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The map label for this gene is ndk

Identifier: 114798716

GI number: 114798716

Start: 2371007

End: 2371429

Strand: Reverse

Name: ndk

Synonym: HNE_2269

Alternate gene names: 114798716

Gene position: 2371429-2371007 (Counterclockwise)

Preceding gene: 114798143

Following gene: 114797737

Centisome position: 64.01

GC content: 61.7

Gene sequence:

>423_bases
ATGGCCGTGCAGCGCACCTTTTCCATCATCAAGCCCGACGCCACCGAGCGTAACCTCACCGGCGCAATCAATGCCGTGAT
CGAGAAAGCTGGTCTGCGCATCGTCGGCCAGCGCCGCATCCAGATGACCCGCGCCCAGGCCGAGCGTTTCTACTCGGTCC
ACTCCGCGCGCCCCTTCTTCGGCGAACTGGTCGATTTCATGATCTCCGGCCCTGTCGTCGTTCAGGTTCTCGAAGCTGAA
GACGCCATCACGAAGTACCGCGAAGTGATGGGCGCCACCAACCCGGCCGACGCCGCAGACGGCACCATCCGCAAACTGTT
CGCCAAGTCGATCGGCGAAAACTCGGTTCATGGCTCGGACTCGGCTGAGAACGCTGCGCTGGAAATCGCGCAGTTCTTCT
CCGAGGCTGACCTCACCAACTAA

Upstream 100 bases:

>100_bases
CTGTGCGCAAGGGCGCCTATCGGCGCTTGCCCCGGCGGCGCCGCGCCGCTATAGGCCGCGCAAATCCACCGAAACAACAG
AAGACTACAGGAAGCCCCTC

Downstream 100 bases:

>100_bases
CCCAAATTTGGCTGCCCTCGGGCACCAGATCAGAGCCGGAGGCAGGGACGCCCGCCTCCGGCTTTTTTGTGTCCGGAAGT
GTCCTGATCTGTCCCAAAGT

Product: nucleoside diphosphate kinase

Products: NA

Alternate protein names: NDK; NDP kinase; Nucleoside-2-P kinase

Number of amino acids: Translated: 140; Mature: 139

Protein sequence:

>140_residues
MAVQRTFSIIKPDATERNLTGAINAVIEKAGLRIVGQRRIQMTRAQAERFYSVHSARPFFGELVDFMISGPVVVQVLEAE
DAITKYREVMGATNPADAADGTIRKLFAKSIGENSVHGSDSAENAALEIAQFFSEADLTN

Sequences:

>Translated_140_residues
MAVQRTFSIIKPDATERNLTGAINAVIEKAGLRIVGQRRIQMTRAQAERFYSVHSARPFFGELVDFMISGPVVVQVLEAE
DAITKYREVMGATNPADAADGTIRKLFAKSIGENSVHGSDSAENAALEIAQFFSEADLTN
>Mature_139_residues
AVQRTFSIIKPDATERNLTGAINAVIEKAGLRIVGQRRIQMTRAQAERFYSVHSARPFFGELVDFMISGPVVVQVLEAED
AITKYREVMGATNPADAADGTIRKLFAKSIGENSVHGSDSAENAALEIAQFFSEADLTN

Specific function: Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate

COG id: COG0105

COG function: function code F; Nucleoside diphosphate kinase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the NDK family

Homologues:

Organism=Homo sapiens, GI37693993, Length=137, Percent_Identity=42.3357664233577, Blast_Score=116, Evalue=7e-27,
Organism=Homo sapiens, GI38045913, Length=138, Percent_Identity=41.304347826087, Blast_Score=112, Evalue=1e-25,
Organism=Homo sapiens, GI4557797, Length=138, Percent_Identity=41.304347826087, Blast_Score=112, Evalue=1e-25,
Organism=Homo sapiens, GI66392227, Length=138, Percent_Identity=39.1304347826087, Blast_Score=108, Evalue=2e-24,
Organism=Homo sapiens, GI66392205, Length=138, Percent_Identity=39.1304347826087, Blast_Score=108, Evalue=2e-24,
Organism=Homo sapiens, GI4505409, Length=138, Percent_Identity=39.1304347826087, Blast_Score=108, Evalue=2e-24,
Organism=Homo sapiens, GI66392192, Length=138, Percent_Identity=39.1304347826087, Blast_Score=108, Evalue=2e-24,
Organism=Homo sapiens, GI66392203, Length=138, Percent_Identity=39.1304347826087, Blast_Score=108, Evalue=2e-24,
Organism=Homo sapiens, GI4826862, Length=137, Percent_Identity=35.036496350365, Blast_Score=93, Evalue=6e-20,
Organism=Homo sapiens, GI37574614, Length=136, Percent_Identity=34.5588235294118, Blast_Score=90, Evalue=7e-19,
Organism=Homo sapiens, GI7019465, Length=136, Percent_Identity=34.5588235294118, Blast_Score=90, Evalue=8e-19,
Organism=Homo sapiens, GI5031951, Length=138, Percent_Identity=37.6811594202899, Blast_Score=85, Evalue=2e-17,
Organism=Homo sapiens, GI4505413, Length=136, Percent_Identity=30.1470588235294, Blast_Score=72, Evalue=1e-13,
Organism=Homo sapiens, GI30023828, Length=135, Percent_Identity=34.0740740740741, Blast_Score=70, Evalue=6e-13,
Organism=Homo sapiens, GI148839372, Length=138, Percent_Identity=27.536231884058, Blast_Score=66, Evalue=9e-12,
Organism=Escherichia coli, GI1788866, Length=139, Percent_Identity=52.5179856115108, Blast_Score=155, Evalue=8e-40,
Organism=Caenorhabditis elegans, GI17506807, Length=137, Percent_Identity=38.6861313868613, Blast_Score=110, Evalue=3e-25,
Organism=Saccharomyces cerevisiae, GI6322783, Length=137, Percent_Identity=37.956204379562, Blast_Score=111, Evalue=3e-26,
Organism=Drosophila melanogaster, GI45549037, Length=135, Percent_Identity=42.962962962963, Blast_Score=120, Evalue=3e-28,
Organism=Drosophila melanogaster, GI18860097, Length=137, Percent_Identity=35.036496350365, Blast_Score=78, Evalue=2e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NDK_HYPNA (Q0BZX9)

Other databases:

- EMBL:   CP000158
- RefSeq:   YP_760964.1
- ProteinModelPortal:   Q0BZX9
- SMR:   Q0BZX9
- STRING:   Q0BZX9
- GeneID:   4290444
- GenomeReviews:   CP000158_GR
- KEGG:   hne:HNE_2269
- NMPDR:   fig|228405.5.peg.2187
- TIGR:   HNE_2269
- eggNOG:   COG0105
- HOGENOM:   HBG445152
- OMA:   ERPFFGA
- PhylomeDB:   Q0BZX9
- BioCyc:   HNEP81032:HNE_2269-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00451
- InterPro:   IPR001564
- Gene3D:   G3DSA:3.30.70.141
- PANTHER:   PTHR11349
- PRINTS:   PR01243
- SMART:   SM00562

Pfam domain/function: PF00334 NDK; SSF54919 NDK

EC number: =2.7.4.6

Molecular weight: Translated: 15246; Mature: 15115

Theoretical pI: Translated: 5.23; Mature: 5.23

Prosite motif: PS00469 NDP_KINASES

Important sites: ACT_SITE 117-117 BINDING 11-11 BINDING 59-59 BINDING 87-87 BINDING 93-93 BINDING 104-104 BINDING 114-114

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAVQRTFSIIKPDATERNLTGAINAVIEKAGLRIVGQRRIQMTRAQAERFYSVHSARPFF
CCCCHHHHHCCCCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCCCHH
GELVDFMISGPVVVQVLEAEDAITKYREVMGATNPADAADGTIRKLFAKSIGENSVHGSD
HHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHCCCCCCCCCC
SAENAALEIAQFFSEADLTN
CHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure 
AVQRTFSIIKPDATERNLTGAINAVIEKAGLRIVGQRRIQMTRAQAERFYSVHSARPFF
CCCHHHHHCCCCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCCCHH
GELVDFMISGPVVVQVLEAEDAITKYREVMGATNPADAADGTIRKLFAKSIGENSVHGSD
HHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHCCCCCCCCCC
SAENAALEIAQFFSEADLTN
CHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA