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The map label for this gene is moeA2 [H]

Identifier: 114798228

GI number: 114798228

Start: 1605475

End: 1606671

Strand: Reverse

Name: moeA2 [H]

Synonym: HNE_1574

Alternate gene names: 114798228

Gene position: 1606671-1605475 (Counterclockwise)

Preceding gene: 114797441

Following gene: 114798040

Centisome position: 43.36

GC content: 63.83

Gene sequence:

>1197_bases
ATGCGGACCCGGATAGAAGCGCTTGCTGCGATCATCGATATAGCGGCGCCAATGGCACCGGAAGCGGTTTCCCTTGGAGC
GGCGCACGGCAGAGTGCTGGCAGTCCCTATACACGCCCGGATAACCCAACCCCCGGCAGCTGTCTCAGCCATGGACGGCT
ACGCTGTGCGCCAATGCGATGCCAACCTCGGCAATTCGCTACGTGTGATCGGTGAGGCGCCAGCGGGCAGGCCTTTTACC
GGCGCATTGGGGCTCGGTGAAGCGGTGCGTATCTTTACCGGATCGGTCGTGCCCAGAGGGGCCGACCATGTGGTGATTCA
GGAAGATACAATGCGCGACGGCGACCAGATCACTGTCACGGCATCTCAGCCGGAACCCAGCAACATCCGAGCCGCAGGGA
TCGATTTCCGCGAAGGGGACCTGCTGCTTCCCGCCGGCCGCCTGCTCGGCGCAGCGGAACTTGCCATCGCTGCGGCGGCC
AACCACGCAGAGGTCAGGGCCTACCCCCGGCCCCGAATTGCGGTAATGGCCAATGGCGATGAGCTGCGCCCACCCGGTAG
CGCGCTGGCAGAAGGCGAGATTATCTGCTCCACCCCGTTTGCACTGGAGGCGCTGATTACCAGTTGGGGCGGAGAGTTTG
TGGACCTCGGCATCGCGCCGGATGATCCAGCGGCGATCCGCGCCCGCATTCAGGCAGCCGATGGTGTTGACGTCATCATC
CCGCTCGGCGGCGCCTCGGTGGGAGATCATGATCACATGCAGGCAGCCTTTGCCGAAGAAGGTCTGGAGCCTGTCTTCTC
CAAAGTGAAGCTCAAGCCTGGTAAGCCGACATGGTTTGGAAAGCTGCACAACACCTATGTGCTCGGCCTTCCGGGCAACC
CCGCCTCCGCGCTGGTCTGCGCGCAGCTGTTCCTGAAACCGTTGATCTGGCAGTTGACGGGGCGCGCGGGCAACGACGCG
CTCGTCTGGCGCCGCGCCCGGTTGACCGGGCCGCTGGAGCCGCCCGGTAGCCGGGAGACATTCCTTCGCGGCGCCGCAGA
GACAGAAAAAGACGGCCGATTGACCTGCACGCCAGCGATAAATCAGGACAGCTCGCTCCTGCGCCCGTTTCTGACCGCAG
ATCTGTTGATCCACCGGCCCGCCAACGCCCCGGCCGCACCGGAAGGATCAATAGTCGATTGCCTGATGATCAGGTAA

Upstream 100 bases:

>100_bases
CAACACCCGTGAGGTCCCGCAGCTTGACGCCCTCTGAGACTGTTGTCATTGGCGTGCGTGTTAGGCCGGGCTATCTCATT
GATTGCTCATGGAGGACGAA

Downstream 100 bases:

>100_bases
AAAAGTCGGCATACTGATTTACACCAGTCAGCATCGCTGCGCGCCACGTTGATCGTCGAGATCGCGTGGCCACAACCGCA
TTTTCGTCAGAGCGCAGTCC

Product: molybdopterin biosynthesis protein MoeA

Products: NA

Alternate protein names: MPT Mo-transferase [H]

Number of amino acids: Translated: 398; Mature: 398

Protein sequence:

>398_residues
MRTRIEALAAIIDIAAPMAPEAVSLGAAHGRVLAVPIHARITQPPAAVSAMDGYAVRQCDANLGNSLRVIGEAPAGRPFT
GALGLGEAVRIFTGSVVPRGADHVVIQEDTMRDGDQITVTASQPEPSNIRAAGIDFREGDLLLPAGRLLGAAELAIAAAA
NHAEVRAYPRPRIAVMANGDELRPPGSALAEGEIICSTPFALEALITSWGGEFVDLGIAPDDPAAIRARIQAADGVDVII
PLGGASVGDHDHMQAAFAEEGLEPVFSKVKLKPGKPTWFGKLHNTYVLGLPGNPASALVCAQLFLKPLIWQLTGRAGNDA
LVWRRARLTGPLEPPGSRETFLRGAAETEKDGRLTCTPAINQDSSLLRPFLTADLLIHRPANAPAAPEGSIVDCLMIR

Sequences:

>Translated_398_residues
MRTRIEALAAIIDIAAPMAPEAVSLGAAHGRVLAVPIHARITQPPAAVSAMDGYAVRQCDANLGNSLRVIGEAPAGRPFT
GALGLGEAVRIFTGSVVPRGADHVVIQEDTMRDGDQITVTASQPEPSNIRAAGIDFREGDLLLPAGRLLGAAELAIAAAA
NHAEVRAYPRPRIAVMANGDELRPPGSALAEGEIICSTPFALEALITSWGGEFVDLGIAPDDPAAIRARIQAADGVDVII
PLGGASVGDHDHMQAAFAEEGLEPVFSKVKLKPGKPTWFGKLHNTYVLGLPGNPASALVCAQLFLKPLIWQLTGRAGNDA
LVWRRARLTGPLEPPGSRETFLRGAAETEKDGRLTCTPAINQDSSLLRPFLTADLLIHRPANAPAAPEGSIVDCLMIR
>Mature_398_residues
MRTRIEALAAIIDIAAPMAPEAVSLGAAHGRVLAVPIHARITQPPAAVSAMDGYAVRQCDANLGNSLRVIGEAPAGRPFT
GALGLGEAVRIFTGSVVPRGADHVVIQEDTMRDGDQITVTASQPEPSNIRAAGIDFREGDLLLPAGRLLGAAELAIAAAA
NHAEVRAYPRPRIAVMANGDELRPPGSALAEGEIICSTPFALEALITSWGGEFVDLGIAPDDPAAIRARIQAADGVDVII
PLGGASVGDHDHMQAAFAEEGLEPVFSKVKLKPGKPTWFGKLHNTYVLGLPGNPASALVCAQLFLKPLIWQLTGRAGNDA
LVWRRARLTGPLEPPGSRETFLRGAAETEKDGRLTCTPAINQDSSLLRPFLTADLLIHRPANAPAAPEGSIVDCLMIR

Specific function: Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP [H]

COG id: COG0303

COG function: function code H; Molybdopterin biosynthesis enzyme

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the moeA family [H]

Homologues:

Organism=Homo sapiens, GI66932975, Length=323, Percent_Identity=32.1981424148607, Blast_Score=144, Evalue=2e-34,
Organism=Homo sapiens, GI10880983, Length=323, Percent_Identity=32.1981424148607, Blast_Score=144, Evalue=2e-34,
Organism=Escherichia coli, GI1787049, Length=373, Percent_Identity=36.7292225201072, Blast_Score=214, Evalue=1e-56,
Organism=Caenorhabditis elegans, GI25147659, Length=393, Percent_Identity=31.0432569974555, Blast_Score=153, Evalue=1e-37,
Organism=Caenorhabditis elegans, GI17562606, Length=335, Percent_Identity=29.5522388059701, Blast_Score=97, Evalue=2e-20,
Organism=Drosophila melanogaster, GI17136978, Length=392, Percent_Identity=27.8061224489796, Blast_Score=117, Evalue=1e-26,
Organism=Drosophila melanogaster, GI24638841, Length=392, Percent_Identity=27.8061224489796, Blast_Score=117, Evalue=1e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020817
- InterPro:   IPR008284
- InterPro:   IPR005111
- InterPro:   IPR005110
- InterPro:   IPR001453 [H]

Pfam domain/function: PF00994 MoCF_biosynth; PF03454 MoeA_C; PF03453 MoeA_N [H]

EC number: NA

Molecular weight: Translated: 41720; Mature: 41720

Theoretical pI: Translated: 5.65; Mature: 5.65

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRTRIEALAAIIDIAAPMAPEAVSLGAAHGRVLAVPIHARITQPPAAVSAMDGYAVRQCD
CCHHHHHHHHHHHHHCCCCCCHHCCCCCCCCEEEEEEEEEECCCCHHHHHCCCCEEEECC
ANLGNSLRVIGEAPAGRPFTGALGLGEAVRIFTGSVVPRGADHVVIQEDTMRDGDQITVT
CCCCCCEEEEECCCCCCCCCCCCCCCCEEEEEECCCCCCCCCEEEEECCCCCCCCEEEEE
ASQPEPSNIRAAGIDFREGDLLLPAGRLLGAAELAIAAAANHAEVRAYPRPRIAVMANGD
ECCCCCCCEEEECCCCCCCCEEECCHHHHHHHHHHHHECCCCCEEEECCCCEEEEEECCC
ELRPPGSALAEGEIICSTPFALEALITSWGGEFVDLGIAPDDPAAIRARIQAADGVDVII
CCCCCCCCCCCCEEEEECCHHHHHHHHHCCCCEEEECCCCCCCHHHEEEEEECCCCEEEE
PLGGASVGDHDHMQAAFAEEGLEPVFSKVKLKPGKPTWFGKLHNTYVLGLPGNPASALVC
ECCCCCCCCCHHHHHHHHHHCHHHHHHHEEECCCCCCEEEECCCEEEEEECCCCHHHHHH
AQLFLKPLIWQLTGRAGNDALVWRRARLTGPLEPPGSRETFLRGAAETEKDGRLTCTPAI
HHHHHHHHHHHHCCCCCCCEEEEEEECCCCCCCCCCCHHHHHCCCCCCCCCCCEEEECCC
NQDSSLLRPFLTADLLIHRPANAPAAPEGSIVDCLMIR
CCCHHHHHHHHHHHEEEECCCCCCCCCCCCEEEEEEEC
>Mature Secondary Structure
MRTRIEALAAIIDIAAPMAPEAVSLGAAHGRVLAVPIHARITQPPAAVSAMDGYAVRQCD
CCHHHHHHHHHHHHHCCCCCCHHCCCCCCCCEEEEEEEEEECCCCHHHHHCCCCEEEECC
ANLGNSLRVIGEAPAGRPFTGALGLGEAVRIFTGSVVPRGADHVVIQEDTMRDGDQITVT
CCCCCCEEEEECCCCCCCCCCCCCCCCEEEEEECCCCCCCCCEEEEECCCCCCCCEEEEE
ASQPEPSNIRAAGIDFREGDLLLPAGRLLGAAELAIAAAANHAEVRAYPRPRIAVMANGD
ECCCCCCCEEEECCCCCCCCEEECCHHHHHHHHHHHHECCCCCEEEECCCCEEEEEECCC
ELRPPGSALAEGEIICSTPFALEALITSWGGEFVDLGIAPDDPAAIRARIQAADGVDVII
CCCCCCCCCCCCEEEEECCHHHHHHHHHCCCCEEEECCCCCCCHHHEEEEEECCCCEEEE
PLGGASVGDHDHMQAAFAEEGLEPVFSKVKLKPGKPTWFGKLHNTYVLGLPGNPASALVC
ECCCCCCCCCHHHHHHHHHHCHHHHHHHEEECCCCCCEEEECCCEEEEEECCCCHHHHHH
AQLFLKPLIWQLTGRAGNDALVWRRARLTGPLEPPGSRETFLRGAAETEKDGRLTCTPAI
HHHHHHHHHHHHCCCCCCCEEEEEEECCCCCCCCCCCHHHHHCCCCCCCCCCCEEEECCC
NQDSSLLRPFLTADLLIHRPANAPAAPEGSIVDCLMIR
CCCHHHHHHHHHHHEEEECCCCCCCCCCCCEEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 3045084; 8905232; 9278503; 9515915 [H]