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The map label for this gene is mutY [H]

Identifier: 114799676

GI number: 114799676

Start: 1984197

End: 1985240

Strand: Reverse

Name: mutY [H]

Synonym: HNE_1914

Alternate gene names: 114799676

Gene position: 1985240-1984197 (Counterclockwise)

Preceding gene: 114797116

Following gene: 114798144

Centisome position: 53.58

GC content: 65.13

Gene sequence:

>1044_bases
ATGACCCGCCGTTCAGATTTCCGTGAACTTGCTGCGATCCTTCTCGCCTGGTTCGACCAGAATGCGCGTGTGCTGCCCTG
GCGGGCACCCATCGGCACGAAACGAGACCCCTACAGGGTGTGGCTGGCCGAGATCATGTTGCAGCAAACGACTGTGCCCC
ATGCGGCGCCGTATTTCGAGGCGTTTACGCGCCGATGGCCCACAGTGGAGGATCTGGCCGCGGCGCAGGACGAGGAAGTC
ATGCGGGCCTGGGCGGGCTTGGGATATTATGCGCGGGCGCGCAACCTTCTGAAATGCGCGCGGGAGGTGGCGGCGCGCGG
CGGATTTCCGGAAACCTCTGCCGGTCTGCGGGAGCTGCCCGGCATTGGCCCCTACACGGCAGGCGCCATAGCAGCGATTG
CATTCGGAGAGCGCGCGGCAGCCGTTGACGGGAATGTTGACCGCGTGTTTGCACGTCTGCTTGCCTTGAAGGGAGAGTGG
GCGGCGGAAAAGAAGCGCATTGCTGCCGAGGTTGCCGCGCTGGTGCCCGAGGAGCGGCCGGGCGACTTTGCCGAAGCGCT
GATGGACCTTGGCGCAACGATCTGTACACCCACTTCACCCAACTGCATGATCTGTCCCCTGACGGGGCTGTGTAAAGCGC
GGGCAGAAGGGCGTCCGGCCGAGTATCCGGTCAAGCCGGCCAAGACCGCCAAGCCGGTGCGTCACGGTCATGCCTGGGTT
TATGTGAAGAAAGACAAGGTGTGGCTGGTGCGGCGGCCTCCGGAAGGATTGCTTGGCGGAATGCTCGCGCTGCCATCGGG
CGTCTGGAAAGAGGGCGCGGCCCAGGAGCCGGCGCCGCCTTCGGATGCAGACTGGCAGCCGGCGGGCGAGGTGCGTCACG
TCTTTACGCATTTCACCTTGAGGCTGGCTGTTTGGCGGGCCAACGTTTCCAACAGCCCTGCGGGCGAGGGGACATGGGCT
GATCCTTCAGAGGAGACCGGATTGCCGACTGTGTTCGCCAAGGCGCTGGCCCTGGCGACGGGCGGAACGGTCAGGCGCCG
GTAA

Upstream 100 bases:

>100_bases
GCTTCACCTGCGCGCGCGCTTCTGCGATGGGATCGAGGCTCGTAAACTGGACCATGGGCGCTACATTGCCCGGCTTCGCG
CCCAAGGGAAAGTTATACGC

Downstream 100 bases:

>100_bases
AGGCGGCAATCTGAACGAAGGCGGCCATGTTGATGGCAACGCTCATCCAGAACAGTGTACGGAAGGCGGGCTTTTTCGTC
TTGTGACGGAAAAACTCCTG

Product: A/G-specific adenine glycosylase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 347; Mature: 346

Protein sequence:

>347_residues
MTRRSDFRELAAILLAWFDQNARVLPWRAPIGTKRDPYRVWLAEIMLQQTTVPHAAPYFEAFTRRWPTVEDLAAAQDEEV
MRAWAGLGYYARARNLLKCAREVAARGGFPETSAGLRELPGIGPYTAGAIAAIAFGERAAAVDGNVDRVFARLLALKGEW
AAEKKRIAAEVAALVPEERPGDFAEALMDLGATICTPTSPNCMICPLTGLCKARAEGRPAEYPVKPAKTAKPVRHGHAWV
YVKKDKVWLVRRPPEGLLGGMLALPSGVWKEGAAQEPAPPSDADWQPAGEVRHVFTHFTLRLAVWRANVSNSPAGEGTWA
DPSEETGLPTVFAKALALATGGTVRRR

Sequences:

>Translated_347_residues
MTRRSDFRELAAILLAWFDQNARVLPWRAPIGTKRDPYRVWLAEIMLQQTTVPHAAPYFEAFTRRWPTVEDLAAAQDEEV
MRAWAGLGYYARARNLLKCAREVAARGGFPETSAGLRELPGIGPYTAGAIAAIAFGERAAAVDGNVDRVFARLLALKGEW
AAEKKRIAAEVAALVPEERPGDFAEALMDLGATICTPTSPNCMICPLTGLCKARAEGRPAEYPVKPAKTAKPVRHGHAWV
YVKKDKVWLVRRPPEGLLGGMLALPSGVWKEGAAQEPAPPSDADWQPAGEVRHVFTHFTLRLAVWRANVSNSPAGEGTWA
DPSEETGLPTVFAKALALATGGTVRRR
>Mature_346_residues
TRRSDFRELAAILLAWFDQNARVLPWRAPIGTKRDPYRVWLAEIMLQQTTVPHAAPYFEAFTRRWPTVEDLAAAQDEEVM
RAWAGLGYYARARNLLKCAREVAARGGFPETSAGLRELPGIGPYTAGAIAAIAFGERAAAVDGNVDRVFARLLALKGEWA
AEKKRIAAEVAALVPEERPGDFAEALMDLGATICTPTSPNCMICPLTGLCKARAEGRPAEYPVKPAKTAKPVRHGHAWVY
VKKDKVWLVRRPPEGLLGGMLALPSGVWKEGAAQEPAPPSDADWQPAGEVRHVFTHFTLRLAVWRANVSNSPAGEGTWAD
PSEETGLPTVFAKALALATGGTVRRR

Specific function: Involved in the GO system responsible for removing an oxidatively damaged form of guanine (7,8-dihydro-8-oxoguanine, 8- oxo-dGTP) from DNA and the nucleotide pool. 8-oxo-dGTP is inserted opposite dA and dC residues of template DNA with almost equal effici

COG id: COG1194

COG function: function code L; A/G-specific DNA glycosylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HhH domain [H]

Homologues:

Organism=Homo sapiens, GI115298650, Length=372, Percent_Identity=34.9462365591398, Blast_Score=193, Evalue=2e-49,
Organism=Homo sapiens, GI115298654, Length=372, Percent_Identity=34.9462365591398, Blast_Score=193, Evalue=2e-49,
Organism=Homo sapiens, GI115298652, Length=372, Percent_Identity=34.9462365591398, Blast_Score=193, Evalue=2e-49,
Organism=Homo sapiens, GI115298648, Length=372, Percent_Identity=34.9462365591398, Blast_Score=193, Evalue=2e-49,
Organism=Homo sapiens, GI6912520, Length=372, Percent_Identity=34.9462365591398, Blast_Score=193, Evalue=2e-49,
Organism=Homo sapiens, GI190358497, Length=372, Percent_Identity=34.9462365591398, Blast_Score=193, Evalue=3e-49,
Organism=Escherichia coli, GI1789331, Length=306, Percent_Identity=42.156862745098, Blast_Score=215, Evalue=3e-57,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011257
- InterPro:   IPR003651
- InterPro:   IPR003265
- InterPro:   IPR023170
- InterPro:   IPR005760
- InterPro:   IPR000086
- InterPro:   IPR015797 [H]

Pfam domain/function: PF00730 HhH-GPD [H]

EC number: 3.2.2.20

Molecular weight: Translated: 37838; Mature: 37707

Theoretical pI: Translated: 9.40; Mature: 9.40

Prosite motif: PS01155 ENDONUCLEASE_III_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTRRSDFRELAAILLAWFDQNARVLPWRAPIGTKRDPYRVWLAEIMLQQTTVPHAAPYFE
CCCHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCHHHHHHHHHHHHHCCCCCCCHHHH
AFTRRWPTVEDLAAAQDEEVMRAWAGLGYYARARNLLKCAREVAARGGFPETSAGLRELP
HHHHCCCCHHHHHHCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHCC
GIGPYTAGAIAAIAFGERAAAVDGNVDRVFARLLALKGEWAAEKKRIAAEVAALVPEERP
CCCCHHHHHHHHHHHCCCHHCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCC
GDFAEALMDLGATICTPTSPNCMICPLTGLCKARAEGRPAEYPVKPAKTAKPVRHGHAWV
CHHHHHHHHCCCEEECCCCCCEEEECCHHHHHHHCCCCCCCCCCCCCCCCCHHHCCCEEE
YVKKDKVWLVRRPPEGLLGGMLALPSGVWKEGAAQEPAPPSDADWQPAGEVRHVFTHFTL
EEECCCEEEEECCCHHHHHHHHHCCCCHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHH
RLAVWRANVSNSPAGEGTWADPSEETGLPTVFAKALALATGGTVRRR
HHHHEECCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure 
TRRSDFRELAAILLAWFDQNARVLPWRAPIGTKRDPYRVWLAEIMLQQTTVPHAAPYFE
CCHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCHHHHHHHHHHHHHCCCCCCCHHHH
AFTRRWPTVEDLAAAQDEEVMRAWAGLGYYARARNLLKCAREVAARGGFPETSAGLRELP
HHHHCCCCHHHHHHCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHCC
GIGPYTAGAIAAIAFGERAAAVDGNVDRVFARLLALKGEWAAEKKRIAAEVAALVPEERP
CCCCHHHHHHHHHHHCCCHHCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCC
GDFAEALMDLGATICTPTSPNCMICPLTGLCKARAEGRPAEYPVKPAKTAKPVRHGHAWV
CHHHHHHHHCCCEEECCCCCCEEEECCHHHHHHHCCCCCCCCCCCCCCCCCHHHCCCEEE
YVKKDKVWLVRRPPEGLLGGMLALPSGVWKEGAAQEPAPPSDADWQPAGEVRHVFTHFTL
EEECCCEEEEECCCHHHHHHHHHCCCCHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHH
RLAVWRANVSNSPAGEGTWADPSEETGLPTVFAKALALATGGTVRRR
HHHHEECCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8946165; 9384377 [H]