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The map label for this gene is murB

Identifier: 114799112

GI number: 114799112

Start: 391893

End: 392864

Strand: Reverse

Name: murB

Synonym: HNE_0397

Alternate gene names: 114799112

Gene position: 392864-391893 (Counterclockwise)

Preceding gene: 114800549

Following gene: 114799909

Centisome position: 10.6

GC content: 68.21

Gene sequence:

>972_bases
ATGACCCCCACATCCCCCTCTCCCGATCTGCTCCCCACCTTGCCAGACGTGCGCGGCAAGCTGCTGCGCGGGGCGGAGCT
TGCGCCTTATACCTGGTTCCGCGTCGGCGGCCCGGCAGACGCCCTCTTCCTGCCCGCCGATGAGGAAGACCTCGAAGCCT
TCCTCAAGGCGCTCGACCCCGCCATCCCTGTCACCCCGCTGGGCGTGGGCTCAAACCTCATCGTCCGTGATGGCGGCATT
CCCGGTATCGTCATCCGCCTGATGGGCAAATACTGGGGCGAGATCGAAGCCCTTGACGGCATCACGCTCACCGCCCGCGC
CGGCGCGCTCGATCTTGCCGTCGCCAAAGCGGCGGCCGCCAACGGCATCACGGGCCTCGAATTCCTCTCCGGCATTCCCG
GCTCGCTGGGCGGGGCCACCCGCACCAATGCCGGCTGCTATGGCAGCGAGCTACGCGACCGCCTCGTCGCCCTGCATGGC
TTCCGCCGCGATGGCAGCCGCGTCGCCTATCGCGGCCCCGGCAAGCCCGGCGCCCTGCCCGAGGCCCACTTCTCCTATCG
CCATACCGATTTGCCAGACGACCTGATCGTCACCCGCCTCATCCTGGAAGGCACCGGCGCTGGCGACCCCGAAGCGATCA
GCGCAGACATCGCCGCCCTTCAGGCCCGCCGCGCGCAAACCCAGCCCATAAAAGAAAAAACCTCCGGCTCCACCTTCGCT
AATCCCGACCCTCCGGGCACGCCCGATCAGCGCTCCGCCTGGAAACTGATCGACGCCGCCGGCTGCCGCGGCCTGAAAGT
CGGCGGCGCGCAGGTCTCGCCCCTGCATTGCAACTTCCTGATCAACACGGGCGACGCCACCGCCGCCGACCTCGAAGCCC
TCGGCGAACTGGTCCGGGCAAGGGTGCTGGAAAATTCAGGCGTGGAACTCCGCTGGGAAGTCCGCCGCATGGGACGTGTG
CAGAGGGTCTAG

Upstream 100 bases:

>100_bases
CGGGCCTCAGCGCTGAGGCCCTGCCCCCGGCGGCTGACTCGGTGGCTGGCCCGGCAGCTGGCTTGACAGGGCGCGCGGTT
GCAGGAAACCCGTTGCAGCC

Downstream 100 bases:

>100_bases
GGGGCGGAGAGCAACCCATCCCGTAGGGCGGGTTAGCCGAAGGCGTAACCCGCCATCTCAATCCCAAACGGTGCGTATCG
CTCCACTCAATCCACCCTAC

Product: UDP-N-acetylenolpyruvoylglucosamine reductase

Products: NA

Alternate protein names: UDP-N-acetylmuramate dehydrogenase

Number of amino acids: Translated: 323; Mature: 322

Protein sequence:

>323_residues
MTPTSPSPDLLPTLPDVRGKLLRGAELAPYTWFRVGGPADALFLPADEEDLEAFLKALDPAIPVTPLGVGSNLIVRDGGI
PGIVIRLMGKYWGEIEALDGITLTARAGALDLAVAKAAAANGITGLEFLSGIPGSLGGATRTNAGCYGSELRDRLVALHG
FRRDGSRVAYRGPGKPGALPEAHFSYRHTDLPDDLIVTRLILEGTGAGDPEAISADIAALQARRAQTQPIKEKTSGSTFA
NPDPPGTPDQRSAWKLIDAAGCRGLKVGGAQVSPLHCNFLINTGDATAADLEALGELVRARVLENSGVELRWEVRRMGRV
QRV

Sequences:

>Translated_323_residues
MTPTSPSPDLLPTLPDVRGKLLRGAELAPYTWFRVGGPADALFLPADEEDLEAFLKALDPAIPVTPLGVGSNLIVRDGGI
PGIVIRLMGKYWGEIEALDGITLTARAGALDLAVAKAAAANGITGLEFLSGIPGSLGGATRTNAGCYGSELRDRLVALHG
FRRDGSRVAYRGPGKPGALPEAHFSYRHTDLPDDLIVTRLILEGTGAGDPEAISADIAALQARRAQTQPIKEKTSGSTFA
NPDPPGTPDQRSAWKLIDAAGCRGLKVGGAQVSPLHCNFLINTGDATAADLEALGELVRARVLENSGVELRWEVRRMGRV
QRV
>Mature_322_residues
TPTSPSPDLLPTLPDVRGKLLRGAELAPYTWFRVGGPADALFLPADEEDLEAFLKALDPAIPVTPLGVGSNLIVRDGGIP
GIVIRLMGKYWGEIEALDGITLTARAGALDLAVAKAAAANGITGLEFLSGIPGSLGGATRTNAGCYGSELRDRLVALHGF
RRDGSRVAYRGPGKPGALPEAHFSYRHTDLPDDLIVTRLILEGTGAGDPEAISADIAALQARRAQTQPIKEKTSGSTFAN
PDPPGTPDQRSAWKLIDAAGCRGLKVGGAQVSPLHCNFLINTGDATAADLEALGELVRARVLENSGVELRWEVRRMGRVQ
RV

Specific function: Cell wall formation

COG id: COG0812

COG function: function code M; UDP-N-acetylmuramate dehydrogenase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 FAD-binding PCMH-type domain

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MURB_HYPNA (Q0C566)

Other databases:

- EMBL:   CP000158
- RefSeq:   YP_759127.1
- ProteinModelPortal:   Q0C566
- SMR:   Q0C566
- STRING:   Q0C566
- GeneID:   4289907
- GenomeReviews:   CP000158_GR
- KEGG:   hne:HNE_0397
- NMPDR:   fig|228405.5.peg.389
- TIGR:   HNE_0397
- eggNOG:   COG0812
- HOGENOM:   HBG686573
- OMA:   ISERHAN
- BioCyc:   HNEP81032:HNE_0397-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00037
- InterPro:   IPR016169
- InterPro:   IPR016166
- InterPro:   IPR016167
- InterPro:   IPR003170
- InterPro:   IPR011601
- InterPro:   IPR006094
- Gene3D:   G3DSA:3.30.465.10
- Gene3D:   G3DSA:3.30.43.10
- Gene3D:   G3DSA:3.90.78.10
- PANTHER:   PTHR21071
- TIGRFAMs:   TIGR00179

Pfam domain/function: PF01565 FAD_binding_4; PF02873 MurB_C; SSF56176 FAD-binding_2; SSF56194 MurB_C

EC number: =1.1.1.158

Molecular weight: Translated: 34020; Mature: 33889

Theoretical pI: Translated: 6.16; Mature: 6.16

Prosite motif: PS51387 FAD_PCMH

Important sites: ACT_SITE 187-187 ACT_SITE 237-237 ACT_SITE 313-313

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
0.6 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTPTSPSPDLLPTLPDVRGKLLRGAELAPYTWFRVGGPADALFLPADEEDLEAFLKALDP
CCCCCCCCCCCCCCHHHHHHHHCCCCCCCEEEEEECCCCCEEEECCCHHHHHHHHHHHCC
AIPVTPLGVGSNLIVRDGGIPGIVIRLMGKYWGEIEALDGITLTARAGALDLAVAKAAAA
CCCCEECCCCCEEEEECCCCCHHHHHHHHHHHCCEECCCCEEEEECCCHHHHHHHHHHHH
NGITGLEFLSGIPGSLGGATRTNAGCYGSELRDRLVALHGFRRDGSRVAYRGPGKPGALP
CCCHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCEEEEECCCCCCCCC
EAHFSYRHTDLPDDLIVTRLILEGTGAGDPEAISADIAALQARRAQTQPIKEKTSGSTFA
CCCCCCCCCCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHCCCCHHHCCCCCCC
NPDPPGTPDQRSAWKLIDAAGCRGLKVGGAQVSPLHCNFLINTGDATAADLEALGELVRA
CCCCCCCCCCHHHHHHHHHCCCCCEEECCCEECCEEEEEEEECCCCCHHHHHHHHHHHHH
RVLENSGVELRWEVRRMGRVQRV
HHHHCCCCEEEEHHHHCCHHCCC
>Mature Secondary Structure 
TPTSPSPDLLPTLPDVRGKLLRGAELAPYTWFRVGGPADALFLPADEEDLEAFLKALDP
CCCCCCCCCCCCCHHHHHHHHCCCCCCCEEEEEECCCCCEEEECCCHHHHHHHHHHHCC
AIPVTPLGVGSNLIVRDGGIPGIVIRLMGKYWGEIEALDGITLTARAGALDLAVAKAAAA
CCCCEECCCCCEEEEECCCCCHHHHHHHHHHHCCEECCCCEEEEECCCHHHHHHHHHHHH
NGITGLEFLSGIPGSLGGATRTNAGCYGSELRDRLVALHGFRRDGSRVAYRGPGKPGALP
CCCHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCEEEEECCCCCCCCC
EAHFSYRHTDLPDDLIVTRLILEGTGAGDPEAISADIAALQARRAQTQPIKEKTSGSTFA
CCCCCCCCCCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHCCCCHHHCCCCCCC
NPDPPGTPDQRSAWKLIDAAGCRGLKVGGAQVSPLHCNFLINTGDATAADLEALGELVRA
CCCCCCCCCCHHHHHHHHHCCCCCEEECCCEECCEEEEEEEECCCCCHHHHHHHHHHHHH
RVLENSGVELRWEVRRMGRVQRV
HHHHCCCCEEEEHHHHCCHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA