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The map label for this gene is prs

Identifier: 114799706

GI number: 114799706

Start: 352622

End: 353560

Strand: Reverse

Name: prs

Synonym: HNE_0362

Alternate gene names: 114799706

Gene position: 353560-352622 (Counterclockwise)

Preceding gene: 114797428

Following gene: 114800417

Centisome position: 9.54

GC content: 59.74

Gene sequence:

>939_bases
ATGAAGCTGATTTCCTGCAATGCAAACCGGCCGCTGTCTGACGCCATTGCCGATTATCTCGACATGCGGCTGACCCGCTC
GGAGGTGAAAACCTTCGCTGACCAGGAAATCTTTGTCCGGATTGATGAGAATGTGCGCGGGGAGGATGTGTTCGTCATTC
AGTCGACCTCCTATCCGGCCAACGATAATCTGATGCAGCTGTTGATCATGATGGACGCGCTGCGGCGCGCCTCGGCCCGG
CGCATTACCGCTGTGATCCCCTATTTCGGCTATGCAAGGCAGGACCGCAAAACCGATGGCCGCACGCCGATTTCGGCCAA
GCTGGTGGCAAATCTCATCTCGACGGCAGGCGCTGACCGGGTTTTGACGGTCGACCTGCATGCCGGGCAGATCCAGGGCT
TTTTCGACATTCCGACCGATAACCTCTTTGGCGGGCCTGTGATGGTGGACGACATCAAGGAGCGTTACGGCAAGGAAAAG
ATCATTGTGGTCTCGCCTGATGTGGGCGGCGTGGTGCGGGCGCGCTCGCTGGCCAAGCGGCTGGATGATGCCGACCTGGC
GATTGTCGACAAGCGCCGTCCGGAAGCGGGCAAATCGGAAGTGATGAACATTATCGGCGATGTGCGCGGGGCGCGCTGCA
TCATGCTGGACGATATGTGCGACAGTGGCGGCACGCTGGCGAACGCCGCCGCCGCGCTGAAGGAGCATGGCGCAAGTTCG
GTTTCAGCCTATGTGACGCATGGGGTGCTGTCGGGCTCAGCCGTGGAGCGGATCGAGAAATCGGTGCTCGACGAGCTGGT
GATGACCGACACGATCCAGCCGTCTGAACATGCGCTGAAATCGAAGAATATCCGCGTGCTTCCGATCTCTCCCCTGCTGG
GCGAAGCGATCCGCCGGATTGCCAATGAAGAGAGCGTGTCGAAGCTGTTTGACCGCTAG

Upstream 100 bases:

>100_bases
GGCCTGATCTGCTGCGGATTCCAGAATCCTGTGGCTTGCGACTCGCGGCTGCCTGTTACAAAAGCGTCGCGAACCCGGCC
GGCCAGAAGAGAGCGACCCC

Downstream 100 bases:

>100_bases
GCAGCCCCGAACACGCGAAAACAAAAAACCCGCGAGATGGCTCGCGGGTTTTTTTGTGACGTTTTCTTCTGGATTAGGAA
GCTACTCGACCGTCCAGCCG

Product: ribose-phosphate pyrophosphokinase

Products: NA

Alternate protein names: RPPK; Phosphoribosyl pyrophosphate synthase; P-Rib-PP synthase; PRPP synthase

Number of amino acids: Translated: 312; Mature: 312

Protein sequence:

>312_residues
MKLISCNANRPLSDAIADYLDMRLTRSEVKTFADQEIFVRIDENVRGEDVFVIQSTSYPANDNLMQLLIMMDALRRASAR
RITAVIPYFGYARQDRKTDGRTPISAKLVANLISTAGADRVLTVDLHAGQIQGFFDIPTDNLFGGPVMVDDIKERYGKEK
IIVVSPDVGGVVRARSLAKRLDDADLAIVDKRRPEAGKSEVMNIIGDVRGARCIMLDDMCDSGGTLANAAAALKEHGASS
VSAYVTHGVLSGSAVERIEKSVLDELVMTDTIQPSEHALKSKNIRVLPISPLLGEAIRRIANEESVSKLFDR

Sequences:

>Translated_312_residues
MKLISCNANRPLSDAIADYLDMRLTRSEVKTFADQEIFVRIDENVRGEDVFVIQSTSYPANDNLMQLLIMMDALRRASAR
RITAVIPYFGYARQDRKTDGRTPISAKLVANLISTAGADRVLTVDLHAGQIQGFFDIPTDNLFGGPVMVDDIKERYGKEK
IIVVSPDVGGVVRARSLAKRLDDADLAIVDKRRPEAGKSEVMNIIGDVRGARCIMLDDMCDSGGTLANAAAALKEHGASS
VSAYVTHGVLSGSAVERIEKSVLDELVMTDTIQPSEHALKSKNIRVLPISPLLGEAIRRIANEESVSKLFDR
>Mature_312_residues
MKLISCNANRPLSDAIADYLDMRLTRSEVKTFADQEIFVRIDENVRGEDVFVIQSTSYPANDNLMQLLIMMDALRRASAR
RITAVIPYFGYARQDRKTDGRTPISAKLVANLISTAGADRVLTVDLHAGQIQGFFDIPTDNLFGGPVMVDDIKERYGKEK
IIVVSPDVGGVVRARSLAKRLDDADLAIVDKRRPEAGKSEVMNIIGDVRGARCIMLDDMCDSGGTLANAAAALKEHGASS
VSAYVTHGVLSGSAVERIEKSVLDELVMTDTIQPSEHALKSKNIRVLPISPLLGEAIRRIANEESVSKLFDR

Specific function: Utilized by both the de novo and the salvage pathways by which endogenously formed or exogenously added pyrimidine, purine, or pyridine bases are converted to the corresponding ribonucleoside monophosphates. [C]

COG id: COG0462

COG function: function code FE; Phosphoribosylpyrophosphate synthetase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ribose-phosphate pyrophosphokinase family

Homologues:

Organism=Homo sapiens, GI4506127, Length=314, Percent_Identity=48.0891719745223, Blast_Score=283, Evalue=1e-76,
Organism=Homo sapiens, GI4506129, Length=312, Percent_Identity=48.3974358974359, Blast_Score=282, Evalue=2e-76,
Organism=Homo sapiens, GI28557709, Length=313, Percent_Identity=47.6038338658147, Blast_Score=281, Evalue=4e-76,
Organism=Homo sapiens, GI84875539, Length=315, Percent_Identity=47.9365079365079, Blast_Score=278, Evalue=4e-75,
Organism=Homo sapiens, GI4506133, Length=344, Percent_Identity=37.7906976744186, Blast_Score=184, Evalue=1e-46,
Organism=Homo sapiens, GI194018537, Length=338, Percent_Identity=36.094674556213, Blast_Score=171, Evalue=6e-43,
Organism=Homo sapiens, GI310128524, Length=138, Percent_Identity=32.6086956521739, Blast_Score=77, Evalue=2e-14,
Organism=Homo sapiens, GI310115209, Length=138, Percent_Identity=32.6086956521739, Blast_Score=77, Evalue=2e-14,
Organism=Homo sapiens, GI310118259, Length=138, Percent_Identity=32.6086956521739, Blast_Score=77, Evalue=2e-14,
Organism=Homo sapiens, GI310119946, Length=138, Percent_Identity=32.6086956521739, Blast_Score=77, Evalue=2e-14,
Organism=Escherichia coli, GI1787458, Length=313, Percent_Identity=56.8690095846645, Blast_Score=355, Evalue=2e-99,
Organism=Caenorhabditis elegans, GI25149168, Length=313, Percent_Identity=46.3258785942492, Blast_Score=278, Evalue=2e-75,
Organism=Caenorhabditis elegans, GI17554702, Length=313, Percent_Identity=46.3258785942492, Blast_Score=278, Evalue=2e-75,
Organism=Caenorhabditis elegans, GI71989924, Length=313, Percent_Identity=46.3258785942492, Blast_Score=277, Evalue=6e-75,
Organism=Caenorhabditis elegans, GI17554704, Length=302, Percent_Identity=47.3509933774834, Blast_Score=276, Evalue=8e-75,
Organism=Caenorhabditis elegans, GI17570245, Length=337, Percent_Identity=32.0474777448071, Blast_Score=177, Evalue=7e-45,
Organism=Saccharomyces cerevisiae, GI6321776, Length=311, Percent_Identity=48.2315112540193, Blast_Score=274, Evalue=1e-74,
Organism=Saccharomyces cerevisiae, GI6320946, Length=312, Percent_Identity=46.1538461538462, Blast_Score=265, Evalue=7e-72,
Organism=Saccharomyces cerevisiae, GI6319403, Length=313, Percent_Identity=46.0063897763578, Blast_Score=258, Evalue=1e-69,
Organism=Saccharomyces cerevisiae, GI6322667, Length=195, Percent_Identity=42.5641025641026, Blast_Score=146, Evalue=5e-36,
Organism=Saccharomyces cerevisiae, GI6324511, Length=112, Percent_Identity=42.8571428571429, Blast_Score=96, Evalue=1e-20,
Organism=Drosophila melanogaster, GI21355239, Length=311, Percent_Identity=46.9453376205788, Blast_Score=275, Evalue=3e-74,
Organism=Drosophila melanogaster, GI45551540, Length=334, Percent_Identity=43.7125748502994, Blast_Score=262, Evalue=3e-70,
Organism=Drosophila melanogaster, GI24651458, Length=354, Percent_Identity=33.8983050847458, Blast_Score=187, Evalue=6e-48,
Organism=Drosophila melanogaster, GI24651456, Length=354, Percent_Identity=33.8983050847458, Blast_Score=187, Evalue=6e-48,
Organism=Drosophila melanogaster, GI281362873, Length=354, Percent_Identity=33.8983050847458, Blast_Score=187, Evalue=8e-48,
Organism=Drosophila melanogaster, GI24651454, Length=354, Percent_Identity=33.8983050847458, Blast_Score=187, Evalue=8e-48,
Organism=Drosophila melanogaster, GI24651462, Length=372, Percent_Identity=31.989247311828, Blast_Score=175, Evalue=3e-44,
Organism=Drosophila melanogaster, GI24651464, Length=372, Percent_Identity=31.989247311828, Blast_Score=175, Evalue=3e-44,
Organism=Drosophila melanogaster, GI45552010, Length=372, Percent_Identity=31.989247311828, Blast_Score=175, Evalue=3e-44,

Paralogues:

None

Copy number: 160 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): KPRS_HYPNA (Q0C5A1)

Other databases:

- EMBL:   CP000158
- RefSeq:   YP_759092.1
- ProteinModelPortal:   Q0C5A1
- SMR:   Q0C5A1
- STRING:   Q0C5A1
- GeneID:   4289124
- GenomeReviews:   CP000158_GR
- KEGG:   hne:HNE_0362
- NMPDR:   fig|228405.5.peg.356
- TIGR:   HNE_0362
- eggNOG:   COG0462
- HOGENOM:   HBG519284
- OMA:   CATHAVF
- PhylomeDB:   Q0C5A1
- BioCyc:   HNEP81032:HNE_0362-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00583_B
- InterPro:   IPR000842
- InterPro:   IPR005946
- InterPro:   IPR000836
- TIGRFAMs:   TIGR01251

Pfam domain/function: PF00156 Pribosyltran

EC number: =2.7.6.1

Molecular weight: Translated: 34131; Mature: 34131

Theoretical pI: Translated: 6.17; Mature: 6.17

Prosite motif: PS00114 PRPP_SYNTHASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKLISCNANRPLSDAIADYLDMRLTRSEVKTFADQEIFVRIDENVRGEDVFVIQSTSYPA
CEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCCEEEEEECCCCCC
NDNLMQLLIMMDALRRASARRITAVIPYFGYARQDRKTDGRTPISAKLVANLISTAGADR
CHHHHHHHHHHHHHHHHHHHHEEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCE
VLTVDLHAGQIQGFFDIPTDNLFGGPVMVDDIKERYGKEKIIVVSPDVGGVVRARSLAKR
EEEEEECCCCCCEEEECCCCCCCCCCEEHHHHHHHHCCCEEEEECCCCCHHHHHHHHHHH
LDDADLAIVDKRRPEAGKSEVMNIIGDVRGARCIMLDDMCDSGGTLANAAAALKEHGASS
CCCCCEEEEECCCCCCCHHHHHHHHHHCCCCEEEEEECCCCCCCCHHHHHHHHHHCCCCH
VSAYVTHGVLSGSAVERIEKSVLDELVMTDTIQPSEHALKSKNIRVLPISPLLGEAIRRI
HHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHCCCEEEEECCHHHHHHHHHH
ANEESVSKLFDR
HCHHHHHHHHCC
>Mature Secondary Structure
MKLISCNANRPLSDAIADYLDMRLTRSEVKTFADQEIFVRIDENVRGEDVFVIQSTSYPA
CEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCCEEEEEECCCCCC
NDNLMQLLIMMDALRRASARRITAVIPYFGYARQDRKTDGRTPISAKLVANLISTAGADR
CHHHHHHHHHHHHHHHHHHHHEEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCE
VLTVDLHAGQIQGFFDIPTDNLFGGPVMVDDIKERYGKEKIIVVSPDVGGVVRARSLAKR
EEEEEECCCCCCEEEECCCCCCCCCCEEHHHHHHHHCCCEEEEECCCCCHHHHHHHHHHH
LDDADLAIVDKRRPEAGKSEVMNIIGDVRGARCIMLDDMCDSGGTLANAAAALKEHGASS
CCCCCEEEEECCCCCCCHHHHHHHHHHCCCCEEEEEECCCCCCCCHHHHHHHHHHCCCCH
VSAYVTHGVLSGSAVERIEKSVLDELVMTDTIQPSEHALKSKNIRVLPISPLLGEAIRRI
HHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHCCCEEEEECCHHHHHHHHHH
ANEESVSKLFDR
HCHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA