Click here to switch to the map view.

The map label for this gene is atpA

Identifier: 114799519

GI number: 114799519

Start: 1960367

End: 1961902

Strand: Reverse

Name: atpA

Synonym: HNE_1894

Alternate gene names: 114799519

Gene position: 1961902-1960367 (Counterclockwise)

Preceding gene: 114798041

Following gene: 114800497

Centisome position: 52.95

GC content: 59.38

Gene sequence:

>1536_bases
ATGGACATTTCACCTGCAGAAATTTCGGGCATCCTGAAGTCCCAGATCGAGAATTTCGGCGTCGAAGCTGAAGTCTCGGA
TGTTGGCCAGGTGCTTTCCGTCGGCGACGGTATCGCTCGTGTCTACGGCCTCGACAGCGTGCAGGCTGGCGAACTCGTTG
AGTTCAACGGCGGCATCAAGGGCATGGCCCTGAACCTCGAGAAAGATAACGTCGGCGTCGTGATCTTCGGCGAAGACCGC
AGCATCAAAGAGGGCGACACCGTCAAGCGGACCTCCGAGATCGTTGCTGCGCCGGTTGGTAAAGCGCTTCTCGGCCGCGT
CGTGAACGCGCTGGGCGAGCCGATCGACGGCAAGGGCCCCCTGAAAGATGTTGCTGCGCGCTCGCAGGTCGACGTCAAGG
CGCCAGGCATCATCCCGCGTAAATCGGTTCATGAGCCGATGATGACGGGCATCAAGGCCATCGACGGCATGATCCCCGTT
GGCCGTGGCCAGCGCGAGCTGATCATCGGTGACCGTCAGACCGGCAAGACCGCTATCTGCATCGACACCATCCTGAACCA
GAAGCCGACCAATGACGCGGCCAAGTCCGACAAGGACAAGCTGTTCTGCGTCTATGTCGCTATCGGCCAGAAGCGCTCCA
CTGTGGCGCAGGTTGTGAAGGTGCTCGAGGAGCGCGGCGCGCTGGATTACACGATTGTTGTTTCGGCAACGGCTTCGGAA
TCGGCTCCGCTTCAGTATCTCGCACCCTTCACCGGTTGCACCATGGGCGAGTGGTTCCGTGACAACGGTATGCACGCCCT
CATCATTTATGATGACCTTTCCAAGCAGGCCGTTGCTTATCGTCAGATGTCCCTGCTGCTCCGCCGCCCACCAGGCCGCG
AAGCCTATCCGGGCGACGTGTTCTATCTCCACTCGCGCCTCCTTGAGCGCGCTGCGAAGCTGAACGACGACAATGGTAAC
GGCTCGCTGACGGCTCTGCCGGTTATCGAAACCCAGGCAAACGACGTTTCGGCCTACATCCCGACGAACGTGATCTCGAT
CACCGACGGTCAGATCTTCCTTGAAACCGACCTGTTCAACTCGGGTATCCGCCCAGCTGTGAACGTCGGTCTGTCGGTCT
CCCGCGTGGGTTCGGCCGCTCAGACGAAGGCAATGAAGAAAGTTGCCGGCTCGATGAAGGGTGAACTCGCCCAGTATCGC
GAGATGGCCGCCTTTGCGAAATTCGGTTCGGACCTCGACGCTGCAACCCAGCGCCTTCTGAACCGCGGCGCGCGCCTCAC
CGAACTCCTGAAACAGCCGCAATATTCGCCGCTGCTGATGGAAGAGCAGGTCGTGATCATCTACGCCGGTACGCGTGGCT
ATCTCGACAAGGTCGCTCTCAAGGACGTGACCCGCTACGAGAAAGAACTGCTCGTGCACATGCGCGGCGCGAAGAAAGAG
CTTCTCGCCAAGCTTCGCGAGAAGAAAGAACTCACCAGCGAGATCGAAGACGAGATCAAGAAAGCGCTGGACGATTTCAC
TTCGAAATTCGCCTGA

Upstream 100 bases:

>100_bases
GCGGCATTCAGCTGCGCCTGGGCTCCAAGCTCGTGGACGCCAGCGTCGCCAAGAAACTTGAACGCATGAACACCGTGATG
AAGGGAGCATAAGAAGCTCG

Downstream 100 bases:

>100_bases
TCTGTTGACTGAACCAAGGACGGTAAAGGCCTGACATGCCCAGCTTGAAGGACCTTAAGAACCGGATCGGAAGCGTGAAA
TCCACGCAGAAGATCACCAA

Product: ATP synthase F1 subunit alpha

Products: NA

Alternate protein names: ATP synthase F1 sector subunit alpha; F-ATPase subunit alpha

Number of amino acids: Translated: 511; Mature: 511

Protein sequence:

>511_residues
MDISPAEISGILKSQIENFGVEAEVSDVGQVLSVGDGIARVYGLDSVQAGELVEFNGGIKGMALNLEKDNVGVVIFGEDR
SIKEGDTVKRTSEIVAAPVGKALLGRVVNALGEPIDGKGPLKDVAARSQVDVKAPGIIPRKSVHEPMMTGIKAIDGMIPV
GRGQRELIIGDRQTGKTAICIDTILNQKPTNDAAKSDKDKLFCVYVAIGQKRSTVAQVVKVLEERGALDYTIVVSATASE
SAPLQYLAPFTGCTMGEWFRDNGMHALIIYDDLSKQAVAYRQMSLLLRRPPGREAYPGDVFYLHSRLLERAAKLNDDNGN
GSLTALPVIETQANDVSAYIPTNVISITDGQIFLETDLFNSGIRPAVNVGLSVSRVGSAAQTKAMKKVAGSMKGELAQYR
EMAAFAKFGSDLDAATQRLLNRGARLTELLKQPQYSPLLMEEQVVIIYAGTRGYLDKVALKDVTRYEKELLVHMRGAKKE
LLAKLREKKELTSEIEDEIKKALDDFTSKFA

Sequences:

>Translated_511_residues
MDISPAEISGILKSQIENFGVEAEVSDVGQVLSVGDGIARVYGLDSVQAGELVEFNGGIKGMALNLEKDNVGVVIFGEDR
SIKEGDTVKRTSEIVAAPVGKALLGRVVNALGEPIDGKGPLKDVAARSQVDVKAPGIIPRKSVHEPMMTGIKAIDGMIPV
GRGQRELIIGDRQTGKTAICIDTILNQKPTNDAAKSDKDKLFCVYVAIGQKRSTVAQVVKVLEERGALDYTIVVSATASE
SAPLQYLAPFTGCTMGEWFRDNGMHALIIYDDLSKQAVAYRQMSLLLRRPPGREAYPGDVFYLHSRLLERAAKLNDDNGN
GSLTALPVIETQANDVSAYIPTNVISITDGQIFLETDLFNSGIRPAVNVGLSVSRVGSAAQTKAMKKVAGSMKGELAQYR
EMAAFAKFGSDLDAATQRLLNRGARLTELLKQPQYSPLLMEEQVVIIYAGTRGYLDKVALKDVTRYEKELLVHMRGAKKE
LLAKLREKKELTSEIEDEIKKALDDFTSKFA
>Mature_511_residues
MDISPAEISGILKSQIENFGVEAEVSDVGQVLSVGDGIARVYGLDSVQAGELVEFNGGIKGMALNLEKDNVGVVIFGEDR
SIKEGDTVKRTSEIVAAPVGKALLGRVVNALGEPIDGKGPLKDVAARSQVDVKAPGIIPRKSVHEPMMTGIKAIDGMIPV
GRGQRELIIGDRQTGKTAICIDTILNQKPTNDAAKSDKDKLFCVYVAIGQKRSTVAQVVKVLEERGALDYTIVVSATASE
SAPLQYLAPFTGCTMGEWFRDNGMHALIIYDDLSKQAVAYRQMSLLLRRPPGREAYPGDVFYLHSRLLERAAKLNDDNGN
GSLTALPVIETQANDVSAYIPTNVISITDGQIFLETDLFNSGIRPAVNVGLSVSRVGSAAQTKAMKKVAGSMKGELAQYR
EMAAFAKFGSDLDAATQRLLNRGARLTELLKQPQYSPLLMEEQVVIIYAGTRGYLDKVALKDVTRYEKELLVHMRGAKKE
LLAKLREKKELTSEIEDEIKKALDDFTSKFA

Specific function: Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit

COG id: COG0056

COG function: function code C; F0F1-type ATP synthase, alpha subunit

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATPase alpha/beta chains family

Homologues:

Organism=Homo sapiens, GI50345984, Length=505, Percent_Identity=68.9108910891089, Blast_Score=710, Evalue=0.0,
Organism=Homo sapiens, GI4757810, Length=505, Percent_Identity=68.9108910891089, Blast_Score=710, Evalue=0.0,
Organism=Homo sapiens, GI19913428, Length=308, Percent_Identity=29.5454545454545, Blast_Score=122, Evalue=6e-28,
Organism=Homo sapiens, GI19913426, Length=318, Percent_Identity=28.6163522012579, Blast_Score=111, Evalue=2e-24,
Organism=Homo sapiens, GI32189394, Length=420, Percent_Identity=24.2857142857143, Blast_Score=92, Evalue=9e-19,
Organism=Homo sapiens, GI19913424, Length=249, Percent_Identity=25.3012048192771, Blast_Score=68, Evalue=2e-11,
Organism=Escherichia coli, GI1790172, Length=517, Percent_Identity=56.4796905222437, Blast_Score=575, Evalue=1e-165,
Organism=Escherichia coli, GI1790170, Length=440, Percent_Identity=25.9090909090909, Blast_Score=110, Evalue=2e-25,
Organism=Escherichia coli, GI1788251, Length=320, Percent_Identity=27.5, Blast_Score=101, Evalue=1e-22,
Organism=Caenorhabditis elegans, GI71988063, Length=507, Percent_Identity=70.2169625246548, Blast_Score=732, Evalue=0.0,
Organism=Caenorhabditis elegans, GI71988080, Length=507, Percent_Identity=70.2169625246548, Blast_Score=731, Evalue=0.0,
Organism=Caenorhabditis elegans, GI71988074, Length=507, Percent_Identity=65.6804733727811, Blast_Score=671, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17570191, Length=335, Percent_Identity=27.7611940298507, Blast_Score=115, Evalue=4e-26,
Organism=Caenorhabditis elegans, GI17510931, Length=381, Percent_Identity=26.7716535433071, Blast_Score=115, Evalue=6e-26,
Organism=Caenorhabditis elegans, GI25144756, Length=418, Percent_Identity=24.6411483253589, Blast_Score=94, Evalue=2e-19,
Organism=Caenorhabditis elegans, GI71988068, Length=77, Percent_Identity=55.8441558441558, Blast_Score=90, Evalue=2e-18,
Organism=Caenorhabditis elegans, GI17509265, Length=50, Percent_Identity=72, Blast_Score=85, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI17565854, Length=261, Percent_Identity=24.904214559387, Blast_Score=65, Evalue=7e-11,
Organism=Saccharomyces cerevisiae, GI6319370, Length=506, Percent_Identity=66.798418972332, Blast_Score=705, Evalue=0.0,
Organism=Saccharomyces cerevisiae, GI6319603, Length=368, Percent_Identity=29.6195652173913, Blast_Score=132, Evalue=2e-31,
Organism=Saccharomyces cerevisiae, GI6322581, Length=419, Percent_Identity=25.5369928400955, Blast_Score=102, Evalue=2e-22,
Organism=Drosophila melanogaster, GI24658560, Length=505, Percent_Identity=68.3168316831683, Blast_Score=702, Evalue=0.0,
Organism=Drosophila melanogaster, GI281361666, Length=335, Percent_Identity=28.6567164179104, Blast_Score=121, Evalue=1e-27,
Organism=Drosophila melanogaster, GI24646341, Length=335, Percent_Identity=28.6567164179104, Blast_Score=121, Evalue=1e-27,
Organism=Drosophila melanogaster, GI17136796, Length=335, Percent_Identity=28.6567164179104, Blast_Score=121, Evalue=1e-27,
Organism=Drosophila melanogaster, GI24638766, Length=322, Percent_Identity=25.1552795031056, Blast_Score=93, Evalue=4e-19,
Organism=Drosophila melanogaster, GI28574560, Length=442, Percent_Identity=26.0180995475113, Blast_Score=92, Evalue=7e-19,
Organism=Drosophila melanogaster, GI24583992, Length=399, Percent_Identity=23.5588972431078, Blast_Score=67, Evalue=3e-11,

Paralogues:

None

Copy number: 9,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): ATPA_HYPNA (Q0C0Z8)

Other databases:

- EMBL:   CP000158
- RefSeq:   YP_760595.1
- ProteinModelPortal:   Q0C0Z8
- SMR:   Q0C0Z8
- STRING:   Q0C0Z8
- GeneID:   4288912
- GenomeReviews:   CP000158_GR
- KEGG:   hne:HNE_1894
- NMPDR:   fig|228405.5.peg.1823
- TIGR:   HNE_1894
- eggNOG:   COG0056
- HOGENOM:   HBG565875
- OMA:   GSDRDIK
- PhylomeDB:   Q0C0Z8
- BioCyc:   HNEP81032:HNE_1894-MONOMER
- HAMAP:   MF_01346
- InterPro:   IPR020003
- InterPro:   IPR000194
- InterPro:   IPR005294
- InterPro:   IPR017458
- InterPro:   IPR018118
- InterPro:   IPR000793
- InterPro:   IPR004100
- PANTHER:   PTHR15184:SF3
- TIGRFAMs:   TIGR00962

Pfam domain/function: PF00006 ATP-synt_ab; PF00306 ATP-synt_ab_C; PF02874 ATP-synt_ab_N; SSF47917 ATPase_a/b_C; SSF50615 ATPase_a/b_N

EC number: =3.6.3.14

Molecular weight: Translated: 55417; Mature: 55417

Theoretical pI: Translated: 6.56; Mature: 6.56

Prosite motif: PS00152 ATPASE_ALPHA_BETA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDISPAEISGILKSQIENFGVEAEVSDVGQVLSVGDGIARVYGLDSVQAGELVEFNGGIK
CCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCCHHHHHCCCCCCCCCEEEECCCCE
GMALNLEKDNVGVVIFGEDRSIKEGDTVKRTSEIVAAPVGKALLGRVVNALGEPIDGKGP
EEEEEEECCCEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
LKDVAARSQVDVKAPGIIPRKSVHEPMMTGIKAIDGMIPVGRGQRELIIGDRQTGKTAIC
HHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCEEEEECCCCCCEEEE
IDTILNQKPTNDAAKSDKDKLFCVYVAIGQKRSTVAQVVKVLEERGALDYTIVVSATASE
HHHHHCCCCCCCCCCCCCCCEEEEEEEECCCHHHHHHHHHHHHHCCCCEEEEEEEECCCC
SAPLQYLAPFTGCTMGEWFRDNGMHALIIYDDLSKQAVAYRQMSLLLRRPPGREAYPGDV
CCCHHHCCCCCCCCHHHHHHCCCCEEEEEEECCCHHHHHHHHHHHHHCCCCCCCCCCCHH
FYLHSRLLERAAKLNDDNGNGSLTALPVIETQANDVSAYIPTNVISITDGQIFLETDLFN
HHHHHHHHHHHHHCCCCCCCCCEEEEEEEECCCCCEEEECCCCEEEEECCEEEEEECCCC
SGIRPAVNVGLSVSRVGSAAQTKAMKKVAGSMKGELAQYREMAAFAKFGSDLDAATQRLL
CCCCHHHHCCEEHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHH
NRGARLTELLKQPQYSPLLMEEQVVIIYAGTRGYLDKVALKDVTRYEKELLVHMRGAKKE
HCCHHHHHHHHCCCCCCEEECCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCHHH
LLAKLREKKELTSEIEDEIKKALDDFTSKFA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MDISPAEISGILKSQIENFGVEAEVSDVGQVLSVGDGIARVYGLDSVQAGELVEFNGGIK
CCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCCHHHHHCCCCCCCCCEEEECCCCE
GMALNLEKDNVGVVIFGEDRSIKEGDTVKRTSEIVAAPVGKALLGRVVNALGEPIDGKGP
EEEEEEECCCEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
LKDVAARSQVDVKAPGIIPRKSVHEPMMTGIKAIDGMIPVGRGQRELIIGDRQTGKTAIC
HHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCEEEEECCCCCCEEEE
IDTILNQKPTNDAAKSDKDKLFCVYVAIGQKRSTVAQVVKVLEERGALDYTIVVSATASE
HHHHHCCCCCCCCCCCCCCCEEEEEEEECCCHHHHHHHHHHHHHCCCCEEEEEEEECCCC
SAPLQYLAPFTGCTMGEWFRDNGMHALIIYDDLSKQAVAYRQMSLLLRRPPGREAYPGDV
CCCHHHCCCCCCCCHHHHHHCCCCEEEEEEECCCHHHHHHHHHHHHHCCCCCCCCCCCHH
FYLHSRLLERAAKLNDDNGNGSLTALPVIETQANDVSAYIPTNVISITDGQIFLETDLFN
HHHHHHHHHHHHHCCCCCCCCCEEEEEEEECCCCCEEEECCCCEEEEECCEEEEEECCCC
SGIRPAVNVGLSVSRVGSAAQTKAMKKVAGSMKGELAQYREMAAFAKFGSDLDAATQRLL
CCCCHHHHCCEEHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHH
NRGARLTELLKQPQYSPLLMEEQVVIIYAGTRGYLDKVALKDVTRYEKELLVHMRGAKKE
HCCHHHHHHHHCCCCCCEEECCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCHHH
LLAKLREKKELTSEIEDEIKKALDDFTSKFA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA