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The map label for this gene is phbA [H]

Identifier: 114798386

GI number: 114798386

Start: 3240139

End: 3241320

Strand: Direct

Name: phbA [H]

Synonym: HNE_3065

Alternate gene names: 114798386

Gene position: 3240139-3241320 (Clockwise)

Preceding gene: 114797596

Following gene: 114798997

Centisome position: 87.45

GC content: 64.47

Gene sequence:

>1182_bases
ATGTCAGAGAAAGATCCGGTCGTCATCGTAGGTATGGCCCGCACCCCCATGGGCGGCCTGCTCGGCGAACTCTCCAGCTT
CTCGGCCAATGAGCTTGGCGCCCATGTTGTCAAAGCCGCCGCCGCTGAAGCAAAGCTCGGCGCTGCGGAAGTCGATGAAG
TCATCATGGGCAACTGCCTGCCCGCTGGCCAGGGCCAGGCGCCTGCCCGCCAGGCGGCCATCAAATCCGGTCTCGACAAG
AACACCGAAGCCACCACCATCAACAAGATGTGCGGCTCGGGCATGGAAGCCGTCATCATGGGCCGCAACGCCCTGCTCGC
CGGTGAAGCCACCGTCATTGTTGCGGGCGGCATGGAATCCATGACCAACGCGCCCCACCTCATCACCCTACGCCAGGGCC
ATAAATACGGCGCGGCGTTCGCGCGCGACCATATGGCCACCGATGGCCTCGAAGACGCGTATGAAGGCGGCCCGATGGGC
AACTTTGCCGACATGATCGCCCGCGAGTACCAGTTCACCCGCGAGCAGCAGGATGCCTACGCCCTCGAAACCCTGCGCCG
CGCGCAGGACGCCACCAAGAACGGCAAGTTCAAGCGCGAAATCGCTCCGCTCACGGTAAAGACCCGCAAGGGCGAAACCG
TCGTCGATACCGACCAGCTGCCCCGCGAAGCGATGCCGGACAAGATCCCGACCCTGAAACCTGCCTTCAACAAGGATGGC
ACGGTAACCGCCGCCAACGCCTCGGCGATTTCCGATGGCGCCGCAGCCCTCGTGCTGATGCGCGAGTCCGAAGCCAAGAA
GCGCGGCCTCACGCCGATTGCGAAAATCGTCTCGGCCTCCAGCCACGCGCAGGAGCCGGCCTACTTCACCACCGCCCCCG
TCCCCGCCATGCAGAAGGCCCTCAAGAAAGCCGGCTGGAAAGCAGAGGATGTCGACCTGTGGGAAGTCAACGAAGCCTTC
GCCGTGGTCCCCATGATCGCGATGAAAGAACTCGGCATCAGCCATGACAAGCTGAACGTGAACGGCGGCGCCTGCGCCAT
GGGCCACCCGATCGGCGCGTCCGGGGCCCGCGTGCTCATCACCCTTCTGGCGGCGATGGAAGATCGCGGCCTCAAGAAGG
GCATGGCCTCCCTCTGCATCGGCGGCGGCGAAGGTATCGCCATGGCTGTCGAGCGCGTCTAA

Upstream 100 bases:

>100_bases
AGGTCAGGCTTGCCCGCCGCCCGGCCTTGACGAAGCGGCATGTCCGGCGCCTATTCTCCCGCGCTGCACAAGAACGCAAA
GTCAGGAAGGAAATAGCCCC

Downstream 100 bases:

>100_bases
GCCGCGCCATGCCGCTCCAGAACAGGGCTGACCCGCTGGGACTGCTGCACGCAGTTCCGCAGCGGGGCACCCTGATGGGC
AATCGGGGCGGCTGCTTTCA

Product: acetyl-CoA acetyltransferase/thiolase family protein

Products: NA

Alternate protein names: Acetoacetyl-CoA thiolase [H]

Number of amino acids: Translated: 393; Mature: 392

Protein sequence:

>393_residues
MSEKDPVVIVGMARTPMGGLLGELSSFSANELGAHVVKAAAAEAKLGAAEVDEVIMGNCLPAGQGQAPARQAAIKSGLDK
NTEATTINKMCGSGMEAVIMGRNALLAGEATVIVAGGMESMTNAPHLITLRQGHKYGAAFARDHMATDGLEDAYEGGPMG
NFADMIAREYQFTREQQDAYALETLRRAQDATKNGKFKREIAPLTVKTRKGETVVDTDQLPREAMPDKIPTLKPAFNKDG
TVTAANASAISDGAAALVLMRESEAKKRGLTPIAKIVSASSHAQEPAYFTTAPVPAMQKALKKAGWKAEDVDLWEVNEAF
AVVPMIAMKELGISHDKLNVNGGACAMGHPIGASGARVLITLLAAMEDRGLKKGMASLCIGGGEGIAMAVERV

Sequences:

>Translated_393_residues
MSEKDPVVIVGMARTPMGGLLGELSSFSANELGAHVVKAAAAEAKLGAAEVDEVIMGNCLPAGQGQAPARQAAIKSGLDK
NTEATTINKMCGSGMEAVIMGRNALLAGEATVIVAGGMESMTNAPHLITLRQGHKYGAAFARDHMATDGLEDAYEGGPMG
NFADMIAREYQFTREQQDAYALETLRRAQDATKNGKFKREIAPLTVKTRKGETVVDTDQLPREAMPDKIPTLKPAFNKDG
TVTAANASAISDGAAALVLMRESEAKKRGLTPIAKIVSASSHAQEPAYFTTAPVPAMQKALKKAGWKAEDVDLWEVNEAF
AVVPMIAMKELGISHDKLNVNGGACAMGHPIGASGARVLITLLAAMEDRGLKKGMASLCIGGGEGIAMAVERV
>Mature_392_residues
SEKDPVVIVGMARTPMGGLLGELSSFSANELGAHVVKAAAAEAKLGAAEVDEVIMGNCLPAGQGQAPARQAAIKSGLDKN
TEATTINKMCGSGMEAVIMGRNALLAGEATVIVAGGMESMTNAPHLITLRQGHKYGAAFARDHMATDGLEDAYEGGPMGN
FADMIAREYQFTREQQDAYALETLRRAQDATKNGKFKREIAPLTVKTRKGETVVDTDQLPREAMPDKIPTLKPAFNKDGT
VTAANASAISDGAAALVLMRESEAKKRGLTPIAKIVSASSHAQEPAYFTTAPVPAMQKALKKAGWKAEDVDLWEVNEAFA
VVPMIAMKELGISHDKLNVNGGACAMGHPIGASGARVLITLLAAMEDRGLKKGMASLCIGGGEGIAMAVERV

Specific function: SHORT-CHAIN FATTY ACIDS METABOLISM. [C]

COG id: COG0183

COG function: function code I; Acetyl-CoA acetyltransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thiolase family [H]

Homologues:

Organism=Homo sapiens, GI148539872, Length=391, Percent_Identity=47.3145780051151, Blast_Score=359, Evalue=2e-99,
Organism=Homo sapiens, GI4557237, Length=389, Percent_Identity=44.2159383033419, Blast_Score=311, Evalue=5e-85,
Organism=Homo sapiens, GI167614485, Length=388, Percent_Identity=39.1752577319588, Blast_Score=273, Evalue=1e-73,
Organism=Homo sapiens, GI4501853, Length=381, Percent_Identity=33.8582677165354, Blast_Score=190, Evalue=2e-48,
Organism=Homo sapiens, GI4504327, Length=426, Percent_Identity=29.81220657277, Blast_Score=147, Evalue=2e-35,
Organism=Homo sapiens, GI194353979, Length=372, Percent_Identity=25.5376344086022, Blast_Score=101, Evalue=1e-21,
Organism=Escherichia coli, GI1788554, Length=389, Percent_Identity=50.8997429305913, Blast_Score=347, Evalue=1e-96,
Organism=Escherichia coli, GI87082165, Length=388, Percent_Identity=45.6185567010309, Blast_Score=331, Evalue=6e-92,
Organism=Escherichia coli, GI1787663, Length=396, Percent_Identity=35.3535353535354, Blast_Score=227, Evalue=8e-61,
Organism=Escherichia coli, GI48994986, Length=399, Percent_Identity=37.844611528822, Blast_Score=227, Evalue=9e-61,
Organism=Escherichia coli, GI1788683, Length=402, Percent_Identity=29.6019900497512, Blast_Score=149, Evalue=2e-37,
Organism=Caenorhabditis elegans, GI133906874, Length=389, Percent_Identity=41.1311053984576, Blast_Score=299, Evalue=2e-81,
Organism=Caenorhabditis elegans, GI25147385, Length=385, Percent_Identity=39.2207792207792, Blast_Score=289, Evalue=2e-78,
Organism=Caenorhabditis elegans, GI17535921, Length=395, Percent_Identity=39.746835443038, Blast_Score=282, Evalue=2e-76,
Organism=Caenorhabditis elegans, GI17535917, Length=397, Percent_Identity=31.2342569269521, Blast_Score=184, Evalue=6e-47,
Organism=Caenorhabditis elegans, GI17551802, Length=421, Percent_Identity=28.978622327791, Blast_Score=159, Evalue=3e-39,
Organism=Saccharomyces cerevisiae, GI6325229, Length=394, Percent_Identity=45.9390862944162, Blast_Score=322, Evalue=5e-89,
Organism=Saccharomyces cerevisiae, GI6322031, Length=407, Percent_Identity=31.9410319410319, Blast_Score=176, Evalue=6e-45,
Organism=Drosophila melanogaster, GI24655093, Length=388, Percent_Identity=47.680412371134, Blast_Score=355, Evalue=3e-98,
Organism=Drosophila melanogaster, GI24640423, Length=389, Percent_Identity=43.9588688946015, Blast_Score=312, Evalue=2e-85,
Organism=Drosophila melanogaster, GI17648125, Length=394, Percent_Identity=36.0406091370558, Blast_Score=238, Evalue=6e-63,
Organism=Drosophila melanogaster, GI17137578, Length=422, Percent_Identity=30.8056872037915, Blast_Score=172, Evalue=4e-43,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002155
- InterPro:   IPR016039
- InterPro:   IPR016038
- InterPro:   IPR020615
- InterPro:   IPR020610
- InterPro:   IPR020617
- InterPro:   IPR020613
- InterPro:   IPR020616 [H]

Pfam domain/function: PF02803 Thiolase_C; PF00108 Thiolase_N [H]

EC number: =2.3.1.9 [H]

Molecular weight: Translated: 41160; Mature: 41029

Theoretical pI: Translated: 6.64; Mature: 6.64

Prosite motif: PS00098 THIOLASE_1 ; PS00099 THIOLASE_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
5.3 %Met     (Translated Protein)
6.4 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
5.1 %Met     (Mature Protein)
6.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSEKDPVVIVGMARTPMGGLLGELSSFSANELGAHVVKAAAAEAKLGAAEVDEVIMGNCL
CCCCCCEEEEEECCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCC
PAGQGQAPARQAAIKSGLDKNTEATTINKMCGSGMEAVIMGRNALLAGEATVIVAGGMES
CCCCCCCHHHHHHHHHCCCCCCCHHHHHHHHCCCCEEEEECCCEEEECCEEEEEECCHHH
MTNAPHLITLRQGHKYGAAFARDHMATDGLEDAYEGGPMGNFADMIAREYQFTREQQDAY
HCCCCEEEEEECCCCHHHHHHHHHHHCCCCHHHHCCCCCCHHHHHHHHHHHHHHHHHHHH
ALETLRRAQDATKNGKFKREIAPLTVKTRKGETVVDTDQLPREAMPDKIPTLKPAFNKDG
HHHHHHHHHHHHCCCCEEEEECCEEEEECCCCEEECHHHCCHHHCCCCCCCCCCCCCCCC
TVTAANASAISDGAAALVLMRESEAKKRGLTPIAKIVSASSHAQEPAYFTTAPVPAMQKA
CEEECCCCCCCCCCEEEEEEECHHHHHHCCCHHHHHHHCCCCCCCCCEEECCCCHHHHHH
LKKAGWKAEDVDLWEVNEAFAVVPMIAMKELGISHDKLNVNGGACAMGHPIGASGARVLI
HHHCCCCCCCCEEEECCCHHHHHHHHHHHHCCCCCCEEECCCCEEECCCCCCCCHHHHHH
TLLAAMEDRGLKKGMASLCIGGGEGIAMAVERV
HHHHHHHHCCHHHHHHHHEECCCCCEEEEEECC
>Mature Secondary Structure 
SEKDPVVIVGMARTPMGGLLGELSSFSANELGAHVVKAAAAEAKLGAAEVDEVIMGNCL
CCCCCEEEEEECCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCC
PAGQGQAPARQAAIKSGLDKNTEATTINKMCGSGMEAVIMGRNALLAGEATVIVAGGMES
CCCCCCCHHHHHHHHHCCCCCCCHHHHHHHHCCCCEEEEECCCEEEECCEEEEEECCHHH
MTNAPHLITLRQGHKYGAAFARDHMATDGLEDAYEGGPMGNFADMIAREYQFTREQQDAY
HCCCCEEEEEECCCCHHHHHHHHHHHCCCCHHHHCCCCCCHHHHHHHHHHHHHHHHHHHH
ALETLRRAQDATKNGKFKREIAPLTVKTRKGETVVDTDQLPREAMPDKIPTLKPAFNKDG
HHHHHHHHHHHHCCCCEEEEECCEEEEECCCCEEECHHHCCHHHCCCCCCCCCCCCCCCC
TVTAANASAISDGAAALVLMRESEAKKRGLTPIAKIVSASSHAQEPAYFTTAPVPAMQKA
CEEECCCCCCCCCCEEEEEEECHHHHHHCCCHHHHHHHCCCCCCCCCEEECCCCHHHHHH
LKKAGWKAEDVDLWEVNEAFAVVPMIAMKELGISHDKLNVNGGACAMGHPIGASGARVLI
HHHCCCCCCCCEEEECCCHHHHHHHHHHHHCCCCCCEEECCCCEEECCCCCCCCHHHHHH
TLLAAMEDRGLKKGMASLCIGGGEGIAMAVERV
HHHHHHHHCCHHHHHHHHEECCCCCEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7582015; 11481430 [H]