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The map label for this gene is yngJ [H]

Identifier: 114798570

GI number: 114798570

Start: 1190384

End: 1191577

Strand: Direct

Name: yngJ [H]

Synonym: HNE_1183

Alternate gene names: 114798570

Gene position: 1190384-1191577 (Clockwise)

Preceding gene: 114799216

Following gene: 114800547

Centisome position: 32.13

GC content: 62.81

Gene sequence:

>1194_bases
ATGAAGCTGACACTCGACCCCCAATATGAAGCCTTTCGCGCAGAAGTCTCTGACACGCTGGCGAAGAACGCTCATCTCGC
GCCCACGTCTGAGGACAAGGGCTACAAGAACGCCAAACGCATCGCCTGGCAGAAACTGCTGATCGCGAACGGGCTGGCGG
CGCGGACCATCCCCAAGGAATATGGGGGGTATGGCGCCGAGCCGGATATTCTCAAAGCGCGGATCATCGCCGAGGAGTTT
GCGCGCACGCGTATTCCGGGCCCGATGGCCGGGCAGGGTATCTCGATGTTCGTGCCGACGCTGCTGGAGCTGGGCACGGA
GGCGCAGAAGCAGGCCTACATCCGTCCGACGATCGAGGGCGAGATGATCTGGTGTCAGGGCTATTCGGAGCCGGGCGCGG
GGTCTGATCTTGCGGCGGTGCGCACCTCCGCGGTTGAGGACGGCGATGATTATGTGATCAACGGATCGAAGATCTGGACC
TCGACGGCCAAGCAGGCGGACATGATCTTCTGCCTTGTGCGGACGGACCCGGCGGCGAAGAAGCATGAGGGCATCACCTA
CATCACCTTCCCGATGACGACGCCGGGCATTGAAGTGCGCCCGCTGGTCGATATGACGGGGAGCGCGAACTTCAACGAGG
TGTTCTTTACCGATGTGCGCGTGCCCAAGAGCGGCGTGATCTTTGCGCCGAACAAAGGCTGGCAGGTGGCCAACGCCACG
CTGACCCATGAGCGCGGGATGCTGGGCGATCCGAACGCGACCAAGGCGCGGCTGCTGGAGCTGATCACGCTGATGAAGGC
GGAGACGGTGAATGGCGCGCGGCTGATTGATAATCCCGTGCTGCGGGACCGGCTGATGAAGCTGCAGGGGGAAGTCTATG
CGATGCAGGCCAATGGGCTGCGTATCACGACGAGCCGGCTTCAGGGGCAGCAGGCGGGGCTGGCGGGCCTGGTGGTGAAG
TTGCAGGGGTGTGATCTCAACCATGAGATTGCGCGCCTCGCGATCGACGCGCTGGGGGAGCTGGGCATCCTCTATGAAGA
GGGCGAGCATCTGCGCGCCGATGGCAACTGGCAGTGGCGGTATATGTACGATCTCGGCCTGATCATCGGCGGGGGCACCG
CGCAGATCCAGAAGAACATCATTGCGGAACGCGGGCTCGACATGCCGCGTGAGCCGAAGCTGGCGAAGGTATAG

Upstream 100 bases:

>100_bases
TCTCCCTTAACTGAGTGGCACTCAGCTAAGAGGGTTTCCGCAACGTCGCGCAAGAACCCCTCTTGCGCGACGTTGGGGCA
AGGGGCGAGAGAGTTACGTC

Downstream 100 bases:

>100_bases
GCTCATGGAATTTGCACTTTCTGAAGACCAGCGCATGCTGCAGGACAGCCTCAAGGGCGTTCTGGGCGAGGCGGCACATC
TTGATCGTATACGGAAAATC

Product: acyl-CoA dehydrogenase

Products: gamma-butyrobetaine; Acceptor; gamma-butyrobetainyl-CoA [C]

Alternate protein names: NA

Number of amino acids: Translated: 397; Mature: 397

Protein sequence:

>397_residues
MKLTLDPQYEAFRAEVSDTLAKNAHLAPTSEDKGYKNAKRIAWQKLLIANGLAARTIPKEYGGYGAEPDILKARIIAEEF
ARTRIPGPMAGQGISMFVPTLLELGTEAQKQAYIRPTIEGEMIWCQGYSEPGAGSDLAAVRTSAVEDGDDYVINGSKIWT
STAKQADMIFCLVRTDPAAKKHEGITYITFPMTTPGIEVRPLVDMTGSANFNEVFFTDVRVPKSGVIFAPNKGWQVANAT
LTHERGMLGDPNATKARLLELITLMKAETVNGARLIDNPVLRDRLMKLQGEVYAMQANGLRITTSRLQGQQAGLAGLVVK
LQGCDLNHEIARLAIDALGELGILYEEGEHLRADGNWQWRYMYDLGLIIGGGTAQIQKNIIAERGLDMPREPKLAKV

Sequences:

>Translated_397_residues
MKLTLDPQYEAFRAEVSDTLAKNAHLAPTSEDKGYKNAKRIAWQKLLIANGLAARTIPKEYGGYGAEPDILKARIIAEEF
ARTRIPGPMAGQGISMFVPTLLELGTEAQKQAYIRPTIEGEMIWCQGYSEPGAGSDLAAVRTSAVEDGDDYVINGSKIWT
STAKQADMIFCLVRTDPAAKKHEGITYITFPMTTPGIEVRPLVDMTGSANFNEVFFTDVRVPKSGVIFAPNKGWQVANAT
LTHERGMLGDPNATKARLLELITLMKAETVNGARLIDNPVLRDRLMKLQGEVYAMQANGLRITTSRLQGQQAGLAGLVVK
LQGCDLNHEIARLAIDALGELGILYEEGEHLRADGNWQWRYMYDLGLIIGGGTAQIQKNIIAERGLDMPREPKLAKV
>Mature_397_residues
MKLTLDPQYEAFRAEVSDTLAKNAHLAPTSEDKGYKNAKRIAWQKLLIANGLAARTIPKEYGGYGAEPDILKARIIAEEF
ARTRIPGPMAGQGISMFVPTLLELGTEAQKQAYIRPTIEGEMIWCQGYSEPGAGSDLAAVRTSAVEDGDDYVINGSKIWT
STAKQADMIFCLVRTDPAAKKHEGITYITFPMTTPGIEVRPLVDMTGSANFNEVFFTDVRVPKSGVIFAPNKGWQVANAT
LTHERGMLGDPNATKARLLELITLMKAETVNGARLIDNPVLRDRLMKLQGEVYAMQANGLRITTSRLQGQQAGLAGLVVK
LQGCDLNHEIARLAIDALGELGILYEEGEHLRADGNWQWRYMYDLGLIIGGGTAQIQKNIIAERGLDMPREPKLAKV

Specific function: Catalyzes the reduction of crotonobetainyl-CoA to gamma-butyrobetainyl-CoA. [C]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the acyl-CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI4557233, Length=199, Percent_Identity=35.1758793969849, Blast_Score=111, Evalue=1e-24,
Organism=Homo sapiens, GI226958412, Length=245, Percent_Identity=31.0204081632653, Blast_Score=103, Evalue=3e-22,
Organism=Homo sapiens, GI226958414, Length=243, Percent_Identity=30.0411522633745, Blast_Score=100, Evalue=4e-21,
Organism=Homo sapiens, GI4501857, Length=355, Percent_Identity=25.6338028169014, Blast_Score=100, Evalue=5e-21,
Organism=Homo sapiens, GI4557231, Length=355, Percent_Identity=27.0422535211268, Blast_Score=99, Evalue=6e-21,
Organism=Homo sapiens, GI187960098, Length=355, Percent_Identity=27.0422535211268, Blast_Score=99, Evalue=7e-21,
Organism=Homo sapiens, GI4501859, Length=202, Percent_Identity=30.6930693069307, Blast_Score=89, Evalue=6e-18,
Organism=Homo sapiens, GI48976061, Length=150, Percent_Identity=36, Blast_Score=86, Evalue=5e-17,
Organism=Homo sapiens, GI211971008, Length=150, Percent_Identity=36, Blast_Score=86, Evalue=5e-17,
Organism=Homo sapiens, GI76496475, Length=350, Percent_Identity=28, Blast_Score=84, Evalue=2e-16,
Organism=Homo sapiens, GI4557235, Length=350, Percent_Identity=28, Blast_Score=84, Evalue=2e-16,
Organism=Homo sapiens, GI38505218, Length=146, Percent_Identity=32.8767123287671, Blast_Score=82, Evalue=9e-16,
Organism=Homo sapiens, GI21361497, Length=261, Percent_Identity=26.0536398467433, Blast_Score=70, Evalue=5e-12,
Organism=Homo sapiens, GI7656849, Length=137, Percent_Identity=32.1167883211679, Blast_Score=68, Evalue=1e-11,
Organism=Escherichia coli, GI1786223, Length=262, Percent_Identity=24.4274809160305, Blast_Score=65, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI17551932, Length=315, Percent_Identity=28.8888888888889, Blast_Score=114, Evalue=6e-26,
Organism=Caenorhabditis elegans, GI71990804, Length=253, Percent_Identity=31.6205533596838, Blast_Score=114, Evalue=9e-26,
Organism=Caenorhabditis elegans, GI17505929, Length=349, Percent_Identity=28.6532951289398, Blast_Score=112, Evalue=4e-25,
Organism=Caenorhabditis elegans, GI17508101, Length=273, Percent_Identity=31.5018315018315, Blast_Score=105, Evalue=4e-23,
Organism=Caenorhabditis elegans, GI17506239, Length=298, Percent_Identity=29.1946308724832, Blast_Score=103, Evalue=2e-22,
Organism=Caenorhabditis elegans, GI17570075, Length=404, Percent_Identity=25.7425742574257, Blast_Score=102, Evalue=3e-22,
Organism=Caenorhabditis elegans, GI17538396, Length=235, Percent_Identity=31.063829787234, Blast_Score=99, Evalue=3e-21,
Organism=Caenorhabditis elegans, GI17534899, Length=241, Percent_Identity=32.7800829875519, Blast_Score=97, Evalue=2e-20,
Organism=Caenorhabditis elegans, GI32563615, Length=231, Percent_Identity=31.6017316017316, Blast_Score=97, Evalue=2e-20,
Organism=Caenorhabditis elegans, GI17569725, Length=191, Percent_Identity=32.9842931937173, Blast_Score=90, Evalue=2e-18,
Organism=Caenorhabditis elegans, GI71982178, Length=187, Percent_Identity=28.3422459893048, Blast_Score=70, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17562446, Length=210, Percent_Identity=27.6190476190476, Blast_Score=67, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17534353, Length=300, Percent_Identity=27.3333333333333, Blast_Score=67, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI71985184, Length=212, Percent_Identity=29.2452830188679, Blast_Score=66, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI71985192, Length=212, Percent_Identity=28.7735849056604, Blast_Score=65, Evalue=4e-11,
Organism=Drosophila melanogaster, GI21356377, Length=215, Percent_Identity=33.4883720930233, Blast_Score=104, Evalue=1e-22,
Organism=Drosophila melanogaster, GI24646207, Length=221, Percent_Identity=32.1266968325792, Blast_Score=99, Evalue=6e-21,
Organism=Drosophila melanogaster, GI24660351, Length=352, Percent_Identity=27.8409090909091, Blast_Score=90, Evalue=3e-18,
Organism=Drosophila melanogaster, GI21355753, Length=217, Percent_Identity=33.1797235023041, Blast_Score=89, Evalue=6e-18,
Organism=Drosophila melanogaster, GI281363737, Length=304, Percent_Identity=26.3157894736842, Blast_Score=82, Evalue=6e-16,
Organism=Drosophila melanogaster, GI24666513, Length=236, Percent_Identity=27.5423728813559, Blast_Score=79, Evalue=7e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006089
- InterPro:   IPR006092
- InterPro:   IPR006090
- InterPro:   IPR006091
- InterPro:   IPR009075
- InterPro:   IPR013786
- InterPro:   IPR009100 [H]

Pfam domain/function: PF00441 Acyl-CoA_dh_1; PF02770 Acyl-CoA_dh_M; PF02771 Acyl-CoA_dh_N [H]

EC number: 1.3.99.- [C]

Molecular weight: Translated: 43515; Mature: 43515

Theoretical pI: Translated: 6.69; Mature: 6.69

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKLTLDPQYEAFRAEVSDTLAKNAHLAPTSEDKGYKNAKRIAWQKLLIANGLAARTIPKE
CEEECCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCHHHCCCHH
YGGYGAEPDILKARIIAEEFARTRIPGPMAGQGISMFVPTLLELGTEAQKQAYIRPTIEG
HCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHCCCHHHCEEECCCCCC
EMIWCQGYSEPGAGSDLAAVRTSAVEDGDDYVINGSKIWTSTAKQADMIFCLVRTDPAAK
CEEEEECCCCCCCCCCHHHHHHHCCCCCCCEEEECCEEEECCCCCCEEEEEEEECCCCCH
KHEGITYITFPMTTPGIEVRPLVDMTGSANFNEVFFTDVRVPKSGVIFAPNKGWQVANAT
HHCCEEEEEECCCCCCCEEEEEEECCCCCCCCEEEEEEEECCCCCEEECCCCCCEEEEEE
LTHERGMLGDPNATKARLLELITLMKAETVNGARLIDNPVLRDRLMKLQGEVYAMQANGL
EECCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCHHCCHHHHHHHHHHCCCEEEEECCCE
RITTSRLQGQQAGLAGLVVKLQGCDLNHEIARLAIDALGELGILYEEGEHLRADGNWQWR
EEEHHHHCCCCCCCEEEEEEEECCCCCHHHHHHHHHHHHHCCEEEECCCEEECCCCEEEE
YMYDLGLIIGGGTAQIQKNIIAERGLDMPREPKLAKV
EEEEEEEEEECCHHHHHHHHHHHCCCCCCCCCCCCCC
>Mature Secondary Structure
MKLTLDPQYEAFRAEVSDTLAKNAHLAPTSEDKGYKNAKRIAWQKLLIANGLAARTIPKE
CEEECCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCHHHCCCHH
YGGYGAEPDILKARIIAEEFARTRIPGPMAGQGISMFVPTLLELGTEAQKQAYIRPTIEG
HCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHCCCHHHCEEECCCCCC
EMIWCQGYSEPGAGSDLAAVRTSAVEDGDDYVINGSKIWTSTAKQADMIFCLVRTDPAAK
CEEEEECCCCCCCCCCHHHHHHHCCCCCCCEEEECCEEEECCCCCCEEEEEEEECCCCCH
KHEGITYITFPMTTPGIEVRPLVDMTGSANFNEVFFTDVRVPKSGVIFAPNKGWQVANAT
HHCCEEEEEECCCCCCCEEEEEEECCCCCCCCEEEEEEEECCCCCEEECCCCCCEEEEEE
LTHERGMLGDPNATKARLLELITLMKAETVNGARLIDNPVLRDRLMKLQGEVYAMQANGL
EECCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCHHCCHHHHHHHHHHCCCEEEEECCCE
RITTSRLQGQQAGLAGLVVKLQGCDLNHEIARLAIDALGELGILYEEGEHLRADGNWQWR
EEEHHHHCCCCCCCEEEEEEEECCCCCHHHHHHHHHHHHHCCEEEECCCEEECCCCEEEE
YMYDLGLIIGGGTAQIQKNIIAERGLDMPREPKLAKV
EEEEEEEEEECCHHHHHHHHHHHCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: crotono-betaine; reduced acceptor; crotonobetainyl-CoA [C]

Specific reaction: reduced acceptor + crotono-betaine = Acceptor + gamma-butyrobetaine reduced acceptor + crotonobetainyl-CoA = Acceptor + gamma-butyrobetainyl-CoA [C]

General reaction: Oxidoreductases; Acting on the CH-CH group of donors; With other acceptors [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9387222; 9384377 [H]