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The map label for this gene is hppD [H]

Identifier: 114798568

GI number: 114798568

Start: 3056797

End: 3057897

Strand: Reverse

Name: hppD [H]

Synonym: HNE_2900

Alternate gene names: 114798568

Gene position: 3057897-3056797 (Counterclockwise)

Preceding gene: 114800555

Following gene: 114797531

Centisome position: 82.53

GC content: 58.86

Gene sequence:

>1101_bases
ATGGCTGATCTTTTCGACAATCCCGCCGGCCTCGATGGATTCGAGTTCATTGAGTTCTCTGCCCCTGAAAAAGGCATTCT
GGAGCCGGTTTTTGAAGGCATGGGCTTCACCAAGGTTGCCCGGCACCGCTCCAAGGATGTCGAGCTGTGGCGCCAGGGCG
GCATCAACCTGATCACCAATTATGAGCCCAAGTCTGCCGCCTGGTATTTTGCGCGCGAGCATGGCGCCTCGGCCTGCGGG
ATGGGCTTTCGCGTGCGTGATGCGCGCAAAGCCTATGACCATCTGCTGACGCAAGGGGCAGAGCCCGTGCAGGTGGAGAC
CGGGCCGATGGAGCTGCATATTCCCGGCATCCGCGGCATCGGCAATTCGATCATCTATCTGATCGACCGGTATGACACCG
GCGCGAATGAGCTGTCGATCTATGACATCGATTTTGAGTATCTGCCGGGCGTGGACAAGACGCCGATGGGCGCAGGCTTC
AAGCTGATCGATCACCTGACGCATAATGTTTACGGCGGCCGCATGAAATATTGGGCGGACTTCTATGAGAAGCTCTTCAA
TTTCCGCGAAATCCGCTATTTCGACATCAAGGGCGAATATACGGGCCTCACCTCCAAGGCGCTGACGGCGCCGGACGGGA
AGATCCGCATACCGCTGAACGAAGAGGGCAAGGGTGGCGGCGGCCAGATCGAGGAATTCCTGCGGGAGTTCAACGGCGAG
GGCATCCAGCATATCGCGCTGATCTGTGACGACCTTTATGCCTGTTGGGACCGGCTGCAGAAGCTGGGCGTGCCGTTCAT
GACGGCGCCGCCGCCAGCTTACTATGAGATGCTCGACGGGCGCCTGCCGGGGCATGGCGAGGACGTGAAAGCGTTGCAGG
CACGCGGCCTTCTCATGGACGGAACGACCGAGGGCGGCGAGCCGCGCCTCTTGTTGCAGATCTTCGCGCAGGCACAGGTT
GGCCCGGTATTCTTCGAGTTCATCCAGCGCAAGGGCGACTATAAGGACGGCTTTGGCGAGGGCAATTTCAAGGCCTTGTT
TGAATCGATGGAACGTGACCAGATTGATCGCGGCGTACTGAAGACTGAGGAAAAGGTTTGA

Upstream 100 bases:

>100_bases
ACATCGGGTTTTCTCTCATCGGAAGCATCTTGCGGGCACGCGTGAAATTAGTTACATATGAAACTATATATTTCACACGC
GCAATATGGAGCCTTTTGCC

Downstream 100 bases:

>100_bases
TGGCAGCCCCCAAACTCAAAGGCGTTCACCACGTCGCCTATCGCTGCAAGGATGCGAAGGAGACGGTGGAGTTCTACAAG
AAGACGCTGGGCATGGAGTT

Product: 4-hydroxyphenylpyruvate dioxygenase

Products: NA

Alternate protein names: 4HPPD; HPD; HPPDase [H]

Number of amino acids: Translated: 366; Mature: 365

Protein sequence:

>366_residues
MADLFDNPAGLDGFEFIEFSAPEKGILEPVFEGMGFTKVARHRSKDVELWRQGGINLITNYEPKSAAWYFAREHGASACG
MGFRVRDARKAYDHLLTQGAEPVQVETGPMELHIPGIRGIGNSIIYLIDRYDTGANELSIYDIDFEYLPGVDKTPMGAGF
KLIDHLTHNVYGGRMKYWADFYEKLFNFREIRYFDIKGEYTGLTSKALTAPDGKIRIPLNEEGKGGGGQIEEFLREFNGE
GIQHIALICDDLYACWDRLQKLGVPFMTAPPPAYYEMLDGRLPGHGEDVKALQARGLLMDGTTEGGEPRLLLQIFAQAQV
GPVFFEFIQRKGDYKDGFGEGNFKALFESMERDQIDRGVLKTEEKV

Sequences:

>Translated_366_residues
MADLFDNPAGLDGFEFIEFSAPEKGILEPVFEGMGFTKVARHRSKDVELWRQGGINLITNYEPKSAAWYFAREHGASACG
MGFRVRDARKAYDHLLTQGAEPVQVETGPMELHIPGIRGIGNSIIYLIDRYDTGANELSIYDIDFEYLPGVDKTPMGAGF
KLIDHLTHNVYGGRMKYWADFYEKLFNFREIRYFDIKGEYTGLTSKALTAPDGKIRIPLNEEGKGGGGQIEEFLREFNGE
GIQHIALICDDLYACWDRLQKLGVPFMTAPPPAYYEMLDGRLPGHGEDVKALQARGLLMDGTTEGGEPRLLLQIFAQAQV
GPVFFEFIQRKGDYKDGFGEGNFKALFESMERDQIDRGVLKTEEKV
>Mature_365_residues
ADLFDNPAGLDGFEFIEFSAPEKGILEPVFEGMGFTKVARHRSKDVELWRQGGINLITNYEPKSAAWYFAREHGASACGM
GFRVRDARKAYDHLLTQGAEPVQVETGPMELHIPGIRGIGNSIIYLIDRYDTGANELSIYDIDFEYLPGVDKTPMGAGFK
LIDHLTHNVYGGRMKYWADFYEKLFNFREIRYFDIKGEYTGLTSKALTAPDGKIRIPLNEEGKGGGGQIEEFLREFNGEG
IQHIALICDDLYACWDRLQKLGVPFMTAPPPAYYEMLDGRLPGHGEDVKALQARGLLMDGTTEGGEPRLLLQIFAQAQVG
PVFFEFIQRKGDYKDGFGEGNFKALFESMERDQIDRGVLKTEEKV

Specific function: Unknown

COG id: COG3185

COG function: function code ER; 4-hydroxyphenylpyruvate dioxygenase and related hemolysins

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 4HPPD family [H]

Homologues:

Organism=Homo sapiens, GI4504477, Length=306, Percent_Identity=27.7777777777778, Blast_Score=92, Evalue=7e-19,
Organism=Homo sapiens, GI285002264, Length=306, Percent_Identity=27.7777777777778, Blast_Score=92, Evalue=7e-19,
Organism=Homo sapiens, GI14249394, Length=356, Percent_Identity=26.123595505618, Blast_Score=70, Evalue=4e-12,
Organism=Caenorhabditis elegans, GI17550752, Length=347, Percent_Identity=29.1066282420749, Blast_Score=117, Evalue=1e-26,
Organism=Caenorhabditis elegans, GI17555220, Length=314, Percent_Identity=31.5286624203822, Blast_Score=112, Evalue=2e-25,
Organism=Drosophila melanogaster, GI21356105, Length=309, Percent_Identity=28.8025889967638, Blast_Score=110, Evalue=2e-24,
Organism=Drosophila melanogaster, GI24667510, Length=309, Percent_Identity=28.8025889967638, Blast_Score=109, Evalue=2e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005956
- InterPro:   IPR004360 [H]

Pfam domain/function: PF00903 Glyoxalase [H]

EC number: =1.13.11.27 [H]

Molecular weight: Translated: 41156; Mature: 41025

Theoretical pI: Translated: 4.80; Mature: 4.80

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MADLFDNPAGLDGFEFIEFSAPEKGILEPVFEGMGFTKVARHRSKDVELWRQGGINLITN
CCCCCCCCCCCCCCCEEEECCCCCCHHHHHHHCCCHHHHHHHCCHHHHHHHCCCCEEEEC
YEPKSAAWYFAREHGASACGMGFRVRDARKAYDHLLTQGAEPVQVETGPMELHIPGIRGI
CCCCCCEEEEEHHCCCCHHCCCCEEHHHHHHHHHHHHCCCCCEEEECCCEEEEECCCCCC
GNSIIYLIDRYDTGANELSIYDIDFEYLPGVDKTPMGAGFKLIDHLTHNVYGGRMKYWAD
CCEEEEEEECCCCCCCEEEEEEECHHHCCCCCCCCCCCCHHHHHHHHHHHCCCHHHHHHH
FYEKLFNFREIRYFDIKGEYTGLTSKALTAPDGKIRIPLNEEGKGGGGQIEEFLREFNGE
HHHHHHCHHHEEEEEECCCCCCCCCCCEECCCCEEEEECCCCCCCCCHHHHHHHHHHCCC
GIQHIALICDDLYACWDRLQKLGVPFMTAPPPAYYEMLDGRLPGHGEDVKALQARGLLMD
CHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHCCCCCCCCCHHHHHHHCCEEEE
GTTEGGEPRLLLQIFAQAQVGPVFFEFIQRKGDYKDGFGEGNFKALFESMERDQIDRGVL
CCCCCCCCHHHHHHHHHHCCCHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHH
KTEEKV
HCCCCC
>Mature Secondary Structure 
ADLFDNPAGLDGFEFIEFSAPEKGILEPVFEGMGFTKVARHRSKDVELWRQGGINLITN
CCCCCCCCCCCCCCEEEECCCCCCHHHHHHHCCCHHHHHHHCCHHHHHHHCCCCEEEEC
YEPKSAAWYFAREHGASACGMGFRVRDARKAYDHLLTQGAEPVQVETGPMELHIPGIRGI
CCCCCCEEEEEHHCCCCHHCCCCEEHHHHHHHHHHHHCCCCCEEEECCCEEEEECCCCCC
GNSIIYLIDRYDTGANELSIYDIDFEYLPGVDKTPMGAGFKLIDHLTHNVYGGRMKYWAD
CCEEEEEEECCCCCCCEEEEEEECHHHCCCCCCCCCCCCHHHHHHHHHHHCCCHHHHHHH
FYEKLFNFREIRYFDIKGEYTGLTSKALTAPDGKIRIPLNEEGKGGGGQIEEFLREFNGE
HHHHHHCHHHEEEEEECCCCCCCCCCCEECCCCEEEEECCCCCCCCCHHHHHHHHHHCCC
GIQHIALICDDLYACWDRLQKLGVPFMTAPPPAYYEMLDGRLPGHGEDVKALQARGLLMD
CHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHCCCCCCCCCHHHHHHHCCEEEE
GTTEGGEPRLLLQIFAQAQVGPVFFEFIQRKGDYKDGFGEGNFKALFESMERDQIDRGVL
CCCCCCCCHHHHHHHHHHCCCHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHH
KTEEKV
HCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1572351; 10467142 [H]