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The map label for this gene is mutA [H]

Identifier: 114798788

GI number: 114798788

Start: 1360287

End: 1362206

Strand: Reverse

Name: mutA [H]

Synonym: HNE_1327

Alternate gene names: 114798788

Gene position: 1362206-1360287 (Counterclockwise)

Preceding gene: 114798034

Following gene: 114799394

Centisome position: 36.77

GC content: 66.77

Gene sequence:

>1920_bases
ATGGCCGATGACATCCTCCCCTTCAGTTCCGCATTTCCCGAAGCCACCGAAGCCGATTGGCTGACCGCCGTTGAAAAGGC
GCTCAAAGGGAAGGGCGTCGATACCCTCACCCGCAAGACCGCCGACGGCATCGCCATCAAGGCGCTTTACCGCGAGAGCG
ACTTTGCCGCCGCTGCCGACCCGCTCGGCGCGCCCGGTGCAGCGCCCTATCTGCGCGGCGCGACGGCAGCGCCGGACAAA
TGGCGCCCCTGGGACATCCGCCAGCTCTTTACCCATCCCTCGGCAGAAGAAACCAATGCCGAAATCCTGCGCGATCTTGA
ACGCGGCGTTTCCTCGGCCGAAATCGCGATCGACGCGTCCGGCAAGGACGGCGTGCAGATCACCACGGTGGAAGCCTTTG
AAACGGCCCTTGCCGGTGTGCGCGCCGATTATGCCGGCGTTGCCCTCAGCCATGTGAATGCCTCCGGCGCGGCAGCCTCT
GCCCTGCTTGGCCTCTGGGCAGAGAAACAGGAAAATCCGGCCGAGCTGACCCTTGATTTCAATATGGACCCGCTGGGCGC
CCTCGCTCGCTCCGGCACACTTGCAGGCGGGCTGGATGCCGCGTTCGAACGCCTTGCCGCCGTTGGCTCTGCGCTGGGCG
CGAAGTTTCCCAAAGCCGGCCTCATCCGCATTGACGCCGCCAGTGTGCACGAAGCAGGCGCCTCTGAAGCGCAGGAACTT
GGCGCGCTGATCGCCTCGGCCATCGACACGCTGCGCCGCCTCGACGGCAAGACAGACATCGCCGCGCTGACCGGCAAGAT
CAGCTTCGCCGTTGCGCTCGACGCAAACTACGGCATCGGCATTGCCAAGCTGCGCGCCGCCCGCCGCCTCTGGGCGCGCT
GCCTGGAGGCGCTGGGCCTGCCTGCCGCCCCCATGCGCCTGCAAGGCATCACCTCGGCCCGCATGCTGACCAAGTATGAT
CCGTGGACCAACATGCTCCGCGTCACCTGCGCAACCTTCGCCGGCGCCGCCGGCGGCGCTGACATCGTCACCTCACGCGC
CTTCAACGAAGCGCTTGGCCGTCCCGAGGGGCTCGGCCGCCGCATCGCGCGCAACACTCAGATCATCGCCATGGAAGAAA
GCCAGCTCGGCCGCGTGGCAGACCCTACCGGCGGCGCCTGGTTTACAGAAACGCTGGCGGACGATCTCGCCAAGGCGGCC
TGGGCCGAGTTCCAGACCATCGAGAGCGAAGGCGGCTATGCAGCCTCGCTGCTCTCCGGGGCATTCCAGGCGCGCGTGAA
AACCGTGCGCGAGGCGCGCACGAAAGACATTGCCCGCCGCAAGATCCCGCTGACCGGCGTTTCGGAATATCCGCTGCTGG
AAGAAATCGGCGCGCCCGTGGCAGACGTGGACGCGCCAGGTCCGCGCGCCGATATTTCCGATGCCGGACTAAAATCCTAC
ATCAACACGCCCCTCGCAACGGGTACGGACGTGACCGCCGAGGCCCTGGCGCCCACCCGGCTCGCCGCGCCGTTTGAAGC
CCTGCGTGACGCGGCCACCCGCGCGCCCAAACCGCCCGCCGCCTTCATCGCCACGTTGGGCGCGCTGGCCGAGTTTACGC
CGCGCGCTGATTTTGCCCGCAACCTGCTGGCCGCAGGCGGCGTCGCGCCGAAGGAAGCCGTTGTTCCGCCCAGGGATGCG
GCCGAGCTTGCTGCCGCCTTCAAGGCCTCGGGGTGCCGGATCGCGGTCATCTGCGGCACGGACAAGGCTTACGAAGCAGG
CGCCGCCGAGGCGGCTGAGGCCCTGAAGAAGGCTGGCGCACAAGCCGTCTGGCTCGCCGGAAAATCAGAAGCCCCCGGCA
TTGATCTCAACATCTTCGCAGGCTGTGATGTGATCCATGCCCTGCAACTTGCCCATGCTGAGCTGGGAGTTTCCAAATGA

Upstream 100 bases:

>100_bases
AGAGCCTTGTTGCAACGCAGAAGGCCCATGCAGGAATGAACGTCACATACCCCTAAGGAAGTAGTTCACAACCTCACCCG
GATTGCCCTAAACCCCCACC

Downstream 100 bases:

>100_bases
CCAAGTTCCCCGATTTCACGAAACTCGATCTGGCGACGCCAAGCACAAAATCCGGCACGCCGAAACTTGGCGAAGCCTGG
GACACGCCCGAAGGCATCGC

Product: methylmalonyl-CoA mutase small subunit

Products: NA

Alternate protein names: MCM-beta [H]

Number of amino acids: Translated: 639; Mature: 638

Protein sequence:

>639_residues
MADDILPFSSAFPEATEADWLTAVEKALKGKGVDTLTRKTADGIAIKALYRESDFAAAADPLGAPGAAPYLRGATAAPDK
WRPWDIRQLFTHPSAEETNAEILRDLERGVSSAEIAIDASGKDGVQITTVEAFETALAGVRADYAGVALSHVNASGAAAS
ALLGLWAEKQENPAELTLDFNMDPLGALARSGTLAGGLDAAFERLAAVGSALGAKFPKAGLIRIDAASVHEAGASEAQEL
GALIASAIDTLRRLDGKTDIAALTGKISFAVALDANYGIGIAKLRAARRLWARCLEALGLPAAPMRLQGITSARMLTKYD
PWTNMLRVTCATFAGAAGGADIVTSRAFNEALGRPEGLGRRIARNTQIIAMEESQLGRVADPTGGAWFTETLADDLAKAA
WAEFQTIESEGGYAASLLSGAFQARVKTVREARTKDIARRKIPLTGVSEYPLLEEIGAPVADVDAPGPRADISDAGLKSY
INTPLATGTDVTAEALAPTRLAAPFEALRDAATRAPKPPAAFIATLGALAEFTPRADFARNLLAAGGVAPKEAVVPPRDA
AELAAAFKASGCRIAVICGTDKAYEAGAAEAAEALKKAGAQAVWLAGKSEAPGIDLNIFAGCDVIHALQLAHAELGVSK

Sequences:

>Translated_639_residues
MADDILPFSSAFPEATEADWLTAVEKALKGKGVDTLTRKTADGIAIKALYRESDFAAAADPLGAPGAAPYLRGATAAPDK
WRPWDIRQLFTHPSAEETNAEILRDLERGVSSAEIAIDASGKDGVQITTVEAFETALAGVRADYAGVALSHVNASGAAAS
ALLGLWAEKQENPAELTLDFNMDPLGALARSGTLAGGLDAAFERLAAVGSALGAKFPKAGLIRIDAASVHEAGASEAQEL
GALIASAIDTLRRLDGKTDIAALTGKISFAVALDANYGIGIAKLRAARRLWARCLEALGLPAAPMRLQGITSARMLTKYD
PWTNMLRVTCATFAGAAGGADIVTSRAFNEALGRPEGLGRRIARNTQIIAMEESQLGRVADPTGGAWFTETLADDLAKAA
WAEFQTIESEGGYAASLLSGAFQARVKTVREARTKDIARRKIPLTGVSEYPLLEEIGAPVADVDAPGPRADISDAGLKSY
INTPLATGTDVTAEALAPTRLAAPFEALRDAATRAPKPPAAFIATLGALAEFTPRADFARNLLAAGGVAPKEAVVPPRDA
AELAAAFKASGCRIAVICGTDKAYEAGAAEAAEALKKAGAQAVWLAGKSEAPGIDLNIFAGCDVIHALQLAHAELGVSK
>Mature_638_residues
ADDILPFSSAFPEATEADWLTAVEKALKGKGVDTLTRKTADGIAIKALYRESDFAAAADPLGAPGAAPYLRGATAAPDKW
RPWDIRQLFTHPSAEETNAEILRDLERGVSSAEIAIDASGKDGVQITTVEAFETALAGVRADYAGVALSHVNASGAAASA
LLGLWAEKQENPAELTLDFNMDPLGALARSGTLAGGLDAAFERLAAVGSALGAKFPKAGLIRIDAASVHEAGASEAQELG
ALIASAIDTLRRLDGKTDIAALTGKISFAVALDANYGIGIAKLRAARRLWARCLEALGLPAAPMRLQGITSARMLTKYDP
WTNMLRVTCATFAGAAGGADIVTSRAFNEALGRPEGLGRRIARNTQIIAMEESQLGRVADPTGGAWFTETLADDLAKAAW
AEFQTIESEGGYAASLLSGAFQARVKTVREARTKDIARRKIPLTGVSEYPLLEEIGAPVADVDAPGPRADISDAGLKSYI
NTPLATGTDVTAEALAPTRLAAPFEALRDAATRAPKPPAAFIATLGALAEFTPRADFARNLLAAGGVAPKEAVVPPRDAA
ELAAAFKASGCRIAVICGTDKAYEAGAAEAAEALKKAGAQAVWLAGKSEAPGIDLNIFAGCDVIHALQLAHAELGVSK

Specific function: Catalyzes the isomerization of succinyl-CoA to methylmalonyl-CoA during synthesis of propionate from tricarboxylic acid-cycle intermediates. This conversion most likely represents an important source of building blocks for polyketide antibiotic biosynthes

COG id: COG1884

COG function: function code I; Methylmalonyl-CoA mutase, N-terminal domain/subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the methylmalonyl-CoA mutase family [H]

Homologues:

Organism=Homo sapiens, GI156105689, Length=473, Percent_Identity=29.8097251585624, Blast_Score=182, Evalue=1e-45,
Organism=Escherichia coli, GI1789284, Length=471, Percent_Identity=30.5732484076433, Blast_Score=187, Evalue=1e-48,
Organism=Caenorhabditis elegans, GI25144500, Length=470, Percent_Identity=29.5744680851064, Blast_Score=184, Evalue=2e-46,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016176
- InterPro:   IPR014348
- InterPro:   IPR006158
- InterPro:   IPR006099
- InterPro:   IPR004608 [H]

Pfam domain/function: PF01642 MM_CoA_mutase [H]

EC number: =5.4.99.2 [H]

