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The map label for this gene is rfbD [C]

Identifier: 114798649

GI number: 114798649

Start: 792151

End: 793041

Strand: Direct

Name: rfbD [C]

Synonym: HNE_0780

Alternate gene names: 114798649

Gene position: 792151-793041 (Clockwise)

Preceding gene: 114799033

Following gene: 114797221

Centisome position: 21.38

GC content: 61.84

Gene sequence:

>891_bases
ATGACAGCTCGCTCCGGGCCAATTCTTGTCATCGGCAGCAGCGGGCAGCTGGCCCAAAGCCTGCGCGCAATGGGCCGCGA
GGATGTGGTGTGTGTGGGCCGGCCGGACGCGGATCTGGCAGACCCCATCAAGCTTGCCGATCTGGTGGCGAAGATGACGC
CGCGCCTCGTGCTGAACGCGGGCGGCTATACCAAGGTTGACCCGGCCGAGACCCAGACAAGTGAAGCCTTTGCGCTGAAC
CGGGACGGCCCTGCCACGCTCGCCCGGCTTTGCGCGTCTGCGGACATTCCGTTGATCCACATTTCGACCGATTGTGTCTT
TGATGGCCGCAAAGAGGCGCCGTACACGCCCGAAGACCTGGCGGAGCCGATAAATGCCTATGGCCGATCAAAGCTGGCCG
GCGAAGAAGCCGTTGCCCTGTCCTGCCGGAAACACCTTATTGTGCGTGTGTCTTGGGTGTTCTCCGAACATGCAGACAAC
TTCGTCCGTACAATGCTGAAGATTGCGCGCCAGCGCGACGAGATTTCGGTTGTCCGCGACCAGATCGGATACCCGACTTA
CTGCCCTGATCTTGCGGCGGGGCTGCTTGAGATTGCCGGCCAGGTGCTTCAGCCCGGATTTGAGGATTGGGGCATCTACC
ATCTGGCGGGCGGCAGCGAGGTGGACCGGGCCAGTATGGCAGAAGCCATCTTTGCGGAAAGCCGCACAATTGGCGGGCCG
GCGGCGCGGGTGTTGCCGGTTCTGACGCAGGATTATCCCACACCGGCCGAGCGGCCATTGAATGCGCGGCTGGACGCGGG
CAAGGCTAACCGCGTATTCGGCGTGGCTTTGCCAAACTGGCAGATTGGTCTTCAGAAATCTGTCAGGGTTCTTGTGGCAC
AAGACAGCTGA

Upstream 100 bases:

>100_bases
TTCCAACGGACTCCCTCATCTTGTCTGATAAAGACCGGAGGCTGCCTGCACTTAAAGATTGTTCAGATTTGGTCTGGCCA
GCTGCCGTGGGCCTGAACCG

Downstream 100 bases:

>100_bases
TTGCGGGCAGGACGGGCGAGGCAGAAAATGAACTCCATCGGTGACATCGAGCAGCGGATATTCCTGACCCTCAAGGAGAA
AGGGCCCCAGATCGGCAAGG

Product: dTDP-4-dehydrorhamnose reductase

Products: NA

Alternate protein names: dTDP-4-keto-L-rhamnose reductase; dTDP-6-deoxy-L-lyxo-4-hexulose reductase; dTDP-6-deoxy-L-mannose dehydrogenase; dTDP-L-rhamnose synthase [H]

Number of amino acids: Translated: 296; Mature: 295

Protein sequence:

>296_residues
MTARSGPILVIGSSGQLAQSLRAMGREDVVCVGRPDADLADPIKLADLVAKMTPRLVLNAGGYTKVDPAETQTSEAFALN
RDGPATLARLCASADIPLIHISTDCVFDGRKEAPYTPEDLAEPINAYGRSKLAGEEAVALSCRKHLIVRVSWVFSEHADN
FVRTMLKIARQRDEISVVRDQIGYPTYCPDLAAGLLEIAGQVLQPGFEDWGIYHLAGGSEVDRASMAEAIFAESRTIGGP
AARVLPVLTQDYPTPAERPLNARLDAGKANRVFGVALPNWQIGLQKSVRVLVAQDS

Sequences:

>Translated_296_residues
MTARSGPILVIGSSGQLAQSLRAMGREDVVCVGRPDADLADPIKLADLVAKMTPRLVLNAGGYTKVDPAETQTSEAFALN
RDGPATLARLCASADIPLIHISTDCVFDGRKEAPYTPEDLAEPINAYGRSKLAGEEAVALSCRKHLIVRVSWVFSEHADN
FVRTMLKIARQRDEISVVRDQIGYPTYCPDLAAGLLEIAGQVLQPGFEDWGIYHLAGGSEVDRASMAEAIFAESRTIGGP
AARVLPVLTQDYPTPAERPLNARLDAGKANRVFGVALPNWQIGLQKSVRVLVAQDS
>Mature_295_residues
TARSGPILVIGSSGQLAQSLRAMGREDVVCVGRPDADLADPIKLADLVAKMTPRLVLNAGGYTKVDPAETQTSEAFALNR
DGPATLARLCASADIPLIHISTDCVFDGRKEAPYTPEDLAEPINAYGRSKLAGEEAVALSCRKHLIVRVSWVFSEHADNF
VRTMLKIARQRDEISVVRDQIGYPTYCPDLAAGLLEIAGQVLQPGFEDWGIYHLAGGSEVDRASMAEAIFAESRTIGGPA
ARVLPVLTQDYPTPAERPLNARLDAGKANRVFGVALPNWQIGLQKSVRVLVAQDS

Specific function: Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4- hexulose to yield dTDP-L-rhamnose. RmlD uses NADH and NADPH nearly equally well [H]

COG id: COG1091

COG function: function code M; dTDP-4-dehydrorhamnose reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the dTDP-4-dehydrorhamnose reductase family [H]

Homologues:

Organism=Homo sapiens, GI33519455, Length=298, Percent_Identity=27.5167785234899, Blast_Score=92, Evalue=6e-19,
Organism=Homo sapiens, GI11034825, Length=298, Percent_Identity=27.5167785234899, Blast_Score=92, Evalue=6e-19,
Organism=Escherichia coli, GI1788352, Length=295, Percent_Identity=34.9152542372881, Blast_Score=177, Evalue=7e-46,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005913
- InterPro:   IPR016040 [H]

Pfam domain/function: PF04321 RmlD_sub_bind [H]

EC number: =1.1.1.133 [H]

Molecular weight: Translated: 31831; Mature: 31699

Theoretical pI: Translated: 5.43; Mature: 5.43

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTARSGPILVIGSSGQLAQSLRAMGREDVVCVGRPDADLADPIKLADLVAKMTPRLVLNA
CCCCCCCEEEECCCCHHHHHHHHCCCCCEEEECCCCCCCCCHHHHHHHHHHHCCCEEEEC
GGYTKVDPAETQTSEAFALNRDGPATLARLCASADIPLIHISTDCVFDGRKEAPYTPEDL
CCCCCCCCCCCCCCCEEEECCCCHHHHHHHHHCCCCCEEEEECCEEECCCCCCCCCHHHH
AEPINAYGRSKLAGEEAVALSCRKHLIVRVSWVFSEHADNFVRTMLKIARQRDEISVVRD
HHHHHHHCCCCCCCCHHHHHHHHHHEEEEEHHHHHHHHHHHHHHHHHHHHCCHHHHHHHH
QIGYPTYCPDLAAGLLEIAGQVLQPGFEDWGIYHLAGGSEVDRASMAEAIFAESRTIGGP
HCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCEEEECCCCCCHHHHHHHHHHHHCCCCCCC
AARVLPVLTQDYPTPAERPLNARLDAGKANRVFGVALPNWQIGLQKSVRVLVAQDS
HHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCEEEEECCCCCCCCCCCEEEEEEECC
>Mature Secondary Structure 
TARSGPILVIGSSGQLAQSLRAMGREDVVCVGRPDADLADPIKLADLVAKMTPRLVLNA
CCCCCCEEEECCCCHHHHHHHHCCCCCEEEECCCCCCCCCHHHHHHHHHHHCCCEEEEC
GGYTKVDPAETQTSEAFALNRDGPATLARLCASADIPLIHISTDCVFDGRKEAPYTPEDL
CCCCCCCCCCCCCCCEEEECCCCHHHHHHHHHCCCCCEEEEECCEEECCCCCCCCCHHHH
AEPINAYGRSKLAGEEAVALSCRKHLIVRVSWVFSEHADNFVRTMLKIARQRDEISVVRD
HHHHHHHCCCCCCCCHHHHHHHHHHEEEEEHHHHHHHHHHHHHHHHHHHHCCHHHHHHHH
QIGYPTYCPDLAAGLLEIAGQVLQPGFEDWGIYHLAGGSEVDRASMAEAIFAESRTIGGP
HCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCEEEECCCCCCHHHHHHHHHHHHCCCCCCC
AARVLPVLTQDYPTPAERPLNARLDAGKANRVFGVALPNWQIGLQKSVRVLVAQDS
HHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCEEEEECCCCCCCCCCCEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9163424 [H]