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The map label for this gene is yngJ [H]

Identifier: 114798530

GI number: 114798530

Start: 2167109

End: 2168263

Strand: Reverse

Name: yngJ [H]

Synonym: HNE_2093

Alternate gene names: 114798530

Gene position: 2168263-2167109 (Counterclockwise)

Preceding gene: 114799055

Following gene: 114797562

Centisome position: 58.52

GC content: 60.95

Gene sequence:

>1155_bases
ATGGATTTCAATTTCACTGAAGAACAGACAATGATCCGCGACAGCCTCGCACGGCTGATCAAGGACCAGTACGACTTCGA
CACCCGCCGCAAGGTCGTCGCCTCGAAAGATGGCTGGCGTCCGGAAATGTGGGCCCAGTTCGCTGAACTTGGCCTGCTTG
CAGCGCCGTTCTCGGAAGAAGATGGCGGCCTCGGCGGCGGCCCGATCGATGCAATGGTCGTGATGGAAGAATTCGGCAAA
GGCCTCGTGGTCGAGCCGTTCCTTCAGACCGTCGTGCTCGCGGGCGGCTTCCTGAAGGCTGGCACCGAGGCGCAGAAGCA
GGACCATCTCGCTGCGCTGATCTCCGGCGAGCGCGTGTTCGCGTTTGCCTATGCCGAGCCCAAAGGCCGCTACAACCTGG
CCGACCTTGAAACCACGGCAACGAAAGACGGCAGCGGCTGGAAAATCTCCGGCCACAAGGCTGTCGTTATCGGCGCGCCC
TGGGCCTCGCACCTCATCGTCACGGCCCGCACCTCCGGTGGCCGCCGCGACGCCAAGGGCGTGGGCGTGTTCATCGTTGC
TAAGGATGCCAAAGGCGTCACGACGCGCGACTATCCGACCGTTGATGGCCGCCGCGCATCGGAAGTTCACTTCGATAACG
TCACCGTTGGCGCTGATGCCGTGATCGGCGATCCGTCTGACAGCCTCGGTCTCGTCGAGAAAGTCACCGATGAAGCCATC
GCAGCGCTGTGCGCTGAAGCCTGCGGCGCCATGAAAGTGGCCAACGCTCAAACTGTTGATTACTCCAAAACCCGCAAACA
GTTCGGCACGCCGATCGGCAAGTTCCAGGTTCTCCAGCACCGCATGGCCGACATGTTCATCGAGCATGAACAGTCGATCT
CCATGACCTACATGGCGACCCTGAAACTGGAAGAAGATGAAGTGACCCGCAAGAAGGCGGCTTCGGCAGCCAAGGTCCGC
ATCGGTCAGGCTGGCCGCTTTGTTGGCCAGCAGTCGATCCAGATCCATGGCGGCATGGGCATGACCGACGAGCTTGCCAT
CGGCCACTATTTCAAGCGTCTCACGATGATCGACTCCGAGTTCGGCAATGTCGACCACCACCTGAAGCGCTACACGGAGC
TGTCCGCAGCTGACGTGGCGGTTGCCGCGGAATAA

Upstream 100 bases:

>100_bases
AGACATCTATCTATGGCGGATCGAACGAGATCCAGCGCAACATTATCAGCAAGATGATCCTCGGCCTTTAAGGCAACGGG
GCAGGGAGGAGATTACATCC

Downstream 100 bases:

>100_bases
GGCCCCGAGGCCATTAACCAGATAAAAGCGGGGCGGCTCCAACGGGCCGCCCCGTTTGTTTCGGCGCCTCATCCGGCCCG
GAATTTGCAGGCGCATTCTG

Product: acyl-CoA dehydrogenase

Products: gamma-butyrobetaine; Acceptor; gamma-butyrobetainyl-CoA [C]

Alternate protein names: NA

Number of amino acids: Translated: 384; Mature: 384

Protein sequence:

>384_residues
MDFNFTEEQTMIRDSLARLIKDQYDFDTRRKVVASKDGWRPEMWAQFAELGLLAAPFSEEDGGLGGGPIDAMVVMEEFGK
GLVVEPFLQTVVLAGGFLKAGTEAQKQDHLAALISGERVFAFAYAEPKGRYNLADLETTATKDGSGWKISGHKAVVIGAP
WASHLIVTARTSGGRRDAKGVGVFIVAKDAKGVTTRDYPTVDGRRASEVHFDNVTVGADAVIGDPSDSLGLVEKVTDEAI
AALCAEACGAMKVANAQTVDYSKTRKQFGTPIGKFQVLQHRMADMFIEHEQSISMTYMATLKLEEDEVTRKKAASAAKVR
IGQAGRFVGQQSIQIHGGMGMTDELAIGHYFKRLTMIDSEFGNVDHHLKRYTELSAADVAVAAE

Sequences:

>Translated_384_residues
MDFNFTEEQTMIRDSLARLIKDQYDFDTRRKVVASKDGWRPEMWAQFAELGLLAAPFSEEDGGLGGGPIDAMVVMEEFGK
GLVVEPFLQTVVLAGGFLKAGTEAQKQDHLAALISGERVFAFAYAEPKGRYNLADLETTATKDGSGWKISGHKAVVIGAP
WASHLIVTARTSGGRRDAKGVGVFIVAKDAKGVTTRDYPTVDGRRASEVHFDNVTVGADAVIGDPSDSLGLVEKVTDEAI
AALCAEACGAMKVANAQTVDYSKTRKQFGTPIGKFQVLQHRMADMFIEHEQSISMTYMATLKLEEDEVTRKKAASAAKVR
IGQAGRFVGQQSIQIHGGMGMTDELAIGHYFKRLTMIDSEFGNVDHHLKRYTELSAADVAVAAE
>Mature_384_residues
MDFNFTEEQTMIRDSLARLIKDQYDFDTRRKVVASKDGWRPEMWAQFAELGLLAAPFSEEDGGLGGGPIDAMVVMEEFGK
GLVVEPFLQTVVLAGGFLKAGTEAQKQDHLAALISGERVFAFAYAEPKGRYNLADLETTATKDGSGWKISGHKAVVIGAP
WASHLIVTARTSGGRRDAKGVGVFIVAKDAKGVTTRDYPTVDGRRASEVHFDNVTVGADAVIGDPSDSLGLVEKVTDEAI
AALCAEACGAMKVANAQTVDYSKTRKQFGTPIGKFQVLQHRMADMFIEHEQSISMTYMATLKLEEDEVTRKKAASAAKVR
IGQAGRFVGQQSIQIHGGMGMTDELAIGHYFKRLTMIDSEFGNVDHHLKRYTELSAADVAVAAE

Specific function: Catalyzes the reduction of crotonobetainyl-CoA to gamma-butyrobetainyl-CoA. [C]

COG id: COG1960

COG function: function code I; Acyl-CoA dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the acyl-CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI4557233, Length=316, Percent_Identity=29.1139240506329, Blast_Score=132, Evalue=4e-31,
Organism=Homo sapiens, GI226958412, Length=355, Percent_Identity=25.9154929577465, Blast_Score=122, Evalue=7e-28,
Organism=Homo sapiens, GI226958414, Length=320, Percent_Identity=27.5, Blast_Score=118, Evalue=1e-26,
Organism=Homo sapiens, GI4501857, Length=358, Percent_Identity=24.0223463687151, Blast_Score=99, Evalue=6e-21,
Organism=Homo sapiens, GI76496475, Length=330, Percent_Identity=26.6666666666667, Blast_Score=98, Evalue=1e-20,
Organism=Homo sapiens, GI4557235, Length=330, Percent_Identity=26.6666666666667, Blast_Score=98, Evalue=1e-20,
Organism=Homo sapiens, GI21361497, Length=372, Percent_Identity=26.0752688172043, Blast_Score=96, Evalue=7e-20,
Organism=Homo sapiens, GI4501859, Length=357, Percent_Identity=26.0504201680672, Blast_Score=88, Evalue=1e-17,
Organism=Homo sapiens, GI7656849, Length=310, Percent_Identity=23.8709677419355, Blast_Score=81, Evalue=1e-15,
Organism=Homo sapiens, GI4503943, Length=386, Percent_Identity=22.5388601036269, Blast_Score=77, Evalue=2e-14,
Organism=Homo sapiens, GI4557231, Length=365, Percent_Identity=24.1095890410959, Blast_Score=76, Evalue=6e-14,
Organism=Homo sapiens, GI187960098, Length=365, Percent_Identity=24.1095890410959, Blast_Score=76, Evalue=7e-14,
Organism=Homo sapiens, GI7669494, Length=378, Percent_Identity=22.2222222222222, Blast_Score=74, Evalue=2e-13,
Organism=Escherichia coli, GI1786223, Length=364, Percent_Identity=25.2747252747253, Blast_Score=95, Evalue=1e-20,
Organism=Escherichia coli, GI87081958, Length=358, Percent_Identity=24.0223463687151, Blast_Score=91, Evalue=1e-19,
Organism=Caenorhabditis elegans, GI17538396, Length=361, Percent_Identity=25.4847645429363, Blast_Score=114, Evalue=6e-26,
Organism=Caenorhabditis elegans, GI17508101, Length=325, Percent_Identity=27.6923076923077, Blast_Score=112, Evalue=4e-25,
Organism=Caenorhabditis elegans, GI17506239, Length=357, Percent_Identity=28.0112044817927, Blast_Score=106, Evalue=2e-23,
Organism=Caenorhabditis elegans, GI71985184, Length=322, Percent_Identity=27.3291925465839, Blast_Score=101, Evalue=8e-22,
Organism=Caenorhabditis elegans, GI17534899, Length=355, Percent_Identity=26.1971830985915, Blast_Score=97, Evalue=1e-20,
Organism=Caenorhabditis elegans, GI17534353, Length=342, Percent_Identity=26.0233918128655, Blast_Score=96, Evalue=3e-20,
Organism=Caenorhabditis elegans, GI17569725, Length=358, Percent_Identity=24.8603351955307, Blast_Score=95, Evalue=5e-20,
Organism=Caenorhabditis elegans, GI71990804, Length=259, Percent_Identity=29.3436293436293, Blast_Score=89, Evalue=5e-18,
Organism=Caenorhabditis elegans, GI71985192, Length=289, Percent_Identity=26.643598615917, Blast_Score=86, Evalue=3e-17,
Organism=Caenorhabditis elegans, GI17570075, Length=357, Percent_Identity=25.2100840336134, Blast_Score=84, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI32563615, Length=229, Percent_Identity=30.5676855895196, Blast_Score=81, Evalue=8e-16,
Organism=Caenorhabditis elegans, GI17551932, Length=359, Percent_Identity=23.3983286908078, Blast_Score=79, Evalue=4e-15,
Organism=Caenorhabditis elegans, GI17505929, Length=362, Percent_Identity=24.0331491712707, Blast_Score=78, Evalue=8e-15,
Organism=Caenorhabditis elegans, GI17533517, Length=309, Percent_Identity=22.0064724919094, Blast_Score=75, Evalue=6e-14,
Organism=Caenorhabditis elegans, GI71982178, Length=233, Percent_Identity=26.1802575107296, Blast_Score=67, Evalue=2e-11,
Organism=Drosophila melanogaster, GI21356377, Length=320, Percent_Identity=30, Blast_Score=135, Evalue=4e-32,
Organism=Drosophila melanogaster, GI24646207, Length=319, Percent_Identity=30.0940438871473, Blast_Score=119, Evalue=3e-27,
Organism=Drosophila melanogaster, GI21355753, Length=358, Percent_Identity=27.6536312849162, Blast_Score=113, Evalue=2e-25,
Organism=Drosophila melanogaster, GI24666513, Length=359, Percent_Identity=26.1838440111421, Blast_Score=102, Evalue=6e-22,
Organism=Drosophila melanogaster, GI281363737, Length=362, Percent_Identity=25.9668508287293, Blast_Score=87, Evalue=3e-17,
Organism=Drosophila melanogaster, GI24660351, Length=362, Percent_Identity=24.3093922651934, Blast_Score=86, Evalue=3e-17,
Organism=Drosophila melanogaster, GI19920834, Length=391, Percent_Identity=23.2736572890026, Blast_Score=68, Evalue=9e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006089
- InterPro:   IPR006092
- InterPro:   IPR006090
- InterPro:   IPR006091
- InterPro:   IPR009075
- InterPro:   IPR013786
- InterPro:   IPR009100 [H]

Pfam domain/function: PF00441 Acyl-CoA_dh_1; PF02770 Acyl-CoA_dh_M; PF02771 Acyl-CoA_dh_N [H]

EC number: 1.3.99.- [C]

Molecular weight: Translated: 41644; Mature: 41644

Theoretical pI: Translated: 5.83; Mature: 5.83

Prosite motif: PS00389 ATPASE_DELTA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDFNFTEEQTMIRDSLARLIKDQYDFDTRRKVVASKDGWRPEMWAQFAELGLLAAPFSEE
CCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHCCCCCCHHHHHHHHHCCEEECCCCCC
DGGLGGGPIDAMVVMEEFGKGLVVEPFLQTVVLAGGFLKAGTEAQKQDHLAALISGERVF
CCCCCCCCHHHHHHHHHHCCCCEEHHHHHHHHHHCCHHHCCCCHHHHHHHHEEECCCEEE
AFAYAEPKGRYNLADLETTATKDGSGWKISGHKAVVIGAPWASHLIVTARTSGGRRDAKG
EEEEECCCCCEEEECCCCCCCCCCCCEEECCCEEEEEECCCCCEEEEEEECCCCCCCCCC
VGVFIVAKDAKGVTTRDYPTVDGRRASEVHFDNVTVGADAVIGDPSDSLGLVEKVTDEAI
EEEEEEEECCCCCCCCCCCCCCCCCCCEEEECCEEECCCEEECCCCCCHHHHHHHHHHHH
AALCAEACGAMKVANAQTVDYSKTRKQFGTPIGKFQVLQHRMADMFIEHEQSISMTYMAT
HHHHHHHHCCEEECCCCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCEEEEEEE
LKLEEDEVTRKKAASAAKVRIGQAGRFVGQQSIQIHGGMGMTDELAIGHYFKRLTMIDSE
EEECHHHHHHHHHHHHHHEEECCCCCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHH
FGNVDHHLKRYTELSAADVAVAAE
CCCHHHHHHHHHHCCHHCEEEECC
>Mature Secondary Structure
MDFNFTEEQTMIRDSLARLIKDQYDFDTRRKVVASKDGWRPEMWAQFAELGLLAAPFSEE
CCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHCCCCCCHHHHHHHHHCCEEECCCCCC
DGGLGGGPIDAMVVMEEFGKGLVVEPFLQTVVLAGGFLKAGTEAQKQDHLAALISGERVF
CCCCCCCCHHHHHHHHHHCCCCEEHHHHHHHHHHCCHHHCCCCHHHHHHHHEEECCCEEE
AFAYAEPKGRYNLADLETTATKDGSGWKISGHKAVVIGAPWASHLIVTARTSGGRRDAKG
EEEEECCCCCEEEECCCCCCCCCCCCEEECCCEEEEEECCCCCEEEEEEECCCCCCCCCC
VGVFIVAKDAKGVTTRDYPTVDGRRASEVHFDNVTVGADAVIGDPSDSLGLVEKVTDEAI
EEEEEEEECCCCCCCCCCCCCCCCCCCEEEECCEEECCCEEECCCCCCHHHHHHHHHHHH
AALCAEACGAMKVANAQTVDYSKTRKQFGTPIGKFQVLQHRMADMFIEHEQSISMTYMAT
HHHHHHHHCCEEECCCCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCEEEEEEE
LKLEEDEVTRKKAASAAKVRIGQAGRFVGQQSIQIHGGMGMTDELAIGHYFKRLTMIDSE
EEECHHHHHHHHHHHHHHEEECCCCCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHH
FGNVDHHLKRYTELSAADVAVAAE
CCCHHHHHHHHHHCCHHCEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: crotono-betaine; reduced acceptor; crotonobetainyl-CoA [C]

Specific reaction: reduced acceptor + crotono-betaine = Acceptor + gamma-butyrobetaine reduced acceptor + crotonobetainyl-CoA = Acceptor + gamma-butyrobetainyl-CoA [C]

General reaction: Oxidoreductases; Acting on the CH-CH group of donors; With other acceptors [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9387222; 9384377 [H]