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The map label for this gene is rnz [H]

Identifier: 114799524

GI number: 114799524

Start: 1324475

End: 1325563

Strand: Reverse

Name: rnz [H]

Synonym: HNE_1292

Alternate gene names: 114799524

Gene position: 1325563-1324475 (Counterclockwise)

Preceding gene: 114799130

Following gene: 114799228

Centisome position: 35.78

GC content: 67.95

Gene sequence:

>1089_bases
ATGAAACTGTGGCATTGGGGGCTGATTGCGCTCGCACTCATCGCGCTGGCGCTCGTCGCCGCGCGCCAGGTCTTCGCCGT
CCAGATCGGTGAGGCCGCCTTCAAGCGCGCCGTTGCCGAAAATGTCGGGCGCGACCCCTCCGCCGACCTGCCCGACGGGC
TCCACCTCTATGTCTGCGGCAGCGGCTCGCCCCTGCCGGACGCTGCCCGCGCGGGCCCCTGCATCGGCGTGCTCGCCGGG
GATCGCGCCTTCATCTTTGATGTCGGCGCGGGCTCCATCCGCCGCCTCACGCGCATGGGCTTCCCCACAGGGCGCACTGA
AAAGCTCTATCTCAGCCATCTGCACTCGGACCATTTTGACGGCATCGGTGAGCTGATGATCGGCGCCTGGGTCGGCGGCA
GCCGGTCTGCGCCCCTGCCCGTCGCCGGGCCTGAAGGCGTCGCCGAAGTCATGAACGGTTTCAACGCCGCCTATCGCATC
GACTCCACCTACCGCATGGCCCATCACGGCCCCGGCGTGGCCAATCCCGACGGCTATGGCCTTGCGCCCGAGGTGATCGA
TCTGCCCGCCGGCCCCGGCAGCCGCGCCGTGCTGCTGGACGAGGGCGATCTCCTCATCACCGCCTTCCTGGTCAACCACT
CCCCCATCGAGCCTGCCTACGGCTTCCGCATCGACTATAAAGGCCGCTCCGCCGTCATCAGCGGCGACACCGTCTATTCG
GAAAACCTCGTCGCTGTGTCCGAGGGCGCCGACATCCTCTTCCACGAGGCGCTCCACCCCGAAATGGTCGCCGCCATGTC
GTCCGCCGCCGCAGAGGCAGGCGCCGCGCCGCTCTCGAAGGTCTTCTCCGACATTCTGAACTACCACGCCTCCCCGGTAG
AGGCCGCCCGCGCCGCCCAATCCGCCGGGGCCGGGCGTCTGGTACTCTACCACACGGTCCCCCCGCTGCCGTCGAAACTC
CTCTACCCCTATTTCCTGGACGGCACCGGCGAGGCGTTTTCCGGGCCGGTCGATATTGCCGAAGATGGCCAGCTCTATTC
CCTCCCGGTCAGCGGCGGCGCGCCAAAGCCGAAGAATGCCCTCAACTGA

Upstream 100 bases:

>100_bases
GCCAGACGAACACCTCCGGCAAGCCCACCCCGCAAAAACAATTGACACGACCCACGCCAAATGATCCACTCCCCCCAACA
AACAGGCTGGGGAGGCACGC

Downstream 100 bases:

>100_bases
CCCCCGCAGGATAAGCGGCCCGCGCGTGTCCGGTTTTGTCCGGATTTGTCCCGAACTGTCCTCAAATTGACACGGAATGT
GTGAGATAGAGGCAGGATCA

Product: ribonuclease Z

Products: NA

Alternate protein names: RNase Z; tRNA 3 endonuclease; tRNase Z [H]

Number of amino acids: Translated: 362; Mature: 362

Protein sequence:

>362_residues
MKLWHWGLIALALIALALVAARQVFAVQIGEAAFKRAVAENVGRDPSADLPDGLHLYVCGSGSPLPDAARAGPCIGVLAG
DRAFIFDVGAGSIRRLTRMGFPTGRTEKLYLSHLHSDHFDGIGELMIGAWVGGSRSAPLPVAGPEGVAEVMNGFNAAYRI
DSTYRMAHHGPGVANPDGYGLAPEVIDLPAGPGSRAVLLDEGDLLITAFLVNHSPIEPAYGFRIDYKGRSAVISGDTVYS
ENLVAVSEGADILFHEALHPEMVAAMSSAAAEAGAAPLSKVFSDILNYHASPVEAARAAQSAGAGRLVLYHTVPPLPSKL
LYPYFLDGTGEAFSGPVDIAEDGQLYSLPVSGGAPKPKNALN

Sequences:

>Translated_362_residues
MKLWHWGLIALALIALALVAARQVFAVQIGEAAFKRAVAENVGRDPSADLPDGLHLYVCGSGSPLPDAARAGPCIGVLAG
DRAFIFDVGAGSIRRLTRMGFPTGRTEKLYLSHLHSDHFDGIGELMIGAWVGGSRSAPLPVAGPEGVAEVMNGFNAAYRI
DSTYRMAHHGPGVANPDGYGLAPEVIDLPAGPGSRAVLLDEGDLLITAFLVNHSPIEPAYGFRIDYKGRSAVISGDTVYS
ENLVAVSEGADILFHEALHPEMVAAMSSAAAEAGAAPLSKVFSDILNYHASPVEAARAAQSAGAGRLVLYHTVPPLPSKL
LYPYFLDGTGEAFSGPVDIAEDGQLYSLPVSGGAPKPKNALN
>Mature_362_residues
MKLWHWGLIALALIALALVAARQVFAVQIGEAAFKRAVAENVGRDPSADLPDGLHLYVCGSGSPLPDAARAGPCIGVLAG
DRAFIFDVGAGSIRRLTRMGFPTGRTEKLYLSHLHSDHFDGIGELMIGAWVGGSRSAPLPVAGPEGVAEVMNGFNAAYRI
DSTYRMAHHGPGVANPDGYGLAPEVIDLPAGPGSRAVLLDEGDLLITAFLVNHSPIEPAYGFRIDYKGRSAVISGDTVYS
ENLVAVSEGADILFHEALHPEMVAAMSSAAAEAGAAPLSKVFSDILNYHASPVEAARAAQSAGAGRLVLYHTVPPLPSKL
LYPYFLDGTGEAFSGPVDIAEDGQLYSLPVSGGAPKPKNALN

Specific function: Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA [H]

COG id: COG1234

COG function: function code R; Metal-dependent hydrolases of the beta-lactamase superfamily III

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the RNase Z family [H]

Homologues:

Organism=Escherichia coli, GI87082078, Length=278, Percent_Identity=24.4604316546763, Blast_Score=64, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001279
- InterPro:   IPR013471 [H]

Pfam domain/function: PF00753 Lactamase_B [H]

EC number: =3.1.26.11 [H]

Molecular weight: Translated: 37784; Mature: 37784

Theoretical pI: Translated: 5.51; Mature: 5.51

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKLWHWGLIALALIALALVAARQVFAVQIGEAAFKRAVAENVGRDPSADLPDGLHLYVCG
CCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEEEC
SGSPLPDAARAGPCIGVLAGDRAFIFDVGAGSIRRLTRMGFPTGRTEKLYLSHLHSDHFD
CCCCCCCHHHCCCEEEEEECCEEEEEECCCCHHHHHHHHCCCCCCCHHHHHHHHCCCCCC
GIGELMIGAWVGGSRSAPLPVAGPEGVAEVMNGFNAAYRIDSTYRMAHHGPGVANPDGYG
CHHHHHEEEECCCCCCCCCCCCCCHHHHHHHHCCCCEEEECCEEEEHHCCCCCCCCCCCC
LAPEVIDLPAGPGSRAVLLDEGDLLITAFLVNHSPIEPAYGFRIDYKGRSAVISGDTVYS
CCCHHEECCCCCCCCEEEEECCCEEEEEEEECCCCCCCCCCEEEEECCCEEEEECCEEEC
ENLVAVSEGADILFHEALHPEMVAAMSSAAAEAGAAPLSKVFSDILNYHASPVEAARAAQ
CCEEEEECCCCEEEHHHCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCHHHHHHHHH
SAGAGRLVLYHTVPPLPSKLLYPYFLDGTGEAFSGPVDIAEDGQLYSLPVSGGAPKPKNA
HCCCCEEEEEECCCCCCCHHCCEEEECCCCCCCCCCCCCCCCCCEEEEECCCCCCCCCCC
LN
CC
>Mature Secondary Structure
MKLWHWGLIALALIALALVAARQVFAVQIGEAAFKRAVAENVGRDPSADLPDGLHLYVCG
CCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEEEC
SGSPLPDAARAGPCIGVLAGDRAFIFDVGAGSIRRLTRMGFPTGRTEKLYLSHLHSDHFD
CCCCCCCHHHCCCEEEEEECCEEEEEECCCCHHHHHHHHCCCCCCCHHHHHHHHCCCCCC
GIGELMIGAWVGGSRSAPLPVAGPEGVAEVMNGFNAAYRIDSTYRMAHHGPGVANPDGYG
CHHHHHEEEECCCCCCCCCCCCCCHHHHHHHHCCCCEEEECCEEEEHHCCCCCCCCCCCC
LAPEVIDLPAGPGSRAVLLDEGDLLITAFLVNHSPIEPAYGFRIDYKGRSAVISGDTVYS
CCCHHEECCCCCCCCEEEEECCCEEEEEEEECCCCCCCCCCEEEEECCCEEEEECCEEEC
ENLVAVSEGADILFHEALHPEMVAAMSSAAAEAGAAPLSKVFSDILNYHASPVEAARAAQ
CCEEEEECCCCEEEHHHCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCHHHHHHHHH
SAGAGRLVLYHTVPPLPSKLLYPYFLDGTGEAFSGPVDIAEDGQLYSLPVSGGAPKPKNA
HCCCCEEEEEECCCCCCCHHCCEEEECCCCCCCCCCCCCCCCCCEEEEECCCCCCCCCCC
LN
CC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12788972 [H]