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The map label for this gene is birA [H]

Identifier: 114798329

GI number: 114798329

Start: 1801266

End: 1802033

Strand: Direct

Name: birA [H]

Synonym: HNE_1759

Alternate gene names: 114798329

Gene position: 1801266-1802033 (Clockwise)

Preceding gene: 114800320

Following gene: 114799332

Centisome position: 48.62

GC content: 56.51

Gene sequence:

>768_bases
TTGGGCCAGCTATGCTGCTTCGGGACTTCTCCCTTGAGCGCTTCCTGGCCACTCTACCGGTTCGAAGAAATTGACAGCAC
CAACACAGAAGCGAAGCGCCGCGCGGCTGAGGGCAGCTTCAATAATCAATGGATTGTTGCCAGCACGCAGACGGCGGGAC
GTGGACGGCAGGATCGCGCCTGGTCTTCTCCTGTAGGAAACATCTTCACTACAGCACTCTTCGCGGAGCCGGGCGGCATT
TCAGTGGCGCTTCGAGTGCCGTTTGCTGCTGCTTTGGCGGTGGTTGATACGGTGCTCTCTGTCGCGCCGGCCGCTCCTGT
GCGTGTGAAATGGCCCAATGATGTGCGTGTCGATCACCAGAAAGTGTCCGGCATTCTGGTTGAGACTGGCGGAGCAGGAG
ACCGGCTGTGGATCGCGGCAGGTACAGGCATCAATGTTGCCTATGCGCCGGACAACGTTGGCCAGGGCGCGACAAGCCTC
AATAGGTTGAGTGCGCAGGTTCTTGATTTAAAAGAAGTATTGGATTTCTATCACTCTGCTTTCGAAGCCCGACTGGCTCA
GGCTAAGGTGACCTTTGATGGTGTGCGCAAAGACTGGCTAAAATATGCTGAGGGCCGCAACGAAAAGGTATCTGTTAGGG
TCGGGGACACATACGAAGAGGGGGTATTCGAGGATCTCGAACAGGATGGTGCCCTTCGTCTTCGGTTGCCGGATGGAAGC
GCGCGCATCATAAGGGCCGGCGAAGTAAACCTTATTGGACGAGCGTAA

Upstream 100 bases:

>100_bases
TTGAGCGTGTGGATGTGACGGTTCTGGGCACCGTTGTCGCTTGCGCCGTGATCGCCGGTGTTGTGTTCATGATCTTTATC
GGGGAACTCGGCACGGGTGG

Downstream 100 bases:

>100_bases
CGCATGCTTCTGGTTATCGACGTTGGGAACACCAATACTGTTTTTGCGCTCCATGATGGTGAGCAGTGGGTCAATCAGTG
GCGCAGCGCCACGGATTCAA

Product: biotin--acetyl-CoA-carboxylase ligase

Products: NA

Alternate protein names: Biotin--protein ligase [H]

Number of amino acids: Translated: 255; Mature: 254

Protein sequence:

>255_residues
MGQLCCFGTSPLSASWPLYRFEEIDSTNTEAKRRAAEGSFNNQWIVASTQTAGRGRQDRAWSSPVGNIFTTALFAEPGGI
SVALRVPFAAALAVVDTVLSVAPAAPVRVKWPNDVRVDHQKVSGILVETGGAGDRLWIAAGTGINVAYAPDNVGQGATSL
NRLSAQVLDLKEVLDFYHSAFEARLAQAKVTFDGVRKDWLKYAEGRNEKVSVRVGDTYEEGVFEDLEQDGALRLRLPDGS
ARIIRAGEVNLIGRA

Sequences:

>Translated_255_residues
MGQLCCFGTSPLSASWPLYRFEEIDSTNTEAKRRAAEGSFNNQWIVASTQTAGRGRQDRAWSSPVGNIFTTALFAEPGGI
SVALRVPFAAALAVVDTVLSVAPAAPVRVKWPNDVRVDHQKVSGILVETGGAGDRLWIAAGTGINVAYAPDNVGQGATSL
NRLSAQVLDLKEVLDFYHSAFEARLAQAKVTFDGVRKDWLKYAEGRNEKVSVRVGDTYEEGVFEDLEQDGALRLRLPDGS
ARIIRAGEVNLIGRA
>Mature_254_residues
GQLCCFGTSPLSASWPLYRFEEIDSTNTEAKRRAAEGSFNNQWIVASTQTAGRGRQDRAWSSPVGNIFTTALFAEPGGIS
VALRVPFAAALAVVDTVLSVAPAAPVRVKWPNDVRVDHQKVSGILVETGGAGDRLWIAAGTGINVAYAPDNVGQGATSLN
RLSAQVLDLKEVLDFYHSAFEARLAQAKVTFDGVRKDWLKYAEGRNEKVSVRVGDTYEEGVFEDLEQDGALRLRLPDGSA
RIIRAGEVNLIGRA

Specific function: Activates biotin to form biotinyl-5'-adenylate and transfers the biotin moiety to biotin-accepting proteins [H]

COG id: COG0340

COG function: function code H; Biotin-(acetyl-CoA carboxylase) ligase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the biotin--protein ligase family [H]

Homologues:

Organism=Homo sapiens, GI46255045, Length=109, Percent_Identity=37.6146788990826, Blast_Score=72, Evalue=7e-13,
Organism=Escherichia coli, GI1790408, Length=244, Percent_Identity=31.9672131147541, Blast_Score=79, Evalue=2e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004408
- InterPro:   IPR003142
- InterPro:   IPR004143 [H]

Pfam domain/function: PF02237 BPL_C; PF03099 BPL_LipA_LipB [H]

EC number: =6.3.4.15 [H]

Molecular weight: Translated: 27521; Mature: 27390

Theoretical pI: Translated: 5.89; Mature: 5.89

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
0.4 %Met     (Translated Protein)
1.2 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
0.0 %Met     (Mature Protein)
0.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGQLCCFGTSPLSASWPLYRFEEIDSTNTEAKRRAAEGSFNNQWIVASTQTAGRGRQDRA
CCCEEEECCCCCCCCCCCEEECCCCCCCHHHHHHHHCCCCCCCEEEEECCCCCCCCCCCC
WSSPVGNIFTTALFAEPGGISVALRVPFAAALAVVDTVLSVAPAAPVRVKWPNDVRVDHQ
CCCCCHHHHHHHEEECCCCEEEEEECCHHHHHHHHHHHHHHCCCCCEEEECCCCCCCCHH
KVSGILVETGGAGDRLWIAAGTGINVAYAPDNVGQGATSLNRLSAQVLDLKEVLDFYHSA
HCCEEEEEECCCCCEEEEEECCCCEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
FEARLAQAKVTFDGVRKDWLKYAEGRNEKVSVRVGDTYEEGVFEDLEQDGALRLRLPDGS
HHHHHHHHEEEHHHHHHHHHHHHCCCCCEEEEEECCCHHHHHHHHHHCCCEEEEEECCCC
ARIIRAGEVNLIGRA
EEEEEECCEEEEECC
>Mature Secondary Structure 
GQLCCFGTSPLSASWPLYRFEEIDSTNTEAKRRAAEGSFNNQWIVASTQTAGRGRQDRA
CCEEEECCCCCCCCCCCEEECCCCCCCHHHHHHHHCCCCCCCEEEEECCCCCCCCCCCC
WSSPVGNIFTTALFAEPGGISVALRVPFAAALAVVDTVLSVAPAAPVRVKWPNDVRVDHQ
CCCCCHHHHHHHEEECCCCEEEEEECCHHHHHHHHHHHHHHCCCCCEEEECCCCCCCCHH
KVSGILVETGGAGDRLWIAAGTGINVAYAPDNVGQGATSLNRLSAQVLDLKEVLDFYHSA
HCCEEEEEECCCCCEEEEEECCCCEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
FEARLAQAKVTFDGVRKDWLKYAEGRNEKVSVRVGDTYEEGVFEDLEQDGALRLRLPDGS
HHHHHHHHEEEHHHHHHHHHHHHCCCCCEEEEEECCCHHHHHHHHHHCCCEEEEEECCCC
ARIIRAGEVNLIGRA
EEEEEECCEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8422400 [H]