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The map label for this gene is hup2 [H]

Identifier: 114799727

GI number: 114799727

Start: 2596517

End: 2596792

Strand: Reverse

Name: hup2 [H]

Synonym: HNE_2469

Alternate gene names: 114799727

Gene position: 2596792-2596517 (Counterclockwise)

Preceding gene: 114800551

Following gene: 114800474

Centisome position: 70.09

GC content: 52.17

Gene sequence:

>276_bases
GTGCTGACACTGAAGCATCTGGCGGCAGAACTTTCTGAGGCCCATGAGATGCCGAAAAAGCAAGCTGAAGCCGTTGTGAG
CGATTTCATCGACCGCATGGGTGGTCATCTTAAAAAAGGAAAGAAGCTGCGCATCGCCGGGCTTGGCATCCTTCAGGTTC
GTAAAAGCCCAGCACGTAAGGGTCGCAATCCGGCAACCGGCGAAGAGATCAAAATCAAGGCATCCAAAAAAGTTGCCTTC
CGTCCATCGAAGGATCTCAAAGAGCGCGTGCTCTAA

Upstream 100 bases:

>100_bases
TGCAACAAAAGTTGCAGTGAAGAAGGCGCCCGCCAAAAAAGTGACGGTCGCAAAAAAGCCTGCTGCGAAAGCCGCGGTTG
CAAAAAAAGTAGTGCCTGAG

Downstream 100 bases:

>100_bases
GTCCCACTTGGTATTTATTCTGAAGCGCCTGGCCTTGATGCAACTCGGTCAGGCGTTTTCTTAACTTCATTCAGCTGCGC
GAGGGTCAATTTCAAGCCGC

Product: DNA-binding protein HU

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 91; Mature: 91

Protein sequence:

>91_residues
MLTLKHLAAELSEAHEMPKKQAEAVVSDFIDRMGGHLKKGKKLRIAGLGILQVRKSPARKGRNPATGEEIKIKASKKVAF
RPSKDLKERVL

Sequences:

>Translated_91_residues
MLTLKHLAAELSEAHEMPKKQAEAVVSDFIDRMGGHLKKGKKLRIAGLGILQVRKSPARKGRNPATGEEIKIKASKKVAF
RPSKDLKERVL
>Mature_91_residues
MLTLKHLAAELSEAHEMPKKQAEAVVSDFIDRMGGHLKKGKKLRIAGLGILQVRKSPARKGRNPATGEEIKIKASKKVAF
RPSKDLKERVL

Specific function: Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions. Seems also to act as a fortuitous virulence factor in delayed sequelae by binding to heparan su

COG id: COG0776

COG function: function code L; Bacterial nucleoid DNA-binding protein

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the bacterial histone-like protein family [H]

Homologues:

Organism=Escherichia coli, GI1788005, Length=89, Percent_Identity=34.8314606741573, Blast_Score=59, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000119
- InterPro:   IPR020816
- InterPro:   IPR010992 [H]

Pfam domain/function: PF00216 Bac_DNA_binding [H]

EC number: NA

Molecular weight: Translated: 10082; Mature: 10082

Theoretical pI: Translated: 11.19; Mature: 11.19

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLTLKHLAAELSEAHEMPKKQAEAVVSDFIDRMGGHLKKGKKLRIAGLGILQVRKSPARK
CCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCCCEEEEECCHHHHHCCCHHHC
GRNPATGEEIKIKASKKVAFRPSKDLKERVL
CCCCCCCCEEEEECCCEEECCCCHHHHHHCC
>Mature Secondary Structure
MLTLKHLAAELSEAHEMPKKQAEAVVSDFIDRMGGHLKKGKKLRIAGLGILQVRKSPARK
CCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCCCEEEEECCHHHHHCCCHHHC
GRNPATGEEIKIKASKKVAFRPSKDLKERVL
CCCCCCCCEEEEECCCEEECCCCHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9423866 [H]