Molecular weight: Translated: 66196; Mature: 66064

Theoretical pI: Translated: 4.96; Mature: 4.96

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MADDILPFSSAFPEATEADWLTAVEKALKGKGVDTLTRKTADGIAIKALYRESDFAAAAD
CCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCHHHHHHCCCCEEEEEEHHCCCCHHCCC
PLGAPGAAPYLRGATAAPDKWRPWDIRQLFTHPSAEETNAEILRDLERGVSSAEIAIDAS
CCCCCCCCHHHCCCCCCCCCCCCCHHHHHHCCCCCCCHHHHHHHHHHHCCCCEEEEEECC
GKDGVQITTVEAFETALAGVRADYAGVALSHVNASGAAASALLGLWAEKQENPAELTLDF
CCCCEEEEEHHHHHHHHHHHHHHHHHHEEECCCCCHHHHHHHHHHHHHCCCCCCEEEEEC
NMDPLGALARSGTLAGGLDAAFERLAAVGSALGAKFPKAGLIRIDAASVHEAGASEAQEL
CCCHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCEEEEEHHHHHHCCHHHHHHH
GALIASAIDTLRRLDGKTDIAALTGKISFAVALDANYGIGIAKLRAARRLWARCLEALGL
HHHHHHHHHHHHHHCCCCCHHHHCCCEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHCC
PAAPMRLQGITSARMLTKYDPWTNMLRVTCATFAGAAGGADIVTSRAFNEALGRPEGLGR
CCCCHHHHCCCHHHHHHCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCHHHHH
RIARNTQIIAMEESQLGRVADPTGGAWFTETLADDLAKAAWAEFQTIESEGGYAASLLSG
HHHCCCEEEEECHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHH
AFQARVKTVREARTKDIARRKIPLTGVSEYPLLEEIGAPVADVDAPGPRADISDAGLKSY
HHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHCCCCCCCCCCCCCCCCCHHHHHHH
INTPLATGTDVTAEALAPTRLAAPFEALRDAATRAPKPPAAFIATLGALAEFTPRADFAR
HCCCCCCCCCCHHHHHCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCHHHHH
NLLAAGGVAPKEAVVPPRDAAELAAAFKASGCRIAVICGTDKAYEAGAAEAAEALKKAGA
HHHHHCCCCCCCCCCCCCCHHHHHHHHHCCCCEEEEEECCCCHHHCCHHHHHHHHHHCCC
QAVWLAGKSEAPGIDLNIFAGCDVIHALQLAHAELGVSK
CEEEEECCCCCCCCCEEEECCHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
ADDILPFSSAFPEATEADWLTAVEKALKGKGVDTLTRKTADGIAIKALYRESDFAAAAD
CCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCHHHHHHCCCCEEEEEEHHCCCCHHCCC
PLGAPGAAPYLRGATAAPDKWRPWDIRQLFTHPSAEETNAEILRDLERGVSSAEIAIDAS
CCCCCCCCHHHCCCCCCCCCCCCCHHHHHHCCCCCCCHHHHHHHHHHHCCCCEEEEEECC
GKDGVQITTVEAFETALAGVRADYAGVALSHVNASGAAASALLGLWAEKQENPAELTLDF
CCCCEEEEEHHHHHHHHHHHHHHHHHHEEECCCCCHHHHHHHHHHHHHCCCCCCEEEEEC
NMDPLGALARSGTLAGGLDAAFERLAAVGSALGAKFPKAGLIRIDAASVHEAGASEAQEL
CCCHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCEEEEEHHHHHHCCHHHHHHH
GALIASAIDTLRRLDGKTDIAALTGKISFAVALDANYGIGIAKLRAARRLWARCLEALGL
HHHHHHHHHHHHHHCCCCCHHHHCCCEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHCC
PAAPMRLQGITSARMLTKYDPWTNMLRVTCATFAGAAGGADIVTSRAFNEALGRPEGLGR
CCCCHHHHCCCHHHHHHCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCHHHHH
RIARNTQIIAMEESQLGRVADPTGGAWFTETLADDLAKAAWAEFQTIESEGGYAASLLSG
HHHCCCEEEEECHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHH
AFQARVKTVREARTKDIARRKIPLTGVSEYPLLEEIGAPVADVDAPGPRADISDAGLKSY
HHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHCCCCCCCCCCCCCCCCCHHHHHHH
INTPLATGTDVTAEALAPTRLAAPFEALRDAATRAPKPPAAFIATLGALAEFTPRADFAR
HCCCCCCCCCCHHHHHCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCHHHHH
NLLAAGGVAPKEAVVPPRDAAELAAAFKASGCRIAVICGTDKAYEAGAAEAAEALKKAGA
HHHHHCCCCCCCCCCCCCCHHHHHHHHHCCCCEEEEEECCCCHHHCCHHHHHHHHHHCCC
QAVWLAGKSEAPGIDLNIFAGCDVIHALQLAHAELGVSK
CEEEEECCCCCCCCCEEEECCHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8099072 [H]