEKGPRSGLVARAMRLIAKAPEPGVVVFVN
CEEEEEECCCCCCHHHEEEEHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCCCEEEEEE
AMQPGSIAERLGLKSGAARDPSAPIREYGIGAQILRELGVRSMIYLSDTQPTRLAGLDGY
CCCCCHHHHHHCCCCCCCCCCCCCHHHHCCHHHHHHHCCCCEEEEEECCCCCEEECCCCC
GLTIEGWRHLSEENT
CEEEHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 1339274 [H]