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The map label for this gene is folE1

Identifier: 114798966

GI number: 114798966

Start: 1915189

End: 1915656

Strand: Reverse

Name: folE1

Synonym: HNE_1855

Alternate gene names: 114798966

Gene position: 1915656-1915189 (Counterclockwise)

Preceding gene: 114798621

Following gene: 114797418

Centisome position: 51.7

GC content: 56.41

Gene sequence:

>468_bases
ATGGCTGACAATCCGATCTATCAAAAACTTGGCCAGCTTGGCCAACACACCGTTCAGCCAGCGAGCCCCGAAGAGGCGCA
GCTGGAGCGGGTGGAAAACCCGCATTCCGGGACGCTGTACCTTACGCGGTTTGTGGCGCCGGAATTTACTTCGCTTTGTC
CGGTTACCGGGCAGCCGGACTTTGCGCATCTGGTAATCGATTATGCGCCGGGTCCCTGGCTAGTCGAATCCAAAAGCCTG
AAACTGTACCTCACAAGCTTTCGAAACCACGGGGCTTTCCACGAGGAGTGCACTGTTTCCATTGGGAAAAAGATCTTCGA
TTTCACCGAAGCGACCTGGTTGCGCATCTCCGGATACTGGTATCCGAGGGGGGGGATACCTATCGATGTATTCTGGCAAT
CAGGCGATGTTCCGAAGGGGCTTTACGTGCCCGATACGGGCGTCGCGTCCTATCGCGGGCGCGGATAA

Upstream 100 bases:

>100_bases
CGCAAGCTGGCGCGCTGGGAAGGCGCAGTGTTGCTCCTGGGGTACGTGCTCTATATGGGCCTGACGTTCGATCTCATTCC
TGTACCGGCGATATTCCCCA

Downstream 100 bases:

>100_bases
TCCCGGACAAACGCGGACAAATCTGGACAAACTTGGACAAACCCGGTCAGTCCGGGACATCCGGAGACCAGGCGGAGACC
AGTCCGGACAGGTCTGGACG

Product: 7-cyano-7-deazaguanine reductase

Products: NA

Alternate protein names: 7-cyano-7-carbaguanine reductase; NADPH-dependent nitrile oxidoreductase; PreQ(0) reductase

Number of amino acids: Translated: 155; Mature: 154

Protein sequence:

>155_residues
MADNPIYQKLGQLGQHTVQPASPEEAQLERVENPHSGTLYLTRFVAPEFTSLCPVTGQPDFAHLVIDYAPGPWLVESKSL
KLYLTSFRNHGAFHEECTVSIGKKIFDFTEATWLRISGYWYPRGGIPIDVFWQSGDVPKGLYVPDTGVASYRGRG

Sequences:

>Translated_155_residues
MADNPIYQKLGQLGQHTVQPASPEEAQLERVENPHSGTLYLTRFVAPEFTSLCPVTGQPDFAHLVIDYAPGPWLVESKSL
KLYLTSFRNHGAFHEECTVSIGKKIFDFTEATWLRISGYWYPRGGIPIDVFWQSGDVPKGLYVPDTGVASYRGRG
>Mature_154_residues
ADNPIYQKLGQLGQHTVQPASPEEAQLERVENPHSGTLYLTRFVAPEFTSLCPVTGQPDFAHLVIDYAPGPWLVESKSLK
LYLTSFRNHGAFHEECTVSIGKKIFDFTEATWLRISGYWYPRGGIPIDVFWQSGDVPKGLYVPDTGVASYRGRG

Specific function: Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)

COG id: COG0780

COG function: function code R; Enzyme related to GTP cyclohydrolase I

Gene ontology:

Cell location: Cytoplasm (Probable)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GTP cyclohydrolase I family. QueF type 1 subfamily

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): QUEF_HYPNA (Q0C137)

Other databases:

- EMBL:   CP000158
- RefSeq:   YP_760556.1
- ProteinModelPortal:   Q0C137
- SMR:   Q0C137
- STRING:   Q0C137
- GeneID:   4287423
- GenomeReviews:   CP000158_GR
- KEGG:   hne:HNE_1855
- NMPDR:   fig|228405.5.peg.1784
- TIGR:   HNE_1855
- eggNOG:   COG0780
- HOGENOM:   HBG294103
- OMA:   HEDCTVA
- ProtClustDB:   PRK13258
- BioCyc:   HNEP81032:HNE_1855-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00818
- InterPro:   IPR016856
- InterPro:   IPR020602
- PIRSF:   PIRSF027377
- TIGRFAMs:   TIGR03139

Pfam domain/function: PF01227 GTP_cyclohydroI

EC number: =1.7.1.13

Molecular weight: Translated: 17332; Mature: 17201

Theoretical pI: Translated: 6.34; Mature: 6.34

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
0.6 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
0.0 %Met     (Mature Protein)
1.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MADNPIYQKLGQLGQHTVQPASPEEAQLERVENPHSGTLYLTRFVAPEFTSLCPVTGQPD
CCCCHHHHHHHHHHHHCCCCCCCCHHHHHHCCCCCCCEEEEEEECCCCCHHCCCCCCCCC
FAHLVIDYAPGPWLVESKSLKLYLTSFRNHGAFHEECTVSIGKKIFDFTEATWLRISGYW
EEEEEEEECCCCEEEECCCEEEEEEECCCCCCCCHHHHHHHHHHHHHCCCCEEEEEEEEE
YPRGGIPIDVFWQSGDVPKGLYVPDTGVASYRGRG
ECCCCCEEEEEECCCCCCCCEECCCCCCCCCCCCC
>Mature Secondary Structure 
ADNPIYQKLGQLGQHTVQPASPEEAQLERVENPHSGTLYLTRFVAPEFTSLCPVTGQPD
CCCHHHHHHHHHHHHCCCCCCCCHHHHHHCCCCCCCEEEEEEECCCCCHHCCCCCCCCC
FAHLVIDYAPGPWLVESKSLKLYLTSFRNHGAFHEECTVSIGKKIFDFTEATWLRISGYW
EEEEEEEECCCCEEEECCCEEEEEEECCCCCCCCHHHHHHHHHHHHHCCCCEEEEEEEEE
YPRGGIPIDVFWQSGDVPKGLYVPDTGVASYRGRG
ECCCCCEEEEEECCCCCCCCEECCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA