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The map label for this gene is copA [H]

Identifier: 114798342

GI number: 114798342

Start: 1514467

End: 1516311

Strand: Reverse

Name: copA [H]

Synonym: HNE_1485

Alternate gene names: 114798342

Gene position: 1516311-1514467 (Counterclockwise)

Preceding gene: 114798721

Following gene: 114797294

Centisome position: 40.93

GC content: 61.14

Gene sequence:

>1845_bases
ATGCTCACACGACGCAATCTGCTCCGCACTGCCGCCGCCGGCGGTTTCTTCGCCGCCTCGGGCGCCCTTCTCCCGGCCTG
GGCGCGCAGCGCCAATGCCGGGAACAAGGGGATCTTCGAGGTCTCCGGCAATGCATTTGACCTGACCATCGGCCATAGCA
ACGTAGAAATCGGTGGCCGCTCCGGCCATGCGATCACGATCAACGGAACCCTGCCCGGCCCGCTCATCCGGTTCCGAGAA
GGCGAAAAAGTGACCCTCAACGTCCATAACACGCTCGATGAAGACACATCGATTCACTGGCACGGACTACTCGTGCCCTT
CCATATGGACGGGGTGCCCGGGGTCTCCTTCCCCGGCATCAAGCCGAAGTCGACCTTCACCTATGAGTTCGCGGTCCCGC
AGAGCGGCACCTACTGGTACCATTCCCATTCCGGGCTTCAGGAACAGCTGGGCCATTACGGCCCGCTGATCATCGATCCT
GCAGGCGCCGACCCCGTCGAAGCGGACCGTGAATACGTGCTGGTCCTGTCAGACTGGACATTCGAGCATCCGCACAAGGT
CTTCGCCCGGCTGAAAAAGGATGCGGCGGTCTATAACTTCCAGCAACGCACTGCCGGCGATTTCCTGCGAGACGCGCGCG
AAAACGGAATTGGGCCAACCTTCACAGACCGTGCCTCCTGGGGCGCCATGCGCATGTCGCCAACCGACATCTCGGACGTC
ACGGCCTCGGTCTACACATATCTCATCAATGGTCATGCGACGGATGACAACTGGACTGCGATCTTCAACTCCGGCGAACG
TGTCCGCCTGCGGATCATCAATGCTTCGGCGATGACCATCTTCAATTTCCGGATTCCGGGACTGCCAATGACGGTAGTTG
CCGCCGACGGCCTCCCTGTGCAGCCGGTGGAAACGGACGAATTCCAGATCGGGGTTGCGGAAACATATGACGTGATCGTC
AGTCCGACCCGTGCCCGGCCGTTTGCGCTCGTCGCCGAATCGATCGACCGGTCCGGTCAGGTTGTCGCAACCCTCGCTCC
TGAAGCCGGACTTGTCGCAACGGCCCCCCTGCTGCGCGAACCTCCTGTTTTGACACACCGCGACATGGGCATGGACATGT
CCTCCATGGACCACGGCTCAATGGCCGGAATGGATCATGGCAGCATGGACCATGGCGCGATGGCCATGACGGACACAGTC
CCGCAAAGCCATGACCACCGGATGGGTGTGGGGGTCGACAACGTTGCGATGGTTCAGGTGAGCCGCATCGACGAGCCGGG
GCTTGGCCTCGAATCTGTCCCGCACAGGGCGCTTCGCTATTCACAACTGCGCAGCCTCACACCGAACCCCGACACACGGG
CGCCGGGCCGCGAAATCGAGATCCACCTCACCGGCAACATGGAACGCTACATGTGGTCATTCGACGGGGTGAAGCTCAGT
GAAGTGACCGGTCCGATCATCTTCCATGAAAGCGAACGCCTGCGCGTCACGCTCGTCAACGACACGATGATGACACATCC
CATCCACCTGCATGGCATGTTCTTCGACCTTGTTGTCGCCGATACCGATCACAAGCCGCGCAAACATACGGTGACCGTCA
AGCCTGCCGAACGCCTGTCCTTTGATGTGACGGCGGACCATGTCGGCGACTGGGCCTTTCATTGCCACCTCCTCTTCCAC
ATGCATGCCGGCATGATGCAGGTCGTCTCGGTCCTGCCACGCGTCGCGGGGGCAACCACACACACTCCCCACAAAGGGCA
CGAGCCTGCCGTTCCTCCGTCAGAGGAGGACATTCCGACCACGGAAACTCCAACGCCGGACAGGCAACATGAAGGGCACC
ACTGA

Upstream 100 bases:

>100_bases
GCGCCAGCGCAGGATCATAGTCACCACTGATCCAGCTGCCTGCCGCGCAAGACGCCACTTGGCGCGCCCGGCAGGCGCTC
CTTTTACGAGGTTCGAACCC

Downstream 100 bases:

>100_bases
TGAAACGCGCGCATTTCATTGCATCATTCTTCATGCTCTCTCCGCTCGTATTCTCGTCTGCTGTTGCGCAAGAGACGCCC
GTCCCGGGCTCACAAGCCGA

Product: CopA family copper resistance protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 614; Mature: 614

Protein sequence:

>614_residues
MLTRRNLLRTAAAGGFFAASGALLPAWARSANAGNKGIFEVSGNAFDLTIGHSNVEIGGRSGHAITINGTLPGPLIRFRE
GEKVTLNVHNTLDEDTSIHWHGLLVPFHMDGVPGVSFPGIKPKSTFTYEFAVPQSGTYWYHSHSGLQEQLGHYGPLIIDP
AGADPVEADREYVLVLSDWTFEHPHKVFARLKKDAAVYNFQQRTAGDFLRDARENGIGPTFTDRASWGAMRMSPTDISDV
TASVYTYLINGHATDDNWTAIFNSGERVRLRIINASAMTIFNFRIPGLPMTVVAADGLPVQPVETDEFQIGVAETYDVIV
SPTRARPFALVAESIDRSGQVVATLAPEAGLVATAPLLREPPVLTHRDMGMDMSSMDHGSMAGMDHGSMDHGAMAMTDTV
PQSHDHRMGVGVDNVAMVQVSRIDEPGLGLESVPHRALRYSQLRSLTPNPDTRAPGREIEIHLTGNMERYMWSFDGVKLS
EVTGPIIFHESERLRVTLVNDTMMTHPIHLHGMFFDLVVADTDHKPRKHTVTVKPAERLSFDVTADHVGDWAFHCHLLFH
MHAGMMQVVSVLPRVAGATTHTPHKGHEPAVPPSEEDIPTTETPTPDRQHEGHH

Sequences:

>Translated_614_residues
MLTRRNLLRTAAAGGFFAASGALLPAWARSANAGNKGIFEVSGNAFDLTIGHSNVEIGGRSGHAITINGTLPGPLIRFRE
GEKVTLNVHNTLDEDTSIHWHGLLVPFHMDGVPGVSFPGIKPKSTFTYEFAVPQSGTYWYHSHSGLQEQLGHYGPLIIDP
AGADPVEADREYVLVLSDWTFEHPHKVFARLKKDAAVYNFQQRTAGDFLRDARENGIGPTFTDRASWGAMRMSPTDISDV
TASVYTYLINGHATDDNWTAIFNSGERVRLRIINASAMTIFNFRIPGLPMTVVAADGLPVQPVETDEFQIGVAETYDVIV
SPTRARPFALVAESIDRSGQVVATLAPEAGLVATAPLLREPPVLTHRDMGMDMSSMDHGSMAGMDHGSMDHGAMAMTDTV
PQSHDHRMGVGVDNVAMVQVSRIDEPGLGLESVPHRALRYSQLRSLTPNPDTRAPGREIEIHLTGNMERYMWSFDGVKLS
EVTGPIIFHESERLRVTLVNDTMMTHPIHLHGMFFDLVVADTDHKPRKHTVTVKPAERLSFDVTADHVGDWAFHCHLLFH
MHAGMMQVVSVLPRVAGATTHTPHKGHEPAVPPSEEDIPTTETPTPDRQHEGHH
>Mature_614_residues
MLTRRNLLRTAAAGGFFAASGALLPAWARSANAGNKGIFEVSGNAFDLTIGHSNVEIGGRSGHAITINGTLPGPLIRFRE
GEKVTLNVHNTLDEDTSIHWHGLLVPFHMDGVPGVSFPGIKPKSTFTYEFAVPQSGTYWYHSHSGLQEQLGHYGPLIIDP
AGADPVEADREYVLVLSDWTFEHPHKVFARLKKDAAVYNFQQRTAGDFLRDARENGIGPTFTDRASWGAMRMSPTDISDV
TASVYTYLINGHATDDNWTAIFNSGERVRLRIINASAMTIFNFRIPGLPMTVVAADGLPVQPVETDEFQIGVAETYDVIV
SPTRARPFALVAESIDRSGQVVATLAPEAGLVATAPLLREPPVLTHRDMGMDMSSMDHGSMAGMDHGSMDHGAMAMTDTV
PQSHDHRMGVGVDNVAMVQVSRIDEPGLGLESVPHRALRYSQLRSLTPNPDTRAPGREIEIHLTGNMERYMWSFDGVKLS
EVTGPIIFHESERLRVTLVNDTMMTHPIHLHGMFFDLVVADTDHKPRKHTVTVKPAERLSFDVTADHVGDWAFHCHLLFH
MHAGMMQVVSVLPRVAGATTHTPHKGHEPAVPPSEEDIPTTETPTPDRQHEGHH

Specific function: Mediates copper resistance by sequestration of copper in the periplasm along with the copper-binding protein CopC. May have oxidase activity [H]

COG id: COG2132

COG function: function code Q; Putative multicopper oxidases

Gene ontology:

Cell location: Periplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the multicopper oxidase family. CopA subfamily [H]

Homologues:

Organism=Escherichia coli, GI1786314, Length=447, Percent_Identity=26.6219239373602, Blast_Score=111, Evalue=2e-25,
Organism=Saccharomyces cerevisiae, GI6321067, Length=561, Percent_Identity=23.5294117647059, Blast_Score=92, Evalue=2e-19,
Organism=Saccharomyces cerevisiae, GI6323703, Length=307, Percent_Identity=29.9674267100977, Blast_Score=86, Evalue=1e-17,
Organism=Drosophila melanogaster, GI28574104, Length=685, Percent_Identity=23.3576642335766, Blast_Score=113, Evalue=5e-25,
Organism=Drosophila melanogaster, GI221329998, Length=576, Percent_Identity=24.6527777777778, Blast_Score=103, Evalue=4e-22,
Organism=Drosophila melanogaster, GI221330000, Length=583, Percent_Identity=24.5283018867925, Blast_Score=96, Evalue=1e-19,
Organism=Drosophila melanogaster, GI18859919, Length=272, Percent_Identity=28.6764705882353, Blast_Score=94, Evalue=3e-19,
Organism=Drosophila melanogaster, GI24650186, Length=583, Percent_Identity=21.7838765008576, Blast_Score=92, Evalue=1e-18,
Organism=Drosophila melanogaster, GI281360167, Length=270, Percent_Identity=30.3703703703704, Blast_Score=92, Evalue=2e-18,
Organism=Drosophila melanogaster, GI24585842, Length=270, Percent_Identity=30.3703703703704, Blast_Score=91, Evalue=2e-18,

Paralogues:

None

Copy number: 40 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001117
- InterPro:   IPR011706
- InterPro:   IPR011707
- InterPro:   IPR006376
- InterPro:   IPR002355
- InterPro:   IPR008972
- InterPro:   IPR006311 [H]

Pfam domain/function: PF00394 Cu-oxidase; PF07731 Cu-oxidase_2; PF07732 Cu-oxidase_3 [H]

EC number: NA

Molecular weight: Translated: 67378; Mature: 67378

Theoretical pI: Translated: 6.30; Mature: 6.30

Prosite motif: PS00079 MULTICOPPER_OXIDASE1 ; PS00080 MULTICOPPER_OXIDASE2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
4.1 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
4.1 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLTRRNLLRTAAAGGFFAASGALLPAWARSANAGNKGIFEVSGNAFDLTIGHSNVEIGGR
CCCHHHHHHHHHCCCEEEECCCCCHHHHHCCCCCCCCEEEECCCEEEEEECCCEEEECCC
SGHAITINGTLPGPLIRFREGEKVTLNVHNTLDEDTSIHWHGLLVPFHMDGVPGVSFPGI
CCCEEEEECCCCCCEEEECCCCEEEEEECCCCCCCCCEEEEEEEEEEECCCCCCCCCCCC
KPKSTFTYEFAVPQSGTYWYHSHSGLQEQLGHYGPLIIDPAGADPVEADREYVLVLSDWT
CCCCEEEEEEECCCCCEEEEECCCCHHHHHCCCCCEEECCCCCCCCCCCCCEEEEEECCC
FEHPHKVFARLKKDAAVYNFQQRTAGDFLRDARENGIGPTFTDRASWGAMRMSPTDISDV
CCCHHHHHHHHHHHHHHEECHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEECCCCHHHH
TASVYTYLINGHATDDNWTAIFNSGERVRLRIINASAMTIFNFRIPGLPMTVVAADGLPV
HHEEEEEEEECCCCCCCEEEEECCCCEEEEEEEECCEEEEEEEECCCCCEEEEEECCCCC
QPVETDEFQIGVAETYDVIVSPTRARPFALVAESIDRSGQVVATLAPEAGLVATAPLLRE
CCCCCCCEEEEEEEEEEEEEECCCCCCHHHHHHHHCCCCCEEEEECCCCCCEEECCHHCC
PPVLTHRDMGMDMSSMDHGSMAGMDHGSMDHGAMAMTDTVPQSHDHRMGVGVDNVAMVQV
CCCCEECCCCCCCCCCCCCCCCCCCCCCCCCCCEEEECCCCCCCCCCCCCCCCCEEEEEE
SRIDEPGLGLESVPHRALRYSQLRSLTPNPDTRAPGREIEIHLTGNMERYMWSFDGVKLS
EECCCCCCCHHHCCHHHHHHHHHHCCCCCCCCCCCCCEEEEEEECCCEEEEEEECCEEEH
EVTGPIIFHESERLRVTLVNDTMMTHPIHLHGMFFDLVVADTDHKPRKHTVTVKPAERLS
HCCCCEEEECCCCEEEEEECCCEEECCEEEEEEEEEEEEECCCCCCCCEEEEECCHHHCE
FDVTADHVGDWAFHCHLLFHMHAGMMQVVSVLPRVAGATTHTPHKGHEPAVPPSEEDIPT
EEEEHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCC
TETPTPDRQHEGHH
CCCCCCCCCCCCCC
>Mature Secondary Structure
MLTRRNLLRTAAAGGFFAASGALLPAWARSANAGNKGIFEVSGNAFDLTIGHSNVEIGGR
CCCHHHHHHHHHCCCEEEECCCCCHHHHHCCCCCCCCEEEECCCEEEEEECCCEEEECCC
SGHAITINGTLPGPLIRFREGEKVTLNVHNTLDEDTSIHWHGLLVPFHMDGVPGVSFPGI
CCCEEEEECCCCCCEEEECCCCEEEEEECCCCCCCCCEEEEEEEEEEECCCCCCCCCCCC
KPKSTFTYEFAVPQSGTYWYHSHSGLQEQLGHYGPLIIDPAGADPVEADREYVLVLSDWT
CCCCEEEEEEECCCCCEEEEECCCCHHHHHCCCCCEEECCCCCCCCCCCCCEEEEEECCC
FEHPHKVFARLKKDAAVYNFQQRTAGDFLRDARENGIGPTFTDRASWGAMRMSPTDISDV
CCCHHHHHHHHHHHHHHEECHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEECCCCHHHH
TASVYTYLINGHATDDNWTAIFNSGERVRLRIINASAMTIFNFRIPGLPMTVVAADGLPV
HHEEEEEEEECCCCCCCEEEEECCCCEEEEEEEECCEEEEEEEECCCCCEEEEEECCCCC
QPVETDEFQIGVAETYDVIVSPTRARPFALVAESIDRSGQVVATLAPEAGLVATAPLLRE
CCCCCCCEEEEEEEEEEEEEECCCCCCHHHHHHHHCCCCCEEEEECCCCCCEEECCHHCC
PPVLTHRDMGMDMSSMDHGSMAGMDHGSMDHGAMAMTDTVPQSHDHRMGVGVDNVAMVQV
CCCCEECCCCCCCCCCCCCCCCCCCCCCCCCCCEEEECCCCCCCCCCCCCCCCCEEEEEE
SRIDEPGLGLESVPHRALRYSQLRSLTPNPDTRAPGREIEIHLTGNMERYMWSFDGVKLS
EECCCCCCCHHHCCHHHHHHHHHHCCCCCCCCCCCCCEEEEEEECCCEEEEEEECCEEEH
EVTGPIIFHESERLRVTLVNDTMMTHPIHLHGMFFDLVVADTDHKPRKHTVTVKPAERLS
HCCCCEEEECCCCEEEEEECCCEEECCEEEEEEEEEEEEECCCCCCCCEEEEECCHHHCE
FDVTADHVGDWAFHCHLLFHMHAGMMQVVSVLPRVAGATTHTPHKGHEPAVPPSEEDIPT
EEEEHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCC
TETPTPDRQHEGHH
CCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 3372485; 1924351 [H]