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The map label for this gene is qor [C]

Identifier: 114799182

GI number: 114799182

Start: 1637611

End: 1638546

Strand: Reverse

Name: qor [C]

Synonym: HNE_1603

Alternate gene names: 114799182

Gene position: 1638546-1637611 (Counterclockwise)

Preceding gene: 114799460

Following gene: 114799629

Centisome position: 44.23

GC content: 66.03

Gene sequence:

>936_bases
ATGCGCGCCCTTGCCGTCGATCCTGCGACGCAATCCTCGCGCATTGTCGATCTGCCGGTGCCAGAAGCGAAGCCGGGTCA
AATCCTGGTTGAGGTGAAAGTCGCCGGGATCAACGAGATGGATGTCGAGGTCAGGGCGGGAGGCTGGGCTGCGCAGGTAA
ACCGCTTCCGGCGCGAAGGACCTGTGCTCACGGGGTTCGAATTTGCCGGCGTTGCCCGGACCTCCGGCACGCACATTCGC
GCTGGCCAGCGGGTGATGGGATACTCTCCCGTGCTGAACGGGCCGCGGGTGCATGCACAGTTTGCCGCCGTGCCGGAAAG
CGGCCTCCTGGCCATATCGGAGTCCCTGAGCGACGAATCAGCTGCGGCCCTGTGCGTCATGGGGCTGACCGCCGTGGAAG
TTCTCGAACGCCTCTGCCCGCTGGCGCCTGCGCAATCCTGCCTTGTCATCGGCGCCGCGGGCGGGTTTGGGGCCTATGCC
GTGCAGCTTGCCGCCAGCCGGGGCGTCAACGTGACCGCAGTCGCCTCGGCAGCGAACGAAAGCTGGGTGCGCGCCCAGGG
CGCACACCAGTTCAGGCCGTATGAGGCAGGCCGCGCTGTATCGCCAGGCGATGCCTTCGACCTCCTGATTGATACACCGG
CGCGCCTGTCGTTCCGCGCAGCAGCGCCCTTTCTGAGCCGCTCGGGCATGTATGTATCCAGCAATCCAACCTCCGATCTC
GCCGGTCTGGCGCGCTCCAGGTTTTCATCCCGCCGCGCCGGCTTCCTGATGATGTTGAAGACTTCCCCCTCCCGCCTCGC
GCGCCTCGTAGACCTGGCGGGAGACGGCACCCTGCGCGCTGCCATCGACAGCGTGTTCGATATTGCCGAGGCAGACAAAG
CCTTCGACCGCTTTGCAACGCGCGGGAAACAGGGCCGCGTGCTGCTCAGGATCTGA

Upstream 100 bases:

>100_bases
CGCCGCCGGAGGGATTGGTTTTTCCGGAATCCACCATCGACCCGGACAAGGCGGTCGCCCGCCTTCGGGCTTTCGGCGTC
AGCATCGAGACCCTGTCATG

Downstream 100 bases:

>100_bases
ACCGCAGGACGTCAGACAAACTCTGCTCAACCGCTCGTCGGGTGATCTGCCAGGTCAGTTCCAGATGGGTGGCCGACGGT
CCTTCCACGGAAGTTCTTTC

Product: putative oxidoreductase

Products: NADP(+); Semiquinone. [C]

Alternate protein names: Oxidoreductase; Alcohol Dehydrogenase GroES Domain Protein; Dehydrogenase; NADPHQuinone Reductase; Quinone Oxidoreductase; Alcohol Dehydrogenase GroES Domain-Containing Protein; NADPH-Quinone Reductase; Zinc-Containing Alcohol Dehydrogenase; Alcohol Dehydrogenase GroES-Like Domain Family; Zn-Dependent Oxidoreductase NADPHQuinone Reductase; Alcohol Dehydrogenase Zinc-Dependent; Zn-Dependent Oxidoreductase NADphQuinone Reductase; NADPHQuinone Reductase Related Zn-Dependent Oxidoreductase; Zinc-Containing Alcohol Dehydrogenase Superfamily Protein; NADPH2Quinone Reductase; NADPHQuinone Oxidoreductase; Zinc-Dependent Oxidoreductase; NADPHQuinone Reductase-Like Zn-Dependent Oxidoreductase; Secretion Protein HlyD; Ic Quinone-Oxidoreductase Family Protein; Zinc-Dependent Alcohol Dehydrogenase Protein; Alcohol Dehydrogenase Zinc-Containing Protein

Number of amino acids: Translated: 311; Mature: 311

Protein sequence:

>311_residues
MRALAVDPATQSSRIVDLPVPEAKPGQILVEVKVAGINEMDVEVRAGGWAAQVNRFRREGPVLTGFEFAGVARTSGTHIR
AGQRVMGYSPVLNGPRVHAQFAAVPESGLLAISESLSDESAAALCVMGLTAVEVLERLCPLAPAQSCLVIGAAGGFGAYA
VQLAASRGVNVTAVASAANESWVRAQGAHQFRPYEAGRAVSPGDAFDLLIDTPARLSFRAAAPFLSRSGMYVSSNPTSDL
AGLARSRFSSRRAGFLMMLKTSPSRLARLVDLAGDGTLRAAIDSVFDIAEADKAFDRFATRGKQGRVLLRI

Sequences:

>Translated_311_residues
MRALAVDPATQSSRIVDLPVPEAKPGQILVEVKVAGINEMDVEVRAGGWAAQVNRFRREGPVLTGFEFAGVARTSGTHIR
AGQRVMGYSPVLNGPRVHAQFAAVPESGLLAISESLSDESAAALCVMGLTAVEVLERLCPLAPAQSCLVIGAAGGFGAYA
VQLAASRGVNVTAVASAANESWVRAQGAHQFRPYEAGRAVSPGDAFDLLIDTPARLSFRAAAPFLSRSGMYVSSNPTSDL
AGLARSRFSSRRAGFLMMLKTSPSRLARLVDLAGDGTLRAAIDSVFDIAEADKAFDRFATRGKQGRVLLRI
>Mature_311_residues
MRALAVDPATQSSRIVDLPVPEAKPGQILVEVKVAGINEMDVEVRAGGWAAQVNRFRREGPVLTGFEFAGVARTSGTHIR
AGQRVMGYSPVLNGPRVHAQFAAVPESGLLAISESLSDESAAALCVMGLTAVEVLERLCPLAPAQSCLVIGAAGGFGAYA
VQLAASRGVNVTAVASAANESWVRAQGAHQFRPYEAGRAVSPGDAFDLLIDTPARLSFRAAAPFLSRSGMYVSSNPTSDL
AGLARSRFSSRRAGFLMMLKTSPSRLARLVDLAGDGTLRAAIDSVFDIAEADKAFDRFATRGKQGRVLLRI

Specific function: Unknown

COG id: COG0604

COG function: function code CR; NADPH:quinone reductase and related Zn-dependent oxidoreductases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI18379349, Length=318, Percent_Identity=27.0440251572327, Blast_Score=73, Evalue=4e-13,
Organism=Homo sapiens, GI47519420, Length=332, Percent_Identity=24.0963855421687, Blast_Score=68, Evalue=1e-11,
Organism=Homo sapiens, GI24308257, Length=334, Percent_Identity=21.8562874251497, Blast_Score=67, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

NA

Pfam domain/function: NA

EC number: 1.6.5.5 [C]

Molecular weight: Translated: 32739; Mature: 32739

Theoretical pI: Translated: 9.90; Mature: 9.90

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRALAVDPATQSSRIVDLPVPEAKPGQILVEVKVAGINEMDVEVRAGGWAAQVNRFRREG
CCCEECCCCCCCCEEEECCCCCCCCCEEEEEEEECCCCEEEEEEECCCHHHHHHHHHHCC
PVLTGFEFAGVARTSGTHIRAGQRVMGYSPVLNGPRVHAQFAAVPESGLLAISESLSDES
CEEECEEECCEEECCCCEEECCCEEECCCCCCCCCEEEEEEEECCCCCCEEEHHHCCCHH
AAALCVMGLTAVEVLERLCPLAPAQSCLVIGAAGGFGAYAVQLAASRGVNVTAVASAANE
HHHHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCCHHHHEEHHCCCCCEEEEECCCCC
SWVRAQGAHQFRPYEAGRAVSPGDAFDLLIDTPARLSFRAAAPFLSRSGMYVSSNPTSDL
CHHCCCCCCCCCCCCCCCCCCCCCCEEEEECCCCCEEEHHHCCHHHCCCEEEECCCCHHH
AGLARSRFSSRRAGFLMMLKTSPSRLARLVDLAGDGTLRAAIDSVFDIAEADKAFDRFAT
HHHHHHHHHCCCCCEEEEEECCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHH
RGKQGRVLLRI
CCCCCEEEEEC
>Mature Secondary Structure
MRALAVDPATQSSRIVDLPVPEAKPGQILVEVKVAGINEMDVEVRAGGWAAQVNRFRREG
CCCEECCCCCCCCEEEECCCCCCCCCEEEEEEEECCCCEEEEEEECCCHHHHHHHHHHCC
PVLTGFEFAGVARTSGTHIRAGQRVMGYSPVLNGPRVHAQFAAVPESGLLAISESLSDES
CEEECEEECCEEECCCCEEECCCEEECCCCCCCCCEEEEEEEECCCCCCEEEHHHCCCHH
AAALCVMGLTAVEVLERLCPLAPAQSCLVIGAAGGFGAYAVQLAASRGVNVTAVASAANE
HHHHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCCHHHHEEHHCCCCCEEEEECCCCC
SWVRAQGAHQFRPYEAGRAVSPGDAFDLLIDTPARLSFRAAAPFLSRSGMYVSSNPTSDL
CHHCCCCCCCCCCCCCCCCCCCCCCEEEEECCCCCEEEHHHCCHHHCCCEEEECCCCHHH
AGLARSRFSSRRAGFLMMLKTSPSRLARLVDLAGDGTLRAAIDSVFDIAEADKAFDRFAT
HHHHHHHHHCCCCCEEEEEECCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHH
RGKQGRVLLRI
CCCCCEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NADPH [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): 0.017 {9,10-phenanthrenequinone}} 0.0153 {2,6-dichlorophenolindophenol}} 0.013 {2,6-dichlorophenolindophenol}} 0.007 {NADPH}} 0.0069 {NADPH}} 0.0024 {1,2-naphthoquinone}} 0.26 {1,4-naphthoquinone}} 0.065 {1,4-benzoquinone}} [C]

Substrates: NADPH; Quinone [C]

Specific reaction: NADPH + Quinone = NADP(+) + Semiquinone. [C]

General reaction: Oxidation; Reduction [C]

Inhibitor: 2, 3-Dimercaptopropanol; 2, 5-Dichloro-3, 6-dihydroxy -1, 4-benzoquinone; 4-Hydroxy coumarin; 5, 5'-Dithiobis (2-nitrobenzoate); ADP; Cibacronblue3GA; Coumarin; Cu2+; Dicoumarol warfarin, coumarin; Dithiothreitol preincubation with 9, 10-phenanthrenequino

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA