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The map label for this gene is mutM [H]

Identifier: 114799193

GI number: 114799193

Start: 3435714

End: 3436607

Strand: Direct

Name: mutM [H]

Synonym: HNE_3274

Alternate gene names: 114799193

Gene position: 3435714-3436607 (Clockwise)

Preceding gene: 114800138

Following gene: 114797158

Centisome position: 92.73

GC content: 62.98

Gene sequence:

>894_bases
ATGGGAACCTATCTTACCTGCGAATGCCTTAGCGTATATGCGATAACGATGCCTGAATTACCTGAAGTCGAGACAGTTCG
CCGCGGACTTGCCCCTGTCATGGAGGGGCGGCGCATCGTCAAGCTGGAACAGCGCCGGGCGGACCTGCGGTTTTCCCTGC
CCGAGCGCTTTGCCGAGCGGCTCTCGGGCGCGCGGATCGACCGGCTCGCCCGGCAGGCGAAATTTCTCGCCGCCCACCTC
TCCACCGGGGAAGTGCTGGTGATGCATCTGGGCATGACCGGGCGGTTTACGATTGGCGGGCAGATGCCGGGGGAGTTTCA
CTATGGCGCCGGCGGGATCGCGGCGCATGACCATGTGGTGTTCCATATGGAGGGGGGCGAGACTGTCACCTACAACGACC
CCCGCCGCTTTGGCTTCATGGAGCTCTGGCCTGCCGCCACATTCCTGGCATACCCAAGGTTAATGACGATGGGGCCTGAG
CCGCTCTCAAACGGCTTTTCCCACGCCTATCTGGACGAGGCGCTGCGCGGCAAGGCAGCGCCGATCAAGGCCGCGCTGCT
GGACCAGAAGGTGATTGCGGGGCTCGGCAACATCTATGTCTGCGAAGCGCTGTTCCGCTCAGGCATCTCGCCCAAGCGGC
TGTCGAAAACCATTCCGGGCCAACGCGCTGCCCGTCTGGCCCCGGCGATCAACGCGGTGATTGCCGAAGCGATTGCGGCG
GGCGGATCGTCGATTTCAGACTTTGCCGCCACGGACGGGGCGCTCGGCTACTTCCAGCACCGGTTTGATGTATATGACCG
CGAGGGGCAGGCGTGCAAAAGCTGCGGGATGGAGATCAAGCGGATCGTGCAATCGGGGCGCTCGACGTTTTATTGCCCGA
GCTGTCAGCGTTAA

Upstream 100 bases:

>100_bases
CACCGAGCGGAAGACGCCCTTCACGCGCGCCACCTTCTCGGTTTCCGTCACATCTTCGAAGCCGAAGGAGACGATGCGTT
CTTTGCTGTCCTGACCGGTC

Downstream 100 bases:

>100_bases
CGCTCTACAGTCAGCCCCATCTTGTTCAGCGGCGCGCCAAAGCCCCCGGCCACGAGCCCAGCCAGCAAGGGCGGCGCGGG
CCAAAGGCGCAGCAGTGGCG

Product: formamidopyrimidine-DNA glycosylase

Products: NA

Alternate protein names: Fapy-DNA glycosylase; DNA-(apurinic or apyrimidinic site) lyase mutM; AP lyase mutM [H]

Number of amino acids: Translated: 297; Mature: 296

Protein sequence:

>297_residues
MGTYLTCECLSVYAITMPELPEVETVRRGLAPVMEGRRIVKLEQRRADLRFSLPERFAERLSGARIDRLARQAKFLAAHL
STGEVLVMHLGMTGRFTIGGQMPGEFHYGAGGIAAHDHVVFHMEGGETVTYNDPRRFGFMELWPAATFLAYPRLMTMGPE
PLSNGFSHAYLDEALRGKAAPIKAALLDQKVIAGLGNIYVCEALFRSGISPKRLSKTIPGQRAARLAPAINAVIAEAIAA
GGSSISDFAATDGALGYFQHRFDVYDREGQACKSCGMEIKRIVQSGRSTFYCPSCQR

Sequences:

>Translated_297_residues
MGTYLTCECLSVYAITMPELPEVETVRRGLAPVMEGRRIVKLEQRRADLRFSLPERFAERLSGARIDRLARQAKFLAAHL
STGEVLVMHLGMTGRFTIGGQMPGEFHYGAGGIAAHDHVVFHMEGGETVTYNDPRRFGFMELWPAATFLAYPRLMTMGPE
PLSNGFSHAYLDEALRGKAAPIKAALLDQKVIAGLGNIYVCEALFRSGISPKRLSKTIPGQRAARLAPAINAVIAEAIAA
GGSSISDFAATDGALGYFQHRFDVYDREGQACKSCGMEIKRIVQSGRSTFYCPSCQR
>Mature_296_residues
GTYLTCECLSVYAITMPELPEVETVRRGLAPVMEGRRIVKLEQRRADLRFSLPERFAERLSGARIDRLARQAKFLAAHLS
TGEVLVMHLGMTGRFTIGGQMPGEFHYGAGGIAAHDHVVFHMEGGETVTYNDPRRFGFMELWPAATFLAYPRLMTMGPEP
LSNGFSHAYLDEALRGKAAPIKAALLDQKVIAGLGNIYVCEALFRSGISPKRLSKTIPGQRAARLAPAINAVIAEAIAAG
GSSISDFAATDGALGYFQHRFDVYDREGQACKSCGMEIKRIVQSGRSTFYCPSCQR

Specific function: Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic/apyr

COG id: COG0266

COG function: function code L; Formamidopyrimidine-DNA glycosylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 FPG-type zinc finger [H]

Homologues:

Organism=Escherichia coli, GI1790066, Length=282, Percent_Identity=39.0070921985816, Blast_Score=194, Evalue=7e-51,
Organism=Escherichia coli, GI1786932, Length=293, Percent_Identity=24.2320819112628, Blast_Score=79, Evalue=4e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015886
- InterPro:   IPR015887
- InterPro:   IPR000191
- InterPro:   IPR012319
- InterPro:   IPR020629
- InterPro:   IPR010979
- InterPro:   IPR000214
- InterPro:   IPR010663 [H]

Pfam domain/function: PF01149 Fapy_DNA_glyco; PF06831 H2TH; PF06827 zf-FPG_IleRS [H]

EC number: =3.2.2.23; =4.2.99.18 [H]

Molecular weight: Translated: 32510; Mature: 32379

Theoretical pI: Translated: 8.84; Mature: 8.84

Prosite motif: PS01242 ZF_FPG_1 ; PS51066 ZF_FPG_2 ; PS51068 FPG_CAT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.4 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
6.1 %Cys+Met (Translated Protein)
2.4 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
5.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGTYLTCECLSVYAITMPELPEVETVRRGLAPVMEGRRIVKLEQRRADLRFSLPERFAER
CCCEEEEHHHHEEEECCCCCCCHHHHHHHHHHHHCCCCEEEEHHHHHCCCCCCHHHHHHH
LSGARIDRLARQAKFLAAHLSTGEVLVMHLGMTGRFTIGGQMPGEFHYGAGGIAAHDHVV
HCCHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCEEEECCCCCCCEECCCCCCEECCEEE
FHMEGGETVTYNDPRRFGFMELWPAATFLAYPRLMTMGPEPLSNGFSHAYLDEALRGKAA
EEECCCCEEEECCCCCCCHHHHHHHHHHHHHHHHHHCCCCHHHCCCHHHHHHHHHCCCCC
PIKAALLDQKVIAGLGNIYVCEALFRSGISPKRLSKTIPGQRAARLAPAINAVIAEAIAA
CHHHHHHHHHHHHHCCHHHHHHHHHHCCCCHHHHHHCCCCHHHHHHHHHHHHHHHHHHHC
GGSSISDFAATDGALGYFQHRFDVYDREGQACKSCGMEIKRIVQSGRSTFYCPSCQR
CCCCCHHHHHCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCCEECCCCCCC
>Mature Secondary Structure 
GTYLTCECLSVYAITMPELPEVETVRRGLAPVMEGRRIVKLEQRRADLRFSLPERFAER
CCEEEEHHHHEEEECCCCCCCHHHHHHHHHHHHCCCCEEEEHHHHHCCCCCCHHHHHHH
LSGARIDRLARQAKFLAAHLSTGEVLVMHLGMTGRFTIGGQMPGEFHYGAGGIAAHDHVV
HCCHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCEEEECCCCCCCEECCCCCCEECCEEE
FHMEGGETVTYNDPRRFGFMELWPAATFLAYPRLMTMGPEPLSNGFSHAYLDEALRGKAA
EEECCCCEEEECCCCCCCHHHHHHHHHHHHHHHHHHCCCCHHHCCCHHHHHHHHHCCCCC
PIKAALLDQKVIAGLGNIYVCEALFRSGISPKRLSKTIPGQRAARLAPAINAVIAEAIAA
CHHHHHHHHHHHHHCCHHHHHHHHHHCCCCHHHHHHCCCCHHHHHHHHHHHHHHHHHHHC
GGSSISDFAATDGALGYFQHRFDVYDREGQACKSCGMEIKRIVQSGRSTFYCPSCQR
CCCCCHHHHHCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCCEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA