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The map label for this gene is alkJ [H]

Identifier: 114798040

GI number: 114798040

Start: 1602374

End: 1603984

Strand: Reverse

Name: alkJ [H]

Synonym: HNE_1572

Alternate gene names: 114798040

Gene position: 1603984-1602374 (Counterclockwise)

Preceding gene: 114798228

Following gene: 114798420

Centisome position: 43.29

GC content: 59.71

Gene sequence:

>1611_bases
ATGGACACTGCAGCCACGCCCTACCCCGGCGACTATGATTACATCGTCGTCGGCGCCGGGTCGGCGGGATGTGTCGTTGC
AAATCGTCTGTCGAAAGATAAATCCCGCCGGGTATTGCTTCTGGAAGCGGGCGGCAAGGATAACTGGATCTGGTTTCACA
TTCCCGTCGGGTATCTTTTTGCCATTGGCAATCCGCGCTGCGACTGGATGTTTGAAACCACACCGCAGCCGGGCCTGAAT
GGCAGAACCCTCGCCTATCCGCGCGGCAAGGTCATAGGGGGATCGTCCGCAATCAATGCCATGATCTCGATGCGCGGCCA
GGCAGCAGATTATGACGCCTGGCGCGACAGCGGGTTGCCCGGTTGGGGCTGGGATGACGTTTTGCCCGTCTTTCGGCAAA
TCGAAGATCATTTCCTCGGCGAAAATGAATTTCATGGCACCGGCGGAGAATGGCGAGTCGAACCGCCACGGGTAAAATGG
GACATCCTCGACGCCGTCCGCAATGCGGCGGAGGAAATCGGCATTCCGAAAACCCCCGATTTCAATACCGGCGATAATAC
TGGCTCAGGTTATTTCCATGTGAATCAGAAAGCAGGGCGGCGGTGGTCTTCGGCGCGCGGTTTTCTGAAACCCGTCCTGA
CGCGCAGCAATCTGCGCCTGGAAACCGCGACCCTTGTGGAAACAGTGACACTGGATCAAGGACGCGCCACCGGCGTTGTA
TTCCGGCAGCACGGCCAGCGCTTTACCGCGCGAGCCAATGCGGAAGTCATTCTATGCGCTGGCGCAATCGGCAGCCCCCA
AATCCTCCAGCGTTCGGGTATTGGTCCCGCTCCGGTTCTGATCCGGGCGGGAATTGAACCGGTTGCAGAGCGGCCCGGTG
TTGGCGCCAATTTGCAGGACCACCTTCAACAGCGCGCCATTTACAAGGTCTCCGGAACGCCTACGCTGAACCAGACTTAC
TACTCCTTGTTTGGCAAAGCGGCGATGGGTCTGGACTATGCCATCCGGCGGCGCGGGCCTTTGACCATGGCGCCGTCTCA
GCTGGGCATTTTTGCGCGCTCGGACGAGAGCCAGACGCGGGCCAACATTCAGTTCCACGTCCAGCCACTGTCTCTGGACC
GGTTCGGCGAGCCGCTGCACCGGTATCCCGCCATCACCATCGCAGCATGTAATCTGCGCCCAACCTCGCGCGGAACGGTA
AACATAAAATCCGCTGAACCAGGGGCCCCGCCCGTTATCGATCCTAACTATCTTGGCACGGAGGAAGACCGGCGTGTCGC
CGCCGATGCGATCAGGCTGACCCGGCGGCTGATGCAACAGCCGGCGCTCAAACGCTTTGATCCGCAGGAAGCTGTTCCCG
GCATTGCCGATGACCGGGCGCTCTCAGAGATCGCCGGGGCGATCGGCACGACCATTTTCCATCCTGTGGGCACCGCAAGG
ATGGGCCGTGATGATGACCCGATGGCCGTCGTCGATGCTCAGCTTCGTGTGCGGGGTATCGGCGGGCTTCGTGTCATTGA
CGCGTCGATCATGCCTGAAATCACATCGGGCAATACAAATACGCCCACCATAATGATTGCGGCAAAGGGCGCCGCCATGA
TTATGAACTGA

Upstream 100 bases:

>100_bases
TGGAACGCCTTGGCGCAGAAGAGGCACGCTTTGCGCCCAGCGCCACGCTTCAACGACTCGCAAAGAACGGCGGCCGCTTC
ATCGATGTGCTTCCCGGCTG

Downstream 100 bases:

>100_bases
GGCGCGCTGCAGGGCTCACCCATTCGCGGCGGCGCTGACTAAAGCGCCGGTCTACGAGGCTTCACCGCATGCAGAATTCT
TGAGAATTCCGGAATGCCGC

Product: GMC oxidoreductase

Products: Betaine Aldehyde; Reduced Acceptor. [C]

Alternate protein names: NA

Number of amino acids: Translated: 536; Mature: 536

Protein sequence:

>536_residues
MDTAATPYPGDYDYIVVGAGSAGCVVANRLSKDKSRRVLLLEAGGKDNWIWFHIPVGYLFAIGNPRCDWMFETTPQPGLN
GRTLAYPRGKVIGGSSAINAMISMRGQAADYDAWRDSGLPGWGWDDVLPVFRQIEDHFLGENEFHGTGGEWRVEPPRVKW
DILDAVRNAAEEIGIPKTPDFNTGDNTGSGYFHVNQKAGRRWSSARGFLKPVLTRSNLRLETATLVETVTLDQGRATGVV
FRQHGQRFTARANAEVILCAGAIGSPQILQRSGIGPAPVLIRAGIEPVAERPGVGANLQDHLQQRAIYKVSGTPTLNQTY
YSLFGKAAMGLDYAIRRRGPLTMAPSQLGIFARSDESQTRANIQFHVQPLSLDRFGEPLHRYPAITIAACNLRPTSRGTV
NIKSAEPGAPPVIDPNYLGTEEDRRVAADAIRLTRRLMQQPALKRFDPQEAVPGIADDRALSEIAGAIGTTIFHPVGTAR
MGRDDDPMAVVDAQLRVRGIGGLRVIDASIMPEITSGNTNTPTIMIAAKGAAMIMN

Sequences:

>Translated_536_residues
MDTAATPYPGDYDYIVVGAGSAGCVVANRLSKDKSRRVLLLEAGGKDNWIWFHIPVGYLFAIGNPRCDWMFETTPQPGLN
GRTLAYPRGKVIGGSSAINAMISMRGQAADYDAWRDSGLPGWGWDDVLPVFRQIEDHFLGENEFHGTGGEWRVEPPRVKW
DILDAVRNAAEEIGIPKTPDFNTGDNTGSGYFHVNQKAGRRWSSARGFLKPVLTRSNLRLETATLVETVTLDQGRATGVV
FRQHGQRFTARANAEVILCAGAIGSPQILQRSGIGPAPVLIRAGIEPVAERPGVGANLQDHLQQRAIYKVSGTPTLNQTY
YSLFGKAAMGLDYAIRRRGPLTMAPSQLGIFARSDESQTRANIQFHVQPLSLDRFGEPLHRYPAITIAACNLRPTSRGTV
NIKSAEPGAPPVIDPNYLGTEEDRRVAADAIRLTRRLMQQPALKRFDPQEAVPGIADDRALSEIAGAIGTTIFHPVGTAR
MGRDDDPMAVVDAQLRVRGIGGLRVIDASIMPEITSGNTNTPTIMIAAKGAAMIMN
>Mature_536_residues
MDTAATPYPGDYDYIVVGAGSAGCVVANRLSKDKSRRVLLLEAGGKDNWIWFHIPVGYLFAIGNPRCDWMFETTPQPGLN
GRTLAYPRGKVIGGSSAINAMISMRGQAADYDAWRDSGLPGWGWDDVLPVFRQIEDHFLGENEFHGTGGEWRVEPPRVKW
DILDAVRNAAEEIGIPKTPDFNTGDNTGSGYFHVNQKAGRRWSSARGFLKPVLTRSNLRLETATLVETVTLDQGRATGVV
FRQHGQRFTARANAEVILCAGAIGSPQILQRSGIGPAPVLIRAGIEPVAERPGVGANLQDHLQQRAIYKVSGTPTLNQTY
YSLFGKAAMGLDYAIRRRGPLTMAPSQLGIFARSDESQTRANIQFHVQPLSLDRFGEPLHRYPAITIAACNLRPTSRGTV
NIKSAEPGAPPVIDPNYLGTEEDRRVAADAIRLTRRLMQQPALKRFDPQEAVPGIADDRALSEIAGAIGTTIFHPVGTAR
MGRDDDPMAVVDAQLRVRGIGGLRVIDASIMPEITSGNTNTPTIMIAAKGAAMIMN

Specific function: Converts aliphatic medium-chain-length alcohols into aldehydes. May be linked to the electron transfer chain [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GMC oxidoreductase family [H]

Homologues:

Organism=Homo sapiens, GI217272839, Length=544, Percent_Identity=40.0735294117647, Blast_Score=374, Evalue=1e-103,
Organism=Escherichia coli, GI1786503, Length=536, Percent_Identity=40.1119402985075, Blast_Score=347, Evalue=1e-96,
Organism=Caenorhabditis elegans, GI17532301, Length=542, Percent_Identity=33.7638376383764, Blast_Score=302, Evalue=3e-82,
Organism=Drosophila melanogaster, GI24642042, Length=567, Percent_Identity=35.8024691358025, Blast_Score=309, Evalue=2e-84,
Organism=Drosophila melanogaster, GI24642048, Length=572, Percent_Identity=37.4125874125874, Blast_Score=306, Evalue=2e-83,
Organism=Drosophila melanogaster, GI24642055, Length=570, Percent_Identity=35.6140350877193, Blast_Score=295, Evalue=5e-80,
Organism=Drosophila melanogaster, GI24642059, Length=566, Percent_Identity=34.6289752650177, Blast_Score=280, Evalue=2e-75,
Organism=Drosophila melanogaster, GI17137792, Length=558, Percent_Identity=34.4086021505376, Blast_Score=273, Evalue=2e-73,
Organism=Drosophila melanogaster, GI18859993, Length=574, Percent_Identity=34.8432055749129, Blast_Score=273, Evalue=2e-73,
Organism=Drosophila melanogaster, GI45549471, Length=568, Percent_Identity=33.9788732394366, Blast_Score=272, Evalue=5e-73,
Organism=Drosophila melanogaster, GI18859995, Length=563, Percent_Identity=35.5239786856128, Blast_Score=272, Evalue=5e-73,
Organism=Drosophila melanogaster, GI45551458, Length=565, Percent_Identity=33.8053097345133, Blast_Score=272, Evalue=5e-73,
Organism=Drosophila melanogaster, GI24642039, Length=563, Percent_Identity=34.6358792184725, Blast_Score=268, Evalue=9e-72,
Organism=Drosophila melanogaster, GI24650267, Length=569, Percent_Identity=32.8646748681898, Blast_Score=264, Evalue=1e-70,
Organism=Drosophila melanogaster, GI24642035, Length=577, Percent_Identity=33.6221837088388, Blast_Score=259, Evalue=2e-69,
Organism=Drosophila melanogaster, GI24642051, Length=575, Percent_Identity=32.695652173913, Blast_Score=244, Evalue=2e-64,
Organism=Drosophila melanogaster, GI24642037, Length=569, Percent_Identity=31.6344463971881, Blast_Score=238, Evalue=5e-63,
Organism=Drosophila melanogaster, GI24645930, Length=573, Percent_Identity=29.1448516579407, Blast_Score=177, Evalue=2e-44,
Organism=Drosophila melanogaster, GI24642057, Length=585, Percent_Identity=30.2564102564103, Blast_Score=170, Evalue=3e-42,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012132
- InterPro:   IPR000172
- InterPro:   IPR007867 [H]

Pfam domain/function: PF05199 GMC_oxred_C; PF00732 GMC_oxred_N [H]

EC number: 1.1.99.1 [C]

Molecular weight: Translated: 58227; Mature: 58227

Theoretical pI: Translated: 9.02; Mature: 9.02

Prosite motif: PS00624 GMC_OXRED_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDTAATPYPGDYDYIVVGAGSAGCVVANRLSKDKSRRVLLLEAGGKDNWIWFHIPVGYLF
CCCCCCCCCCCCCEEEEECCCCCEEEHHHHCCCCCCEEEEEECCCCCCEEEEEECCEEEE
AIGNPRCDWMFETTPQPGLNGRTLAYPRGKVIGGSSAINAMISMRGQAADYDAWRDSGLP
EECCCCCCEEEECCCCCCCCCCEEECCCCCEECCHHHHHHHHHHCCCCCCCCHHHCCCCC
GWGWDDVLPVFRQIEDHFLGENEFHGTGGEWRVEPPRVKWDILDAVRNAAEEIGIPKTPD
CCCHHHHHHHHHHHHHHHCCCCCCCCCCCCEEECCCCCHHHHHHHHHHHHHHCCCCCCCC
FNTGDNTGSGYFHVNQKAGRRWSSARGFLKPVLTRSNLRLETATLVETVTLDQGRATGVV
CCCCCCCCCCEEEECHHHCCCHHHHHHHHHHHHCCCCCEEEEEHEEEEEEECCCCCEEEE
FRQHGQRFTARANAEVILCAGAIGSPQILQRSGIGPAPVLIRAGIEPVAERPGVGANLQD
EECCCCEEEECCCCCEEEEECCCCCHHHHHHCCCCCCCEEEECCCCHHHHCCCCCCCHHH
HLQQRAIYKVSGTPTLNQTYYSLFGKAAMGLDYAIRRRGPLTMAPSQLGIFARSDESQTR
HHHHCEEEEECCCCCCHHHHHHHHHHHHHCHHHHHHCCCCCEECCCCCEEEEECCCCCCC
ANIQFHVQPLSLDRFGEPLHRYPAITIAACNLRPTSRGTVNIKSAEPGAPPVIDPNYLGT
CEEEEEEEEECHHHCCCHHHHCCEEEEEEECCCCCCCCEEEEECCCCCCCCCCCCCCCCC
EEDRRVAADAIRLTRRLMQQPALKRFDPQEAVPGIADDRALSEIAGAIGTTIFHPVGTAR
CHHHHHHHHHHHHHHHHHHCHHHHCCCHHHHCCCCCCHHHHHHHHHHHHHHHHCCCCCCC
MGRDDDPMAVVDAQLRVRGIGGLRVIDASIMPEITSGNTNTPTIMIAAKGAAMIMN
CCCCCCCEEEEEEEEEEEECCCEEEEEHHHCCEECCCCCCCCEEEEEECCEEEECC
>Mature Secondary Structure
MDTAATPYPGDYDYIVVGAGSAGCVVANRLSKDKSRRVLLLEAGGKDNWIWFHIPVGYLF
CCCCCCCCCCCCCEEEEECCCCCEEEHHHHCCCCCCEEEEEECCCCCCEEEEEECCEEEE
AIGNPRCDWMFETTPQPGLNGRTLAYPRGKVIGGSSAINAMISMRGQAADYDAWRDSGLP
EECCCCCCEEEECCCCCCCCCCEEECCCCCEECCHHHHHHHHHHCCCCCCCCHHHCCCCC
GWGWDDVLPVFRQIEDHFLGENEFHGTGGEWRVEPPRVKWDILDAVRNAAEEIGIPKTPD
CCCHHHHHHHHHHHHHHHCCCCCCCCCCCCEEECCCCCHHHHHHHHHHHHHHCCCCCCCC
FNTGDNTGSGYFHVNQKAGRRWSSARGFLKPVLTRSNLRLETATLVETVTLDQGRATGVV
CCCCCCCCCCEEEECHHHCCCHHHHHHHHHHHHCCCCCEEEEEHEEEEEEECCCCCEEEE
FRQHGQRFTARANAEVILCAGAIGSPQILQRSGIGPAPVLIRAGIEPVAERPGVGANLQD
EECCCCEEEECCCCCEEEEECCCCCHHHHHHCCCCCCCEEEECCCCHHHHCCCCCCCHHH
HLQQRAIYKVSGTPTLNQTYYSLFGKAAMGLDYAIRRRGPLTMAPSQLGIFARSDESQTR
HHHHCEEEEECCCCCCHHHHHHHHHHHHHCHHHHHHCCCCCEECCCCCEEEEECCCCCCC
ANIQFHVQPLSLDRFGEPLHRYPAITIAACNLRPTSRGTVNIKSAEPGAPPVIDPNYLGT
CEEEEEEEEECHHHCCCHHHHCCEEEEEEECCCCCCCCEEEEECCCCCCCCCCCCCCCCC
EEDRRVAADAIRLTRRLMQQPALKRFDPQEAVPGIADDRALSEIAGAIGTTIFHPVGTAR
CHHHHHHHHHHHHHHHHHHCHHHHCCCHHHHCCCCCCHHHHHHHHHHHHHHHHCCCCCCC
MGRDDDPMAVVDAQLRVRGIGGLRVIDASIMPEITSGNTNTPTIMIAAKGAAMIMN
CCCCCCCEEEEEEEEEEEECCCEEEEEHHHCCEECCCCCCCCEEEEEECCEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: Coenzyme Q [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): 7 {choline}} 1.1 {phenazine}} [C]

Substrates: Choline; Acceptor [C]

Specific reaction: Choline + Acceptor = Betaine Aldehyde + Reduced Acceptor. [C]

General reaction: Redox reaction [C]

Inhibitor: 2-Dimethylaminoethanol; Betaine aldehyde; Monoethanolamine; Semicarbazide [C]

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 1453953 [H]