| Definition | Hyphomonas neptunium ATCC 15444 chromosome, complete genome. |
|---|---|
| Accession | NC_008358 |
| Length | 3,705,021 |
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The map label for this gene is yxbG [H]
Identifier: 114798306
GI number: 114798306
Start: 3504422
End: 3505309
Strand: Direct
Name: yxbG [H]
Synonym: HNE_3357
Alternate gene names: 114798306
Gene position: 3504422-3505309 (Clockwise)
Preceding gene: 114797298
Following gene: 114800316
Centisome position: 94.59
GC content: 63.4
Gene sequence:
>888_bases ATGGCAGATCTCAAGGGCAAAGTGGCCGTCATCACCGGCGCGGCAAGCGGTATCGGGCTGGCCGGCGTTGAAGTGTTCAT CGCAGCGGGCGCCAGGGTCATCGCCGGAGACATCCAGGATGAAAAAGGCAAGGCGCTCGAAACACGCTTTGGCCCGGAGA AGCTCCGCTTTGTGCATTGCGACGTGACCGATATGGACCAGCTGAAAGCCGTGATGGACGCCGCCCCCGCCGCCTTCGGA TCGCTCGACATTGTCTGGAACAATGCCGGCCATGGCGGCACGAATACGTCCGTCGAGGAACTGGATCTCGACGGTTACGA CCAGACGATGAACCTGCTTCTGAAACAGGTGTTCGCCGGTACGAAATTCGCCATCCCGCACATGAAGGACAAAGGCGGCG CGATCATCAACACCTCCTCGATCAGCGCGGTTTCGGCCGGCTATGCCCCGATCACCTATTCGGTGGCCAAGAAGGGCGTC GCCCACTTCTCCAAGCTCGCGGCCGCTGAGCTTTCCAAATACAAGATCCGCGTCAATGCGATCCTGCCCGGCTTCATCGC CACCTCGATCTTTGGCGCCTCGCTCGGCCTGCCGCGCGAAGTGGCCGACCAGATGGCCGAGATGCTGTATCAGGCCGGCG GCAAGATGCAGCCCATCGGGCGCGTCGGCAAAGGCACCGACATCGCCGAGATGGCCGCGTTCCTGGCCTCTGATGCGGGC GAGTTCATCACCGGCGGGGAATTCCTCGTCGATGGCGGCATGACCGTCGGCCCGCGCCATAGCTGGGACGCAACCGCCGC CAGCCCGGTTCTGGAATCCCTCGGCATCAGCCCGGAACAGGCCGAGCAGATGCGCCTCGCCCAACAGGCAGCTGCCGCTC AGTCCTGA
Upstream 100 bases:
>100_bases CTTCGGCCTGCAGAAGAAAGACTGACACTCCCGTCAACTTTCGCCCTTGACGCCCCTCGCGGAAAGGCGACCCATGTCGC CCGAAACGGGAGGAACAAAC
Downstream 100 bases:
>100_bases TCGGCAACCCGCAGCTGGGGCACGGCTTCCACCGCCTTGAGCAGGTCTTCCAGGGTCGCCGCTTCACGGAAGAGGCGGCC CTGATCATCGCCCAGGGCAT
Product: short chain dehydrogenase/reductase family oxidoreductase
Products: (3R)-hydroxyacyl-[acyl-carrier-protein]; NADP; NADPH; Proton; beta-ketoacyl-ACP [C]
Alternate protein names: NA
Number of amino acids: Translated: 295; Mature: 294
Protein sequence:
>295_residues MADLKGKVAVITGAASGIGLAGVEVFIAAGARVIAGDIQDEKGKALETRFGPEKLRFVHCDVTDMDQLKAVMDAAPAAFG SLDIVWNNAGHGGTNTSVEELDLDGYDQTMNLLLKQVFAGTKFAIPHMKDKGGAIINTSSISAVSAGYAPITYSVAKKGV AHFSKLAAAELSKYKIRVNAILPGFIATSIFGASLGLPREVADQMAEMLYQAGGKMQPIGRVGKGTDIAEMAAFLASDAG EFITGGEFLVDGGMTVGPRHSWDATAASPVLESLGISPEQAEQMRLAQQAAAAQS
Sequences:
>Translated_295_residues MADLKGKVAVITGAASGIGLAGVEVFIAAGARVIAGDIQDEKGKALETRFGPEKLRFVHCDVTDMDQLKAVMDAAPAAFG SLDIVWNNAGHGGTNTSVEELDLDGYDQTMNLLLKQVFAGTKFAIPHMKDKGGAIINTSSISAVSAGYAPITYSVAKKGV AHFSKLAAAELSKYKIRVNAILPGFIATSIFGASLGLPREVADQMAEMLYQAGGKMQPIGRVGKGTDIAEMAAFLASDAG EFITGGEFLVDGGMTVGPRHSWDATAASPVLESLGISPEQAEQMRLAQQAAAAQS >Mature_294_residues ADLKGKVAVITGAASGIGLAGVEVFIAAGARVIAGDIQDEKGKALETRFGPEKLRFVHCDVTDMDQLKAVMDAAPAAFGS LDIVWNNAGHGGTNTSVEELDLDGYDQTMNLLLKQVFAGTKFAIPHMKDKGGAIINTSSISAVSAGYAPITYSVAKKGVA HFSKLAAAELSKYKIRVNAILPGFIATSIFGASLGLPREVADQMAEMLYQAGGKMQPIGRVGKGTDIAEMAAFLASDAGE FITGGEFLVDGGMTVGPRHSWDATAASPVLESLGISPEQAEQMRLAQQAAAAQS
Specific function: Fatty acid biosynthesis pathway; first reduction step. [C]
COG id: COG1028
COG function: function code IQR; Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)
Gene ontology:
Cell location: Cytoplasm [C]
Metaboloic importance: Essential [C]
Operon status: Not Known
Operon components: None
Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family [H]
Homologues:
Organism=Homo sapiens, GI59889578, Length=248, Percent_Identity=34.6774193548387, Blast_Score=128, Evalue=6e-30, Organism=Homo sapiens, GI31542939, Length=229, Percent_Identity=34.061135371179, Blast_Score=110, Evalue=2e-24, Organism=Homo sapiens, GI15277342, Length=265, Percent_Identity=30.9433962264151, Blast_Score=99, Evalue=4e-21, Organism=Homo sapiens, GI66933014, Length=263, Percent_Identity=32.6996197718631, Blast_Score=98, Evalue=7e-21, Organism=Homo sapiens, GI32483357, Length=256, Percent_Identity=30.859375, Blast_Score=93, Evalue=4e-19, Organism=Homo sapiens, GI224922801, Length=177, Percent_Identity=35.0282485875706, Blast_Score=91, Evalue=1e-18, Organism=Homo sapiens, GI19923817, Length=269, Percent_Identity=26.7657992565056, Blast_Score=88, Evalue=8e-18, Organism=Homo sapiens, GI40254992, Length=252, Percent_Identity=27.3809523809524, Blast_Score=80, Evalue=1e-15, Organism=Homo sapiens, GI4758504, Length=274, Percent_Identity=27.007299270073, Blast_Score=77, Evalue=2e-14, Organism=Homo sapiens, GI5031737, Length=261, Percent_Identity=26.0536398467433, Blast_Score=74, Evalue=2e-13, Organism=Homo sapiens, GI126723750, Length=259, Percent_Identity=27.027027027027, Blast_Score=73, Evalue=3e-13, Organism=Homo sapiens, GI4503301, Length=263, Percent_Identity=29.277566539924, Blast_Score=73, Evalue=4e-13, Organism=Homo sapiens, GI7705925, Length=252, Percent_Identity=26.5873015873016, Blast_Score=70, Evalue=3e-12, Organism=Homo sapiens, GI20149619, Length=202, Percent_Identity=31.6831683168317, Blast_Score=68, Evalue=9e-12, Organism=Homo sapiens, GI10190704, Length=254, Percent_Identity=27.5590551181102, Blast_Score=67, Evalue=2e-11, Organism=Escherichia coli, GI1787335, Length=254, Percent_Identity=33.4645669291339, Blast_Score=110, Evalue=1e-25, Organism=Escherichia coli, GI1789208, Length=257, Percent_Identity=33.4630350194552, Blast_Score=109, Evalue=3e-25, Organism=Escherichia coli, GI87082100, Length=259, Percent_Identity=31.6602316602317, Blast_Score=103, Evalue=2e-23, Organism=Escherichia coli, GI87082160, Length=263, Percent_Identity=31.1787072243346, Blast_Score=95, Evalue=5e-21, Organism=Escherichia coli, GI1787905, Length=254, Percent_Identity=30.7086614173228, Blast_Score=93, Evalue=2e-20, Organism=Escherichia coli, GI1790717, Length=262, Percent_Identity=30.5343511450382, Blast_Score=81, Evalue=7e-17, Organism=Escherichia coli, GI1789378, Length=258, Percent_Identity=27.5193798449612, Blast_Score=75, Evalue=6e-15, Organism=Escherichia