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The map label for this gene is map2 [H]

Identifier: 114798034

GI number: 114798034

Start: 1365251

End: 1366042

Strand: Reverse

Name: map2 [H]

Synonym: HNE_1332

Alternate gene names: 114798034

Gene position: 1366042-1365251 (Counterclockwise)

Preceding gene: 114797710

Following gene: 114798788

Centisome position: 36.87

GC content: 62.37

Gene sequence:

>792_bases
ATGACAAAAACGCCGGACGAACTCGCCGCGATGGCCCATTCCGGTCGCCTGCTCGCTTCGGTGTTCGGGCTGATCGACCA
GATGCAGCTCATCGGCATGAGCACGCTGGAAGTGAACGACCGGGTTGAGCGCTTCATCGTCGATGAGCTGAAATCCCGCC
CCGCCAGCAAGGGGCAATACGGCTTTGAGTACGTTCTCAATTCCTCCGTGAACGATGTGGTTTGCCACGCCATTCCCTCG
GCCCGCGAAATCCTGAAAGACGGCGACATCGTCAATTTCGACATCACGTTGGAAAAGAACGGCTACATCGCCGATTCCAG
CAAGACGTACATGCTCGGCAACGTCGCCACGCCCGCCCGCCGCCTCGTGCGCACCACCTATGAAGCCATGTGGAAAGGCA
TCCGCGCCGTCCGCCCCGGCGCCACGCTGGGCGACATCGGCCACGCCATCGAGCGCCATGCCAAGCAAGCGGGCTATTCC
ATCGTCCGCGAATTCTGCGGCCACGGCATCGGCCGGGAAATGCACGAAGAACCCTCCGTACTCCACTTCGGCCGCCGCGG
CACCGGCCTCCCCCTCCGCCCCGGCATGACCTTCACCATAGAGCCCATGCTTAACGAAGGCCGCCGCGGCGTGTACACGG
AAGAGGACGACTGGACCGTCCGCACCGAAGACGGAAAACTCTCAGCCCAGTTCGAGCATACAATCGCCGTGACAGAGCGC
GGCGTGGACGTGCTGACGCTAAGGCCGGAAGAAGCGCATCTGGTAAAAGAAGCAACCCGCAGGGCGGGTTAG

Upstream 100 bases:

>100_bases
TGCTCTGCGAGATGCACCCGACCCTCTCCTTCAACGAAATCGTCCAGCGCGAGATGGCCGCCGCCGGCGTCACGCCGGAG
CCGCTGGGCGCCGCCGCCGC

Downstream 100 bases:

>100_bases
CCGAAGGCGTACATTCGCCCTCGTCACTCTCGACCGGCGCAGCCGGTCTGAGAGCACCGTCCCATCCCCGTTGTTTGGTG
CATTGCGCTTCGCTTAATGC

Product: methionine aminopeptidase, type I

Products: NA

Alternate protein names: MAP; Peptidase M [H]

Number of amino acids: Translated: 263; Mature: 262

Protein sequence:

>263_residues
MTKTPDELAAMAHSGRLLASVFGLIDQMQLIGMSTLEVNDRVERFIVDELKSRPASKGQYGFEYVLNSSVNDVVCHAIPS
AREILKDGDIVNFDITLEKNGYIADSSKTYMLGNVATPARRLVRTTYEAMWKGIRAVRPGATLGDIGHAIERHAKQAGYS
IVREFCGHGIGREMHEEPSVLHFGRRGTGLPLRPGMTFTIEPMLNEGRRGVYTEEDDWTVRTEDGKLSAQFEHTIAVTER
GVDVLTLRPEEAHLVKEATRRAG

Sequences:

>Translated_263_residues
MTKTPDELAAMAHSGRLLASVFGLIDQMQLIGMSTLEVNDRVERFIVDELKSRPASKGQYGFEYVLNSSVNDVVCHAIPS
AREILKDGDIVNFDITLEKNGYIADSSKTYMLGNVATPARRLVRTTYEAMWKGIRAVRPGATLGDIGHAIERHAKQAGYS
IVREFCGHGIGREMHEEPSVLHFGRRGTGLPLRPGMTFTIEPMLNEGRRGVYTEEDDWTVRTEDGKLSAQFEHTIAVTER
GVDVLTLRPEEAHLVKEATRRAG
>Mature_262_residues
TKTPDELAAMAHSGRLLASVFGLIDQMQLIGMSTLEVNDRVERFIVDELKSRPASKGQYGFEYVLNSSVNDVVCHAIPSA
REILKDGDIVNFDITLEKNGYIADSSKTYMLGNVATPARRLVRTTYEAMWKGIRAVRPGATLGDIGHAIERHAKQAGYSI
VREFCGHGIGREMHEEPSVLHFGRRGTGLPLRPGMTFTIEPMLNEGRRGVYTEEDDWTVRTEDGKLSAQFEHTIAVTERG
VDVLTLRPEEAHLVKEATRRAG

Specific function: Removes the amino-terminal methionine from nascent proteins [H]

COG id: COG0024

COG function: function code J; Methionine aminopeptidase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M24A family [H]

Homologues:

Organism=Homo sapiens, GI164420681, Length=247, Percent_Identity=40.080971659919, Blast_Score=186, Evalue=2e-47,
Organism=Homo sapiens, GI40385867, Length=250, Percent_Identity=37.6, Blast_Score=174, Evalue=6e-44,
Organism=Escherichia coli, GI1786364, Length=249, Percent_Identity=45.7831325301205, Blast_Score=241, Evalue=3e-65,
Organism=Escherichia coli, GI1788728, Length=233, Percent_Identity=27.8969957081545, Blast_Score=67, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI71996291, Length=218, Percent_Identity=39.4495412844037, Blast_Score=170, Evalue=7e-43,
Organism=Saccharomyces cerevisiae, GI6323273, Length=213, Percent_Identity=43.1924882629108, Blast_Score=188, Evalue=6e-49,
Organism=Drosophila melanogaster, GI21355531, Length=245, Percent_Identity=38.7755102040816, Blast_Score=179, Evalue=1e-45,
Organism=Drosophila melanogaster, GI24583427, Length=244, Percent_Identity=36.8852459016393, Blast_Score=162, Evalue=3e-40,

Paralogues:

None

Copy number: 3,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001714
- InterPro:   IPR000994
- InterPro:   IPR002467 [H]

Pfam domain/function: PF00557 Peptidase_M24 [H]

EC number: =3.4.11.18 [H]

Molecular weight: Translated: 29226; Mature: 29094

Theoretical pI: Translated: 6.61; Mature: 6.61

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTKTPDELAAMAHSGRLLASVFGLIDQMQLIGMSTLEVNDRVERFIVDELKSRPASKGQY
CCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCCCCCC
GFEYVLNSSVNDVVCHAIPSAREILKDGDIVNFDITLEKNGYIADSSKTYMLGNVATPAR
CHHHEECCCCHHHHHHCCHHHHHHHCCCCEEEEEEEECCCCEEECCCCEEEEECCCHHHH
RLVRTTYEAMWKGIRAVRPGATLGDIGHAIERHAKQAGYSIVREFCGHGIGREMHEEPSV
HHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHCCCCE
LHFGRRGTGLPLRPGMTFTIEPMLNEGRRGVYTEEDDWTVRTEDGKLSAQFEHTIAVTER
EEECCCCCCCCCCCCCEEEECHHHCCCCCCCCCCCCCCEEEECCCCEEEEEHHEEEEECC
GVDVLTLRPEEAHLVKEATRRAG
CCEEEEECCCHHHHHHHHHHHCC
>Mature Secondary Structure 
TKTPDELAAMAHSGRLLASVFGLIDQMQLIGMSTLEVNDRVERFIVDELKSRPASKGQY
CCCHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCCCCCC
GFEYVLNSSVNDVVCHAIPSAREILKDGDIVNFDITLEKNGYIADSSKTYMLGNVATPAR
CHHHEECCCCHHHHHHCCHHHHHHHCCCCEEEEEEEECCCCEEECCCCEEEEECCCHHHH
RLVRTTYEAMWKGIRAVRPGATLGDIGHAIERHAKQAGYSIVREFCGHGIGREMHEEPSV
HHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHCCCCE
LHFGRRGTGLPLRPGMTFTIEPMLNEGRRGVYTEEDDWTVRTEDGKLSAQFEHTIAVTER
EEECCCCCCCCCCCCCEEEECHHHCCCCCCCCCCCCCCEEEECCCCEEEEEHHEEEEECC
GVDVLTLRPEEAHLVKEATRRAG
CCEEEEECCCHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]