coli, GI1788459, Length=259, Percent_Identity=25.8687258687259, Blast_Score=70, Evalue=1e-13, Organism=Escherichia coli, GI2367175, Length=256, Percent_Identity=26.953125, Blast_Score=67, Evalue=1e-12, Organism=Escherichia coli, GI1786812, Length=261, Percent_Identity=26.8199233716475, Blast_Score=65, Evalue=4e-12, Organism=Caenorhabditis elegans, GI17559104, Length=274, Percent_Identity=34.3065693430657, Blast_Score=130, Evalue=1e-30, Organism=Caenorhabditis elegans, GI17560150, Length=270, Percent_Identity=31.8518518518519, Blast_Score=115, Evalue=4e-26, Organism=Caenorhabditis elegans, GI72000259, Length=266, Percent_Identity=30.8270676691729, Blast_Score=112, Evalue=2e-25, Organism=Caenorhabditis elegans, GI17544670, Length=265, Percent_Identity=30.9433962264151, Blast_Score=110, Evalue=7e-25, Organism=Caenorhabditis elegans, GI17562990, Length=268, Percent_Identity=31.3432835820896, Blast_Score=109, Evalue=2e-24, Organism=Caenorhabditis elegans, GI17563726, Length=275, Percent_Identity=30.5454545454545, Blast_Score=108, Evalue=4e-24, Organism=Caenorhabditis elegans, GI17562910, Length=266, Percent_Identity=30.4511278195489, Blast_Score=107, Evalue=6e-24, Organism=Caenorhabditis elegans, GI17562908, Length=275, Percent_Identity=28.7272727272727, Blast_Score=106, Evalue=2e-23, Organism=Caenorhabditis elegans, GI17555706, Length=253, Percent_Identity=30.8300395256917, Blast_Score=105, Evalue=2e-23, Organism=Caenorhabditis elegans, GI25147288, Length=259, Percent_Identity=31.2741312741313, Blast_Score=104, Evalue=5e-23, Organism=Caenorhabditis elegans, GI17560220, Length=272, Percent_Identity=31.6176470588235, Blast_Score=103, Evalue=9e-23, Organism=Caenorhabditis elegans, GI17562906, Length=266, Percent_Identity=27.4436090225564, Blast_Score=103, Evalue=1e-22, Organism=Caenorhabditis elegans, GI17562904, Length=271, Percent_Identity=29.8892988929889, Blast_Score=102, Evalue=2e-22, Organism=Caenorhabditis elegans, GI17531453, Length=283, Percent_Identity=28.6219081272085, Blast_Score=102, Evalue=3e-22, Organism=Caenorhabditis elegans, GI17560332, Length=271, Percent_Identity=31.3653136531365, Blast_Score=102, Evalue=3e-22, Organism=Caenorhabditis elegans, GI17538480, Length=264, Percent_Identity=29.5454545454545, Blast_Score=100, Evalue=8e-22, Organism=Caenorhabditis elegans, GI17565030, Length=263, Percent_Identity=30.4182509505703, Blast_Score=95, Evalue=4e-20, Organism=Caenorhabditis elegans, GI17561402, Length=265, Percent_Identity=30.188679245283, Blast_Score=95, Evalue=5e-20, Organism=Caenorhabditis elegans, GI71994600, Length=255, Percent_Identity=30.5882352941176, Blast_Score=94, Evalue=1e-19, Organism=Caenorhabditis elegans, GI17538486, Length=272, Percent_Identity=29.4117647058824, Blast_Score=92, Evalue=2e-19, Organism=Caenorhabditis elegans, GI17551412, Length=261, Percent_Identity=27.9693486590038, Blast_Score=92, Evalue=4e-19, Organism=Caenorhabditis elegans, GI193204405, Length=268, Percent_Identity=27.9850746268657, Blast_Score=91, Evalue=6e-19, Organism=Caenorhabditis elegans, GI71994604, Length=258, Percent_Identity=27.5193798449612, Blast_Score=91, Evalue=6e-19, Organism=Caenorhabditis elegans, GI17560676, Length=263, Percent_Identity=28.1368821292776, Blast_Score=84, Evalue=1e-16, Organism=Caenorhabditis elegans, GI17536651, Length=282, Percent_Identity=29.7872340425532, Blast_Score=82, Evalue=4e-16, Organism=Caenorhabditis elegans, GI17536025, Length=269, Percent_Identity=30.4832713754647, Blast_Score=80, Evalue=1e-15, Organism=Caenorhabditis elegans, GI17538182, Length=217, Percent_Identity=28.110599078341, Blast_Score=69, Evalue=4e-12, Organism=Caenorhabditis elegans, GI17561272, Length=200, Percent_Identity=30.5, Blast_Score=67, Evalue=9e-12, Organism=Caenorhabditis elegans, GI193207185, Length=146, Percent_Identity=30.8219178082192, Blast_Score=66, Evalue=2e-11, Organism=Caenorhabditis elegans, GI17568967, Length=187, Percent_Identity=29.4117647058824, Blast_Score=65, Evalue=3e-11, Organism=Saccharomyces cerevisiae, GI6324126, Length=260, Percent_Identity=28.4615384615385, Blast_Score=69, Evalue=1e-12, Organism=Saccharomyces cerevisiae, GI6322227, Length=193, Percent_Identity=26.9430051813472, Blast_Score=63, Evalue=4e-11, Organism=Drosophila melanogaster, GI23397609, Length=258, Percent_Identity=33.3333333333333, Blast_Score=126, Evalue=2e-29, Organism=Drosophila melanogaster, GI24644339, Length=254, Percent_Identity=31.1023622047244, Blast_Score=108, Evalue=6e-24, Organism=Drosophila melanogaster, GI21357041, Length=268, Percent_Identity=31.3432835820896, Blast_Score=107, Evalue=9e-24, Organism=Drosophila melanogaster, GI28571526, Length=267, Percent_Identity=32.5842696629214, Blast_Score=106, Evalue=2e-23, Organism=Drosophila melanogaster, GI24639444, Length=257, Percent_Identity=32.6848249027237, Blast_Score=105, Evalue=3e-23, Organism=Drosophila melanogaster, GI24643142, Length=254, Percent_Identity=29.1338582677165, Blast_Score=94, Evalue=1e-19, Organism=Drosophila melanogaster, GI21355319, Length=261, Percent_Identity=31.0344827586207, Blast_Score=92, Evalue=3e-19, Organism=Drosophila melanogaster, GI17737361, Length=271, Percent_Identity=26.5682656826568, Blast_Score=80, Evalue=2e-15, Organism=Drosophila melanogaster, GI116007234, Length=221, Percent_Identity=30.316742081448, Blast_Score=74, Evalue=9e-14, Organism=Drosophila melanogaster, GI24644337, Length=262, Percent_Identity=31.2977099236641, Blast_Score=74, Evalue=1e-13, Organism=Drosophila melanogaster, GI116007236, Length=218, Percent_Identity=28.4403669724771, Blast_Score=71, Evalue=9e-13, Organism=Drosophila melanogaster, GI28571387, Length=228, Percent_Identity=28.5087719298246, Blast_Score=70, Evalue=1e-12, Organism=Drosophila melanogaster, GI24665243, Length=196, Percent_Identity=29.0816326530612, Blast_Score=67, Evalue=1e-11, Organism=Drosophila melanogaster, GI221331218, Length=196, Percent_Identity=29.0816326530612, Blast_Score=67, Evalue=1e-11, Organism=Drosophila melanogaster, GI18859837, Length=187, Percent_Identity=29.9465240641711, Blast_Score=66, Evalue=3e-11, Organism=Drosophila melanogaster, GI24665247, Length=197, Percent_Identity=28.9340101522843, Blast_Score=65, Evalue=7e-11, Organism=Drosophila melanogaster, GI221331216, Length=197, Percent_Identity=28.9340101522843, Blast_Score=64, Evalue=9e-11,
Paralogues:
None
Copy number: NA
Swissprot (AC and ID): NA
Other databases:
- InterPro: IPR002198 - InterPro: IPR002347 - InterPro: IPR016040 - InterPro: IPR020904 [H]
Pfam domain/function: PF00106 adh_short [H]
EC number: 1.1.1.100 [C]
Molecular weight: Translated: 30605; Mature: 30474
Theoretical pI: Translated: 5.14; Mature: 5.14
Prosite motif: PS00061 ADH_SHORT
Important sites: NA
Signals:
None
Transmembrane regions:
None
Cys/Met content:
0.3 %Cys (Translated Protein) 3.7 %Met (Translated Protein) 4.1 %Cys+Met (Translated Protein) 0.3 %Cys (Mature Protein) 3.4 %Met (Mature Protein) 3.7 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MADLKGKVAVITGAASGIGLAGVEVFIAAGARVIAGDIQDEKGKALETRFGPEKLRFVHC CCCCCCCEEEEEECCCCCCHHHHHHHHHCCCEEEECCCCCCCCCCHHHCCCCCCEEEEEC DVTDMDQLKAVMDAAPAAFGSLDIVWNNAGHGGTNTSVEELDLDGYDQTMNLLLKQVFAG CCCCHHHHHHHHHHCCCCCCCEEEEECCCCCCCCCCCHHHCCCCCHHHHHHHHHHHHHCC TKFAIPHMKDKGGAIINTSSISAVSAGYAPITYSVAKKGVAHFSKLAAAELSKYKIRVNA CEEECCCCCCCCCEEEECCCCHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHEEEEEEE ILPGFIATSIFGASLGLPREVADQMAEMLYQAGGKMQPIGRVGKGTDIAEMAAFLASDAG ECHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHCCC EFITGGEFLVDGGMTVGPRHSWDATAASPVLESLGISPEQAEQMRLAQQAAAAQS CEEECCEEEEECCEEECCCCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCC >Mature Secondary Structure ADLKGKVAVITGAASGIGLAGVEVFIAAGARVIAGDIQDEKGKALETRFGPEKLRFVHC CCCCCCEEEEEECCCCCCHHHHHHHHHCCCEEEECCCCCCCCCCHHHCCCCCCEEEEEC DVTDMDQLKAVMDAAPAAFGSLDIVWNNAGHGGTNTSVEELDLDGYDQTMNLLLKQVFAG CCCCHHHHHHHHHHCCCCCCCEEEEECCCCCCCCCCCHHHCCCCCHHHHHHHHHHHHHCC TKFAIPHMKDKGGAIINTSSISAVSAGYAPITYSVAKKGVAHFSKLAAAELSKYKIRVNA CEEECCCCCCCCCEEEECCCCHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHEEEEEEE ILPGFIATSIFGASLGLPREVADQMAEMLYQAGGKMQPIGRVGKGTDIAEMAAFLASDAG ECHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHCCC EFITGGEFLVDGGMTVGPRHSWDATAASPVLESLGISPEQAEQMRLAQQAAAAQS CEEECCEEEEECCEEECCCCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCC
PDB accession: NA
Resolution: NA
Structure class: Alpha Beta
Cofactors: NADPH [C]
Metal ions: NA
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): NA
Substrates: Oxoacyl-[acyl-carrier-protein]; NADPH; D-3-hydroxy-acyl-ACP; NADP [C]
Specific reaction: Oxoacyl-[acyl-carrier-protein] + NADPH = (3R)-hydroxyacyl-[acyl-carrier-protein] + NADP+ D-3-hydroxy-acyl-ACP + NADP = NADPH + Proton + beta-ketoacyl-ACP [C]
General reaction: Redox reaction [C]
Inhibitor: NA
Structure determination priority: 10.0
TargetDB status: NA
Availability: NA
References: 7584049; 9384377 [H]